LOCUS       MED193         4674670 bp    DNA     linear   CON 09-NOV-2005
DEFINITION  Roseobacter sp. MED193.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Roseobacter sp. MED193
  ORGANISM  Roseobacter sp. MED193
            Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
            Rhodobacteraceae; Roseobacter.
REFERENCE   1  (bases 1 to 4674670)
  AUTHORS   Pinhassi,J., Pedros-Alio,C., Ferriera,S., Johnson,J., Kravitz,S., Halpern,A.,
            Remington,K., Beeson,K., Tran,B., Rogers,Y.-H., Friedman,R. and
            Venter,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-NOV-2005) J Craig Venter Institute, 9704 Medical
            Center Drive, Rockville, MD 20850, USA
FEATURES             Location/Qualifiers
     source          1..4674670
                     /organism="Roseobacter sp. MED193"
                     /mol_type="genomic DNA"
                     /strain="MED193"
                     /db_xref="taxon:314262"
     gene            complement(<1..823)
                     /locus_tag="MED193_00005"
     CDS             complement(<1..823)
                     /locus_tag="MED193_00005"
                     /note="COG0582 Integrase"
                     /codon_start=1
                     /transl_table=11
                     /product="integrase/recombinase"
                     /db_xref="CDD:27734"
                     /translation="MTEERVTPLRQRMIDDMRIRGMGEKAQKSHIRAIKDFAAFLGRP
                     PDTATPEDLRAYQLHMTDSGVTPSTFNVRIVALRFFFSMTCGREEMKRYMQFRTEPRK
                     LPVVFSVEEVSDILMAAPGPGLKYRAALSISYGAGLRASEVCNLKISDIDSDRMLIHV
                     ELGKGQKDRKVMLSPGLLELLRAWWREARPEGWLFPGKPKINPISPRQLSRAFTSAKH
                     MAGVKKPATLHTLRHSFATHLLEQHRRAGYSVLLGTQLTTLRDTLMWHRRSATLSA"
     gene            1182..2108
                     /locus_tag="MED193_00010"
     CDS             1182..2108
                     /locus_tag="MED193_00010"
                     /note="COG0697 Permeases of the drug/metabolite
                     transporter (DMT) superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="putative membrane protein"
                     /db_xref="CDD:12307"
                     /translation="MATASTQSRPAIPYALAIAGVLFASVCFGLVPYFSRGLTEQGIA
                     PYAVAFYRYIVAAILLLPVLFKHRQAWSEISWGLSAGAVMGLGWIGYVMALETLPAST
                     VGVLYMTYPVFTLVIAWAFFSDAPTKRALLASGLITVAAIIAGSPASVPLQHIPMLLL
                     SLAAPFGFGFGICVLVHRLSRIPPLARIASVSLGSVLGLLPLMAGADIAELLPAGQSD
                     WVLIVGIGLITALVPQLVYTICSPLIGASQTAVVGSIELPTMFAVGVIAFDEVITMHQ
                     AVACALVLGAIAITRSRKTRTVTTVIARKPKK"
     gene            2274..4205
                     /locus_tag="MED193_00015"
     CDS             2274..4205
                     /locus_tag="MED193_00015"
                     /EC_number="1.14.13.7"
                     /note="COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="phenol 2-monooxygenase"
                     /db_xref="CDD:10524"
                     /translation="MQYYVDGFRPGDPDVKAPAPGRDRSLNGAIPDKVDVLIAGCGPA
                     GLCLAAQLAGFSEITTMIVEPKHGPMEKGQADGVNVRSMEMFQAFGFAEKVKREAYWV
                     NQTTFWKPDPGNSDHITRVGIAQDVADDQSEMPHTIVNQARIHQLFLDVMRKSPTRLE
                     PHYGLRVLDIEIDTGAEEYPVTVTLERVKEDGSAGETLTLRANYVVGCDGARSNVRKA
                     IGGKLHGDAAHQAWGVMDILANSDFPDLRRKCLIQSAKEGNVLIIPREGGYLFRMYVE
                     LDKLNPDERVSNRNLTSDHIIAAANRIMRPYTIDVKEVVWWSVYEIGHRLTDKFDDVP
                     EGETATRNPRVFTAGDACHTHSPKAGQGMNVSMGDTFNLGWKLAHVLTGRADASLLHS
                     YSAERLEEAKRLVETDHKWARVMSAPPGESELDGTDMPRFQKQFIENLEFTGGLAVHY
                     DPSRIIAETEHQRLATGQIIGKRFHSAPVLRLSDAKPLHLGHVAQADGRWRLYAFAGK
                     DDVGTSGGAIDRLCAWLESDPASPVQRFTRKTEDIDGLIDLRAVFQQDFKSLNYEAMP
                     SLLRPAKGRYGLRDFEKVFCVDHKLGDDIYDMRGIDRTKGCTIVVRPDQYVAHILPLD
                     AFDDLTAFFDGVFKPRDEA"
     gene            4319..5242
                     /locus_tag="MED193_00020"
     CDS             4319..5242
                     /locus_tag="MED193_00020"
                     /note="COG0679 Predicted permeases"
                     /codon_start=1
                     /transl_table=11
                     /product="predicted permease"
                     /db_xref="CDD:10548"
                     /translation="MTDVVLLMLPIFTMIAIGSLFVWRGWFPTEGLPVLNKFVMNACI
                     PVLLFSAITNGESLSDFSWLNSVTYAAGSLGSVVFLWVLLRYGFREAQPQSVILALGG
                     ATANTIFLGFPIASAFIPGRAAEAFAWVVFAEVAIIMPLITTLALLAEERHEGNALST
                     ALKALFRSPVVLGLLGGFAFLATGLSLPGWGDQVVTSIVSAAPFVALFVIGGSILQFR
                     MSRSGPRVLAVTLTKLVVHPLVVGVAFWAVFGWADPVTRDAILFACMPLFLSFVAFCG
                     RHSVGDVGASAIVMSTLLGAVTVPVVLGFLF"
     gene            complement(5263..5451)
                     /locus_tag="MED193_00025"
     CDS             complement(5263..5451)
                     /locus_tag="MED193_00025"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTQQELEDVYAALAHRIDAVGPDNCQLFLAKLSLLLAYENGDAE
                     KVADCIDAAAASLSLRDI"
     gene            complement(5448..6947)
                     /locus_tag="MED193_00030"
     CDS             complement(5448..6947)
                     /locus_tag="MED193_00030"
                     /note="COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="Monooxygenase, FAD-binding"
                     /db_xref="CDD:10524"
                     /translation="MTAALALAREGIRSVVFDNKSTFNDGSRAICIARPSFYILEQIG
                     AVEPFLEKALGWTTGRSFFRGDQILEFQMPDSKDEKYRPMYNLQQQYIEQFLWQTVER
                     SDLIEVRWQSEVIGVEDTETGARLTVSDPHGDYPFEATWILACDGARSPMRKMRGLRL
                     KGENFEGRYVIADIRMAHDYPTIRRALFDPECRPGGTVLIHKQPDDIWRIDYQLGDDE
                     NTEDAIKEQTVRDSVTSVLRDIGHDGPWELEWWSVYSANTLALDDYRDGRVFFVGDSA
                     HIVPIFGVRGLNNGLADAANIGWKLGWVLNGKASEALLDSYTPERRGATLDVFANASK
                     SARFMTPNTQGWRIMRDAALSLALTKPFAGELANPRQMTAFTYADSPAVLPDDPAFTE
                     GPSVGALMPDMPLGGAFLSDRLGAGFNVICFSQELKEQLAELLPSYDALCVMCLPFPC
                     AISDKLGAGKMTAYLIRPDMHIAARWKETGAETIFNALLSVTFTKGTGQ"
     gene            complement(7199..8686)
                     /locus_tag="MED193_00035"
     CDS             complement(7199..8686)
                     /locus_tag="MED193_00035"
                     /note="COG1593 TRAP-type C4-dicarboxylate transport
                     system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter, DctM subunit,
                     putative"
                     /db_xref="CDD:11306"
                     /translation="MIGLLSFPALLILIFLRVPIGLAMFLAGLVGLVAVTGDTTIPFA
                     RLKSETFGTFSNYSLSIVPMFLLMGYFATLGGMSQSLFKAAESWLGHRKGGVAMASVG
                     ACAGFGAICGSSLATAATMSRVALPELKAYGYAGGFSTATLAAGGTLGILIPPSVVLV
                     IYAILTEQNIAKLFLAAFIPGILAAAGYMITIAIYVRINPANGGTTRARMPYLDRFRA
                     LFDVWPVLLVFFLVVGGIYLGWFTPTEGAAVGAFGTGLIAWLAGGLTRTTLSESFFVT
                     ARASAMIFFIVLGAAFYNGFLALTQLPQEAASWVGGSGLSPWLILMIILVFYLLLGCL
                     MDSLSMILLTIPIFWPIMQELDFGLVSMVELQSAKLDDLVASGAEISASVLQEAQALL
                     ASGQELSREMTRELGLRGVNQGALNRVNVEYTAIWFGILVLIVVEVGLITPPVGMNLF
                     VINAMDKKTPMVDTYKAVLYFVGSDLIRVMILVAFPFITLALLPL"
     gene            complement(8695..9279)
                     /locus_tag="MED193_00040"
     CDS             complement(8695..9279)
                     /locus_tag="MED193_00040"
                     /note="COG4606 ABC-type enterochelin transport system,
                     permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:9849"
                     /translation="MHTFFDGLARTFARLGGYVLTILIVLTCLSILGRSLNTILNGEF
                     IQSVMPGLAAALLNTGVGPIKGDFEIVEAGMAFAIFAFLPLCQLNGAHASVDIFSSKL
                     PLRANRLLRAVIEVVFAAVLILIAWQLFEGMQSKRNSGETTFYLEFPIWWAYAVSLVA
                     AIVAAIVSIYVATMRVVESATGNRVLPPELEADH"
     gene            complement(9340..10386)
                     /locus_tag="MED193_00045"
     CDS             complement(9340..10386)
                     /locus_tag="MED193_00045"
                     /note="COG1638 TRAP-type C4-dicarboxylate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter, DctP subunit"
                     /db_xref="CDD:8627"
                     /translation="MTMLKKTRNLLLGSAVAAMAATGALAQEVTLKLHQFLPAQANVP
                     KLVLDVWADKVEADSNGRIKVDRFPSMQLGGKPPELYSQAVDGIADVIWTVVGYTPGR
                     FPTTEVFELPFFVQDARAASCAFWKMHEEHTRDGEFKDTKILATWVHGPGAFHTSDPV
                     ESPEDLQGMKIRGGSRLVNKLLEQVGATPVGLPVPSIPESLSKGVIDGATIPWEVTTA
                     LKVPELVEFHTEFEGAGLYTLTFVVAMNQAKYDSLPDDLKAVIDANAGLEFSVFGGGT
                     QADADGPARQIAVDNGNEIYTVTDTQPWLDVVEPVYAEWVADMDSKGIDGQALIDQAR
                     ALMSGECAGANAKF"
     gene            10868..11044
                     /locus_tag="MED193_00050"
     CDS             10868..11044
                     /locus_tag="MED193_00050"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MVSARIAAQDSGAIGGCLTHGVARDRTWNITSEAVGHSVNQGAA
                     LFEFLEHHGIASKR"
     gene            complement(11166..12095)
                     /locus_tag="MED193_00055"
     CDS             complement(11166..12095)
                     /locus_tag="MED193_00055"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="pca operon transcriptional activator PcaQ"
                     /db_xref="CDD:10453"
                     /translation="MDRRIKFRHLDTFSAIARAGSFKKAAAELNLSQPAISKALKELE
                     GILGTDLMERDRSGIKLTQKGEVFLQFAEQSTAALRHGLRSVRTSGDAKEHLNIGVLP
                     SVASGLLPAAVSAFLKGNPDTLLEVHEGPHTDLTSRLRSGKLDLVVGRLGRPQSMQGL
                     VFRQLCSEEVVVVAAPQSNARSIHRFEDLDRFRVLYPPQDSAIRPLVARMLISRGIPL
                     FPNRIETASAAFGRALTLADPNTVWIISRGVVLGDIEEGRLVRLEVDTGPTVGAVGIM
                     SIADDVPTPAIRAFSSALIRAANRGAEANANSD"
     gene            12189..13358
                     /locus_tag="MED193_00060"
     CDS             12189..13358
                     /locus_tag="MED193_00060"
                     /EC_number="1.14.13.2"
                     /note="COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybenzoate 3-monooxygenase"
                     /db_xref="CDD:10524"
                     /translation="MKTQVAIIGGGPSGLLLSQLLHTRGIESIVLERKTKDYVLSRIR
                     AGVLEQGLVRLLEEAGCAERLHAEGYVHDGTLVSYGDEMFRVDFTEHTGTPVIVYGQT
                     EVTRDLYAAREAAGGIIEYEVEDVVINNADSDAPYITYTVGGEPRRVDCDFVAGCDGF
                     HGISRQTIPLDVRREYEKVYPFGWLGILSETPPVNHELIYANSTRGFALCSMRNENLS
                     RYYIQCSLSDKPEDWTDEAFWQELKRRIPADQAAKLVTGPSIEKSIAPLRSFVTEPMR
                     YGNLFLCGDAAHIVPPTGAKGLNTAASDVHYLYNGLRAFYETGSREGIDSYSEKALKR
                     VWKAERFSWWFSSLMHRYPHQSEFDLKMQIADLEFLRSNKAAQQAMAENYVGLPY"
     gene            13380..13763
                     /locus_tag="MED193_00065"
     CDS             13380..13763
                     /locus_tag="MED193_00065"
                     /note="COG0599 Uncharacterized homolog of
                     gamma-carboxymuconolactone decarboxylase subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="4-carboxymuconolactone decarboxylase"
                     /db_xref="CDD:10469"
                     /translation="MTDRYNTGMATRRSVLGDAHVNRAEAAKSDFDLPFQTLITEGAW
                     GTVWADDSISRRERSMLTLALLAATGNFEEIPMHIRATANTGASKDDVMQALLHVAIY
                     AGVPKANHAIKLAKSTYAEMEEMTS"
     gene            13760..14488
                     /locus_tag="MED193_00070"
     CDS             13760..14488
                     /locus_tag="MED193_00070"
                     /note="COG3485 Protocatechuate 3,4-dioxygenase beta
                     subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="protocatechuate 3,4-dioxygenase beta subunit"
                     /db_xref="CDD:12813"
                     /translation="MTTPGEFYQRDRSVHPPALTPNYKTSVARSPRYSLISLQNSVSE
                     ITGPVFGHNDIDAGDNDLLTNYAKAGESPIGERIILHGRVLDENVKPVPNTLVEVWQA
                     NAGGRYRHKKDTYLAPIEPNFGGCGRTLTDENGYYYFRTVKPGAYPWRNMVNNWRPAH
                     VHVSVFGSSFVQRLITQCYFEGDPLIPICPIVQTIPDPDAIEQLTAKLDLKASIPLDT
                     IAYRFDIVLRGRRSTLFENRLEGN"
     gene            14492..15112
                     /locus_tag="MED193_00075"
     CDS             14492..15112
                     /locus_tag="MED193_00075"
                     /note="COG3485 Protocatechuate 3,4-dioxygenase beta
                     subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="protocatechuate 3,4-dioxygenase alpha subunit"
                     /db_xref="CDD:12813"
                     /translation="MSEQLNYLKESASQTAGPYVHIGLAPGAAGFDIYKQELGWDIAG
                     PNAKGERIRVEGRVIDGMGAPIKDVLLEVWQANAEGHHAHPEGGGPVEDGFRGWGRVI
                     TDFETGEWGFDTVKPGKTRGRNVGTQAPHLNFWIVARGINIGLNTRMYFDDEVEANAK
                     DPVLNLIEWEHRRATLVAKRSERDGVLVYRFDITLQGEDETVFFDV"
     gene            complement(15196..16257)
                     /locus_tag="MED193_00080"
     CDS             complement(15196..16257)
                     /locus_tag="MED193_00080"
                     /EC_number="5.5.1.2"
                     /note="COG0015 Adenylosuccinate lyase"
                     /codon_start=1
                     /transl_table=11
                     /product="3-carboxy-cis,cis-muconate cycloisomerase"
                     /db_xref="CDD:9891"
                     /translation="MTNPFLQSGLFGTLFRDQTIAAEFGVDAFLARMCRFEVAWTRAL
                     EAAGQITRFEADAAVEVIAQSSWRDYSAASDKDGLPVPGLVASLREGRETRVASAIHT
                     GATSQDVIDTAMVLTCLNVLDELEDRLATLVDRLETLLDASRDLPLMARTRMQAAVPA
                     TVGLRVSSWLRPLVDHQSRIQALRQDLAKVQVGGAVGKRDTPADHAELVAEHVAHALG
                     LSLGPVWHTDRTSLVGFGHWLTLVSGSLGKIGQDIALMTQQGVDEIVLDGGGGSSAMP
                     HKQNPVLAEAIVALSRFVAHQQGLLAQSMIHEQERSGSALALEWMTLPAMAEATGASL
                     RHTDGLIASIKRIGSQQTA"
     gene            complement(16327..18594)
                     /locus_tag="MED193_00085"
     CDS             complement(16327..18594)
                     /locus_tag="MED193_00085"
                     /EC_number="2.3.1.8"
                     /note="COG0281 Malic enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /db_xref="CDD:10155"
                     /translation="MTTDLKTEALDYHARGPAGKMQTLPTKPMTTQHDLALAYSPGVA
                     YPCEEIAADPATAALYTARAHTVAVITNGTAVLGLGNIGALASKPVMEGKAALFKKFS
                     GLDCVDLEVDETDPTQFIEAVARLEPSFGGINLEDIKAPECFVIEKALKQRMGIPVFH
                     DDQHGTAIVTAAGILNALRLVEKRIEDVRIVANGAGAASLACLDLLVSFGASKDNIIV
                     CDSKGPIHTERDNLDQYKGAYAAKTNARDLAEAMVDSDIFLGLSVAGAVTKEMVASMA
                     DQPIIFAMANPEPELRPELVREVRDDAIIATGRSDYPNQVNNVLCFPFIFRGALDCGA
