LOCUS       MED193         4674670 bp    DNA     linear   CON 09-NOV-2005
DEFINITION  Roseobacter sp. MED193.
ACCESSION   
VERSION
KEYWORDS    .
SOURCE      Roseobacter sp. MED193
  ORGANISM  Roseobacter sp. MED193
            Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
            Rhodobacteraceae; Roseobacter.
REFERENCE   1  (bases 1 to 4674670)
  AUTHORS   Pinhassi,J., Pedros-Alio,C., Ferriera,S., Johnson,J., Kravitz,S., Halpern,A.,
            Remington,K., Beeson,K., Tran,B., Rogers,Y.-H., Friedman,R. and
            Venter,J.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-NOV-2005) J Craig Venter Institute, 9704 Medical
            Center Drive, Rockville, MD 20850, USA
FEATURES             Location/Qualifiers
     source          1..4674670
                     /organism="Roseobacter sp. MED193"
                     /mol_type="genomic DNA"
                     /strain="MED193"
                     /db_xref="taxon:314262"
     gene            complement(<1..823)
                     /locus_tag="MED193_00005"
     CDS             complement(<1..823)
                     /locus_tag="MED193_00005"
                     /note="COG0582 Integrase"
                     /codon_start=1
                     /transl_table=11
                     /product="integrase/recombinase"
                     /db_xref="CDD:27734"
                     /translation="MTEERVTPLRQRMIDDMRIRGMGEKAQKSHIRAIKDFAAFLGRP
                     PDTATPEDLRAYQLHMTDSGVTPSTFNVRIVALRFFFSMTCGREEMKRYMQFRTEPRK
                     LPVVFSVEEVSDILMAAPGPGLKYRAALSISYGAGLRASEVCNLKISDIDSDRMLIHV
                     ELGKGQKDRKVMLSPGLLELLRAWWREARPEGWLFPGKPKINPISPRQLSRAFTSAKH
                     MAGVKKPATLHTLRHSFATHLLEQHRRAGYSVLLGTQLTTLRDTLMWHRRSATLSA"
     gene            1182..2108
                     /locus_tag="MED193_00010"
     CDS             1182..2108
                     /locus_tag="MED193_00010"
                     /note="COG0697 Permeases of the drug/metabolite
                     transporter (DMT) superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="putative membrane protein"
                     /db_xref="CDD:12307"
                     /translation="MATASTQSRPAIPYALAIAGVLFASVCFGLVPYFSRGLTEQGIA
                     PYAVAFYRYIVAAILLLPVLFKHRQAWSEISWGLSAGAVMGLGWIGYVMALETLPAST
                     VGVLYMTYPVFTLVIAWAFFSDAPTKRALLASGLITVAAIIAGSPASVPLQHIPMLLL
                     SLAAPFGFGFGICVLVHRLSRIPPLARIASVSLGSVLGLLPLMAGADIAELLPAGQSD
                     WVLIVGIGLITALVPQLVYTICSPLIGASQTAVVGSIELPTMFAVGVIAFDEVITMHQ
                     AVACALVLGAIAITRSRKTRTVTTVIARKPKK"
     gene            2274..4205
                     /locus_tag="MED193_00015"
     CDS             2274..4205
                     /locus_tag="MED193_00015"
                     /EC_number="1.14.13.7"
                     /note="COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="phenol 2-monooxygenase"
                     /db_xref="CDD:10524"
                     /translation="MQYYVDGFRPGDPDVKAPAPGRDRSLNGAIPDKVDVLIAGCGPA
                     GLCLAAQLAGFSEITTMIVEPKHGPMEKGQADGVNVRSMEMFQAFGFAEKVKREAYWV
                     NQTTFWKPDPGNSDHITRVGIAQDVADDQSEMPHTIVNQARIHQLFLDVMRKSPTRLE
                     PHYGLRVLDIEIDTGAEEYPVTVTLERVKEDGSAGETLTLRANYVVGCDGARSNVRKA
                     IGGKLHGDAAHQAWGVMDILANSDFPDLRRKCLIQSAKEGNVLIIPREGGYLFRMYVE
                     LDKLNPDERVSNRNLTSDHIIAAANRIMRPYTIDVKEVVWWSVYEIGHRLTDKFDDVP
                     EGETATRNPRVFTAGDACHTHSPKAGQGMNVSMGDTFNLGWKLAHVLTGRADASLLHS
                     YSAERLEEAKRLVETDHKWARVMSAPPGESELDGTDMPRFQKQFIENLEFTGGLAVHY
                     DPSRIIAETEHQRLATGQIIGKRFHSAPVLRLSDAKPLHLGHVAQADGRWRLYAFAGK
                     DDVGTSGGAIDRLCAWLESDPASPVQRFTRKTEDIDGLIDLRAVFQQDFKSLNYEAMP
                     SLLRPAKGRYGLRDFEKVFCVDHKLGDDIYDMRGIDRTKGCTIVVRPDQYVAHILPLD
                     AFDDLTAFFDGVFKPRDEA"
     gene            4319..5242
                     /locus_tag="MED193_00020"
     CDS             4319..5242
                     /locus_tag="MED193_00020"
                     /note="COG0679 Predicted permeases"
                     /codon_start=1
                     /transl_table=11
                     /product="predicted permease"
                     /db_xref="CDD:10548"
                     /translation="MTDVVLLMLPIFTMIAIGSLFVWRGWFPTEGLPVLNKFVMNACI
                     PVLLFSAITNGESLSDFSWLNSVTYAAGSLGSVVFLWVLLRYGFREAQPQSVILALGG
                     ATANTIFLGFPIASAFIPGRAAEAFAWVVFAEVAIIMPLITTLALLAEERHEGNALST
                     ALKALFRSPVVLGLLGGFAFLATGLSLPGWGDQVVTSIVSAAPFVALFVIGGSILQFR
                     MSRSGPRVLAVTLTKLVVHPLVVGVAFWAVFGWADPVTRDAILFACMPLFLSFVAFCG
                     RHSVGDVGASAIVMSTLLGAVTVPVVLGFLF"
     gene            complement(5263..5451)
                     /locus_tag="MED193_00025"
     CDS             complement(5263..5451)
                     /locus_tag="MED193_00025"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTQQELEDVYAALAHRIDAVGPDNCQLFLAKLSLLLAYENGDAE
                     KVADCIDAAAASLSLRDI"
     gene            complement(5448..6947)
                     /locus_tag="MED193_00030"
     CDS             complement(5448..6947)
                     /locus_tag="MED193_00030"
                     /note="COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="Monooxygenase, FAD-binding"
                     /db_xref="CDD:10524"
                     /translation="MTAALALAREGIRSVVFDNKSTFNDGSRAICIARPSFYILEQIG
                     AVEPFLEKALGWTTGRSFFRGDQILEFQMPDSKDEKYRPMYNLQQQYIEQFLWQTVER
                     SDLIEVRWQSEVIGVEDTETGARLTVSDPHGDYPFEATWILACDGARSPMRKMRGLRL
                     KGENFEGRYVIADIRMAHDYPTIRRALFDPECRPGGTVLIHKQPDDIWRIDYQLGDDE