                     TEINEEMKRACAIGISEMTRKAAPHTVLAAYGIDSLKFGRDYIIPKPFDPRLIIEIAP
                     LVAEAAMKSGVAARPIEDLDAYREELRRHVFRSGLLMKPVFDLAMRNPVRIAFAEGVE
                     ERVLHCADQAIRQGIAKPVLIGSVERIEAKIKDLGLSLANGTDIEIVDPHTMDRSALS
                     EDLHKRIGRDGINVVEAERWVRNDRTVLANLLLAHDKVDAVICGTGGRFGHQLGMVEK
                     IIGRRDGARALSTLNALVMAKGTIFIADAYANLDPTAEDIAEIAILSARAVRRMGVTP
                     RAALISHANFGDRPSPSAVKMRQALDLLRGTSVDFEVDGEMHVNAALDPAQRERAYAH
                     STLKGPANLLVMPNADAAHIALNLLREMGEGVSVGPILVGAAKPVHIASQSVTVRGLL
                     NLTALAAVDAAKNSA"
     gene            complement(18677..19885)
                     /locus_tag="MED193_00090"
     CDS             complement(18677..19885)
                     /locus_tag="MED193_00090"
                     /note="COG3135 Uncharacterized protein involved in
                     benzoate metabolism"
                     /codon_start=1
                     /transl_table=11
                     /product="Benzoate membrane transport protein"
                     /db_xref="CDD:5636"
                     /translation="MSDAIGYRRPRLSDISGSAIGAGFLAVLVSYAGPLLIYLSAAEA
                     MGIGKEAFSSWVFAISVAAGLSSIGLSLWFRVPIAMAWSAPGTVLLIALGTSLSPAEM
                     VGAYIAVAAVLVLIGVSGVFERLVQFLPPSVTNGMMAGILFGFGLKAAGGLASDPAAI
                     GLLIAVFAMSAVIFPRYAMLVLLASALLISAVFYDASVGTVSLAFASPEVTGATFSTG
                     AMLSLALPLLITTLSGQYLPGMAILRASGFSVSANPILIVGGLVSVAGAFLGGITTAL
                     ASITAAFCAGPDSHEDPDRRYVAGVACGVFFCLGGLFAGSIVEILILLPSALIALLAG
                     LALLQPILKFTSAMLASDDVQAGLLTFIFTASGVSLFGIGAAFWGVVVGIAVHFLTKA
                     VTALKNGTKT"
     gene            complement(19878..20501)
                     /locus_tag="MED193_00095"
     CDS             complement(19878..20501)
                     /locus_tag="MED193_00095"
                     /note="COG2057 Acyl CoA:acetate/3-ketoacid CoA
                     transferase, beta subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoadipate CoA-succinyl transferase, beta
                     subunit"
                     /db_xref="CDD:11765"
                     /translation="MPWDRNQMAARAAQELEDGMYVNLGIGIPTLVANYVGDKDITLQ
                     SENGMLGMGPFPFEGEEDPDLINAGKQTITELARTSYFDSATSFGMIRGGKIAAAVLG
                     AMEVSEKGDLANWMIPGKLVKGMGGAMDLVAGVGRVIVVMDHTNKHGDSKVLKECTLP
                     LTGKGVVDRIITNLGVLDVTNKGLHIVECADGVSREDIVKATEATIV"
     gene            complement(20501..21205)
                     /locus_tag="MED193_00100"
     CDS             complement(20501..21205)
                     /locus_tag="MED193_00100"
                     /note="COG1788 Acyl CoA:acetate/3-ketoacid CoA
                     transferase, alpha subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoadipate CoA-succinyl transferase, alpha
                     subunit"
                     /db_xref="CDD:11499"
                     /translation="MKKVYGTAAEALDGLLHDGMLIAAGGFGLCGIPELLIDALVDSG
                     VKNLTVASNNAGVDDFGLGKLLATRQIKKMMSSYVGENAEFMRQYLAGELELEFNPQG
                     TLAERMRAGGAGIPGFYTQTGVGTQIAEGKEVKVWGEKEYILEEGIFADLSIVKAWKA
                     DDTGNLIFRKTARNFNPPAAMCGRFCVAEVEEIVPRGSIDPDHIHLPGIYVHRLIQGA
                     HEKRIEQRTVRKREDA"
     gene            complement(21202..22062)
                     /locus_tag="MED193_00105"
     CDS             complement(21202..22062)
                     /locus_tag="MED193_00105"
                     /note="COG3246 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:24077"
                     /translation="MTNPCIICVAITGSLPTKANNPAVPISVSEQVESTQEAFEAGAT
                     IVHAHVRNDDETPSSDPDKFAALKEGIEKHCPGMIIQFSTGGRSGAGQTRGGMLSLKP
                     DMASLSVGSNNFPTRVYENPPDLVDWLASEMLKYDVKPEIEAFDLSHILKAKDMADKG
                     QLAGTPYVQFVMGVKNAMPVDRDVFDYYIHTVHRLFGDDAPWCAAGIGANQLKLNEWA
                     IAAGGHARTGLEDNVRLDRDTLAPSNAALVRRAVEICNRNNRPVASWQEARRILGLRL
                     SESAEKGHAA"
     gene            complement(22123..22200)
                     /locus_tag="MED193_00110"
     CDS             complement(22123..22200)
                     /locus_tag="MED193_00110"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MFFTDEERQAAEASTTAPSLVDEHS"
     gene            complement(22296..23153)
                     /locus_tag="MED193_00115"
     CDS             complement(22296..23153)
                     /locus_tag="MED193_00115"
                     /note="COG0596 Predicted hydrolases or acyltransferases
                     (alpha/beta hydrolase superfamily)"
                     /codon_start=1
                     /transl_table=11
                     /product="putative hydrolase"
                     /db_xref="CDD:23022"
                     /translation="MSIEPITGRYVTVMIEGAPRRIYFEEAGQGRPVICLHTAGADTR
                     QWRHLMNDAEITTSNRLIAFDMPWHGKSLPPEGFETQEYLLTTEAYIETILAVIDGLG
                     LDRPVLAGCSMGGRIALQLAALHPEKFSGFIAIEASDFQPAWYDIDWFHRPDAHGGEM
                     GAALVSANISPYAPASERWNTLWMFMQSGPGVFRGDLSFYTKDDSLIPRLPTIDTAQT
                     PVHIIVGAYDLTCTPEDAERTAKAIPGATLSVMDELGHFPMSEHPEGFRPFFVEALEK
                     MPKRAAEAA"
     gene            complement(23150..23551)
                     /locus_tag="MED193_00120"
     CDS             complement(23150..23551)
                     /locus_tag="MED193_00120"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNAWETKVINTFKQIQTRLEATPHLQRLGRLFSETVLIEIDGNE
                     YYLTFEKGHIVSVVEGPSRKTPWRFALRTDAEALDKFWQARPEPGFHDIFGLVKIGRG
                     RIDGDILSLVKNLRFFKEVLGLARAKEEVAA"
     gene            23797..24672
                     /locus_tag="MED193_00125"
     CDS             23797..24672
                     /locus_tag="MED193_00125"
                     /note="COG3485 Protocatechuate 3,4-dioxygenase beta
                     subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="dioxygenase"
                     /db_xref="CDD:25612"
                     /translation="MGIVNQDNITDVVIDSLGKHGDITDREREIATGLIKHMHAFVKD
                     VKLQHDEFLAACDYLARAGKLCDDNRQEFILLGDILGIEVLVDMMTNPVEGGESESTV
                     LGPFYRENPPVLPKGASTIQKHFDNEETAYFEGYIKDENGNGIAGVTLDVWEDAPNGI
                     YENLDPDQPEYNLRGRFETDENGHYAFVAVRPVPYPIPDDETAGELLRFMGHHPNRPG
                     HMHFIISKDGYRPLISQIYDADSAWLDEDSVFAVKESLIGKFKPADKDLGTDLHFEFD
                     FVLKEGVSEQAVAAE"
     gene            24769..25668
                     /locus_tag="MED193_00130"
     CDS             24769..25668
                     /locus_tag="MED193_00130"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator CatR"
                     /db_xref="CDD:10453"
                     /translation="MNFKQLTYFIAVAEELHFGRAAERLDMAQPPLSRQIKQLEDELE
                     AILFNRGRSAITLTQAGERLLKRGKAIVAQLEDTRLEVRRLGQGAEGRLRIGFVGSAT
                     FGILPNIIRSYRANYPEMNLSLTPMNNAQLYRALVSREIDVAFARPTLKDPEFLSKHL
                     VEEKLILALPDIVDTGNRTVAKLERLMTHNLILYPERPRPSYADMVIKAVEDAGFKAP
                     MRLWCMDLQTALSLVAVGEGVCIVPESVSNAPRKGMKFLNIEPEIARTELSVNYRVDE
                     QGVHVKNFVNIAQKVARKSPVKK"
     gene            complement(25787..26566)
                     /locus_tag="MED193_00135"
     CDS             complement(25787..26566)
                     /locus_tag="MED193_00135"
                     /EC_number="1.3.1.-"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="cis-diol dehydrogenase"
                     /db_xref="CDD:25396"
                     /translation="MTRRFEDKVMVVTGAAQGIGRRVAERAASEGASVLIVDRSPARK
                     DVVTAIRDAGGTAEAISVNLETWAGCEKAMQKAVDLWGRIDILVNNVGGTIWAKPYEH
                     YEPKQIEAEVRRSLFPTLFCCRAAIEHMLPCASGVIVNVSSIATRGLNRVPYAAAKGG
                     VNAITASLAWEVAERGIRVVATAPGGTEAPPRVVPRNPNAEEEQREDWYQTIVDQTIQ
                     SSLMKRYGTLDEQVGPILFLASEDASYITGVTVPVGGGDLG"
     gene            complement(26563..27585)
                     /locus_tag="MED193_00140"
     CDS             complement(26563..27585)
                     /locus_tag="MED193_00140"
                     /EC_number="1.18.1.3"
                     /note="COG0543 2-polyprenylphenol hydroxylase and related
                     flavodoxin oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="benzoate 1,2-dioxygenase ferredoxin reductase
                     subunit"
                     /db_xref="CDD:10746"
                     /translation="MTTYNIALNFEDGVTRIIQCDDDEKVTDAAFRQKINLPMDCRDG
                     VCGTCKCFVEKGEYELEFYMDESMSDEEAEEGYALTCQMTPESDCVVRVPASSAICKT
                     APEAVEAEVQGVDQLSETSFGLRVKLSKPIGFLPGQYVNLTVPGTDKHRSYSFSSAPG
                     ADEATFLIRNLPGGVMSSYLGGQVKAGDALTATGPMGAFYLRPIERAQLWLAGGTGLA
                     PFLSMLEQVAEQGSDQPIVLYYAVTRAADLVELDRVNALAEKIGNVTVITILAAEEDA
                     HERKGFVTDHVTAEDLNDGDCDVYLCGPPPMVDAVRTHFDELGVAPANFFYEKFNPTE
                     AAEEAA"
     gene            complement(27658..28185)
                     /locus_tag="MED193_00145"
     CDS             complement(27658..28185)
                     /locus_tag="MED193_00145"
                     /note="COG5517 Small subunit of phenylpropionate
                     dioxygenase"
                     /codon_start=1
                     /transl_table=11
                     /product="BENZOATE DIOXYGENASE SMALL SUBUNIT"
                     /db_xref="CDD:14601"
                     /translation="MNTATLERNDAATAMSYDEIQAFLFAEARALDDREWDTWLTFYH
                     KDCPFWMPAWDDYDTLTEDPQNEMSLMYYPNKQGIEDRVFRIKTDRSSATSLPEPRTN
                     HYLSGIEVLSREGSEIKLRFNWQTLSYRYGKTDQHWGTSFYTIDTSGPKPLITDKKVV
                     LKNDHIHHVIDVYHT"
     gene            complement(28198..29586)
                     /locus_tag="MED193_00150"
     CDS             complement(28198..29586)
                     /locus_tag="MED193_00150"
                     /note="COG4638 Phenylpropionate dioxygenase and related
                     ring-hydroxylating dioxygenases, large terminal subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="benzoate dioxygenase, alpha subunit"
                     /db_xref="CDD:13782"
                     /translation="MFTQSNLDEFEARLDGAIQDDPENGIFRCRRDIFTDEELFELEI
                     KHIFEGNWMYMAHESQIPEPGDYFTLTMGRTPVVITRDKDGELHALVNACSHRGAQLC
                     RFKRRNQKTFTCPFHGWTFSNTGKLLKVKDPKGAGYPEQFNKDGSHDLTKVARFESYR
                     GFLFGSLNADVKPLEEYLGEARKMIDIMVDQADEGLEVLRGSSTYTYDGNWKLQAENG
                     ADGYHVSAVHWNYVATTAHRTDDGKEDNIKATDASKWAKQRGGFHAYENGHILLWTEW
                     ADPTNRPGYPRLEEWTEKFGKTKADWMVGVLRNLCLYPNVFLMDQFSSQIRVFRPISV
                     NETEVTIYCIAPKGESQEARTRRIRQYEDFFNASGMATPDDTEEFRATQRGYAGASHA
                     KWNDLTRGATQWIEGPDEDAKALGINPVMSGARTEDEGLFVIQHSNWSERMGEAIAKE
                     RETAPGAAVAAE"
     gene            complement(29658..30857)
                     /locus_tag="MED193_00155"
     CDS             complement(29658..30857)
                     /locus_tag="MED193_00155"
                     /note="COG4948 L-alanine-DL-glutamate epimerase and
                     related enzymes of enolase superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="Mandelate racemase/muconate lactonizing enzyme"
                     /db_xref="CDD:24520"
                     /translation="MGGQSASQRNFADVVNPVTKIDQIETLILDIPTIRGHVLSMATM
                     RTQTAVLVKIKFSDGSEGIGEGTTIGGLSYGAESPESIQSAIDTYIAPALIGRGADDV
                     NGAIQLVDKIVKGNRIAKTAVEIALWDGLGKRLNVPVSQLFGGAVHDKLPVAWTLASG
                     NSDTDIAEAQEMIETRRHNIFKLKIGKRSVRDDVAHVARIKEAVGDAASVRVDINTAW
                     SLQDARWGLKGLQDAGCELVEQPVPARYRKAMAELTSGYEIAVMADEALNGPEDALEV
                     AAAHAADVFAVKIGQSGGLKRASEVIAIGQSAGLGLYGGTMLETGLSTAAALQLFSTV
                     EDLAWGTELFGPLLLTEDILAEPIIYCDFCVDIPKGTGIGATLDPDKIDFFRRDGGRT
                     IKAVAGQ"
     gene            complement(30997..31962)
                     /locus_tag="MED193_00160"
     CDS             complement(30997..31962)
                     /locus_tag="MED193_00160"
                     /note="COG2423 Predicted ornithine cyclodeaminase,
                     mu-crystallin homolog"
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase/mu-crystallin family
                     protein"
                     /db_xref="CDD:12077"
                     /translation="MLIIPEQEIADLMTRAAAFEAVESVFAAMASGDAYNFSVVREAI
                     GHEDALYGFKGGFDKAGLTLGLKAGGYWPNNLEKRGLINHQSTVFLFDPDTGKPSAMV
                     GGNLLTALRTAAASSVSIKHLARENATVIGMIGAGHQATFQLRAALEQRSFEKVIGWN
                     YHPEMLPNIEKVAREAVLPFEAVDLPGMVEADVIISITSAFAPSLMAEHVGPGTHVAC
                     MGTDTKGKQEVEAALLARATVFTDEVAQSISIGEAQHAVAEGLIEQSDIHQIGAVING
                     TNPGRISDDQITLFDGTGVGLQDLAVASAVVDLAVEKGVAIEVDF"
     gene            complement(32078..33244)
                     /locus_tag="MED193_00165"
     CDS             complement(32078..33244)
                     /locus_tag="MED193_00165"
                     /note="COG3616 Predicted amino acid aldolase or racemase"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine aldolase, low-specificity"
                     /db_xref="CDD:12940"
                     /translation="MKDSIDFDAYEVGFDIPAKPGMDAADIQTPALVLDLDALERNIK
                     KMGDYAKAHGMRHRAHGKMHKSVDVLKLQMEIGGAIGVCCQKVSEAEVFARAGIKEIL
                     VSNQVRDPGKIARLVQLPKFSGGEVIVCVDDVASVADLSSAAKNAGTELGVFIEIDCG
                     AGRCGVTTTPAVVEIAKAVVAADNLTYRGIQAYQGAMQHMDSFDDRKAKIDTAIRQVQ
                     DAVNALKDEGIETDLVSGGGTGSYYFESNSGLYNELQCGSYAFMDADYGRILDQDGKR
                     IDAGEWENAFFILTSVMSHAKADKAICDAGLKAQSVDSGLPFIYGRDDVEYVKCSDEH
                     GVIADPKGVLKVNEKLKLVPGHCDPTANVHDWYVGVRNGKVETVWPVSARGRAY"
     gene            complement(33259..34212)
                     /locus_tag="MED193_00170"
     CDS             complement(33259..34212)
                     /locus_tag="MED193_00170"
                     /note="COG1171 Threonine dehydratase"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-phosphate dependent enzyme"
                     /db_xref="CDD:10889"
                     /translation="MYIPTYDDMLAAHVRIAPHIRRTPVRTSDYLSDLAGCQLFFKCE
                     NFQEPGAFKVRGATNAVFGLDDAQAEKGVATHSSGNHASCLSYAAMLRGIPCNVVMPR
                     TAPQAKKDTVRRYGGKITECKPSTTSREATFAEVQAKTGGDFVHPYNDPRVIAGQGTC
                     SKEFMEQTDGLDMVVAPIGGGGMISGTCLTLSTLAPQTKVIAAEPEQADDAYRSFKAG
                     HIIADDAPKTIADGLLVPLKELTWHFVSNHVSEIYTASEQEIIDAMKLIWKHLRIVME
                     PSSAVPLATILKNPDAFEGKRVGIIITGGNVDLDKLPWALG"
     gene            complement(34212..35495)
                     /locus_tag="MED193_00175"
     CDS             complement(34212..35495)
                     /locus_tag="MED193_00175"
                     /EC_number="1.4.99.1"
                     /note="COG0665 Glycine/D-amino acid oxidases
                     (deaminating)"
                     /codon_start=1
                     /transl_table=11
                     /product="D-amino acid dehydrogenase small subunit"
                     /db_xref="CDD:10534"
                     /translation="MTRIAVIGAGITGVTTASSLMDRGYDVTLFDRNRYAAMQTSFAN
                     GGQLSASNAETWTRWSTVFKGMKWMLSRGAPLLVNPKPSWHKYSWMAEFVASIPQYRA
                     NTVETTRMAIAARGLLRDKAERHGFEFDCENRGILHIYTDKSEFDHATEVNTLLAEGG
                     LDRRAVAPEEVRQIEPALSGEFYGGYYTESDFTGDIHRYTTGLAKSIEKGGAVLRFGT
                     DVEALAVDKKEVRLTWSRNNESQTETFDGIVVCAGVESRAIAAQVGDRVNVYPVKGYS
                     ITVRLDDEESQSAAPWISLLDDEAKVVTSRLGKDRFRIAGTAEFNGYNMDIRDDRIRP
                     LVKWCERFFPDVSTEHAIPWAGLRPMMPNMMPRVGQGARDRVFYNTGHGHLGWTLSAV
                     TAEMVAETVAASNTVNCSKTTSARTPTTLASQGAV"
     gene            complement(35731..36219)
                     /locus_tag="MED193_00180"
     CDS             complement(35731..36219)
                     /locus_tag="MED193_00180"
                     /note="COG1846 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:15281"
                     /translation="MQSDKTFKNERLTYRLNIVAQEAIQANDEIFLSETGCRIRDLRV
                     LRLIDDTPGTTFAKISKITGFDRSLTSRIIQNLIASGLIERENSTEDARVFLLSTTSK
                     GKKVRQVARRLSDRLEVILTDPLSAQELRAFNEILARLGAWVTSEDYQSALTQETNKG
                     SR"
     gene            36366..37556
                     /locus_tag="MED193_00185"
     CDS             36366..37556
                     /locus_tag="MED193_00185"
                     /note="COG1473 Metal-dependent
                     amidase/aminoacylase/carboxypeptidase"
                     /codon_start=1
                     /transl_table=11
                     /product="hippurate hydrolase"
                     /db_xref="CDD:11187"
                     /translation="MFTTWYETQSRTSQNWLQTLHRHPETGFEVARTAAFVADRLSEL
                     GYTVVTGIAGTGVVGTLHGQDASPESPGRCIAFRAELDGLPMQEKAKVDYASEDPSRF
                     HGCGHDGHMVTALTAAAYLAEHRQFDGTVRFIFQPAEELLTGARAMIADGLFDRFPCD
                     EIYALHNSPDLPAGQVGIPTTAALSSADNIDVTIRANGAHGSMPHTGEDAILAAAQLI
                     TSVQQATTRLVDAREAGVISFGLFQGGTARNILPEAVRLEGTMRTTSSTVRDRLADLL
                     QDAVRATELLFGVLIEIDVEKVAPVTLNDPTCVSAAVSSATRVVGVERVVENARNLMA
                     SEDFSELSSIVPGAYFFIGQGGYAPHHPEFVFDPDIIPVGAAIFADLAKLRTSKTLNS
                     HKLT"
     gene            37585..38622
                     /locus_tag="MED193_00190"
     CDS             37585..38622
                     /locus_tag="MED193_00190"
                     /note="COG1638 TRAP-type C4-dicarboxylate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative extracellular solute-binding protein"
                     /db_xref="CDD:11350"
                     /translation="MINFTTKMLKGAVAATALVSATAQIASAEVLTMSSWVPPTHFVH
                     TDFLVPFTEKVAEVTEGRVTVTILPAPLASPPQHWELARNGVADITWGNFTYEPERFV
                     SMWFAEFPNAGTNAEAQSRALWQTYETYLADNAAFDGVKMLGVGMFGGGQLHHGSETV
                     TSPEDVANVKFRMGGPIQEKLLTSLGAVPVAAPATKAYEMLESGVIDGSLHTMESVVN
                     FRLEDSLKHHTIFPNGFYDATFFVIMNGAKWDGLSDEDKAAIEGIIGEELSAAWGKNF
                     DLQNPAATEKLGAAGHDIVEASPELIAAVDTIYDTMVADWVEAAKAAGVADPQAMLTF
                     YNDTYKSLAGE"
     gene            38690..39190
                     /locus_tag="MED193_00195"
     CDS             38690..39190
                     /locus_tag="MED193_00195"
                     /note="COG3090 TRAP-type C4-dicarboxylate transport
                     system, small permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative membrane protein"
                     /db_xref="CDD:9849"
                     /translation="MQSMAWKIRRGVETVMALFLLAMVALTFADVIGRRIVGKPIYGA
                     NDITEHLMALVVFAGLPLVTAAGAHLTIDLLDKLVSKPWMAWWRVLISILVTVVLAVI
                     AWLFVKHGLNASRIFEVSQALRVPRGPLYFFMAASCALSALAALAVTFTGPMVDPEDT
                     HEEEAL"
     gene            39187..40479
                     /locus_tag="MED193_00200"
     CDS             39187..40479
                     /locus_tag="MED193_00200"
                     /note="COG1593 TRAP-type C4-dicarboxylate transport
                     system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP-type C4-dicarboxylate transport system,
                     large permeasecomponent"
                     /db_xref="CDD:11306"
                     /translation="MIVGSIAMISAILLAFLRVPLAFSLLAVSVAGIGFAINWNIAFQ
                     LLPLTISDAVLSYDLAVVPMFILMGNVISKTGIAHDLFRAAYAFVGHVRGGLSLSTMV
                     ACSGFSAVCGSSYATAATMAKVAYPSMKKYNYSDELAAGTIAAGGTLGILIPPSIIMV
                     VYGILTQTNIGDLFIAGVIPGLLGLALYMIAIRVVAARNPEHAPQGELTAWPDRLKAL
                     SGIWPFVLLFGLIIGGLYAKLFTPTEAAGMGAGLAILIATFHGRLTWKVLRTVIIDTA
                     YTSVSLYTVLFGALMLSKLLTLSGLAAGVLALVQSTGLEGYALIFAIMLVFLVLGCVM
                     DSMAIILIFVPLFAPIVVSQGFDLVWFGIIVIVVTEIALVTPPVGMNVFVLKAVLPDV
                     PVVRIFKGLVPFIAVDVVRLALLVAFPAITLWLGTTVG"
     gene            40602..40763
                     /locus_tag="MED193_00205"
     CDS             40602..40763
                     /locus_tag="MED193_00205"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MVSKEPKLPNADEGLAQTKVDEKSTLLARVCKRFWRYTEKTRQM
                     AIKPFKGIL"
     gene            complement(40806..41762)
                     /locus_tag="MED193_00210"
     CDS             complement(40806..41762)
                     /locus_tag="MED193_00210"
                     /note="COG0435 Predicted glutathione S-transferase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative Glutathione S-transferase"
                     /db_xref="CDD:10309"
                     /translation="MLVDGKWMENWQPVQKADEQGRFVRQVSSFRNWITADGRAGPTG
                     EGGFEAEPGRYRLYVALICPWASRTLIARKLKGLEDMIEVIVVNPTLTDQGWSFGGFP
                     GAVEDPMFGARYVHELYTRADPKFTGRATVPVLWDMKRNVMVNNESADILRMLDTAFE
                     HLVPSEIRLYPKAYAAEIDALNPRLYNLLNNGVYKAGFATTQAAYDEAMDGIFAMLDE
                     LEELLTGDFLFGDTLTETDIRAFVTLIRFDAVYHGLFKTNRREIRDYPRLWAYLALIA
                     QIPGVRETVDMDRILHGYYSIKALNPLGVVSKAPAHIATLLG"
     gene            complement(41775..42596)
                     /locus_tag="MED193_00215"
     CDS             complement(41775..42596)
                     /locus_tag="MED193_00215"
                     /note="COG3384 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12716"
                     /translation="MQTQSLQDLRDRLAPSDRLPLVFLGHGSPMNVIEDNAYSRAWSV
                     LGKSLPRPKAILVVSAHWMTRDTTLVDVSAMPRTIHDFYGFPEALYAQAYLAPGQPDL
                     AQEVVTLLKSHRAQEDDRWGLDHGAWAVLKFLYPEADVPVFQVSIDMSRGLAHQLDIG
                     RTLSELRNRGVLILGSGNVVHNLRAMRRGGEPLEFALEFDALFADRLADRDFAALADA
                     KNLGTLLPAAHPTVDHYLPALTIAGASDARDDLTFMTDAIDLGSVSMRSFIFHAN"
     gene            complement(42655..43086)
                     /locus_tag="MED193_00220"
     CDS             complement(42655..43086)
                     /locus_tag="MED193_00220"
                     /note="COG2259 Predicted membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="DoxX family membrane protein"
                     /db_xref="CDD:11965"
                     /translation="MSTNSETNNTDYAALVLRVTSGVAFLAHGWMKVSLFTIPGTVAF
                     FESLGLPGFFAYLTILGELGGGLALILGVGVRAVSIPLIAILLGSVWAHSGFGWTFSN
                     EGGGWEFPLFWAVVQGVILLLGAGAHALRLPVFDRTLGKFA"
     gene            43165..44136
                     /locus_tag="MED193_00225"
     CDS             43165..44136
                     /locus_tag="MED193_00225"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, LysR family"
                     /db_xref="CDD:10453"
                     /translation="MQTINKIEMLENDYLQNVLNRAMDRIDQIRAFVATAQTGSFTAA
                     ADQMGISNRLTSKYVAELEARLGVRLLQRTTRRVGLTPAGEDLLTRAPALLDDFDAVL
                     SEVTESSKGFSGTLRVSAPITFGEIYVVGMLARFAAAHPAVSIELRLDDKYLDLASEG
                     LDLTFRLGHFDQASLKVRRLGEFRSVLVASPDYLARCGTPTTPEELSNHACIVDTNRR
                     NPRRWMFRKGGSETIAHVTGRFHVNSASAAVALAISGIGLAYVPSFALRGAVKSGDLV
                     ALLDEYRSESGPVGAAYLEGRTLPRKVRALIDFALSDIKSLKPLQAL"
     gene            complement(44202..44834)
                     /locus_tag="MED193_00230"
     CDS             complement(44202..44834)
                     /locus_tag="MED193_00230"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTGGPRPEIDLAAFLDRRDPGTIEDSAERLEDRARGWLEVMAAA
                     ADLHPITRACMGFHLWSLAGLGQHGDRIEAAVTAARIAVSDGDGAIFAPLAMGGAGGL
                     RASGLPPKRLTGWLDGMNSAILTAMRHLNDIETWTSKTEKEMSRLSGRTPPALRAVLT
                     EWPMISAPMAENLTGASRTAVQRNLSWMEAQGLIREVTRQGRYRMWQASH"
     gene            complement(44861..45268)
                     /locus_tag="MED193_00235"
     CDS             complement(44861..45268)
                     /locus_tag="MED193_00235"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNPQTSNNPDYFDDPLVTTEGGQDASEDDLWFLPGPIEDEPDYL
                     PPGPRAEPPETGVIDEWVNAEACCAARLATVAGRLGALDDRLLRGPEGWRHRLALIEA
                     ADLSWFAGDRVSSDRLALWMSMRLSGVQVDPED"
     gene            45567..47726
                     /locus_tag="MED193_00240"
     CDS             45567..47726
                     /locus_tag="MED193_00240"
                     /note="COG1475 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11189"
                     /translation="MAKTTTRTKPTTVKKSEAAGSAAPEGAADIRMIPLNQLEPSPLN
                     VRKVAASASDDAELFASIRETGIKQNLVVHALSDTRFAVDAGGRRLKALKQLAEDGVI
                     PADHPVPCLIEDERNAILTSTTENLQRAAMHPADQFEAFEAMIAEGRSEDEIALKFGV
                     SVDLVRRRLKLARVAPEIIEQFRAGDLTLECVMAFTLTDDHDRQLAVWNAVKGGYHIH
                     PQSIKRQLTETAHSANSALGRFVGIEAYEAAGGVLLRDLFDDRASAHMENPELLERLA
                     IEKLQAAAKPFEAAWKWVEVHLSVDYGAFRSFGRVYPQDVDPDPELLAEETRLIAREE
                     ELAAQNDGEDWTDAETEEYYAIEPRLREIEALQRERQPYADEDRAIAGVVLTIGHDGA
                     QRVEKGLVRPEDIPAAPKPDETTEDAGGAASPARPNVTPPTSSTPVPTSDPAATLRKA
                     DGISASLADDLRATRQHILRAHLAADFEVAFDAMLYALCEQALGRSYNNEALDISIRP
                     FQAQNREVLHADTVAQKMLEALEQDLATDWMTLEKPEDFRAMSALPIADKQALFAWAT
                     GLAVKPQLSSDNRPSAIIEEIGGRLDVDVAACWRPTAQNYWGRVNKGHAVATARKLIG
                     DDYAEERNRERKGDIAAAMERAFAETAGETEGFDAATVAKTTLWLPDGMVFAGASRSD
                     VVEVPDQVDPEPAADMSDGVSDEEPSSLPAFLSGDAA"
     gene            47853..48203
                     /locus_tag="MED193_00245"
     CDS             47853..48203
                     /locus_tag="MED193_00245"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTTALDLDPFREAAMIAAQNDAFRRSILGNPPVADAPQGQFVMT
                     RGVAALGPDAQLELTRHVAAFDAFNADSDPQGWHEMGGIEFDGTTVWFKIDGVDAPSH
                     NGIAMCQTGFVGSQ"
     gene            48222..49256
                     /locus_tag="MED193_00250"
     CDS             48222..49256
                     /locus_tag="MED193_00250"
                     /note="COG3547 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="IS1111A/IS1328/IS1533 family transposase"
                     /db_xref="CDD:12874"
                     /translation="MTDVSILAIDLAKHSFQVCATTAEGVIVFNRKYTRGKLSELLAN
                     HPQCLVAMEACATSHYWGREAQGHGHDVRLIPPIYVKPFVKRSKNDANDAAAIAVAVR
                     QPDMRFVAVKSPDQQAQAMLFRTHQTFTRQRSQLLITLRGHLAEHGIIVAKGNAALIA
                     YEKVLEAEPDLVPDLVLEAARLYFHQIAQLNNSIAAFERQMKDTAKRNDTARRLQTMP
                     GIGPINAAAFLAFAPPMESFKRGRDFAAWLGLVPRQHSTGGKTRLGRVSKMGQSDMRR
                     LLITGATVCLRWAVAKGIDPQSWLGRLLARKPAKMVAVAMANKMARALWAMMTKGQDY
                     SGSLVQYAKM"
     gene            49763..50059
                     /locus_tag="MED193_00255"
     CDS             49763..50059
                     /locus_tag="MED193_00255"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAKTLDYQITLYPAHRDGAFVVTEFQMMANYPEKRIQAAGMDDL
                     IDKVTQFAMEHGESCSASVRCLAPRKPPGFKRATENLYFNLVDRTAEKRGDAAA"
     gene            50137..50520
                     /locus_tag="MED193_00260"
     CDS             50137..50520
                     /locus_tag="MED193_00260"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTQATDFYAQMLEAQKRAAEERVETRAALLSELRALGVTSIEVQ
                     YEGYGDAGNVEDVVVTPDTITLTEELRRRVEDFGWDFAYALSPGFENNEGGYGELTWS
                     LETDKIDVSHSNRYIETDTTEHEGL"
     gene            50522..50998
                     /locus_tag="MED193_00265"
     CDS             50522..50998
                     /locus_tag="MED193_00265"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAHPLHHAESSARKFGGIPDDYQHVHDWFDSSKEHLGLFIHRAH
                     RHHTLGIFEAERLFGRSLTNSAGRVVPIRWIGEQHVREDCQGRIPSLADWLGRIQPEP
                     WMANGRIDNDPTQIGSDPRAAWATAVSNHQTILGFEDWLLKVSVEHVQHRQNRAAA"
     gene            51104..51733
                     /locus_tag="MED193_00270"
     CDS             51104..51733
                     /locus_tag="MED193_00270"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MHDPVYEEVHQGHNIKIYHDPDSESPREWCNLGTLICWHRRYRL
                     GDSHQHDSPEAFLRNLADVSDQSDLSMDRLRDRAECKAIILPVFLYDHSGLAMNTIGF
                     HCPWDSGQVGFVYMTLADVRNEFGVKRVTKALREKAVDVLRGEIVDYDSYLGGRVYGY
                     VVEQGGEEIDACWGFVGGYETHCLPEARNAVPRSDPHAPPATGALTAYP"
     gene            complement(51934..52092)
                     /locus_tag="MED193_00275"
     CDS             complement(51934..52092)
                     /locus_tag="MED193_00275"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGVVAQTHARLLGHGRACILGTSNETEPTQSNFGDRMANQEKSQ
                     ELRMGICK"
     gene            52249..56646
                     /locus_tag="MED193_00280"
     CDS             52249..56646
                     /locus_tag="MED193_00280"
                     /note="COG2263 Predicted RNA methylase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative methylase/helicase"
                     /db_xref="CDD:11969"
                     /translation="MNAHPHSVQLATEPEAPALPAAAGFAEQLMQAAKTLLPLFEAGR
                     SIDAAALRAAMEEAFGANDTSGTWVWKDAYEAAEVAQILMLSRYGALMQRQAATPHAF
                     LNMIEHLAGLAPSHTRRSEDSVRLQQFSTPLPLAAIVAQAAGFRGDDLVLEPSAGTGM
                     LAIFARIAGARLSLNELAETRRNLLQQLFPEAVVSDHDAASIDDRLDRSITPSVIVMN
                     PPFSAANHVEGQFRQATSQHVLSSLARLAPGGRLLVITGESFRPSTKCFQSTFQRIGQ
                     SSEVVFSAAIDGKVFSRHGTSIDTRLTVIDKRAMGEGETAPVNIDGAYHPTCATTAAL
                     LSAVLTHCPERRSPPPCPTSSALSVPTRPTRTNLHALRNAARQETRALAEERARHPFD
                     DIEMAPLDYLPKAWSEPDGVLQDTVYEAYDLQAIRIDSAVEHPTALVQSAAMASVPPP
                     VPTYRPVLPKTLVADGLLSAPQLESVIYAGNAHETHLKGWFKRGEIEGQLMAAAEGDE