                     NTEDAIKEQTVRDSVTSVLRDIGHDGPWELEWWSVYSANTLALDDYRDGRVFFVGDSA
                     HIVPIFGVRGLNNGLADAANIGWKLGWVLNGKASEALLDSYTPERRGATLDVFANASK
                     SARFMTPNTQGWRIMRDAALSLALTKPFAGELANPRQMTAFTYADSPAVLPDDPAFTE
                     GPSVGALMPDMPLGGAFLSDRLGAGFNVICFSQELKEQLAELLPSYDALCVMCLPFPC
                     AISDKLGAGKMTAYLIRPDMHIAARWKETGAETIFNALLSVTFTKGTGQ"
     gene            complement(7199..8686)
                     /locus_tag="MED193_00035"
     CDS             complement(7199..8686)
                     /locus_tag="MED193_00035"
                     /note="COG1593 TRAP-type C4-dicarboxylate transport
                     system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter, DctM subunit,
                     putative"
                     /db_xref="CDD:11306"
                     /translation="MIGLLSFPALLILIFLRVPIGLAMFLAGLVGLVAVTGDTTIPFA
                     RLKSETFGTFSNYSLSIVPMFLLMGYFATLGGMSQSLFKAAESWLGHRKGGVAMASVG
                     ACAGFGAICGSSLATAATMSRVALPELKAYGYAGGFSTATLAAGGTLGILIPPSVVLV
                     IYAILTEQNIAKLFLAAFIPGILAAAGYMITIAIYVRINPANGGTTRARMPYLDRFRA
                     LFDVWPVLLVFFLVVGGIYLGWFTPTEGAAVGAFGTGLIAWLAGGLTRTTLSESFFVT
                     ARASAMIFFIVLGAAFYNGFLALTQLPQEAASWVGGSGLSPWLILMIILVFYLLLGCL
                     MDSLSMILLTIPIFWPIMQELDFGLVSMVELQSAKLDDLVASGAEISASVLQEAQALL
                     ASGQELSREMTRELGLRGVNQGALNRVNVEYTAIWFGILVLIVVEVGLITPPVGMNLF
                     VINAMDKKTPMVDTYKAVLYFVGSDLIRVMILVAFPFITLALLPL"
     gene            complement(8695..9279)
                     /locus_tag="MED193_00040"
     CDS             complement(8695..9279)
                     /locus_tag="MED193_00040"
                     /note="COG4606 ABC-type enterochelin transport system,
                     permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:9849"
                     /translation="MHTFFDGLARTFARLGGYVLTILIVLTCLSILGRSLNTILNGEF
                     IQSVMPGLAAALLNTGVGPIKGDFEIVEAGMAFAIFAFLPLCQLNGAHASVDIFSSKL
                     PLRANRLLRAVIEVVFAAVLILIAWQLFEGMQSKRNSGETTFYLEFPIWWAYAVSLVA
                     AIVAAIVSIYVATMRVVESATGNRVLPPELEADH"
     gene            complement(9340..10386)
                     /locus_tag="MED193_00045"
     CDS             complement(9340..10386)
                     /locus_tag="MED193_00045"
                     /note="COG1638 TRAP-type C4-dicarboxylate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter, DctP subunit"
                     /db_xref="CDD:8627"
                     /translation="MTMLKKTRNLLLGSAVAAMAATGALAQEVTLKLHQFLPAQANVP
                     KLVLDVWADKVEADSNGRIKVDRFPSMQLGGKPPELYSQAVDGIADVIWTVVGYTPGR
                     FPTTEVFELPFFVQDARAASCAFWKMHEEHTRDGEFKDTKILATWVHGPGAFHTSDPV
                     ESPEDLQGMKIRGGSRLVNKLLEQVGATPVGLPVPSIPESLSKGVIDGATIPWEVTTA
                     LKVPELVEFHTEFEGAGLYTLTFVVAMNQAKYDSLPDDLKAVIDANAGLEFSVFGGGT
                     QADADGPARQIAVDNGNEIYTVTDTQPWLDVVEPVYAEWVADMDSKGIDGQALIDQAR
                     ALMSGECAGANAKF"
     gene            10868..11044
                     /locus_tag="MED193_00050"
     CDS             10868..11044
                     /locus_tag="MED193_00050"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MVSARIAAQDSGAIGGCLTHGVARDRTWNITSEAVGHSVNQGAA
                     LFEFLEHHGIASKR"
     gene            complement(11166..12095)
                     /locus_tag="MED193_00055"
     CDS             complement(11166..12095)
                     /locus_tag="MED193_00055"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="pca operon transcriptional activator PcaQ"
                     /db_xref="CDD:10453"
                     /translation="MDRRIKFRHLDTFSAIARAGSFKKAAAELNLSQPAISKALKELE
                     GILGTDLMERDRSGIKLTQKGEVFLQFAEQSTAALRHGLRSVRTSGDAKEHLNIGVLP
                     SVASGLLPAAVSAFLKGNPDTLLEVHEGPHTDLTSRLRSGKLDLVVGRLGRPQSMQGL
                     VFRQLCSEEVVVVAAPQSNARSIHRFEDLDRFRVLYPPQDSAIRPLVARMLISRGIPL
                     FPNRIETASAAFGRALTLADPNTVWIISRGVVLGDIEEGRLVRLEVDTGPTVGAVGIM
                     SIADDVPTPAIRAFSSALIRAANRGAEANANSD"
     gene            12189..13358
                     /locus_tag="MED193_00060"
     CDS             12189..13358
                     /locus_tag="MED193_00060"
                     /EC_number="1.14.13.2"
                     /note="COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="4-hydroxybenzoate 3-monooxygenase"
                     /db_xref="CDD:10524"
                     /translation="MKTQVAIIGGGPSGLLLSQLLHTRGIESIVLERKTKDYVLSRIR
                     AGVLEQGLVRLLEEAGCAERLHAEGYVHDGTLVSYGDEMFRVDFTEHTGTPVIVYGQT
                     EVTRDLYAAREAAGGIIEYEVEDVVINNADSDAPYITYTVGGEPRRVDCDFVAGCDGF
                     HGISRQTIPLDVRREYEKVYPFGWLGILSETPPVNHELIYANSTRGFALCSMRNENLS
                     RYYIQCSLSDKPEDWTDEAFWQELKRRIPADQAAKLVTGPSIEKSIAPLRSFVTEPMR
                     YGNLFLCGDAAHIVPPTGAKGLNTAASDVHYLYNGLRAFYETGSREGIDSYSEKALKR
                     VWKAERFSWWFSSLMHRYPHQSEFDLKMQIADLEFLRSNKAAQQAMAENYVGLPY"
     gene            13380..13763
                     /locus_tag="MED193_00065"
     CDS             13380..13763
                     /locus_tag="MED193_00065"
                     /note="COG0599 Uncharacterized homolog of
                     gamma-carboxymuconolactone decarboxylase subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="4-carboxymuconolactone decarboxylase"
                     /db_xref="CDD:10469"
                     /translation="MTDRYNTGMATRRSVLGDAHVNRAEAAKSDFDLPFQTLITEGAW
                     GTVWADDSISRRERSMLTLALLAATGNFEEIPMHIRATANTGASKDDVMQALLHVAIY