                     GAFRLRKGWFLGDGTGCGKGRQVAGIILDNWLKGRRRAAWVSKSDKLIEDARRDWMAL
                     GGRESDIVPLSKFRQGSDIRLPEGILFVTYATLRSAEREGKASRLDQVTSWLGEGFDG
                     VIAFDESHAMANAAGEKSDRGDKKASQQGLAGLALQNAAPDARVLYVSATGATVVGNL
                     AYASRLGLWGTGDFPFVTRAEFVAAMEAGGIAAMEMISRDLKALGLYLARSLSYAGVE
                     YEMLVHDLTPAQVAIYDNYADAYQIIHTNLEAALQASGISSETGTLNAQAKSAARSAF
                     ESNKQRFFNHLITAMKCPSLIRAIEADLAAGHAAVIQVVSTSEAVMERRLEEIPPSDW
                     DDLQVDFTPRENIMDYLMHSFPTQLFEPYTDENGDLRSRPALDADGNPITCREAERRR
                     DELVEHLGALAPLQGALDQILWHFGGDAVAEVTGRKRRIVKTREGRLKVENRAASSNL
                     GETQAFMDDAKRILIFSDAGGTGRSYHADLEAKNQRLRVHYLLEPGWKADNAIQGLGR
                     TNRTNQAQPPLFRPVATNVKGEKRFLSTIARRLDTLGAITKGQRETGGQNMFRAEDNL
                     ESPYARAALRQFFYKLRAGKIEACSYAKFQEMTGLTLDEADGTMKENLPPIRQFLNRC
                     LALRIDMQDAIFEAFGGFLSAIIEDARQAGTLDVGLETLRAEKFVITDRRVIFEHEAT
                     GATATALTVERTDRNDPLTLPRVKAICADMKGATLCWNKTSKRAALMVKAPAFMDEDG
                     VPILRVKLLRPMATEILALSEFSRSHWEEIDDAMFEHLWQAEVDAVPKFTTSKITLIC
                     GLLLPIWDRLPSDNMRIYRLQTEDGERAIGRLVSQEQLLNVYARLGLDCQIEMTPQEV
                     FAAVMHAKTTLNLLGGYQLRRSLVMGQPRLELIGASGAVLPALKAMGCFTEVIQWKTR
                     VFIPVDGTDVLARVLSEHPVGTSAAGTAA"
     gene            56643..57689
                     /locus_tag="MED193_00285"
     CDS             56643..57689
                     /locus_tag="MED193_00285"
                     /note="COG0358 DNA primase (bacterial type)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNARRSIADLSADVADRAESFCRQYFPEGRRQGNYWQVGDTSGA
                     KGQSLAIRLQAQGGRKAGSWQDFATGEYGDLIDLLHERLGSVTLKETLREARSFLGEA
                     PCPAVPHATRNPEPPDAASGKRIARARKLFAVGKPVLGTLAATYLQARGITRLGPALR
                     YHPRIFLWRGEDDSDPPQSAPALLAKITDNRGQITGCARFYLDPSTGGLAAIESPKRI
                     LGQLHGHAIRFWSGKARSDLIVGEGLENTLSVGTALPEFDLASCLTATHLGLFIPPPG
                     IKRIWIARDDDEAGRNASQKLRNHWESLGIACGDLVPTMGDFNDDLRALGKDALRRSL
                     LGAMKAQSLEIEDR"
     gene            58001..58912
                     /locus_tag="MED193_00290"
     CDS             58001..58912
                     /locus_tag="MED193_00290"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPHQTDIQEETGATSAILDHLALHGATPGPGETDHRPLPQPDEV
                     DLAMATLFETTIGLLNGSQLEDNLEEMLWSLTSIFHRRLTHIQKLLDDNEFEVRESLA
                     VQDGSEVASVELERLQMIGLKLWDHRDAFEQMRDLAVDHFSAATGSPWLPRTGSKVSH
                     RGLTSAVVDSRAYLSAKRRKETEVHCPEGTRIAFSGGDYQAYDLIWSVLDATHAKYPD
                     MVLLHGGTPKGAEMIAARWADTRGVTQVVFKPDWKSHGKAAPFKRNDKMLETMPQGLI
                     ATPGSGITENIVDKARKLGIRIKRIGA"
     gene            complement(58921..59214)
                     /locus_tag="MED193_00295"
     CDS             complement(58921..59214)
                     /locus_tag="MED193_00295"
                     /note="COG2944 Predicted transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, XRE family"
                     /db_xref="CDD:12292"
                     /translation="MSAFESVSKGLEEALAFANGDLANAKVHEVSVAEVDVAQVRQRT
                     GLSQAEFAKSIGVAKGTLLNWEHGRRQPTGPAQVLLALIAKKPSVVQDLLRGA"
     gene            complement(59211..59603)
                     /locus_tag="MED193_00300"
     CDS             complement(59211..59603)
                     /locus_tag="MED193_00300"
                     /note="COG4737 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="RelE-like Cytotoxic translational repressor of
                     toxin-antitoxinstability system"
                     /db_xref="CDD:13877"
                     /translation="MLYVIDTYAAETYMELHMTRLQTVVELPEFQRRAKAIMSDQERE
                     AAINFIAANPEAGISLGGGLRKVRIPRERSGKSGGFRTVYVFGGTHMPIFLITVFAKN
                     EKANLSKTEQAAAVEMSKALVAKYGDAT"
     gene            60190..60528
                     /locus_tag="MED193_00305"
     CDS             60190..60528
                     /locus_tag="MED193_00305"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:17661"
                     /translation="MTTNCIKFTSTDIETAKGTGSISTLTFDLDITVEPVASTNPMAP
                     THRVLGRSPRGKLVECGGIWKKQNKETGADYYTLTIRDHGFNANLGKAANQDDPSLQA
                     VIPWGPKDVA"
     gene            60737..62092
                     /locus_tag="MED193_00310"
     CDS             60737..62092
                     /locus_tag="MED193_00310"
                     /note="COG1192 ATPases involved in chromosome
                     partitioning"
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein a"
                     /db_xref="CDD:10910"
                     /translation="MSGSLEQFLTDLSRGLERTMVAVNKELTLRQRIKRTWSMRQCAR
                     FLNVSIQYLTKFANSSDDFPAGEYVGRERVFTLSELMHMRALLAASAKRPYDYLAWRK
                     PDAPLPVISFASQKGGTAKSLSAAHFAQYLSLHYGMRVGVMDADPQSTITLYFVGGEG
                     LPQMPDENTASMVDFAGLFQSEDAPYTDHDAQTLDSFFLKTSWPGLRLLPAHGETSEG
                     EIQIARLVREAPSGKSFYRYLRDAIDRWKAGHPPKTLPNELVVEGKVDQQRLDAALTE
                     TLDVIIIDYQPALTLFQLNNVIASTSLVIPQTMKGFDIATLSTFVTGLLGMLQHILAH
                     ERIEIGTGANMLLPTIVQRSNAQDLNHIGNLLEHCPTEILPVFYLRSDAISNASDVYQ
                     SVYEYEPDTPGKRKGINRFIMNADAVNDAIVSRLWPGLERGYADAWMDEFYEDDGEGE
                     A"
     gene            62089..63111
                     /locus_tag="MED193_00315"
     CDS             62089..63111
                     /locus_tag="MED193_00315"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:424"
                     /translation="MKRSIPRSLVSKATNPDASKERTPGSEGRAEPGDAVSTPFKGAG
                     SAWKSGALAQSQAAVERSRAELCSDILNGRHEISLSPDQISDPMGTDRRQDWMSQEAF
                     RSLVSSIASNGQDTPILVWPEDPDWQPDPLEPSNVTGVPFVMLTGRRRLAAASELGLP
                     LRAILASPDARNAENSKFEMLFLRFRENEERENLSPFERLVSIGEMYETLASGEDKLT
                     AVAFAKKIGVHESLVSRARSVFAAQDQILNAFKNVYDMSFRDLQGALASLERVNTSKP
                     KPKAKPSKLTVKRKVGKRNLSATSVDGNLSIKVAGVPIDQERLEKLGDLVADYLSAEG
                     SGKDSD"
     gene            63338..64618
                     /locus_tag="MED193_00320"
     CDS             63338..64618
                     /locus_tag="MED193_00320"
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein C"
                     /translation="MKHTGWRKPTPGLGVAEQLAQAGERVAVPKTRAFVALKRVGAHI
                     GLKAGDMMLLDTLGAFTQAQDWDEGQRPIVWASNAYLMEQTGFSRSALKRHARRLAEI
                     GVISFQDSPNGKRWGRRDAEGRIVEAYGFDLSPLSARVEEFEELHADLQAERELCQRL
                     KRQITVARRMIRARIEAALSSALRGPWSQFTGLFEELLDRLPRRHEASEQLVRLLTWF
                     KELQERVEAAYLKATGAVKPVENTGNNDIQVMEKTQKMNPREVNSEPHILITKQLNPV
                     ISNSSEREEAAGVVPNAQPEERVDRELEDWVAEVRKKRTALDLPTIMQACPEFASWAR
                     NMGGFLKDWGDLHRVAGQLRPMIGISEHAWNVAQDRLGTQVATAAFALVFEKHSAGEV
                     ASPGGYLRGMVEKAGAGELHLERSFYGRLSEQAA"
     gene            complement(64733..65863)
                     /locus_tag="MED193_00325"
     CDS             complement(64733..65863)
                     /locus_tag="MED193_00325"
                     /note="COG0582 Integrase"
                     /codon_start=1
                     /transl_table=11
                     /product="yld, resembles DNA integrases; possible role in
                     plasmid maitenance"
                     /db_xref="CDD:27720"
                     /translation="MEQERQSENNEKSISKPPNGPSVSENNERDHPSSEALSLPSFVA
                     GSGTLDRLVDTARDYARAAASENTLKAYAKDWANFARWCRMKGAEPLPPSPEMIGLYL
                     ADLASGSGPFPTQSASRPLSVSTIERRLSGLAWNYAQRGFALDRKNRHIATVLAGIKR
                     RHARPPVQKEAILAEDILAMVATLPYDLRGLRDRAILLLGYAGGLRRSEIVSLDVHKD
                     DTPDSGGWIEIFDKGALLTLNAKTGWREVEIGRGSKDQTCPVHALEQWLHFAKIDFGP
                     IFVGTSRDGKRASETRLNDKHVARLIKRTVLDAGIRSDLPEKDRLALFSGHSLRAGLA
                     SSAEVDERYVQKQLGHASAEMTRRYQRRRDRFRVNLTKAAGL"
     gene            65968..67614
                     /locus_tag="MED193_00330"
     CDS             65968..67614
                     /locus_tag="MED193_00330"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:25582"
                     /translation="MVDRSDINAVDDAAWEQAVAREAVIRRLASKTPPNRAEFLKACR
                     DLGLKRSRLYELISAYKARPVASSLLAAQVGTPTGSRRLPDEIEAVISGAIEEFYKSL
                     QKPSINALQKEVRRRCSQRGLRPPCWTTLRDRVAAIDPAELTAAREGAKASRQRHHPV
                     PGSYQVERAYEVVQIDHTLVDVIVVDRVHRKPLQRPWLTLAIDVASRMVAGFYLTLEP
                     PSVLSVALAIQHLVQPKLDWLEGLGIDADWPAEGLPETIHVDNAKEFRSKAMKRGAEE
                     HGISLQYRPIGAPHYGGHIERLIGTMMGAVHLLPGSTFSSIKDRGDYDSVSKSAMTLD
                     ELEHWLALEITRYHAERHRALGIPPVAAWNEAYERREAPLRRPYDPEGFRVDFLPSTE
                     RMVRRDGIHLFGLRYWDDVLSLWAGRQDRQLRVSYDPRDLSTIFVLGPEGQRYPVRFS
                     DLRHPSITLAEHRRAQAILRERGRALEDEDLIFAVIEEQRALVDAASSRTREARRFSE
                     RRDRALDGVGAYEALDAGPEPRESESVLRDHPGFEVEEWS"
     gene            67605..68543
                     /locus_tag="MED193_00335"
     CDS             67605..68543
                     /locus_tag="MED193_00335"
                     /note="COG1474 Cdc6-related protein, AAA superfamily
                     ATPase"
                     /codon_start=1
                     /transl_table=11
                     /product="TniB"
                     /db_xref="CDD:23845"
                     /translation="MVVNEGTAFAHLDPTYRRFAALPDDERIAWIRADRWIGFDQSGA
                     ALARLENLLTYPPRDRMPCLLIYGDTGMGKTKIVRKFERDHPPKFSQITGVDHRPVVV
                     AQVPSEPIERDLYRELLASMGAPAMTGGTLAREKDICRSLLRTVGAKMIILDEVNGML
                     AGTFRQQRIFLNAIRFLANDLRIPLVCAGTDLARQALLTDAQLAERFEAFYLKPWQND
                     AAFAGLLKSFERILPLREASDLISGEARERIHKLTSGVTARIFRLIETAAEDAVRSGK
                     ERLDADSFGDNLVLPLVSMTQTARRRGKPVQQRVGA"
     gene            68540..69667
                     /locus_tag="MED193_00340"
     CDS             68540..69667
                     /locus_tag="MED193_00340"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:26639"
                     /translation="MMVSARLPVAPRPFMDELLSSWMARVAARYGSEALELVVYLAGQ
                     GGRNAGARQVDDVAPDMELLRLWAKACRVDPERLCRRSLASRYPDRPQDWFLTETVPV
                     CLACFDADVAARRDAYLRGHWRLAEQVVCPPHRTMLLDRCPACLGRLRLSFRMLNGLL
                     RPFCRKCDAILTGGGGETEDPLKADFAAGVLDLQSQISRIVRGNPGRFDRLEHAIRTL
                     WAPLDRDGAARPVLALWYDESGWNCPYEARAAVGRSAPLQHLSVSWRALTLVILHDLF
                     GADLVPGAVLPEAALVLFQRAAPLPWLTDGPDLRTGKGKRTIDAGAERVHRLSKRRVH
                     RLNGNFEGERRFRPNPPMKLKRQEFFWEPIALCPIMQTYWT"
     gene            69742..70626
                     /locus_tag="MED193_00345"
     CDS             69742..70626
                     /locus_tag="MED193_00345"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKPELEIHKATSDTLPRMPSWVTSIRAETLEDVAFLSGAALATL
                     HLVVRRKDVPQTLLRERLALSSAEACVLLSGRPERARELRDEVHLLRHDDVPGPAGKV
                     YQCWRRAVERPVSLKALHRAIPAQDPSQIAAWLDVGQGSSVNRAALVIEAVLSDVPRA
                     EEVALILADAALAQAMGWEHLVPLLAANLTARDLRMTGDALRRSCHRSLVVSATAAVQ
                     LAHDLARRTARLEAVVPKLRAKGAGEAVQMFLMRDAVMPAALPLSDRGARRLCDRLVE
                     LGVVRELTGRDMFRLYAV"
     gene            70629..71225
                     /locus_tag="MED193_00350"
     CDS             70629..71225
                     /locus_tag="MED193_00350"
                     /note="COG1386 Predicted transcriptional regulator
                     containing the HTH domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:26185"
                     /translation="MATRPEPDFDRDLDDLPAELRWREWMRRIEAVLFASATPVPRED
                     LARVVGQQASVELLIEDLGADLADRPYELAAVSGSWMLRTRSSYAPAIRAAADVGEQL
                     LDLNEFDVAVLAAVAYNQPVTRDGLKDIFGKEISRDLIGRLFVSDLITTGPRAPRRGA
                     PYTFVTTEKFLVAFGLESLRDLPDREQLDDAGMTRFAS"
     gene            complement(71222..72580)
                     /locus_tag="MED193_00355"
     CDS             complement(71222..72580)
                     /locus_tag="MED193_00355"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIMTQLDRRRFEALAGYTRHPMITLITKELDWFSDPLERVLGTL
                     VWDRVDGDYSWAVFARDAVKKFRAIQANTSYSTSQEAYNALMAAMVENSRKPDEAFHQ
                     NDEDGPAVDFFTPAVDEARFHPSFQILLEDQRYSPAREIIEAMMRYHEDVDGNFVQKF
                     QTAGWDALLWELYLYATFNELRFIRVGTGPTPDFVLRGNEGGLAVEATSVNPSNVGPN
                     DVPEDSEAFKAYLENYVPIRLSNALRSKLNHKPPYWKQEGAEDVPFCIAVQDYHLQGS
                     MRYLTSAATEYVFGVRHWMDSGEHKIARIGTHRYGKKRAQSGFFDLKGAENVSAVIIN
                     PQGTLTKFNRLGIAAGFGDPRVKMVRMGMKRNDTNSQAPFPTPFEEEVGPQSSETWVE
                     GMVVLHNPNARIPLDPDIIPGAAHEFLQRDGSIMSLLPDFHPFVSQSIVTIEDDEKNG
                     TD"
     gene            complement(72836..73474)
                     /locus_tag="MED193_00360"
     CDS             complement(72836..73474)
                     /locus_tag="MED193_00360"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MEPEIVVLGFSKGPTQTGAMASSPHDEIAYKGSRMAVGKILVHI
                     GVVPQPENSDYRGMVDRLISDRNGRFHFGSLVRCTVERFDEKTRNWKGSGGGMLDKFM
                     GTQFGNEVATNCASQFLGALPTKTRLVIMFGLGSKLNYISAARKLVEAARPGNWRMLN
                     EVTYSDGNLTFVHVEHFASQGALIPNWLGINDHPRSEYGRKSREAVQAALAD"
     gene            complement(73823..77008)
                     /locus_tag="MED193_00365"
     CDS             complement(73823..77008)
                     /locus_tag="MED193_00365"
                     /note="COG0553 Superfamily II DNA/RNA helicases, SNF2
                     family"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase:Helicase, C-terminal"
                     /db_xref="CDD:24402"
                     /translation="MIERFEAAPALRSLKAFQRATVDYVSRRLLIDEDAVRHFLVADE
                     VGLGKTMVARGVIARTIEALQDTVKRIDIVYICSNAAIARQNVARLNVMGEAHAKVLP
                     TRLTMLALELARAGGIKEEGVNFFSLTPGTSLDLKQGGGMKQERALILRLIWDQLKDR
                     KAVAKMLQGYAGAQGWRETRRWIDAQPIEPQIAMQFQSAIAARPALLEDLENCAHAYK
                     GQRLNNTELNRRRDSLVGELRTILARESAEALEPDLIVLDEFQRFTELLHGDSEAAEL
                     ARRLFDATDPDGNQAKVLLLSATPYRILSLRDDAADAGDHYKEFLDVLGFLFGEEHGA
                     KARQELEMEMRRMRNALQMLPSSFEQAKDIKMGIERQLKQVIARTERVSETAERDAMV
                     RDMSAPITLKSQDLLEARAIARVAEAAEAPGTVEYWKSAPYLLSFLRDYKLGQKLEAQ
                     KDSPSETLLAAIRGAGTAQVDVAAVKAYRPIHLSNGRMRALQDIASLNGLDRRLWMPP
                     SLPYFGARIAASKVLVFSQWAMVPDSIAALLSYESERRMGMGDQWGSYTATHSQRLNF
                     RRAKGRLTGLRVLSLVIPSPTLATAVDPLEIFQSVRAMPDANAMRSVVKERLKNFADD
                     LALRFTAAKPSGFLERFRNNADDGADERVANWDWACAASMDISHKRFGTWLAEGRGLD
                     TIVREDGLEAWNEHLAALHEAASEKHLFGSPDRSQVLDHLTDLALGSPANCALRALAR
                     VAPDLGFDHPNMLSAATRIGMAFRGLFNQPESIALLRGSSDEFYWQAVLQYCAEHDLQ
                     SVMDEYVHMLLESEGLSDADPCNAVTRIAEAIDEALSLKPAQIDIKSYKAKRGRIEIQ
                     SNLRMRGRFATRLLQKSQEDGQMQRTDNVRGAFNSPFRPFVLATTSVGQEGLDFHYYC
                     HRLVHWNLPTNPVDLEQREGRVHRFKNHAVRLNVSEKYANDMRLSESESDPWKQMFSA
                     ALSQAKRGGELEPFWLFDGEISIERYALSLPFSREISLMAWLKRSVAIYRLAFGQPRQ
                     DDLMSFLEKAGSELSNDDLAELQINLRPPEI"
     gene            complement(77001..78848)
                     /locus_tag="MED193_00370"
     CDS             complement(77001..78848)
                     /locus_tag="MED193_00370"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTNKTALDPENRALYGEILRAPAGYELDQALATTYTLDFETALV
                     IPATLAFHAAESRQQTLDTPLALLEGLERLAKRIAIFCEAGRIKAMPSGANRLTALLE
                     DTVTEVIAPRGGAFHPKLWALRFKPVTRKGPARLRIALLSRNLTTDTSWDLSLCLDGQ
                     LGQFTNAANDPLVALLLALPNLTPGRNTPRRASQIAQSIAADLATAIWEHPEHIRKIS
                     FAVNGLSQRVWHPRIGSTLGVISPFVTDAALLKLGHKVSNENAYLLGRGEELAKLKSD
                     TLQTFGNVMILDELAETEDGDETEDQGRNVVPARGLHAKAFLTERYSSTEITLGSGNA
                     TTAALINGSNVEVFATLSGYTRDLGTVQQQLSEGSLGRYLCEFSPYELPDSDKEDAAE
                     KRLDGVRRQLAEAGLKLSCYVDNEGRIELSLSAKVPVELSDGIKLHVWPLVTGQKNGT
                     LLSTITKKPKLIGRAALKDVTRWLGVELQDAATGFKRVFTLGTDLIDLPETRTAEILR
                     SIIENQDAFLNYLRLLLGDVSDAAKALFVAGSGGTYSGLFGSMQDAPLLEDMVKALSG
                     DGRQLHDIERLIERLTNPKTGKSDVIPEDFLTLWETFRTVLPKERSRRD"
     gene            complement(78838..80004)
                     /locus_tag="MED193_00375"
     CDS             complement(78838..80004)
                     /locus_tag="MED193_00375"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSFFAWVDFDQADRDRTRRIMDLFDQKDSRDELGLGSVRDALSD
                     LLFPGTSTIQTRLRYMLFVPWIYRMAGATVGTSSARQDKARAYEIRLIDALVRGGETI
                     NVIGSEARDTLKRLPSDVYWAGMLTFGIRRFQGSRTACLELAPGEADALWAAGIPDAP
                     IGFLENGSKIDFTLRPEEADFIRDRLAQQAPDSLLTWLSRQNDAAECNMIWEHPQSSE
                     WPNDIKVLVDHAERFSSLMHGASLLYNLMLSERAAQMQATEESVWHERIEDYTSRLSK
                     WASDTPLETFEAWDMNDLWDQSQRTIHSVKPKTKRFVEDWRLAVANSKGDVAKDFSAR
                     SLVRDREKRLKGLKSRFRNDGALTRWGGASGLTPLSYRWQPVVMNHVRDLTRDK"
     gene            complement(80004..83156)
                     /locus_tag="MED193_00380"
     CDS             complement(80004..83156)
                     /locus_tag="MED193_00380"
                     /note="COG1074 ATP-dependent exoDNAse (exonuclease V) beta
                     subunit (contains helicase and exonuclease domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10797"
                     /translation="MTQLSIVPAGAGAGKTYHIQKTLADWVQDGSVAPGRILAVTFTE
                     AAASELRGRVQAELMKRDRISDALEIDHAYVGTIHALGQRLLTEHAFAAGRSPRNRLL
                     SEPERDLLIRMELAKCVGLRPLMENLARFGYRWNFLTGASAEDAFRSDVLRTVDLIRG
                     LGDRGSDPEILAPAIAALKKGYGPCAPDGAALSAALRRTVVALLDMFPESLGTILECN
                     ATAKKAFISDHQNLRKAAQNETLETDWALWQKLRGLRKSMRGSPTPEGYDELAEAVTV
                     SADELLRHPRPLADACAKVNALVIGAQEVLEAYQAAKRKAGLIDYADMIVETETLLRT
                     QPDILAAVLGEIDCVVIDEFQDTNPVQFALLWQLAQGAKRALIVGDTKQSIMGFQGAD
                     ARLSQALQDFHASAVTPLDRNWRSDPRIMGFVNALGPVLFPQGYNALTPVREETGEPA
                     LEVINLPGGRSDSTAGCVADRIARILAGNTHVFDKVTKAMRPAKASDIAVLCYTGSKC
                     EAVAAAIEAHGHPVRLQQSGWLGSLAMRVARAALAYIADPSDRLAALTWLTLGPPRMP
                     IEDALRNAVDRVLDTHTALVPLAALHEAEQQRPVVDTVAEMLRSTNLREWAAGIDGPA
                     QALADLARLEAEAQTFDSLATDLRSAAGFHGYGMQIFLGWINAQTDKAWDKHPDPDGW
                     SSSGIEISTWHSAKGREWPITIIAGLDRAFAERPGTLSAEFDGFKDLGNVLSHANLGY
                     LPKFDAPETQAVFAEAHQEQDEQEAARELYVALTRARDRLILALPREKTKARDSAERM
                     VDLLRDRGGLQSGAGFLEVCGEQFVANVTDGASDVPEVEPTSASLGYPRFGTSRQNVD
                     APHTPWRQSPSTQEPIASQAPAVIDTVKLGAAIDTSDAVFASAADRGTILHLAFRVLT
                     NQPNLSERLIAATGLAPKVIDEIATQAKILRNRLAAEGYDQLHFELPVQDIRPDGSQT
                     NAIIDCLAEGPDGFLILDHKSGPCPDPEARFHAYLPQLKSYAQLMALTRRDKPVRGLA
                     INWIDEGRLSLCSVDTMEFI"
     gene            complement(83156..85747)
                     /locus_tag="MED193_00385"
     CDS             complement(83156..85747)
                     /locus_tag="MED193_00385"
                     /note="COG2887 RecB family exonuclease"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12238"
                     /translation="MRIDPLLTASPVTDAVRHLTDDLLKEIYLAPLGKPLALQDLLTG
                     NNAPWSESFSAAPAETIAAVEDGLLTVMRATRTLDPNEINLSTLPEGRARTHLTALID
                     LWHKLDGLPAPFSTWAHVLRSNASDALEALPILDYVQCPFADPAETALAEALQAHHGT
                     APLEAALAWRNLAAAHDAFANGALGAIQAGLGKTASEVSPDETIEIFGLRDPREEAEF
                     AAARVQSLLDAGIVESPAQVGLLVPDDASYQRALEEAFDRVGLPLSGKPIEPALRDTV
                     GELMILLLALLERPAPRTAIASLYISPTMPWAKETGLRMAREQMDYGWSRTAAGLDGP
                     ARELLDALRPCSTPEQLFGRLTAIAKAAPEAGLWPKLQAIRTAVVDQIDWPLLRSIAL
                     PRPSEPSGHNRFVEGVSLFAETALPWRPVRQLIVLGLAGRTWPRPPASNPFFTESEIV
                     LIREKTGLYLAGRQQKMARGVELFRRQLCAASEAATFLVPSCTLGGEKLASSTGLSLI
                     THMMGFESSEKAIRDIHAEDQSLWPVAAEAPLPIASGGKPSVPAIGLLHLGSDLLRLR
                     EDDETGHAPQSPSRLETLIVSPLAWLLDELGAKDRTWAPETLDVMALGTLLHHVMEVV
                     FPEGTKMPDQTIIANAVPAAVDDAIRRYAAWLSNDAWDTERQSLLREAYNVTSNWVVF
                     LHETQAEVLHNEIRLAGDHGGLLLRGNADCLLKLPDGRILIIDHKRSSSGGRRDRMAK
                     GWDLQVALYQAMLERPSIQTALTDLVAQGADIVTAYHTMLDGTVLSDAAGAGLPRVEH
                     ASIDASKQAMDHLAQVVAEVGGGTIRLNHEDDAAALKKDRGITAYALEDNAFVSAFLT
                     SNDEGDQ"
     gene            complement(85781..86506)
                     /locus_tag="MED193_00390"
     CDS             complement(85781..86506)
                     /locus_tag="MED193_00390"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAEWNLPEMMSSLHNGIQNELHTARKALAHPGTKGDASEQVWLE
                     LLQTYLPKRYQVESAHVVDSEGNFSDQMDVVVFDRQYSPFIFNFKAAKIVPAESVYAV
                     FEAKQTMDAGLLKYAKDKISTVRQLKRTSLPIPHAGGEYSAKPPIHILGGMLSLESEW
                     SPPLGGSMVKNLGDPTAIGHLDLGCIASHGYFGLDRKSQDYEIHPGAKPATGFLFHLI
                     SELQFSGTVPMIDIKAYARWLNV"
     gene            complement(86578..87516)
                     /locus_tag="MED193_00395"
     CDS             complement(86578..87516)
                     /locus_tag="MED193_00395"
                     /note="COG1223 Predicted ATPase (AAA+ superfamily)"
                     /codon_start=1
                     /transl_table=11
                     /product="ATPases of the AAA+ class"
                     /db_xref="CDD:25355"
                     /translation="MNAQGQNIALFERTMLLPDPEAQERLSRLVGLDDQKLRLSKMLG
                     TLINSAGLVAWASRFHPGAEDFVSDILRRPPLVVLSGDVGSGKTELAETIGDMVARQE
                     DIEITLLPMSLSTRGQGRVGEMTQMVTAAFDHAVQEASKLVSSQGKARGGVILLIDEA
                     DALAQSRESSQMHHEDKAGVNAFIRGIDRLANGSLPAAVIMCTNRLSALDPAVKRRAA
                     EILVFGRPELEQRNLVLSSALTPFGLTAVEIEALVDATGETNERNHGFAFSDLTQRLI
                     PSIILDAYPSSKVTASRALKIARQTIPTPPFQDGVS"
     gene            complement(87513..88031)
                     /locus_tag="MED193_00400"
     CDS             complement(87513..88031)
                     /locus_tag="MED193_00400"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTMSFTHTESQTFTITHARHMASKMATDLKRIQRFYNDPSDREI
                     DDYEGELTALLKAGYLREVTYGFQRNGNWIEPTVTYTALDLNGWNGVDDDPGKIRPRA
                     NVSGASFTSFLTYSSAWSQLTENQKTDFKRGLPITRGYGDVPGVSGYLEQDRSYSAGG
                     RALNRSSVRSWT"
     gene            complement(88041..89006)
                     /locus_tag="MED193_00405"
     CDS             complement(88041..89006)
                     /locus_tag="MED193_00405"
                     /note="COG1746 tRNA nucleotidyltransferase (CCA-adding
                     enzyme)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11457"
                     /translation="MSRDHIGHAEIAKFGTDKINLPKDKADKFRMQARNLRDKLEGYL
                     KDHPDFALRKMLLSGSLAKGTGLRTLNDIDVGCYISGSDVPSDIDALMEYLAERLRKA
                     FPNFKPEQVQPKTYCVTVSFLGSGLDVDIVPILYDGDPDWYGNLVNQEDGSFLRTCVP
                     RHLEFIRKRKTLADKDFAQVIRLVKYWVRKEKREKDGFRFKSFMAEMVLSKMLDEGQD
                     FSDYPEALQAFFSYIANSGLNERIIFDDYYPKSTAKVFGTPVEIIDPVNAENNVSQLY
                     TQAQADDIVDAALDAGDAIETALRCPTKQDTIRHWQRVFGSAFQG"
     gene            89152..90084
                     /locus_tag="MED193_00410"
     CDS             89152..90084
                     /locus_tag="MED193_00410"
                     /note="COG2378 Predicted transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12050"
                     /translation="MGEIDGAKALKKAKWNVKKRLEFIEFRLFWDAKLNRKDLVDTFG
                     ISAQQASADIATYEEMGPQNLAYDSAQKTYLRTDRFSPKLIGAWTHRYLLQLVAIENG
                     WMDAEDTWFEEEQPVEIKTLTRKRVDSQVLMSVLDAIRGHKSLEMFYRSMTGSTASDR
                     LIEPHALSYNSGRWYVRAWSAEHNDFRDYNLNRIERAKAGVPASIDRALDFQWHHTID
                     LIIVPNPKLPKERQAAVEYEYEMSNGRIEVNCRLSVSFYLMSEHNLDVEPGVLDPLKQ
                     QLVLENKDEVLQTRKVARKLSKDALKRIGGSGHL"
     gene            90081..90761
                     /locus_tag="MED193_00415"
     CDS             90081..90761
                     /locus_tag="MED193_00415"
                     /note="COG1708 Predicted nucleotidyltransferases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:25840"
                     /translation="MILDALLLFGSRARGDHSASSDIDLLAVTDNKKPTVSGSADASL
                     FHYSFDWLRDKASAGDLFVWHLVTEAIAIYDPADNLSALGQEFRFKDDYRKQITHASD
                     VGWLISLLGDEMSAKEANRWLAWAVRTISIAHAATIQKPAFSGSALAEVLGYSDIEVL
                     VRQKDRKTFDDAARRLLKKFLGALGSGEPIHPPHSIDRFRSHFEATENEVGLTILNGR
                     LLGPPYHS"
     gene            90727..91068
                     /locus_tag="MED193_00420"
     CDS             90727..91068
                     /locus_tag="MED193_00420"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGGCSDHPTTVKCTSILAVWDAFVFSKFNDGELKDIEYIASKLG
                     QIFDLSDVKLKDQNYGSFQTLSLEVQLLKDPPFFNQKRSTGLDHHSIGSVLFTRLMAS
                     FTLLSGFGSAK"
     gene            complement(91979..92959)
                     /locus_tag="MED193_00425"
     CDS             complement(91979..92959)
                     /locus_tag="MED193_00425"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MQNDIDLHAFEIEASCTYRGEDYCVRDNGAVLRRARAAKRKRPL
                     DETWTFGTPSPSDGYMAVSAHKVHRIVATAFNGEPPSKGHVVDHIDTNRRNNRPNNLR
                     WVTRLENILLNPISAKRVEFLYGSIEEFLADPRNPKNGTLTKDFEWMRAVSPSEAATS
                     RKRMLDWAQSDRPSGSGTLGDWIFGRDATPEEEPTEQLVTSKTPGAVQRNWRVPAEFP
                     LCPDTTEEMPLDTYYRRLKEGSVAVVTPFDQTIVGKAAKSADCTALFILGAHGEGAIK
                     PWSLAQVTFEDNTFVHESLGTFFTKEGAEKEFTLAQGLPWEGGETFDDFC"
     gene            93006..93152
                     /locus_tag="MED193_00430"
     CDS             93006..93152
                     /locus_tag="MED193_00430"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIALVGLDCFYLFLPALQFKGMSQIFLYTSFAEAAADPHNLQGF
                     KSLL"
     gene            93625..93963
                     /locus_tag="MED193_00435"
     CDS             93625..93963
                     /locus_tag="MED193_00435"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:17661"
                     /translation="MTTNCIKFTSDDIETAKGVGSISTLNFDIDITVEPIASSNPMAP
                     THRVLGRSPRGKLVECGGIWKKQNKDTGSDYFTLTVRDHAFNANLGKAASQDDMSLQA
                     IIPWGPKEAA"
     gene            94103..94765
                     /locus_tag="MED193_00440"
     CDS             94103..94765
                     /locus_tag="MED193_00440"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTDDAQPKTLPDLLRARINDAPRQVWTPADFADIGARAAVDKAL
                     QRMVASGQLRRIERGLYDKPAQNALTGKSTVPDYRAVIDAIARRDQVRWLIDGMTAAN
                     TLGLTNAVPAKIEVLVDARLKPVTLGNQKIVFKHAAPSRLYWAGRPGMYLVQALHWLH
                     DVMSNDVEGAVVRKTVRRLLADKKSGSGLADDLKAGLSAMPIWMQDILRAPLFDAAEG
                     DQ"
     gene            94765..95805
                     /locus_tag="MED193_00445"
     CDS             94765..95805
                     /locus_tag="MED193_00445"
                     /note="COG2253 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11959"
                     /translation="MSTAGFQKIIAASAADRADLFLTTANRLGAPLINIEKDFWVCWT
                     LNALYHRLPAGGPRLLFKGGTSVSKAYGLIDRFSEDIDVTVFRDDLGHGASPEELAAL
                     SGKKRKAAIEAIQNDCQAYITGPLLEALSQLIAEDTVGEGRIEIDPDDGTGQTLLVWY
                     PRVDGSDTGYVQATVKIESGAKSALDPNSPQLIRPYISDDLDGIDLDVPDVRTIDAER
                     TFWDKVVILHGLRNWFDTRGELKQDGQRISRHYYDLHCMLETETGKAAVADIELGADC
                     VAHAKTFFNRPDFNLATAEPGTFSLLPSDDMATRLIGDYKNTEAMIFGEAPPFDAILA
                     SIGSLEDQLNQP"
     gene            complement(95828..96088)
                     /locus_tag="MED193_00450"
     CDS             complement(95828..96088)
                     /locus_tag="MED193_00450"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MEHATGDVCCAQSARRQPSRNLAQALQTARLRASDLMGQQVNGK
                     GHNGMIDRTSSTSFPALDRGPFYALKREVAANHTQAKPPRNI"
     gene            96124..96357
                     /locus_tag="MED193_00455"
     CDS             96124..96357
                     /locus_tag="MED193_00455"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPPVFSTIRPTTINGKDHNMTYEQSLDLAELQADMAFETYLSAF
                     EEGDHPEVIDSLATEALIAQDRCADLRSHDLAH"
     gene            96869..97591
                     /locus_tag="MED193_00460"
     CDS             96869..97591
                     /locus_tag="MED193_00460"
                     /note="COG0183 Acetyl-CoA acetyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKTGRPKRLKLEQRIELARRYHAGETPKVLAEAYGVSRRHVTRL
                     AKEEQGEGLAVRDPSERVSFRASASELAAFDAEWQTRGFANRSQALNAVLRGRCGLLD
                     VPRDLVAEFCASWRQAKDVSDAGLALAKAVHRGKISVSLEDRALLVDLLDLAQSMSRE
                     LGQIKDAAQVRRKQDWPLKEEGDAALRAHPEEPARAASGLRLVAGEGGREGARVSVAL
                     APAGGVASKASDAVVDRNISNG"
     gene            97584..99512
                     /locus_tag="MED193_00465"
     CDS             97584..99512
                     /locus_tag="MED193_00465"
                     /note="COG3843 Type IV secretory pathway, VirD2 components
                     (relaxase)"
                     /codon_start=1
                     /transl_table=11
                     /product="T-DNA border endonuclease"
                     /db_xref="CDD:26076"
                     /translation="MADPLALYSSVMGKLWEDERIRGKAAARIDARIAGRRQGRSFGR
                     VGSMSARNVAKAASGQSRAAVFKRIRAGGCKTQASLGNQLAYINDKAVYTYSTMTNAL
                     TEDAVLSEDQKADIIEAWSETWRGSTKLGFTSHMLLSFPTDVTVDQVRDIAVDWTEHF