                     AGVPKANHAIKLAKSTYAEMEEMTS"
     gene            13760..14488
                     /locus_tag="MED193_00070"
     CDS             13760..14488
                     /locus_tag="MED193_00070"
                     /note="COG3485 Protocatechuate 3,4-dioxygenase beta
                     subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="protocatechuate 3,4-dioxygenase beta subunit"
                     /db_xref="CDD:12813"
                     /translation="MTTPGEFYQRDRSVHPPALTPNYKTSVARSPRYSLISLQNSVSE
                     ITGPVFGHNDIDAGDNDLLTNYAKAGESPIGERIILHGRVLDENVKPVPNTLVEVWQA
                     NAGGRYRHKKDTYLAPIEPNFGGCGRTLTDENGYYYFRTVKPGAYPWRNMVNNWRPAH
                     VHVSVFGSSFVQRLITQCYFEGDPLIPICPIVQTIPDPDAIEQLTAKLDLKASIPLDT
                     IAYRFDIVLRGRRSTLFENRLEGN"
     gene            14492..15112
                     /locus_tag="MED193_00075"
     CDS             14492..15112
                     /locus_tag="MED193_00075"
                     /note="COG3485 Protocatechuate 3,4-dioxygenase beta
                     subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="protocatechuate 3,4-dioxygenase alpha subunit"
                     /db_xref="CDD:12813"
                     /translation="MSEQLNYLKESASQTAGPYVHIGLAPGAAGFDIYKQELGWDIAG
                     PNAKGERIRVEGRVIDGMGAPIKDVLLEVWQANAEGHHAHPEGGGPVEDGFRGWGRVI
                     TDFETGEWGFDTVKPGKTRGRNVGTQAPHLNFWIVARGINIGLNTRMYFDDEVEANAK
                     DPVLNLIEWEHRRATLVAKRSERDGVLVYRFDITLQGEDETVFFDV"
     gene            complement(15196..16257)
                     /locus_tag="MED193_00080"
     CDS             complement(15196..16257)
                     /locus_tag="MED193_00080"
                     /EC_number="5.5.1.2"
                     /note="COG0015 Adenylosuccinate lyase"
                     /codon_start=1
                     /transl_table=11
                     /product="3-carboxy-cis,cis-muconate cycloisomerase"
                     /db_xref="CDD:9891"
                     /translation="MTNPFLQSGLFGTLFRDQTIAAEFGVDAFLARMCRFEVAWTRAL
                     EAAGQITRFEADAAVEVIAQSSWRDYSAASDKDGLPVPGLVASLREGRETRVASAIHT
                     GATSQDVIDTAMVLTCLNVLDELEDRLATLVDRLETLLDASRDLPLMARTRMQAAVPA
                     TVGLRVSSWLRPLVDHQSRIQALRQDLAKVQVGGAVGKRDTPADHAELVAEHVAHALG
                     LSLGPVWHTDRTSLVGFGHWLTLVSGSLGKIGQDIALMTQQGVDEIVLDGGGGSSAMP
                     HKQNPVLAEAIVALSRFVAHQQGLLAQSMIHEQERSGSALALEWMTLPAMAEATGASL
                     RHTDGLIASIKRIGSQQTA"
     gene            complement(16327..18594)
                     /locus_tag="MED193_00085"
     CDS             complement(16327..18594)
                     /locus_tag="MED193_00085"
                     /EC_number="2.3.1.8"
                     /note="COG0281 Malic enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphate acetyltransferase"
                     /db_xref="CDD:10155"
                     /translation="MTTDLKTEALDYHARGPAGKMQTLPTKPMTTQHDLALAYSPGVA
                     YPCEEIAADPATAALYTARAHTVAVITNGTAVLGLGNIGALASKPVMEGKAALFKKFS
                     GLDCVDLEVDETDPTQFIEAVARLEPSFGGINLEDIKAPECFVIEKALKQRMGIPVFH
                     DDQHGTAIVTAAGILNALRLVEKRIEDVRIVANGAGAASLACLDLLVSFGASKDNIIV
                     CDSKGPIHTERDNLDQYKGAYAAKTNARDLAEAMVDSDIFLGLSVAGAVTKEMVASMA
                     DQPIIFAMANPEPELRPELVREVRDDAIIATGRSDYPNQVNNVLCFPFIFRGALDCGA
                     TEINEEMKRACAIGISEMTRKAAPHTVLAAYGIDSLKFGRDYIIPKPFDPRLIIEIAP
                     LVAEAAMKSGVAARPIEDLDAYREELRRHVFRSGLLMKPVFDLAMRNPVRIAFAEGVE
                     ERVLHCADQAIRQGIAKPVLIGSVERIEAKIKDLGLSLANGTDIEIVDPHTMDRSALS
                     EDLHKRIGRDGINVVEAERWVRNDRTVLANLLLAHDKVDAVICGTGGRFGHQLGMVEK
                     IIGRRDGARALSTLNALVMAKGTIFIADAYANLDPTAEDIAEIAILSARAVRRMGVTP
                     RAALISHANFGDRPSPSAVKMRQALDLLRGTSVDFEVDGEMHVNAALDPAQRERAYAH
                     STLKGPANLLVMPNADAAHIALNLLREMGEGVSVGPILVGAAKPVHIASQSVTVRGLL
                     NLTALAAVDAAKNSA"
     gene            complement(18677..19885)
                     /locus_tag="MED193_00090"
     CDS             complement(18677..19885)
                     /locus_tag="MED193_00090"
                     /note="COG3135 Uncharacterized protein involved in
                     benzoate metabolism"
                     /codon_start=1
                     /transl_table=11
                     /product="Benzoate membrane transport protein"
                     /db_xref="CDD:5636"
                     /translation="MSDAIGYRRPRLSDISGSAIGAGFLAVLVSYAGPLLIYLSAAEA
                     MGIGKEAFSSWVFAISVAAGLSSIGLSLWFRVPIAMAWSAPGTVLLIALGTSLSPAEM
                     VGAYIAVAAVLVLIGVSGVFERLVQFLPPSVTNGMMAGILFGFGLKAAGGLASDPAAI
                     GLLIAVFAMSAVIFPRYAMLVLLASALLISAVFYDASVGTVSLAFASPEVTGATFSTG
                     AMLSLALPLLITTLSGQYLPGMAILRASGFSVSANPILIVGGLVSVAGAFLGGITTAL
                     ASITAAFCAGPDSHEDPDRRYVAGVACGVFFCLGGLFAGSIVEILILLPSALIALLAG
                     LALLQPILKFTSAMLASDDVQAGLLTFIFTASGVSLFGIGAAFWGVVVGIAVHFLTKA
                     VTALKNGTKT"
     gene            complement(19878..20501)
                     /locus_tag="MED193_00095"
     CDS             complement(19878..20501)
                     /locus_tag="MED193_00095"
                     /note="COG2057 Acyl CoA:acetate/3-ketoacid CoA
                     transferase, beta subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoadipate CoA-succinyl transferase, beta
                     subunit"
                     /db_xref="CDD:11765"
                     /translation="MPWDRNQMAARAAQELEDGMYVNLGIGIPTLVANYVGDKDITLQ
                     SENGMLGMGPFPFEGEEDPDLINAGKQTITELARTSYFDSATSFGMIRGGKIAAAVLG
                     AMEVSEKGDLANWMIPGKLVKGMGGAMDLVAGVGRVIVVMDHTNKHGDSKVLKECTLP
                     LTGKGVVDRIITNLGVLDVTNKGLHIVECADGVSREDIVKATEATIV"
     gene            complement(20501..21205)
                     /locus_tag="MED193_00100"
     CDS             complement(20501..21205)
                     /locus_tag="MED193_00100"
                     /note="COG1788 Acyl CoA:acetate/3-ketoacid CoA
                     transferase, alpha subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoadipate CoA-succinyl transferase, alpha
                     subunit"
                     /db_xref="CDD:11499"
                     /translation="MKKVYGTAAEALDGLLHDGMLIAAGGFGLCGIPELLIDALVDSG
                     VKNLTVASNNAGVDDFGLGKLLATRQIKKMMSSYVGENAEFMRQYLAGELELEFNPQG
                     TLAERMRAGGAGIPGFYTQTGVGTQIAEGKEVKVWGEKEYILEEGIFADLSIVKAWKA
                     DDTGNLIFRKTARNFNPPAAMCGRFCVAEVEEIVPRGSIDPDHIHLPGIYVHRLIQGA
                     HEKRIEQRTVRKREDA"
     gene            complement(21202..22062)
                     /locus_tag="MED193_00105"
     CDS             complement(21202..22062)
                     /locus_tag="MED193_00105"
                     /note="COG3246 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:24077"
                     /translation="MTNPCIICVAITGSLPTKANNPAVPISVSEQVESTQEAFEAGAT
                     IVHAHVRNDDETPSSDPDKFAALKEGIEKHCPGMIIQFSTGGRSGAGQTRGGMLSLKP
                     DMASLSVGSNNFPTRVYENPPDLVDWLASEMLKYDVKPEIEAFDLSHILKAKDMADKG
                     QLAGTPYVQFVMGVKNAMPVDRDVFDYYIHTVHRLFGDDAPWCAAGIGANQLKLNEWA
                     IAAGGHARTGLEDNVRLDRDTLAPSNAALVRRAVEICNRNNRPVASWQEARRILGLRL
                     SESAEKGHAA"
     gene            complement(22123..22200)
                     /locus_tag="MED193_00110"
     CDS             complement(22123..22200)
                     /locus_tag="MED193_00110"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MFFTDEERQAAEASTTAPSLVDEHS"
     gene            complement(22296..23153)
                     /locus_tag="MED193_00115"
     CDS             complement(22296..23153)
                     /locus_tag="MED193_00115"
                     /note="COG0596 Predicted hydrolases or acyltransferases
                     (alpha/beta hydrolase superfamily)"
                     /codon_start=1
                     /transl_table=11
                     /product="putative hydrolase"
                     /db_xref="CDD:23022"
                     /translation="MSIEPITGRYVTVMIEGAPRRIYFEEAGQGRPVICLHTAGADTR
                     QWRHLMNDAEITTSNRLIAFDMPWHGKSLPPEGFETQEYLLTTEAYIETILAVIDGLG
                     LDRPVLAGCSMGGRIALQLAALHPEKFSGFIAIEASDFQPAWYDIDWFHRPDAHGGEM
                     GAALVSANISPYAPASERWNTLWMFMQSGPGVFRGDLSFYTKDDSLIPRLPTIDTAQT
                     PVHIIVGAYDLTCTPEDAERTAKAIPGATLSVMDELGHFPMSEHPEGFRPFFVEALEK
                     MPKRAAEAA"
     gene            complement(23150..23551)
                     /locus_tag="MED193_00120"
     CDS             complement(23150..23551)
                     /locus_tag="MED193_00120"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNAWETKVINTFKQIQTRLEATPHLQRLGRLFSETVLIEIDGNE
                     YYLTFEKGHIVSVVEGPSRKTPWRFALRTDAEALDKFWQARPEPGFHDIFGLVKIGRG
                     RIDGDILSLVKNLRFFKEVLGLARAKEEVAA"
     gene            23797..24672
                     /locus_tag="MED193_00125"
     CDS             23797..24672
                     /locus_tag="MED193_00125"
                     /note="COG3485 Protocatechuate 3,4-dioxygenase beta
                     subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="dioxygenase"
                     /db_xref="CDD:25612"
                     /translation="MGIVNQDNITDVVIDSLGKHGDITDREREIATGLIKHMHAFVKD
                     VKLQHDEFLAACDYLARAGKLCDDNRQEFILLGDILGIEVLVDMMTNPVEGGESESTV
                     LGPFYRENPPVLPKGASTIQKHFDNEETAYFEGYIKDENGNGIAGVTLDVWEDAPNGI
                     YENLDPDQPEYNLRGRFETDENGHYAFVAVRPVPYPIPDDETAGELLRFMGHHPNRPG
                     HMHFIISKDGYRPLISQIYDADSAWLDEDSVFAVKESLIGKFKPADKDLGTDLHFEFD
                     FVLKEGVSEQAVAAE"
     gene            24769..25668
                     /locus_tag="MED193_00130"
     CDS             24769..25668
                     /locus_tag="MED193_00130"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator CatR"
                     /db_xref="CDD:10453"
                     /translation="MNFKQLTYFIAVAEELHFGRAAERLDMAQPPLSRQIKQLEDELE
                     AILFNRGRSAITLTQAGERLLKRGKAIVAQLEDTRLEVRRLGQGAEGRLRIGFVGSAT
                     FGILPNIIRSYRANYPEMNLSLTPMNNAQLYRALVSREIDVAFARPTLKDPEFLSKHL
                     VEEKLILALPDIVDTGNRTVAKLERLMTHNLILYPERPRPSYADMVIKAVEDAGFKAP
                     MRLWCMDLQTALSLVAVGEGVCIVPESVSNAPRKGMKFLNIEPEIARTELSVNYRVDE
                     QGVHVKNFVNIAQKVARKSPVKK"
     gene            complement(25787..26566)
                     /locus_tag="MED193_00135"
     CDS             complement(25787..26566)
                     /locus_tag="MED193_00135"
                     /EC_number="1.3.1.-"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="cis-diol dehydrogenase"
                     /db_xref="CDD:25396"
                     /translation="MTRRFEDKVMVVTGAAQGIGRRVAERAASEGASVLIVDRSPARK
                     DVVTAIRDAGGTAEAISVNLETWAGCEKAMQKAVDLWGRIDILVNNVGGTIWAKPYEH
                     YEPKQIEAEVRRSLFPTLFCCRAAIEHMLPCASGVIVNVSSIATRGLNRVPYAAAKGG
                     VNAITASLAWEVAERGIRVVATAPGGTEAPPRVVPRNPNAEEEQREDWYQTIVDQTIQ
                     SSLMKRYGTLDEQVGPILFLASEDASYITGVTVPVGGGDLG"
     gene            complement(26563..27585)
                     /locus_tag="MED193_00140"
     CDS             complement(26563..27585)