                     FESGEYGDQWDYVLAVHDDRAHKHAHIILNNRGLDQGTWFSCWAEGVMSPQLMREKQA
                     EIAEGYGVMLDATTRLERGIFEKPAGLAEIYRAKEEARLPREIIMTAEQSAVAQAQVV
                     GFAKDYTEFADLLDRMDQRHLARAVRGMANNLGTVTPWKFTEGEIDMKDIKTVGDAID
                     YSERTIEALRLKAEELDVTERAAFEAKAAPVIADLSQMVPDPELRTRFGKQLEEPYPP
                     GAGSEVLIAALQSGNGDGLKDVLAQADEAGMDGDELVARITAGGTKNYGMAQDWVERD
                     MNAVLSKDGLTVESASDEQLDRALERVDGVMEALTERAKELGVAIGLGLAEEEAADLP
                     LIDEDDRSPNTYLQDLADMLRDGQLSEAQEETVERTLQAELFKELGEEGLGELRRGNY
                     EVLDDVLPSKIDQITVTQEFLEMTFEETGDQVFTDRASSLQQDKATEVAQLKGQQEAQ
                     ALGKDLGRDRGLDDDMEF"
     gene            99528..101441
                     /locus_tag="MED193_00470"
     CDS             99528..101441
                     /locus_tag="MED193_00470"
                     /note="COG3505 Type IV secretory pathway, VirD4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system coupling protein"
                     /db_xref="CDD:12833"
                     /translation="MNKAFPLWAALPFGAICGAILGTIVASFYLTLALRTGFGNFDML
                     AVWNASTGLRAAHPEAFKVAYGAVGFGSLGLGGLALAWTWKKERDDYGSAHWQTKAEL
                     MKNDMLHEPGEGFVCGKLGLPRSKGGFISSAAIPHVMMVAPTRAGKGVGFVIPNLMAF
                     AGSVVVLDVKGENFEKTSRLRALNGDEVYRFSPFDWSNATHRYNPLSRIAKAPTFAQR
                     FTEVSILADLFLDKDNKTLDTFSEAGKSIFVAACLLAIQRGTANLGEVNKIVAGGEYK
                     NAQYKTYADEAEEAILRELWTNAASASSRLLTSNIQALMTAGLKQWDNPAVRSATQDS
                     DFDFATFRKTPQSLYIAVSEDHIATLAPLLRLMFADLIASIRLKEPGPDEPWPVMMMI
                     DEFQQMGAMPYLERAIHSLASYGGRVAMIAQSLASLDRIYGSEGRESLENGAGLKLYI
                     TPRDQRTVKEVSAAVGSTTREAVTRMYGRNKGILGATSTSARLEERPLLSETEARLMD
                     PDEVIILASPQHPIKAQRVKYFDDPVFKAMDAKQKDMPFPYPPSVEGVGPWGVGSDED
                     RAQGANDTAGHPPARERAERREARGMRVMAEGVEMEQQPTPETLEREADVPKAWERTL
                     DMREEMIEEMLGE"
     gene            complement(101950..102840)
                     /locus_tag="MED193_00475"
     CDS             complement(101950..102840)
                     /locus_tag="MED193_00475"
                     /note="COG1802 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11512"
                     /translation="MNAKASKSDLQVRLARQLLQLVADGEIKPGHHLREVELSEQFGV
                     SRTPIRATLNFLVGLGAVEKLANRGFFVVAPASVALKTIKQLPKEDDEKLKEQIAKDW
                     FNGKVPKEVSEGEIRTRYDLGKMTASRVLGTLAEEGLVSRMPGYGWQFEPTLNSASAH
                     DESFDFRAMVEPAALLSPEFRYDADRAESLRTRHERVLGGRRQHNLAEIIRLDEDFHE
                     FLAKCSNNRFVVQAVAHQNRLRRLMEYQSLIDAGRLTDSCLEHIGILDNLDRKDLVGA
                     SAALRDHLTRAKQAGPEFND"
     gene            complement(102900..105128)
                     /locus_tag="MED193_00480"
     CDS             complement(102900..105128)
                     /locus_tag="MED193_00480"
                     /codon_start=1
                     /transl_table=11
                     /product="large subunit of N,N-dimethylformamidase"
                     /translation="MLPIVGYTNKLTVEPGETIDVMVSSFGAKSYRPDFRQIIQGDTN
                     PDGPGYKDKLIDLDLGGARDAIAKPFLPGSCVLIPDLDALGQIDEFTLAAVVKPSLLD
                     GRRRSIIALPGLAEIGIDEKGRLTGVAGGACLTSATPLSTEHWHIVSLSYSKSDGLLS
                     LAMSQDHDAASEPPRAEVISAPLDRTGETAKECIIAATRGPDGALTGFLDGRVDRPAL
                     FNTVVAPETLRNLLGDFALLRRQRSLLGAWDFSHKMTTQTICDISPYQLHGQIHNAPT
                     RAMTGWLWKGQELDWKLRPDLYSAIHFHSTDMYDAGWDVDFSLTIPKDLKSGVYSVRL
                     VPDGDEDNAYYCVFAVRPPRNKPSGNKVAFLFPTCSYLAYANHRLGMDVPGTEIGMGR
                     AVELDHHHMFLQDNPGIGFSVYETHDDEMGVFHSSRLRPIVDLQPKVKSFLGGFGSNI
                     WQFNADTHILGWLDAIEQDYDVITDEDMHEDGLRLLQRYNVILTGTHPEYYTRNMVEA
                     LQGFTDRGGRLMYLGGNGFYWVVSFNEDMPGIMECRRSEAGIRPWEPGHGQFYHGFTG
                     EYGGLWRRNDHPPNHLCGVGMTSQGFDVSEPYVLSPEATNPRVAFIFDGIEGPKIGDF
                     GLAGGGAAGLEVDRADAVQGTPGHALVLASSTRHTDIYLMTPEDLLDPTPDWSGTQAD
                     IIRADLTFFETIGGGAVFSTGSIAWAGAMAWNSYDNEIARMTANVLRRFNDETPFDML
                     PQ"
     gene            complement(105140..105466)
                     /locus_tag="MED193_00485"
     CDS             complement(105140..105466)
                     /locus_tag="MED193_00485"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MARYQISDSDHPFAREFLAQPIGYHSPGLQRVLNRMRGADWAFK
                     YILVIEERHSKWRLGKLPKARGSKVEMVEGVVYFDLLEAERDIFKRRWMDLTGQDVDA
                     LLSQTG"
     gene            complement(105583..106524)
                     /locus_tag="MED193_00490"
     CDS             complement(105583..106524)
                     /locus_tag="MED193_00490"
                     /note="COG4608 ABC-type oligopeptide transport system,
                     ATPase component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13764"
                     /translation="MSSVISVRNADVQFSSGPPWAKSVVHALQDVSIDIEPGQIFGLV
                     GESGSGKTTLGRACLGLQGLTNGEIEFAGTPFNQLGRKQLKGQLAAVLQNPRSSLNPA
                     LKVATSVEEPLKINQHAHGPEARKQVDRMLERVGLASGVGDRFPNELSGGQRQRVSIA
                     RALITKPRFILFDEAVSALDVSVQAQILNLIKELQASVGFAALFISHDLAATRYVCDR
                     VVVLYHGRIMEDCGRRLLYGRARHPYTRGLQAASGLIDDDTVHLEVDDKGASPTGCPL
                     AGRCPERMAMCGETLPQAYSAGGGKVFCHLYDEVSER"
     gene            complement(106521..107486)
                     /locus_tag="MED193_00495"
     CDS             complement(106521..107486)
                     /locus_tag="MED193_00495"
                     /note="COG0444 ABC-type dipeptide/oligopeptide/nickel
                     transport system, ATPase component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative ABC transport ATP-binding subunit"
                     /db_xref="CDD:10318"
                     /translation="MSDLLTVENLTVSYHTKTREVTALLDVSLSLAPGEVFGIVGESG
                     CGKSTFSSVIGHLLGPAGQVESGLVEVAGHNVLALSGKTLRAYRSNDIAYVFQDPMSV
                     LDPTKTLGKQYRRLLGSSDWKQKAIDALNHVGLGDHQRVLSSFPHQLSGGMAQRVVIA
                     MALMRMPKLLIADEPTAALDASIRSGVMELLTKWCSEIGAAMLIISHDIPIISRFCDR
                     IGVMYAGRFVEIGPAAEFITSPLHPYPIALLASEPGHEGEDGVLQSLEGAPPLSISRD
                     RACAFADRCAHRDDVCTSDFPAPVKVGSSTVSCCRIDAIHAEATR"
     gene            complement(107491..108351)
                     /locus_tag="MED193_00500"
     CDS             complement(107491..108351)
                     /locus_tag="MED193_00500"
                     /note="COG1173 ABC-type dipeptide/oligopeptide/nickel
                     transport systems, permease components"
                     /codon_start=1
                     /transl_table=11
                     /product="oligopeptide ABC transporter permease protein"
                     /db_xref="CDD:10891"
                     /translation="MNLRPLIHHWLEFHRADRLAGFASLTMATLILAALLAPLLPIDP
                     PDQVAAYPRLSPPSADIVFGSDNLGRNMLSRVLQGIQVTILLATTAVLCSALAGIVIG
                     LIAAYSGKVLDEIISRLSDIVFSFPAVLMGLLITAIIGPGEFAAICAIILVTLPPMVR
                     VVRAAAMDVTGADFVTISKLSGASPARQLLVHILPNIAVPVVTQVAYSISVGMLVESA
                     LSFLGLGSQPPAASLGSLLREGSLYITFAPWLVFAPALFLVLAIWSVNLIGEGMRVFF
                     DPVRARSLED"
     gene            complement(108356..109309)
                     /locus_tag="MED193_00505"
     CDS             complement(108356..109309)
                     /locus_tag="MED193_00505"
                     /note="COG0601 ABC-type dipeptide/oligopeptide/nickel
                     transport systems, permease components"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-transport protein, inner membrane component"
                     /db_xref="CDD:10471"
                     /translation="MTQLLKFIAFRVGSALLTLIGVSIFIFLAIHMLPGSFEDVLAPR
                     GPEELRQQIAEKFGLNQPLPIQYAKWLGSVATGDLGISLITQDPIVDSFASRVPVTIE
                     LALLATFTSAVIGIPLGLWSGLAHRRAGVSGIARVLGSFIMSVPDFVIASVFLFVFSR
                     YSLGLTVGQWVPFQEDFGGHIRSIILPAVTLSAVGIGLFITTTRNAVIGILSKDYIMA
                     ALARGEEPREIVQGHVLRNISNPLVTTLSIYLGYLIGGAIIVEYVYSVPGMGRFLVQG
                     LLNRDYPIVQATVLVIACAVVFINMTADIAYGLIDPRLRKG"
     gene            complement(109313..110917)
                     /locus_tag="MED193_00510"
     CDS             complement(109313..110917)
                     /locus_tag="MED193_00510"
                     /note="COG0747 ABC-type dipeptide transport system,
                     periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transport protein, solute binding component"
                     /db_xref="CDD:10615"
                     /translation="MTNEHHSADLSAEDLRSALTRRSFLRTAAMTGLAAASATGVPGA
                     LYAQGASTMTWAKPLETTMLDPHTAILGSSWQMLHLVYDSLIDVDEELNPIPAIAESW
                     EQESPTSYLFTIRSGVKFSNGADLTIADVVGSLKRVQDPATGSWWVRPMGMIDDVVAV
                     GDNQVRVTLQEPHTPLIAALAATMCSILPMSLVESGELDVSKDMLGSGPYKIVSHEQD
                     DNWVLERNPHYYQQGLPKIDRIVVKIVPSDNTRIAQLRDGSIDIASFEASPDAGLLLR
                     GVANVEVNVEDVTNYYILGLNAVAEDSPFKDIKLRQAVALTLDRELIANIALGGGGQP
                     TAVMAPAHKACDTSKLPLFGQDLDRARQLLAESGNEDLSFELLVRNIPADIQMAQVIA
                     QGVAKIGLTANIAVVDEGIWVQRAWIDNPSKFEAMITWYAGYADPAISTLWWNPGVAG
                     FTAGHVENNDDINAAIDAAYQTGGEARGAVLQNLCAKIDESANVIPLVTRQDTIAYRS
                     DKLKAKLAHLEGYVHTLRNVETFELM"
     gene            complement(110944..112044)
                     /locus_tag="MED193_00515"
     CDS             complement(110944..112044)
                     /locus_tag="MED193_00515"
                     /note="COG0123 Deacetylases, including yeast histone
                     deacetylase and acetoin utilization protein"
                     /codon_start=1
                     /transl_table=11
                     /product="histone deacetylase/AcuC/AphA family protein"
                     /db_xref="CDD:24480"
                     /translation="MATGLVYHEICMWHDAGNVSSFVPAGLDVQPDRHAEEPETKRRI
                     RNLLDVSGLLDQLILIKPEPAEISQIARVHPDSYISGIEEASKSGGAEVGLNTFIGNE
                     GFDIARVSTGGSIAIMDGVLNGQMKNGYALVRPPGHHARPTEAMGFCIFANASIAIRE
                     MQEKYQLDRVAIVDWDAHHGNGAEEIFYEDPSVLTISLHQDNLFPLDSGAMSSIGEGR
                     GEGNNINVPLPPGSGRGAYQAAFDRVVIPALQAYKPQLIVVCSGFDACGLDPLARLML
                     HSSVYANLTKQLMECADDLCQGRIAMLHEGGYSRALAPYCGLAVMETLSGIKTNITDP
                     FDEYVSAFGGQDLQPHQEAVVNEARGLVDNLR"
     gene            complement(112155..113129)
                     /locus_tag="MED193_00520"
     CDS             complement(112155..113129)
                     /locus_tag="MED193_00520"
                     /note="COG2207 AraC-type DNA-binding domain-containing
                     proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, AraC family"
                     /db_xref="CDD:14970"
                     /translation="MGAMPIHADLIYCTSEFSKASRLEEWRASMSDAYYALDIVEDDR
                     HALDAKIEIVTLSNVCISKFRSTTAKGFRTRKSIAHDTTEHFVFVFVTEGEMFFNQLA
                     RWGTLSAGQYVMLRSGEPYELSCLSPSNAITLHLPVSDVEDRYKLAHLHCAKAIESDA
                     VLFPMAASVMQSVGSVPVSARKAMSHDLRRQVIDTILLLLRAERIQANVDGNDGHLGR
                     LIDYIEQNYANTDLSARTAAQDMGMSVSHVHRAFGSFNLTFGSTLRDTRLAQSYELLR
                     SSEGQNSNIGEIAFKVGFLDHSHFSKSFRTAFGISPTEVQQGASRPGK"
     gene            complement(113357..114751)
                     /locus_tag="MED193_00525"
     CDS             complement(113357..114751)
                     /locus_tag="MED193_00525"
                     /note="COG1012 NAD-dependent aldehyde dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="succinate semialdehyde dehydrogenase"
                     /db_xref="CDD:10741"
                     /translation="MSNAIKCISPVDGSVYAERPATSVTQARSVFAAAKQAQAKWSAL
                     SLEDRCALLHRAVDHFVSHASDIAIEISWQMGRPVSQAAGEIGGLEERARYMIDIAPE
                     ALHQDALPQSGLALRTIRREALGTVFVIAPWNFPFLTATNAVFPALAAGNSVVLKHSA
                     QTLVCGERFAQAFAAAGLPEGVFQQIMPTNADTTTLIEEGHHDHIVFTGSVGVGRYLQ
                     QVNAVNFSGIDLELGGKDPAYVRSDANIGFAAESLVDGAFFNSGQSCCGIERIYVHKD
                     VFQSFVDKVVEHVNAYRLGNPTLPETTLGPVVNTTAADFVRGQVAEAVASGARMLIDP
                     THFPTDQPGSPYLAPQVLVDVTHDMRVMTEESFGPVVGIIAVEDDAQAIALMNDSDFG
                     LTTSIWTSDLDAAEALSAQLATGTCFANRCDYLDPGLAWTGVKDTGRGCSLSSHAYGH
                     LTRLKSYHFRAQPQ"
     gene            complement(114799..116169)
                     /locus_tag="MED193_00530"
     CDS             complement(114799..116169)
                     /locus_tag="MED193_00530"
                     /note="COG0174 Glutamine synthetase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:22916"
                     /translation="MGKQLHLKTVEEVRQYVSEKDPKHIKVGFFDVDGVFRGKFMAQG
                     KFLSALQDGYGFCDAVLGWDVADTLYDNSKFTGWHTGFPDATLRIIPESGVILPFDNE
                     TLFFSSEFSGRAESICPRGVLRRVLQRAHDMGFIAKAAMEFEFFMFQETPDSLEEKGF
                     RDLKNLSPGNMSYSALRSIVQEDLYQDILDTFGSIGIELEGLHAETGPGVVETALAVD
                     GALAMADKASIFKAFMKILAQKRGLMATFMAKWNQNLSGQSGHTHMSLWSLDGAPRFY
                     DANGDHRMSQTMRHFLGGQLAYLREFAAMIAPNINSYARLTPGHWAPTSATWGVDNRT
                     VGIRVIPESEKSHRLEYRIPGSDVNPYLSMAAAIGSGLLGIEQGIEPGDAATGNAYDL
                     DVPTTRQLPTNLESAGILFGASQAANAMFGKAFVEHFSASRIFEAREFGRAVTDWELR
                     RYFEVL"
     gene            116098..116265
                     /locus_tag="MED193_00535"
     CDS             116098..116265
                     /locus_tag="MED193_00535"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLGILLGYILPNLFDSLQVELFTHHVPVPELEIVVFGKCPERLR
                     QQGGPNSDLPF"
     gene            complement(116188..117012)
                     /locus_tag="MED193_00540"
     CDS             complement(116188..117012)
                     /locus_tag="MED193_00540"
                     /note="COG3931 Predicted N-formylglutamate amidohydrolase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative N-formylglutamate amidohydrolase"
                     /db_xref="CDD:13238"
                     /translation="MSVFDQHPWDIGFQEGSVPRRPLLGAKEPTPAKVLNGSGKGPFV
                     FGCEHAGNRIPKSLGTLGLTKAERSRHIAWDIGAAHLTEKLSEKLDSPAVLQRYSRLV
                     FDCNRTASHPGAFVVEADGSNVSGNENLGKEEKLEREEAIYRPFHNTLSEITDRRRWM
                     GERIAYVAVHSFNDQVHGETRPWHVGFLYNQRSGMSRFMIDWFQSNTEYEVGDNQPYS
                     PLDAVDHTLRNQAETRGLPYTMVEIRNDLLRSERQIAVWAALLTQALRAFAKDHNL"
     gene            complement(116999..118369)
                     /locus_tag="MED193_00545"
     CDS             complement(116999..118369)
                     /locus_tag="MED193_00545"
                     /note="COG0161 Adenosylmethionine-8-amino-7-oxononanoate