                     /locus_tag="MED193_00140"
                     /EC_number="1.18.1.3"
                     /note="COG0543 2-polyprenylphenol hydroxylase and related
                     flavodoxin oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="benzoate 1,2-dioxygenase ferredoxin reductase
                     subunit"
                     /db_xref="CDD:10746"
                     /translation="MTTYNIALNFEDGVTRIIQCDDDEKVTDAAFRQKINLPMDCRDG
                     VCGTCKCFVEKGEYELEFYMDESMSDEEAEEGYALTCQMTPESDCVVRVPASSAICKT
                     APEAVEAEVQGVDQLSETSFGLRVKLSKPIGFLPGQYVNLTVPGTDKHRSYSFSSAPG
                     ADEATFLIRNLPGGVMSSYLGGQVKAGDALTATGPMGAFYLRPIERAQLWLAGGTGLA
                     PFLSMLEQVAEQGSDQPIVLYYAVTRAADLVELDRVNALAEKIGNVTVITILAAEEDA
                     HERKGFVTDHVTAEDLNDGDCDVYLCGPPPMVDAVRTHFDELGVAPANFFYEKFNPTE
                     AAEEAA"
     gene            complement(27658..28185)
                     /locus_tag="MED193_00145"
     CDS             complement(27658..28185)
                     /locus_tag="MED193_00145"
                     /note="COG5517 Small subunit of phenylpropionate
                     dioxygenase"
                     /codon_start=1
                     /transl_table=11
                     /product="BENZOATE DIOXYGENASE SMALL SUBUNIT"
                     /db_xref="CDD:14601"
                     /translation="MNTATLERNDAATAMSYDEIQAFLFAEARALDDREWDTWLTFYH
                     KDCPFWMPAWDDYDTLTEDPQNEMSLMYYPNKQGIEDRVFRIKTDRSSATSLPEPRTN
                     HYLSGIEVLSREGSEIKLRFNWQTLSYRYGKTDQHWGTSFYTIDTSGPKPLITDKKVV
                     LKNDHIHHVIDVYHT"
     gene            complement(28198..29586)
                     /locus_tag="MED193_00150"
     CDS             complement(28198..29586)
                     /locus_tag="MED193_00150"
                     /note="COG4638 Phenylpropionate dioxygenase and related
                     ring-hydroxylating dioxygenases, large terminal subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="benzoate dioxygenase, alpha subunit"
                     /db_xref="CDD:13782"
                     /translation="MFTQSNLDEFEARLDGAIQDDPENGIFRCRRDIFTDEELFELEI
                     KHIFEGNWMYMAHESQIPEPGDYFTLTMGRTPVVITRDKDGELHALVNACSHRGAQLC
                     RFKRRNQKTFTCPFHGWTFSNTGKLLKVKDPKGAGYPEQFNKDGSHDLTKVARFESYR
                     GFLFGSLNADVKPLEEYLGEARKMIDIMVDQADEGLEVLRGSSTYTYDGNWKLQAENG
                     ADGYHVSAVHWNYVATTAHRTDDGKEDNIKATDASKWAKQRGGFHAYENGHILLWTEW
                     ADPTNRPGYPRLEEWTEKFGKTKADWMVGVLRNLCLYPNVFLMDQFSSQIRVFRPISV
                     NETEVTIYCIAPKGESQEARTRRIRQYEDFFNASGMATPDDTEEFRATQRGYAGASHA
                     KWNDLTRGATQWIEGPDEDAKALGINPVMSGARTEDEGLFVIQHSNWSERMGEAIAKE
                     RETAPGAAVAAE"
     gene            complement(29658..30857)
                     /locus_tag="MED193_00155"
     CDS             complement(29658..30857)
                     /locus_tag="MED193_00155"
                     /note="COG4948 L-alanine-DL-glutamate epimerase and
                     related enzymes of enolase superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="Mandelate racemase/muconate lactonizing enzyme"
                     /db_xref="CDD:24520"
                     /translation="MGGQSASQRNFADVVNPVTKIDQIETLILDIPTIRGHVLSMATM
                     RTQTAVLVKIKFSDGSEGIGEGTTIGGLSYGAESPESIQSAIDTYIAPALIGRGADDV
                     NGAIQLVDKIVKGNRIAKTAVEIALWDGLGKRLNVPVSQLFGGAVHDKLPVAWTLASG
                     NSDTDIAEAQEMIETRRHNIFKLKIGKRSVRDDVAHVARIKEAVGDAASVRVDINTAW
                     SLQDARWGLKGLQDAGCELVEQPVPARYRKAMAELTSGYEIAVMADEALNGPEDALEV
                     AAAHAADVFAVKIGQSGGLKRASEVIAIGQSAGLGLYGGTMLETGLSTAAALQLFSTV
                     EDLAWGTELFGPLLLTEDILAEPIIYCDFCVDIPKGTGIGATLDPDKIDFFRRDGGRT
                     IKAVAGQ"
     gene            complement(30997..31962)
                     /locus_tag="MED193_00160"
     CDS             complement(30997..31962)
                     /locus_tag="MED193_00160"
                     /note="COG2423 Predicted ornithine cyclodeaminase,
                     mu-crystallin homolog"
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase/mu-crystallin family
                     protein"
                     /db_xref="CDD:12077"
                     /translation="MLIIPEQEIADLMTRAAAFEAVESVFAAMASGDAYNFSVVREAI
                     GHEDALYGFKGGFDKAGLTLGLKAGGYWPNNLEKRGLINHQSTVFLFDPDTGKPSAMV
                     GGNLLTALRTAAASSVSIKHLARENATVIGMIGAGHQATFQLRAALEQRSFEKVIGWN
                     YHPEMLPNIEKVAREAVLPFEAVDLPGMVEADVIISITSAFAPSLMAEHVGPGTHVAC
                     MGTDTKGKQEVEAALLARATVFTDEVAQSISIGEAQHAVAEGLIEQSDIHQIGAVING
                     TNPGRISDDQITLFDGTGVGLQDLAVASAVVDLAVEKGVAIEVDF"
     gene            complement(32078..33244)
                     /locus_tag="MED193_00165"
     CDS             complement(32078..33244)
                     /locus_tag="MED193_00165"
                     /note="COG3616 Predicted amino acid aldolase or racemase"
                     /codon_start=1
                     /transl_table=11
                     /product="threonine aldolase, low-specificity"
                     /db_xref="CDD:12940"
                     /translation="MKDSIDFDAYEVGFDIPAKPGMDAADIQTPALVLDLDALERNIK
                     KMGDYAKAHGMRHRAHGKMHKSVDVLKLQMEIGGAIGVCCQKVSEAEVFARAGIKEIL
                     VSNQVRDPGKIARLVQLPKFSGGEVIVCVDDVASVADLSSAAKNAGTELGVFIEIDCG
                     AGRCGVTTTPAVVEIAKAVVAADNLTYRGIQAYQGAMQHMDSFDDRKAKIDTAIRQVQ
                     DAVNALKDEGIETDLVSGGGTGSYYFESNSGLYNELQCGSYAFMDADYGRILDQDGKR
                     IDAGEWENAFFILTSVMSHAKADKAICDAGLKAQSVDSGLPFIYGRDDVEYVKCSDEH
                     GVIADPKGVLKVNEKLKLVPGHCDPTANVHDWYVGVRNGKVETVWPVSARGRAY"
     gene            complement(33259..34212)
                     /locus_tag="MED193_00170"
     CDS             complement(33259..34212)
                     /locus_tag="MED193_00170"
                     /note="COG1171 Threonine dehydratase"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-phosphate dependent enzyme"
                     /db_xref="CDD:10889"
                     /translation="MYIPTYDDMLAAHVRIAPHIRRTPVRTSDYLSDLAGCQLFFKCE
                     NFQEPGAFKVRGATNAVFGLDDAQAEKGVATHSSGNHASCLSYAAMLRGIPCNVVMPR
                     TAPQAKKDTVRRYGGKITECKPSTTSREATFAEVQAKTGGDFVHPYNDPRVIAGQGTC
                     SKEFMEQTDGLDMVVAPIGGGGMISGTCLTLSTLAPQTKVIAAEPEQADDAYRSFKAG
                     HIIADDAPKTIADGLLVPLKELTWHFVSNHVSEIYTASEQEIIDAMKLIWKHLRIVME
                     PSSAVPLATILKNPDAFEGKRVGIIITGGNVDLDKLPWALG"
     gene            complement(34212..35495)
                     /locus_tag="MED193_00175"
     CDS             complement(34212..35495)
                     /locus_tag="MED193_00175"
                     /EC_number="1.4.99.1"
                     /note="COG0665 Glycine/D-amino acid oxidases
                     (deaminating)"
                     /codon_start=1
                     /transl_table=11
                     /product="D-amino acid dehydrogenase small subunit"
                     /db_xref="CDD:10534"
                     /translation="MTRIAVIGAGITGVTTASSLMDRGYDVTLFDRNRYAAMQTSFAN
                     GGQLSASNAETWTRWSTVFKGMKWMLSRGAPLLVNPKPSWHKYSWMAEFVASIPQYRA
                     NTVETTRMAIAARGLLRDKAERHGFEFDCENRGILHIYTDKSEFDHATEVNTLLAEGG
                     LDRRAVAPEEVRQIEPALSGEFYGGYYTESDFTGDIHRYTTGLAKSIEKGGAVLRFGT
                     DVEALAVDKKEVRLTWSRNNESQTETFDGIVVCAGVESRAIAAQVGDRVNVYPVKGYS
                     ITVRLDDEESQSAAPWISLLDDEAKVVTSRLGKDRFRIAGTAEFNGYNMDIRDDRIRP
                     LVKWCERFFPDVSTEHAIPWAGLRPMMPNMMPRVGQGARDRVFYNTGHGHLGWTLSAV
                     TAEMVAETVAASNTVNCSKTTSARTPTTLASQGAV"
     gene            complement(35731..36219)
                     /locus_tag="MED193_00180"
     CDS             complement(35731..36219)
                     /locus_tag="MED193_00180"
                     /note="COG1846 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:15281"
                     /translation="MQSDKTFKNERLTYRLNIVAQEAIQANDEIFLSETGCRIRDLRV
                     LRLIDDTPGTTFAKISKITGFDRSLTSRIIQNLIASGLIERENSTEDARVFLLSTTSK
                     GKKVRQVARRLSDRLEVILTDPLSAQELRAFNEILARLGAWVTSEDYQSALTQETNKG
                     SR"
     gene            36366..37556
                     /locus_tag="MED193_00185"
     CDS             36366..37556
                     /locus_tag="MED193_00185"
                     /note="COG1473 Metal-dependent
                     amidase/aminoacylase/carboxypeptidase"
                     /codon_start=1
                     /transl_table=11
                     /product="hippurate hydrolase"
                     /db_xref="CDD:11187"
                     /translation="MFTTWYETQSRTSQNWLQTLHRHPETGFEVARTAAFVADRLSEL
                     GYTVVTGIAGTGVVGTLHGQDASPESPGRCIAFRAELDGLPMQEKAKVDYASEDPSRF
                     HGCGHDGHMVTALTAAAYLAEHRQFDGTVRFIFQPAEELLTGARAMIADGLFDRFPCD
                     EIYALHNSPDLPAGQVGIPTTAALSSADNIDVTIRANGAHGSMPHTGEDAILAAAQLI
                     TSVQQATTRLVDAREAGVISFGLFQGGTARNILPEAVRLEGTMRTTSSTVRDRLADLL
                     QDAVRATELLFGVLIEIDVEKVAPVTLNDPTCVSAAVSSATRVVGVERVVENARNLMA
                     SEDFSELSSIVPGAYFFIGQGGYAPHHPEFVFDPDIIPVGAAIFADLAKLRTSKTLNS
                     HKLT"
     gene            37585..38622
                     /locus_tag="MED193_00190"
     CDS             37585..38622
                     /locus_tag="MED193_00190"
                     /note="COG1638 TRAP-type C4-dicarboxylate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative extracellular solute-binding protein"
                     /db_xref="CDD:11350"
                     /translation="MINFTTKMLKGAVAATALVSATAQIASAEVLTMSSWVPPTHFVH
                     TDFLVPFTEKVAEVTEGRVTVTILPAPLASPPQHWELARNGVADITWGNFTYEPERFV
                     SMWFAEFPNAGTNAEAQSRALWQTYETYLADNAAFDGVKMLGVGMFGGGQLHHGSETV
                     TSPEDVANVKFRMGGPIQEKLLTSLGAVPVAAPATKAYEMLESGVIDGSLHTMESVVN
                     FRLEDSLKHHTIFPNGFYDATFFVIMNGAKWDGLSDEDKAAIEGIIGEELSAAWGKNF
                     DLQNPAATEKLGAAGHDIVEASPELIAAVDTIYDTMVADWVEAAKAAGVADPQAMLTF
                     YNDTYKSLAGE"
     gene            38690..39190
                     /locus_tag="MED193_00195"
     CDS             38690..39190
                     /locus_tag="MED193_00195"
                     /note="COG3090 TRAP-type C4-dicarboxylate transport
                     system, small permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative membrane protein"
                     /db_xref="CDD:9849"
                     /translation="MQSMAWKIRRGVETVMALFLLAMVALTFADVIGRRIVGKPIYGA
                     NDITEHLMALVVFAGLPLVTAAGAHLTIDLLDKLVSKPWMAWWRVLISILVTVVLAVI
                     AWLFVKHGLNASRIFEVSQALRVPRGPLYFFMAASCALSALAALAVTFTGPMVDPEDT
                     HEEEAL"
     gene            39187..40479
                     /locus_tag="MED193_00200"
     CDS             39187..40479
                     /locus_tag="MED193_00200"
                     /note="COG1593 TRAP-type C4-dicarboxylate transport
                     system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP-type C4-dicarboxylate transport system,
                     large permeasecomponent"
                     /db_xref="CDD:11306"
                     /translation="MIVGSIAMISAILLAFLRVPLAFSLLAVSVAGIGFAINWNIAFQ