                     aminotransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminotransferase protein"
                     /db_xref="CDD:10036"
                     /translation="MNKQASNSWEQRDMTNVFHGFTDLGTLNSNGPVVLSHGEGIYVF
                     DVHGKSYMDANSGLWNNVAGFNHQGLIDTICEQARRFPGYHAFFGRIADTTVALSEKL
                     IDVSPFDAGKVYYTNSGSEANDTMVKMLWMLHRRNGQPQRRKIITRLNAYHGVTVASA
                     SMTGKSYNAEFGLPLPGFLHADCPHYWRYGLGGESELEFSQRLARNLEELIIKEGPDT
                     IAGMFAEPVMGAGGVIPPSEGYFEAIRPILRKYSIPFVADEVICGFGRTGAMWGSVKY
                     NMEPDAIIASKCITAGYFPMGAIILGKEFSDELLRVSENAEEFPHGFTAGGNPLGSAV
                     ALKALDVLENEGLLENVNLVSPRFLERLHKLGAHKYAGEARGVGLMGAVELVANKDTK
                     EALPGEMQVSERIANKALEKGLICRPLGASIVLGPPFIITEDQIDEMFDILEETMAEV
                     FADVGL"
     gene            complement(118842..119792)
                     /locus_tag="MED193_00550"
     CDS             complement(118842..119792)
                     /locus_tag="MED193_00550"
                     /note="COG0630 Type IV secretory pathway, VirB11
                     components, and related ATPases involved in archaeal
                     flagella biosynthesis"
                     /codon_start=1
                     /transl_table=11
                     /product="VirB11 protein"
                     /db_xref="CDD:14094"
                     /translation="MERYLEPFRELLLRDDIVEIAINPDGKVWIEAAGDAAMRHEGQI
                     VDRATAFNLAQTIVGDANARVSEKNPLVSGKVEYGGRPLRVQVAVPPAIEQGASITIR
                     LFATAGVTGYTPSYLFGKAVSLDQLRAEKMKGIANQAEENLEAALEALVHQRLNVLIS
                     GGTSTGKTTFARHLLTHVDDGERLITIEDAFELFPSQPNTVALLASRGTGTQRSSNAL
                     LQASLRMRPDRIIVGELRGDEALTYLEAINTGHGGSVSTIHAETAELAIDRLAIMVLQ
                     AGTPLNFAEVRQYIQKSIDVIVQLVRVDGRRGIAEFYLPN"
     gene            complement(119819..121249)
                     /locus_tag="MED193_00555"
     CDS             complement(119819..121249)
                     /locus_tag="MED193_00555"
                     /note="COG2948 Type IV secretory pathway, VirB10
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein B10, putative"
                     /db_xref="CDD:8701"
                     /translation="MADENTPDLRDRLSTFSQKNKTKRRGGNIGVGALAIALALGGGG
                     AAYLLATNLQEGTTGLETSDVETFQDQRTGNGGRLEFPPDEAEQQVNDALIAVEEALD
                     VPSPVPAAEPSAAVLEEIAKLREALAASQSARNAEIQEAVSDLREAFQVQTDALEASI
                     AAKDTEIENAQRQSEARLAGLQAMLDAERAQREGLEAEMARDGLIADQRLLEERQRQE
                     EEQRQREVEQAAQELLNAQIVSPSVVYADGPRSTSAGGTNPTAALAGADGPTLSENEQ
                     YLRQGARPLDVQEASQMAFPERTLSQGSVIQAALQTAINSDLPGSVVAVVSEPVPAFS
                     GDQILIPRGSRLFGQYRSGIELNQKRILILWTRVLTPDGTSIEIASVGGDQLGRSGLT
                     GIVDTKFAERFGGAALISLIGAAPAVAANSTDNEIASEVLEGVSGDLEDAVGSVIAEQ
                     VSISPTIYIDQGASVTVLVDRDVVIY"
     gene            complement(121252..121983)
                     /locus_tag="MED193_00560"
     CDS             complement(121252..121983)
                     /locus_tag="MED193_00560"
                     /note="COG3504 Type IV secretory pathway, VirB9
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein, trbG"
                     /db_xref="CDD:15554"
                     /translation="MNTAACLICAAALLSASPAMSETVPRSGPLDNRVRTATYVENQV
                     FVIETDLRHSTTIHFGQGERFDVVIVGDTESFQVDPIPELGNVLTIKPHVQGASTNMT
                     VITNRRTYSFHLREGAIPGRSGMFFEVRFRYPEDERRAAAASTQPKGFEAPRNYSYRV
                     AGEGDFRPTHIYDDGRYTYFTFPENGRQPAVFKADEQGRERTVNWTQQGNTVRVLGVN
                     EFWTLRIGDEAICALRDDSAIYVSN"
     gene            complement(121988..122659)
                     /locus_tag="MED193_00565"
     CDS             complement(121988..122659)
                     /locus_tag="MED193_00565"
                     /note="COG3736 Type IV secretory pathway, component VirB8"
                     /codon_start=1
                     /transl_table=11
                     /product="VirB8 type IV secretion protein"
                     /db_xref="CDD:13056"
                     /translation="MKSQTSQDQSDAFAVDFIYGPRRRERFAYFVAAAGVLVGLAGIV
                     AGASLFPLKSIETFVVVVDKETGQMDRVAAVQALSLSESDAIIQANLVAYVDDRETYD
                     LTDGEQRINSVLERSDGDAARTLRDLWTSSNEDYPIAVYGRDAVIEVVIKSVNQIEPG
                     VAQVRFTRTLRRARDTRSVTRSYVATVGYAFEPETRQRLQDVWANPMGFVVTSYRVDA
                     ETLEN"
     gene            complement(122679..123692)
                     /locus_tag="MED193_00570"
     CDS             complement(122679..123692)
                     /locus_tag="MED193_00570"
                     /note="COG3704 Type IV secretory pathway, VirB6
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:15907"
                     /translation="MGIIRDILDQVDAAVDSVAQEGFISSAAAVGDVITAGAILLLIL
                     LGINVVMQLRPMTFGSAFAFGIKISLVAIFAQSWDNFSVIYGIATQVPDSVGASILAL
                     TGSGDEAGVYESLDNMVARITAYGDTIGDQAGWVFGAVLGAIFFVLSALFAAVTAGII
                     AFAKIVFALMIVIAPFMIITSLFKPTQSLFEAWSRATIGYALMPVAAAGAAGIIVAIA
                     EAIGDASADPVDVETVSLILPFLVILLLSAGIMASVPYIASNLTGVMGIASNAVGLTG
                     LARRGIVNTSDYGTGSATRFATGKSPQELQQAVNSGVVKTGEAIRRTPATALNTVKSF
                     RAP"
     gene            complement(123696..123992)
                     /locus_tag="MED193_00575"
     CDS             complement(123696..123992)
                     /locus_tag="MED193_00575"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAVAPDAEEFCRVPRPPAGLAETAYLRNGYRAILRILVAERQLE
                     TETCDCPLSDFTWDMALAELPRFQTTDNPRLPFKVLDLYAMADALEAEHAEGCS"
     gene            complement(124112..124852)
                     /locus_tag="MED193_00580"
     CDS             complement(124112..124852)
                     /locus_tag="MED193_00580"
                     /note="COG0840 Methyl-accepting chemotaxis protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MITTLGVSSPAKAQGVPTFDGSQLGQLVAQLEHMAEDLNVQLQQ
                     LATMRLELETQLSQLLNLEAQLTSLIEGSGLSGLFASIEEFRALRGKLVAPLNTARAL
                     ADGDFLSGFNPGAELEASVERVLSGSGFTSETLSTLSSSPEPADNRIATSAGASAMLS
                     VAAQESHAEAGQSLERLETMVGLIDDQDGLKAAVDLNTRVTAELGIILTQIWRLEAAQ
                     GVSAGQLGVVDAATLADERRFRSMAVDP"
     gene            complement(124876..125946)
                     /locus_tag="MED193_00585"
     CDS             complement(124876..125946)
                     /locus_tag="MED193_00585"
                     /note="COG0741 Soluble lytic murein transglycosylase and
                     related regulatory proteins (some contain LysM/invasin
                     domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:27995"
                     /translation="MHATSGFAQGVPTQDNAAIGQTIARVTALVQDLGTQGDKEAERS
                     SIADVQADQLRTLEAISAAMTGPGFDISALEGNADFGVASVYPNIDTSPMNSRLFGEG
                     RETVEMMIVRVAGEYAGAPGVARAGLSATQWRCLFQALIKQESRFNITAESHVGAYGL
                     TQLMPGTASDLGVNPYDPMDNLRGGARYITTQLNRFGNIPHALAAYNAGPGRVIEYGG
                     VPPFTETQGYVRNISKFYNEYLAVVGGADALGTLSSSDFALAEYANISDAGVYYAASS
                     HATTMQVINRLRAIILQIDAQPNAKAAWELNTYAKAEIARILNLRVRLMAANQQREAT
                     HAQHLVADRLSEREFMQMGVPN"
     gene            complement(126188..128578)
                     /locus_tag="MED193_00590"
     CDS             complement(126188..128578)
                     /locus_tag="MED193_00590"
                     /note="COG3451 Type IV secretory pathway, VirB4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein B4, putative"
                     /db_xref="CDD:12779"
                     /translation="MGVTALALDGGTLSGIGPAVREAGGTGFARESYLAEHLPYFALA
                     TDDVMVLREGDLLATLRLDGLNPMTTEDDRLDALKRAVAAIVAQTGNTFGFYIHRVSV
                     PQNLDLKPVEGDTFASQVDARWAAHIKGLRPSKRQMYLSVIRRPNLAARIPFLRALAR
                     KAWVKDRAARVQELNEVMGFFAVALSSANPVRLTKTGGEWLGYLNTLNAGSFSPIAFG
                     QSPLPLSHTISDCRATFDGDVATITCATTGAVKYGALFSIKSYPALTDVTLLDALDLP
                     LDIVLTNSFSPIPNNIMAERIQRIIRQMHASDDAAVSLRDQLALAADDQEAGRIAFGD
                     HHLSIAVYAPDRDTLERAAAQIKRVGQEIMAVIVRENMALKATYFAQSPGNFGYRARK
                     TPISSTNFSDFAALHGSVEGRSNDESPWGQSIAVLPTVGTSGYRFNFHEAGSASKEPT
                     VGHTLVLGRTGTGKTLTTAFLTAQAQRIGARLFFFDKDRGLEMAVRALGGRYNEIRAG
                     VPTGLNPLASEIDERGRAWLSDWLATLLTRSGALSGEQSRHIQGAVTQNADAGAALQR
                     FASFETLFQSLDDDGELQSRVAEWAPGGRFGWVFDEPDRGQRLDLSGDIVGFDMTEIL
                     DMTTERMAVLSYIFRQIERVVEDRRPTIIVLDEAWKLLDDPYFGARLENWLVTLRKMN
                     CVVIMMTQYPSQLRDSRVGKTIVETVPTQILFPNDRATVADYDFLRVNSKEAALLVQP
                     TIGQRIALVRSAGDSVFVDADLCALGDLLPILGGGATGEARVPADWRSNPDFWRPQ"
     gene            complement(128553..128831)
                     /locus_tag="MED193_00595"
     CDS             complement(128553..128831)
                     /locus_tag="MED193_00595"
                     /note="COG3702 Type IV secretory pathway, VirB3
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13022"
                     /translation="MAERSPLFLGLARPPKYLGLPVGYLVVLAMGVVLPFIWTKSLIF
                     FLIGIIAYPVLWFVADKEPHFFEVLRISFGTVRPTKNRAHHGGDSFGA"
     gene            complement(128963..129211)
                     /locus_tag="MED193_00600"
     CDS             complement(128963..129211)
                     /locus_tag="MED193_00600"
                     /note="COG3838 Type IV secretory pathway, VirB2 components
                     (pilins)"
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein, trbC"
                     /db_xref="CDD:13155"
                     /translation="MVATLALLASPAFAQDLSPIQTMLETVEAALTGPIGIAVATLAV
                     IGTGFMCMMGRLNWGWFASVIIGIVLIFSAGTIVDGFT"
     gene            complement(129259..129804)
                     /locus_tag="MED193_00605"
     CDS             complement(129259..129804)
                     /locus_tag="MED193_00605"
                     /note="COG0741 Soluble lytic murein transglycosylase and
                     related regulatory proteins (some contain LysM/invasin
                     domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase SLT domain protein"
                     /db_xref="CDD:27995"
                     /translation="MEAQPVAVAPIAPAAGASAQVLSLIRQTASRHQNNRAIAQAGLS
                     TRDWHVLFQAMIEAESSYNPTAISPKGAYGLGQLMPATARELGVDPRDISQNLDGAAR
                     YLLTQLAEFRSVELALAAYNAGPHRVEQYSGVPPFSETRAYIARIHDIRERLSGGTSQ
                     PAPIRVANTAPTRAPVIIELN"
     gene            complement(129896..130210)
                     /locus_tag="MED193_00610"
     CDS             complement(129896..130210)
                     /locus_tag="MED193_00610"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPIARNQILITLDGVKDLQKREVAFRCRYELVGFTDDGKPRYQC
                     IYLREGEPEAILVSTRITPLGPEARYFNIWPGLFKHHLEFGDGRDLRFGADYNITLEG
                     NG"
     gene            130343..130921
                     /locus_tag="MED193_00615"
     CDS             130343..130921
                     /locus_tag="MED193_00615"
                     /note="COG0047 Phosphoribosylformylglycinamidine (FGAM)
                     synthase, glutamine amidotransferase domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKRLILSAIFGVLMTFGAPKKAQAYDIDCAIMLCMAGGFPPSAV
                     CARAYRTMIRRITPWPSRPPFGICTFAAVPIELGGPGGEGEVDTDLPEYEWLNRTHVI
                     WFTGRSYTPRDDPRQWDWSIRSCDRENRTCRYIARVYGSHTRWPSSFVSESGQTILLP
                     VGRGFGNFYSRDIMVEYGDYGGNMGHSDWFSY"
     gene            complement(130939..131250)
                     /locus_tag="MED193_00620"
     CDS             complement(130939..131250)
                     /locus_tag="MED193_00620"
                     /note="COG0685 5,10-methylenetetrahydrofolate reductase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MATVQKLAFALEVDPIELIEPVLITRGKKSGTADHETSDDQKVS
                     GGSQLLAVPFQEGFEKRQDDLTLVLIDYRWNDGSTVRRWLVDPKKVKQSAIVVKPCIL
                     L"
     gene            131546..131800
                     /locus_tag="MED193_00625"
     CDS             131546..131800
                     /locus_tag="MED193_00625"
                     /codon_start=1
                     /transl_table=11
                     /product="hicA protein"
                     /translation="MNSKHRKTLAVVFADPVSGTVEWSAVERLLVAAGAQVIEGRGSR
                     VRFEKDGEVETFHRPHPAKEAKRYQVRAARAFLERIGVTP"
     gene            131797..132129
                     /locus_tag="MED193_00630"
     CDS             131797..132129
                     /locus_tag="MED193_00630"
                     /note="COG4226 Uncharacterized protein encoded in
                     hypervariable junctions of pilus gene clusters"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23758"
                     /translation="MTNTMTYKGYSARIEYDDEDGIFTGRLAGISDGVGFHADTVEAL
                     RDAFQEAVEDYVETCAKVGKEPQKAFSGQVMFRVDPEVHRKAALAAELSGKSLNQWAE
                     EVLGRAAE"
     gene            132273..133868
                     /locus_tag="MED193_00635"
     CDS             132273..133868
                     /locus_tag="MED193_00635"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MERVKLDNGNQKRPPLSARAASATGRSALFLAKVAGKAGWAIAK
                     PVGRQTGKLAAKGGKAVKDHAAVKFAEFELRHTKYTPENFFEKGAISLEDLVDALLIE
                     KRGTSARIVTALSGKLAAAGTTASLFSIASILGTASTGTAISSLSGAAFNSAALAWIG
                     GSVVTGGWIVLGVAAAGGAAAYFGSRKLVGKWTGVRRKKKSLDPQEMRFVETCLMLAT
                     AFRERANQNAVLDPLTAETLQQNLKHDLLEQLDVCIAKVSDWPDLPLMRLEDRKVDLV
                     ELLDALPMAHVQNPSIRRKSTAAAPVVTGVVSATILKLMSDTSPSFTEDEELVLQALR
                     RSNNSLADASELELSEYVQSLSVEQISGLKNNVKGIYHELAFQRQENLDGDEYIVELF
                     GDTNHAGADVRIINVETGDVSEVQLKATNYASYVREHNEKYENIDVLVTSEVAGSSPD
                     WSSSEFSNADLTADTSSALQKLGHEADVDIVHSMGVAAMVALATNAKSMLKGDALSTE
                     AKQKIIQDGVVAASVAGMVQLII"
     gene            complement(134001..134159)
                     /locus_tag="MED193_00640"
     CDS             complement(134001..134159)
                     /locus_tag="MED193_00640"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLVTARSRMAGEISIREFKTVTGIVSFLTDCGFTKISFPVIEGD
                     TVRLPLDT"
     gene            complement(134475..135749)
                     /locus_tag="MED193_00645"
     CDS             complement(134475..135749)
                     /locus_tag="MED193_00645"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MDNRFAYMRKYLGFSQKDASNIFSTRLDTIKKWDSGKLLVPGPV
                     LEELYDYIRFSNDMVVEFCDERQAEDEDEGIDEIYLRTFTVEGLAEQGLPPSLGWQDQ
                     VIGAIIGRLASIHVYGADTLPEHHDPDYHWYEYWGFEPVKKPTEFFTIQDEALFANEL
                     AKAVEGNFWQVDFDPDENYYLIGFRTKSVSKVTRHIWIRAVRAGRGSELVERFAGEPL