                     LLPLTISDAVLSYDLAVVPMFILMGNVISKTGIAHDLFRAAYAFVGHVRGGLSLSTMV
                     ACSGFSAVCGSSYATAATMAKVAYPSMKKYNYSDELAAGTIAAGGTLGILIPPSIIMV
                     VYGILTQTNIGDLFIAGVIPGLLGLALYMIAIRVVAARNPEHAPQGELTAWPDRLKAL
                     SGIWPFVLLFGLIIGGLYAKLFTPTEAAGMGAGLAILIATFHGRLTWKVLRTVIIDTA
                     YTSVSLYTVLFGALMLSKLLTLSGLAAGVLALVQSTGLEGYALIFAIMLVFLVLGCVM
                     DSMAIILIFVPLFAPIVVSQGFDLVWFGIIVIVVTEIALVTPPVGMNVFVLKAVLPDV
                     PVVRIFKGLVPFIAVDVVRLALLVAFPAITLWLGTTVG"
     gene            40602..40763
                     /locus_tag="MED193_00205"
     CDS             40602..40763
                     /locus_tag="MED193_00205"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MVSKEPKLPNADEGLAQTKVDEKSTLLARVCKRFWRYTEKTRQM
                     AIKPFKGIL"
     gene            complement(40806..41762)
                     /locus_tag="MED193_00210"
     CDS             complement(40806..41762)
                     /locus_tag="MED193_00210"
                     /note="COG0435 Predicted glutathione S-transferase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative Glutathione S-transferase"
                     /db_xref="CDD:10309"
                     /translation="MLVDGKWMENWQPVQKADEQGRFVRQVSSFRNWITADGRAGPTG
                     EGGFEAEPGRYRLYVALICPWASRTLIARKLKGLEDMIEVIVVNPTLTDQGWSFGGFP
                     GAVEDPMFGARYVHELYTRADPKFTGRATVPVLWDMKRNVMVNNESADILRMLDTAFE
                     HLVPSEIRLYPKAYAAEIDALNPRLYNLLNNGVYKAGFATTQAAYDEAMDGIFAMLDE
                     LEELLTGDFLFGDTLTETDIRAFVTLIRFDAVYHGLFKTNRREIRDYPRLWAYLALIA
                     QIPGVRETVDMDRILHGYYSIKALNPLGVVSKAPAHIATLLG"
     gene            complement(41775..42596)
                     /locus_tag="MED193_00215"
     CDS             complement(41775..42596)
                     /locus_tag="MED193_00215"
                     /note="COG3384 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12716"
                     /translation="MQTQSLQDLRDRLAPSDRLPLVFLGHGSPMNVIEDNAYSRAWSV
                     LGKSLPRPKAILVVSAHWMTRDTTLVDVSAMPRTIHDFYGFPEALYAQAYLAPGQPDL
                     AQEVVTLLKSHRAQEDDRWGLDHGAWAVLKFLYPEADVPVFQVSIDMSRGLAHQLDIG
                     RTLSELRNRGVLILGSGNVVHNLRAMRRGGEPLEFALEFDALFADRLADRDFAALADA
                     KNLGTLLPAAHPTVDHYLPALTIAGASDARDDLTFMTDAIDLGSVSMRSFIFHAN"
     gene            complement(42655..43086)
                     /locus_tag="MED193_00220"
     CDS             complement(42655..43086)
                     /locus_tag="MED193_00220"
                     /note="COG2259 Predicted membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="DoxX family membrane protein"
                     /db_xref="CDD:11965"
                     /translation="MSTNSETNNTDYAALVLRVTSGVAFLAHGWMKVSLFTIPGTVAF
                     FESLGLPGFFAYLTILGELGGGLALILGVGVRAVSIPLIAILLGSVWAHSGFGWTFSN
                     EGGGWEFPLFWAVVQGVILLLGAGAHALRLPVFDRTLGKFA"
     gene            43165..44136
                     /locus_tag="MED193_00225"
     CDS             43165..44136
                     /locus_tag="MED193_00225"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, LysR family"
                     /db_xref="CDD:10453"
                     /translation="MQTINKIEMLENDYLQNVLNRAMDRIDQIRAFVATAQTGSFTAA
                     ADQMGISNRLTSKYVAELEARLGVRLLQRTTRRVGLTPAGEDLLTRAPALLDDFDAVL
                     SEVTESSKGFSGTLRVSAPITFGEIYVVGMLARFAAAHPAVSIELRLDDKYLDLASEG
                     LDLTFRLGHFDQASLKVRRLGEFRSVLVASPDYLARCGTPTTPEELSNHACIVDTNRR
                     NPRRWMFRKGGSETIAHVTGRFHVNSASAAVALAISGIGLAYVPSFALRGAVKSGDLV
                     ALLDEYRSESGPVGAAYLEGRTLPRKVRALIDFALSDIKSLKPLQAL"
     gene            complement(44202..44834)
                     /locus_tag="MED193_00230"
     CDS             complement(44202..44834)
                     /locus_tag="MED193_00230"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTGGPRPEIDLAAFLDRRDPGTIEDSAERLEDRARGWLEVMAAA
                     ADLHPITRACMGFHLWSLAGLGQHGDRIEAAVTAARIAVSDGDGAIFAPLAMGGAGGL
                     RASGLPPKRLTGWLDGMNSAILTAMRHLNDIETWTSKTEKEMSRLSGRTPPALRAVLT
                     EWPMISAPMAENLTGASRTAVQRNLSWMEAQGLIREVTRQGRYRMWQASH"
     gene            complement(44861..45268)
                     /locus_tag="MED193_00235"
     CDS             complement(44861..45268)
                     /locus_tag="MED193_00235"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNPQTSNNPDYFDDPLVTTEGGQDASEDDLWFLPGPIEDEPDYL
                     PPGPRAEPPETGVIDEWVNAEACCAARLATVAGRLGALDDRLLRGPEGWRHRLALIEA
                     ADLSWFAGDRVSSDRLALWMSMRLSGVQVDPED"
     gene            45567..47726
                     /locus_tag="MED193_00240"
     CDS             45567..47726
                     /locus_tag="MED193_00240"
                     /note="COG1475 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11189"
                     /translation="MAKTTTRTKPTTVKKSEAAGSAAPEGAADIRMIPLNQLEPSPLN
                     VRKVAASASDDAELFASIRETGIKQNLVVHALSDTRFAVDAGGRRLKALKQLAEDGVI
                     PADHPVPCLIEDERNAILTSTTENLQRAAMHPADQFEAFEAMIAEGRSEDEIALKFGV
                     SVDLVRRRLKLARVAPEIIEQFRAGDLTLECVMAFTLTDDHDRQLAVWNAVKGGYHIH
                     PQSIKRQLTETAHSANSALGRFVGIEAYEAAGGVLLRDLFDDRASAHMENPELLERLA
                     IEKLQAAAKPFEAAWKWVEVHLSVDYGAFRSFGRVYPQDVDPDPELLAEETRLIAREE
                     ELAAQNDGEDWTDAETEEYYAIEPRLREIEALQRERQPYADEDRAIAGVVLTIGHDGA
                     QRVEKGLVRPEDIPAAPKPDETTEDAGGAASPARPNVTPPTSSTPVPTSDPAATLRKA
                     DGISASLADDLRATRQHILRAHLAADFEVAFDAMLYALCEQALGRSYNNEALDISIRP