                     RYCDSFGEGAPYIEGPNKAKIPVGFASGHDDDTVDPHTLAETLFAALATSYPTEGAMR
                     EACRDRYAALVGADEGYTADFMNDWDVKDTRFVSHNFIAALFFETQKQTGLTLHPEAM
                     VELCSILAKSEPSIRSMDHEVVVIDMGEMVFTITLDLRDVLSQSGDGRDFHTEASKAL
                     DVIQASIGNDGLTRIEPFSTIEIEFTSDDAEG"
     gene            complement(135742..135876)
                     /locus_tag="MED193_00650"
     CDS             complement(135742..135876)
                     /locus_tag="MED193_00650"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MQMALEPLAPSTEDNYASKQPEDWSTGFWFQVQFQQQMEDYRYG
                     "
     gene            136207..136986
                     /locus_tag="MED193_00655"
     CDS             136207..136986
                     /locus_tag="MED193_00655"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MALCASYRAGRGWLDIQRPSGRFFPLQPHFGVNRIATWAPSSGT
                     TVNTNGMPRTAVGTVATPTLATTKLSTSMRRWRVASAASADAAAEERSAGWGCWRGNA
                     EGLGGFTYVNRLSLVTLQATGMGFFGLYGSTAALTTTLTLSAVVNCIGIGFQRGTHTN
                     WQLVQNDASGAPTLTDLGASFPVASTTSVLTLTLLAAPNSSEIGVRMVEEVSGAVVEF
                     TLDTDIPVATQLLSPRNSMNNGGTAAAVGYDCSGVYVETDY"
     gene            complement(136980..138089)
                     /locus_tag="MED193_00660"
     CDS             complement(136980..138089)
                     /locus_tag="MED193_00660"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSDDFSVRWVRVTGREGTMMPRLTFSGLLVPYLHFTDMTLVWSD
                     PSQIGFQNLFLRDAVIQGAFSTISATRLEKITGVPAQFWRPSLLALESAGLLAVVDDE
                     PQDATAGGVTYRLVDGAKADPAALDEWDHISTRIRVIRDVLVFPETGELMVSTGNPNH
                     PVDRFMAFFLQTDPKKTFDWFSSVLPRVDSAESLKSYLTALGAASPPVGVPEQVTNLD
                     FRITGGRPRVAPVRAVSGIFDTTRTDLQPFLTRVLQENEKGLWFLPPGAMTIPEGAQS
                     IENLHGLPAMLRRRLDQCQSDEVISAARRRAPKAFPQLSALALTDPYCWTIDGTTTSP
                     YVLEVHFSEVRIRIGIPNSTAEAIDAVPASAEAVQ"
     gene            complement(138082..142326)
                     /locus_tag="MED193_00665"
     CDS             complement(138082..142326)
                     /locus_tag="MED193_00665"
                     /note="COG1112 Superfamily I DNA and RNA helicases and
                     helicase subunits"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10834"
                     /translation="MTRPEQKKLIAAVQSLQAWQAHIQDRGSLRLQVSLSCLLRSRYR
                     PFSISVREFQKQVSNGVLLRRDDTAPDEAVDTSAQPTRAHFRLVTNQHAFSVTSALDP
                     IDGMGMLHARDYLWTRKPITFGMAVSAAPIKVAPIITLHLLPWTRLPTDWQDWVRSLE
                     TEGLLVPFNPKTKELDTGSRHVWHSGPFVFEVQLLAAEGEEPANAVVNWVGRRKNGKN
                     LPSRGSKAVLHLDADSLRLETSLPLVLPPTLLGSNVFPRTRSPRHFKSLGLDKARDLR
                     RPEETEIEDLSPLPEDTRFSNDDIAPLMQNGVVALDFATGRNRFSLFARPTVSPLTGR
                     PYLAVVGAKRTPKKTGTGHRNAETATLRNDCLRPVSAFALELKKPALERLWKGAAPPP
                     TPQAVFSDLDHGFNLLNFASEPVDGGGIKLNSTQFYLIVRPEQGQPREPIPGVRVHIA
                     THIQPNDWPLRVCFQADLIPVNRIEPLFPDELLIERSNDSTRRTLDAHYHFSSHFAQL
                     LNIRDAGTFHYSPRPSWRAPVNVLGVQDRTRRVFPNVPERIAQVLGSVRPRVLLRLNA
                     PPGRGLFLDGSAVGLVDDQGNVSPFRIEVISGQHVLLRAVRRPVGPDKEPPIDQYECP
                     FSPGDKAWIFRRHAVDRADLEQQIRDLRAGKYFVASQEVFARVVSQPDALSGAFEPNA
                     PVEQLMARNTRKRACANPLNARQKEAVSKAARTPHAFFIKGPPGTGKTEVIRELVEIL
                     AARGERILLTSAQNKPLADATERCMNSYGVVPTRITGRRPDLNPSEASCLWASLVERL
                     TAAFDKDDGFGDRLDAEEHRLHALWQSRIALGGLDAAARDARIEDLVRQLLSSVNLYV
                     INIDALAGRIGSLRARLERATAGPRPDDEPDGGPIHAGITSVAATQSARNSPTITPDF
                     EAEFDTLIIDEASRVNDSAFVTAALRCRRWILVGDERQLPPFLADTDASFFHALCALY
                     LVEGRMIGALAQKGIQKHQVPTLDAYLTDTATSDTELRDAVERVGNLWLMKDDRRPIQ
                     SDQVQDIAAALLWQGAFAGRTATANPEEEDAQPRQSTIGKKFDKIIQGQARHHAQPRR
                     PSLQAPQTEWQAYQDMLASYFDAVIDGVQNNFDKFFVRSFFERGYATGNTTEDDNGQA
                     EGFRATLVEQFRMVPEIANLVSERVYDGEYVTPETPPVCPLHLPSFPHQVHFVDLSLL
                     GRISPATQIGTSWANPDEAEHVIEIIRKISAELPGGTTVSVMVLSLFAAQTEFIRARA
                     TEVFGSSGAAPALKGISRLDFGNVDAVQGGEADIVVMSFVRVATGGMPEPGMALFLQD
                     MRRLNVAITRARRKIIFVGHGTTIENLSGTAKAADFLAWMASAESGTVRDMPLRLPYE
                     QLVAGRRALRRFAGSDRTLAQDAEADGIPDEEAADE"
     gene            complement(142323..147248)
                     /locus_tag="MED193_00670"
     CDS             complement(142323..147248)
                     /locus_tag="MED193_00670"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKSDSVTQRELSDRLDRAFSEASGKAPTGPYVFVLQSPALSGKS
                     EAVARYLQRRIQHGPEGRETAGHHWVALRTHHETQRELNLSKARARPTKYVPDFFWFC
                     TGARRHRSFSRDENARIDSPLWDLAEQVADKEVRKKLSPGARAVDFLENIQDRFSLKG
                     LMINAGNAILGTSMEAFAPGMAEAQPFIQRSIDTVAEQMSQVWAETNGEDIRRTLRSI
                     DRALGDAFFDNLRDFSQSISGKPTFLVLDDFDEMSEMAQAIILKNMSTDGFERLIVIL
                     TLQEGTAQANSLAEELGRGDLARNTVLLTLSAPTGVELLSQLQEDFGAAVSRELVDHL
                     SNRSGGSNPVIIREIIQALLGWYGGRPYLVIDGQADERTLTFTSNVTLEDINSEFFSV
                     GSKSSDELSDILGNIWGDAIRRLDDLDQFILAAIAFGGNEVSEDFIVAALQQDTGFTS
                     TAVTEVAHWRERVRDLAARLSFLVSDAENIFRFDGAYTRFAILKVTERIWAPRRAVLL
                     AAAVVDAFRLGHALQQSAAFGSTCAELVLSVADGNQPLCRMRVSGSSLHAFGESSLER
                     VESLRSGLASIVISSLPDDRQTEADISERADKILSAAAEHFYVQSLSGRDRSAQDRLR
                     FLASALRASGYPDFPHARARASVLQLRLALNRRPLTSGGLQNVIKLSEIERKAAREHL
                     DEMKPEENWRLALLAIEMDILHAEAVLGAIKSGQAKSGTSNRDREEARQQVFRSLREA
                     VERLSRDPGTEADRNGEKNRLLDRLLSGEIDKMAYLDLLSEVEKSESTTNFAWPKGAK
                     AEVDFQLVRARERLVFLLEFHASPDDDRSQLEETRAELSRSLEDYVKMGPQPHLQARF
                     AWATRKLGLILRDQACDTQGDLGTASPETINISERAVQFLSISYDQSKAPNVAMELLR
                     AIEFHVGLVGDTRSLTRLRDRLLDLGRELVTAPLASRTIVGVAEIESRICARLGDGAD
                     VSPPSLWAGYVAGDTEALFVETAFTDFARIPSRNDRYWVLSRLFSEPELAETNVLERL
                     LASGRDIGGLSIAAIVDTLDVFEQQRFEAVPDKTPLTDQASSELLRALDQIGPKIQTV
                     APPTRVALDMLRFRVLAQKAIVAISHSNDSASVFEANKSVETLARSIGDLAQALRDEK
                     SAKKLIGYAKQIGDAFLARAASMEDRAFHFALRDAALAWYQLATTTLQTCPDLKISVS
                     ILRSHAGFHRDHGNFSEARLLNNACARLERYRKWGNDLGGTVYAATDAILTASAESQE
                     RGARLLLLAVLKAEIVDPQIIARMPAFEAERRQLRTRLAAVLWQSLRSRQPKQVSASM
                     SLAPPIDAVRKFAEPSSAPDTGERPGRANSLVGDILSFWAAEPPPAPTPGTLVVARIS
                     AVLPNGIELLDLRGQRFRIDDNLLPSSYYQFLKYAVGRDGSDLAASLRKKKLAAMLPI
                     IVLAGDGEAGLGDGVLPATARGLAYLGDLIGCLLPGLSRGLVVGGSNSVVALRLAQPD
                     FEPFRVGGWTLHKQIAAELLCVKRLILAPAPYVPQAPNSMYDRHALLQQELADFARAT
                     WSALSLVSLRQDLSEATFEIAIDAPVSPQTERTTRSLLRKAFPDVHLIRFLGGALEEE
                     AFSDITGDTATDTGQATGETTSPNAQSGAVL"
     gene            147634..149034
                     /locus_tag="MED193_00675"
     CDS             147634..149034
                     /locus_tag="MED193_00675"
                     /note="COG3505 Type IV secretory pathway, VirD4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12833"
                     /translation="MEDVHPEPLPYGFSYGPRPRPTYPEDWDPILQSGEGHLMTIAPT
                     GAGKGVSAVIPTLLRYPGQAVVIDPKGENYHVTAAARRAMGQRVVLLDPFDVCGTGET
                     DRLDPLDLMRAGLIPANTAQRTGKGLPADEEKAREFLGDTARQIARALVPDIPQLRDP
                     FWENSARRMVGALLAYIMAESPKALTNFAELVYTLSQSDKDLGLTVKDMARSKHPFVQ
                     SAASGAFPAEPKVRASVVSTALAAVEFLQGKALEVTQKSTFHLSDVLEGEPMTIYMVL
                     PPEKLASQGRLLRLWMTTLISTLSQRRRLPETPTLFLMDEAAQLGRMDEFLSAVTLMR
                     GYGVKVWSFWQDLSQITAHYPSEWRTILNNTHALQMFGLWNTHMRKDAMNITGFDDLW
                     ELRDMDRNEQLLVLSGDDPVITRRANYLDDPAFDGLAAPNPYYRGSEGEAERLRPIVE
                     PRSYARGPSTDGEAPA"
     gene            149031..149837
                     /locus_tag="MED193_00680"
     CDS             149031..149837
                     /locus_tag="MED193_00680"
                     /note="COG1253 Hemolysins and related proteins containing
                     CBS domains"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSLVWDEPEYPTARVVEHVQQSLPVRLIMVPRSQIQTCAMGDTA
                     ADVAKRNIDDFSYVPVADDAGEIVGLYHAAQWFNRAAPDHTIDLGVAPLSDEMFIDVQ
                     ASILDFILGADRAPTLLVRNRDRISGLVCVSDLQKLPVRMALFGLITGLEMAWAQAIE
                     LHWNGGDGWMHHLSSNRQAKLRDRMAYLRRTDAFVDALETTQLSDKFTILLRENLLPG
                     TERQLRGQYDRIEELRNDLAHANGYAETPARARGLSQTARDILRLQDHAL"
     gene            complement(150095..151603)
                     /locus_tag="MED193_00685"
     CDS             complement(150095..151603)
                     /locus_tag="MED193_00685"
                     /note="COG3436 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:3544"
                     /translation="MLEMPQTLPSDPDELSALTAQLRDLDRAQALKIEKLEHQLAGHR
                     KARFGSKSESLDQLAFDLHEDADIAAAAATQQEEDGQDGEGKRRHSRAPLPDHLERQS
                     EVLSPGETCADCGGTLRALGEDVTQELEYIPGRFVVREIVRPRMACNCCEAFAQVPLP
                     SRPIERGRAGPGLLAHVLVGKYCDHLPLYRQSEIYAREKVDLHRSTLTDWVGRSTALL
                     APLADYIGKQVRAGPALFADDTPVKMQIGGKTGKAQTARMWSYVRDERPWCGQAPPCA
                     WYQFSVDRKGKHPAAHLAAYKGTVHADGFTGFNGLFGEGLASEQACMVHVRRKFVDVF
                     ERNGSTIAKETIERISRLYAVEKDARYKPPEERVALRQTKAKPIFDDLETWLKSQLPK
                     ISGKTKLAEAIRYALSRMPKARAYLENGQLELDNNICERSIRPLTLGRKNYLFMGSEG
                     GGKAAAIAYTLIETARMNRVDPEAWLTWVLTHIADHKINRIDELAPWNWQPS"
     gene            complement(151642..152013)
                     /locus_tag="MED193_00690"
     CDS             complement(151642..152013)
                     /locus_tag="MED193_00690"
                     /note="COG3436 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="70 kDa peroxisomal membrane protein"
                     /db_xref="CDD:23941"
                     /translation="MIPVPSNTRVWLAAGVTDMRRGFNTLAAQTEKVLAEDPYSGHLF
                     VFRGRRGDLLKIIWWDVQGACLFSKRLERGRFVWPAAKEGKISLSPSQLSMLLEGIDW
                     RMPQKTWRPLTTGNLPENPAP"
     gene            151696..152028
                     /locus_tag="MED193_00695"
     CDS             151696..152028
                     /locus_tag="MED193_00695"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRHAPVNPLQEHRQLRRAEADFALLGGRPDEAPAFQAFREQTGA
                     LHVPPDDFQQVSPAPAEHEQVARIRILRQHLFRLRGERVEAAPHVRDPGSQPDPRVAG
                     HRDQVISP"
     gene            complement(152010..152417)
                     /locus_tag="MED193_00700"
     CDS             complement(152010..152417)
                     /locus_tag="MED193_00700"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23225"
                     /translation="MAGKKGQKKRFWSDEEKRSICNQTQVPGVSVAQVARRYSMNSNL
                     IFTWLRDPRYAPGPKEESCGPDGGDVFLPVEVSGPTLEDRTDAARVETVGLYNGTVLA
                     NRIDITLSDGRRIVVEGPTALSAVVRLVQGLIT"
     gene            152694..154046
                     /locus_tag="MED193_00705"
     CDS             152694..154046
                     /locus_tag="MED193_00705"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MASKTTLNAKNLAALGAERLADLLLEVTKGNAGAKRRLRLELAK
                     EAGSGNVAREIRKRLSTIARSRSFVDWQGRNAFAADLDMQRRAIVSQVGPVDPTGAFD
                     LIWRFVALANGVYERCDDSTGKVQSIFYEACEDLIDLAEVAAPDPLVLADQLLEALAD
                     DDYGHYPTLISGLASVLGSEGLQHLKAGITTSGIDLSNNYALRMALEQIADVEGDVDA
                     YIDQQSDLARKAPQVAAEIARRLLEAGRVEDARGAINAPDGKDRGWIPYEWEAIRISV
                     MRAMGEPEAARDFMWACYARSLNQDHLRAWLGGLPDFEDVEAETRAMEHALGFESFTT
                     ALHFLMTWPEIEQAAVLITNRASEIDGHHYELLGPASDALEDRHPLAATLLKRGLIDF
                     ALQNSRVKRYRHAARHLRECKNLAVRIDDFAQFETHEAYLDGLKQSHGKKTSFWGAVV
                     "
     gene            complement(154151..154594)
                     /locus_tag="MED193_00710"
     CDS             complement(154151..154594)
                     /locus_tag="MED193_00710"
                     /note="COG1846 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulatory protein"
                     /db_xref="CDD:15281"
                     /translation="MNVYYMPGHLIRRLNQMSTQVFSHHVQVAGYDLTPVQFAAMDAV
                     RANPGLDQAGIAALIAYDRATIGGVIDRLEQKGLVTRSISKRDRRAREVALSDMGHKV
                     YQDVLPTIVRVQGEILEGLTDDEQKQFLRLAEKALRSASNSYSKT"
     gene            complement(154713..155318)
                     /locus_tag="MED193_00715"
     CDS             complement(154713..155318)
                     /locus_tag="MED193_00715"
                     /note="COG1961 Site-specific recombinases, DNA invertase
                     Pin homologs"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA integration/recombination/invertion protein"
                     /db_xref="CDD:11669"
                     /translation="MGQRAAIYARVSTSDQSCERQLRELTEFAERGGYEVMGVFKETA
                     SGTKSNRAERSKIMELAQARKIDAVLVTELSRWGRSTQDLLDTLNKLSGWKVSVVAMS
                     GMTFELDTPHGRMMATMLAGIAQFERDLISERVKSGLAAARARGKKLGRQPGQRPKSD
                     KLAPDVLAAVEEGRSYRWIARDLGVSKNTVLSIVKRHRENA"
     gene            155412..158300
                     /locus_tag="MED193_00720"
     CDS             155412..158300
                     /locus_tag="MED193_00720"
                     /note="COG4644 Transposase and inactivated derivatives,
                     TnpA family"
                     /codon_start=1
                     /transl_table=11
                     /product="Transposase"
                     /db_xref="CDD:6485"
                     /translation="MPRRNILTERQRAALFDLASDEPSLLRHYTLSDEDLEHINLRRR
                     PENRLGFALQLCALRYPGRALTPGELIPHDVLAFIGAQLGLTGEALLSYAARRQTRQE
                     HMEALRNLYGYRAFSGRGARDLKAWLDEEAEISISNEDIARRFVDECRRAQTILPAIT
                     TVERLCADALVAAERRIETRIAQRLSDDLCGQLDALLSERIDDRLTRFVWLRQFEVGN
                     NSAGANRLLDRLGFLQDIELPPDLIDGVPDHRVTRLRRQGERYFADGLRDLPGDRRLA
                     ILAVCALEWRAAISDAIVETHDRIVGKTWREGQRLCAARVENARSAVQQTVRFFRDLG
                     AALLEAKEDGASLEKAVEGSLGWDRLPDLVAIAARLSDTLSSDPVAHVVQGHNRFRRY
                     FPRMLRLLNMEGAKVASPLIEATALIQSGAKHDQPRDFLRRTSKWHRHLDSQETGDKR
                     LWEVAACFHLRDAFRSGDVWLKKSRRYGDLKQVLVPATVAAENGRLAVPLDPEAWLAD
                     RHAQMEIGLQQLSKAAKNGAIPGGVIKDGVLSLSRLPTKTPSDAADLLFDLYKRVPET
                     RITDIMLEVDEATGFTDAFTHLRTGAPPKDKIGLMNVLLAEGLNLGLSKMAEASNSHG
                     FWELMRISRWHIESEAYGRALASVVDGQGNLPMARFWGMGLTASSDGQFFPTTRQGEA
                     MNLINAKYGNEPGLKVYTHVSDQFAPFASQTIPATVSEAPYILDGLLNNDVGKRIKEQ
                     YADTGGFTDHVFAVTSILGHRFIPRIRDLPSKRFYVLDPGGTPPNLKGMVGGKIREEL
                     IASNWPDILRIAATMTAGTIAPSQILRKLASYPRQNDLAVALREVGRVERTLFMMDWV
                     LNTDMQRRVQIGLNKGEAHHALKNALRIGRQGEIRDRTAEGQHYRMAALNLLAAIVIY