                     FQAQNREVLHADTVAQKMLEALEQDLATDWMTLEKPEDFRAMSALPIADKQALFAWAT
                     GLAVKPQLSSDNRPSAIIEEIGGRLDVDVAACWRPTAQNYWGRVNKGHAVATARKLIG
                     DDYAEERNRERKGDIAAAMERAFAETAGETEGFDAATVAKTTLWLPDGMVFAGASRSD
                     VVEVPDQVDPEPAADMSDGVSDEEPSSLPAFLSGDAA"
     gene            47853..48203
                     /locus_tag="MED193_00245"
     CDS             47853..48203
                     /locus_tag="MED193_00245"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTTALDLDPFREAAMIAAQNDAFRRSILGNPPVADAPQGQFVMT
                     RGVAALGPDAQLELTRHVAAFDAFNADSDPQGWHEMGGIEFDGTTVWFKIDGVDAPSH
                     NGIAMCQTGFVGSQ"
     gene            48222..49256
                     /locus_tag="MED193_00250"
     CDS             48222..49256
                     /locus_tag="MED193_00250"
                     /note="COG3547 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="IS1111A/IS1328/IS1533 family transposase"
                     /db_xref="CDD:12874"
                     /translation="MTDVSILAIDLAKHSFQVCATTAEGVIVFNRKYTRGKLSELLAN
                     HPQCLVAMEACATSHYWGREAQGHGHDVRLIPPIYVKPFVKRSKNDANDAAAIAVAVR
                     QPDMRFVAVKSPDQQAQAMLFRTHQTFTRQRSQLLITLRGHLAEHGIIVAKGNAALIA
                     YEKVLEAEPDLVPDLVLEAARLYFHQIAQLNNSIAAFERQMKDTAKRNDTARRLQTMP
                     GIGPINAAAFLAFAPPMESFKRGRDFAAWLGLVPRQHSTGGKTRLGRVSKMGQSDMRR
                     LLITGATVCLRWAVAKGIDPQSWLGRLLARKPAKMVAVAMANKMARALWAMMTKGQDY
                     SGSLVQYAKM"
     gene            49763..50059
                     /locus_tag="MED193_00255"
     CDS             49763..50059
                     /locus_tag="MED193_00255"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAKTLDYQITLYPAHRDGAFVVTEFQMMANYPEKRIQAAGMDDL
                     IDKVTQFAMEHGESCSASVRCLAPRKPPGFKRATENLYFNLVDRTAEKRGDAAA"
     gene            50137..50520
                     /locus_tag="MED193_00260"
     CDS             50137..50520
                     /locus_tag="MED193_00260"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTQATDFYAQMLEAQKRAAEERVETRAALLSELRALGVTSIEVQ
                     YEGYGDAGNVEDVVVTPDTITLTEELRRRVEDFGWDFAYALSPGFENNEGGYGELTWS
                     LETDKIDVSHSNRYIETDTTEHEGL"
     gene            50522..50998
                     /locus_tag="MED193_00265"
     CDS             50522..50998
                     /locus_tag="MED193_00265"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAHPLHHAESSARKFGGIPDDYQHVHDWFDSSKEHLGLFIHRAH
                     RHHTLGIFEAERLFGRSLTNSAGRVVPIRWIGEQHVREDCQGRIPSLADWLGRIQPEP
                     WMANGRIDNDPTQIGSDPRAAWATAVSNHQTILGFEDWLLKVSVEHVQHRQNRAAA"
     gene            51104..51733
                     /locus_tag="MED193_00270"
     CDS             51104..51733
                     /locus_tag="MED193_00270"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MHDPVYEEVHQGHNIKIYHDPDSESPREWCNLGTLICWHRRYRL
                     GDSHQHDSPEAFLRNLADVSDQSDLSMDRLRDRAECKAIILPVFLYDHSGLAMNTIGF
                     HCPWDSGQVGFVYMTLADVRNEFGVKRVTKALREKAVDVLRGEIVDYDSYLGGRVYGY
                     VVEQGGEEIDACWGFVGGYETHCLPEARNAVPRSDPHAPPATGALTAYP"
     gene            complement(51934..52092)
                     /locus_tag="MED193_00275"
     CDS             complement(51934..52092)
                     /locus_tag="MED193_00275"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGVVAQTHARLLGHGRACILGTSNETEPTQSNFGDRMANQEKSQ
                     ELRMGICK"
     gene            52249..56646
                     /locus_tag="MED193_00280"
     CDS             52249..56646
                     /locus_tag="MED193_00280"
                     /note="COG2263 Predicted RNA methylase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative methylase/helicase"
                     /db_xref="CDD:11969"
                     /translation="MNAHPHSVQLATEPEAPALPAAAGFAEQLMQAAKTLLPLFEAGR
                     SIDAAALRAAMEEAFGANDTSGTWVWKDAYEAAEVAQILMLSRYGALMQRQAATPHAF
                     LNMIEHLAGLAPSHTRRSEDSVRLQQFSTPLPLAAIVAQAAGFRGDDLVLEPSAGTGM
                     LAIFARIAGARLSLNELAETRRNLLQQLFPEAVVSDHDAASIDDRLDRSITPSVIVMN
                     PPFSAANHVEGQFRQATSQHVLSSLARLAPGGRLLVITGESFRPSTKCFQSTFQRIGQ
                     SSEVVFSAAIDGKVFSRHGTSIDTRLTVIDKRAMGEGETAPVNIDGAYHPTCATTAAL
                     LSAVLTHCPERRSPPPCPTSSALSVPTRPTRTNLHALRNAARQETRALAEERARHPFD
                     DIEMAPLDYLPKAWSEPDGVLQDTVYEAYDLQAIRIDSAVEHPTALVQSAAMASVPPP
                     VPTYRPVLPKTLVADGLLSAPQLESVIYAGNAHETHLKGWFKRGEIEGQLMAAAEGDE
                     GAFRLRKGWFLGDGTGCGKGRQVAGIILDNWLKGRRRAAWVSKSDKLIEDARRDWMAL
                     GGRESDIVPLSKFRQGSDIRLPEGILFVTYATLRSAEREGKASRLDQVTSWLGEGFDG
                     VIAFDESHAMANAAGEKSDRGDKKASQQGLAGLALQNAAPDARVLYVSATGATVVGNL
                     AYASRLGLWGTGDFPFVTRAEFVAAMEAGGIAAMEMISRDLKALGLYLARSLSYAGVE
                     YEMLVHDLTPAQVAIYDNYADAYQIIHTNLEAALQASGISSETGTLNAQAKSAARSAF
                     ESNKQRFFNHLITAMKCPSLIRAIEADLAAGHAAVIQVVSTSEAVMERRLEEIPPSDW
                     DDLQVDFTPRENIMDYLMHSFPTQLFEPYTDENGDLRSRPALDADGNPITCREAERRR
                     DELVEHLGALAPLQGALDQILWHFGGDAVAEVTGRKRRIVKTREGRLKVENRAASSNL
                     GETQAFMDDAKRILIFSDAGGTGRSYHADLEAKNQRLRVHYLLEPGWKADNAIQGLGR
                     TNRTNQAQPPLFRPVATNVKGEKRFLSTIARRLDTLGAITKGQRETGGQNMFRAEDNL
                     ESPYARAALRQFFYKLRAGKIEACSYAKFQEMTGLTLDEADGTMKENLPPIRQFLNRC
                     LALRIDMQDAIFEAFGGFLSAIIEDARQAGTLDVGLETLRAEKFVITDRRVIFEHEAT
                     GATATALTVERTDRNDPLTLPRVKAICADMKGATLCWNKTSKRAALMVKAPAFMDEDG
                     VPILRVKLLRPMATEILALSEFSRSHWEEIDDAMFEHLWQAEVDAVPKFTTSKITLIC
                     GLLLPIWDRLPSDNMRIYRLQTEDGERAIGRLVSQEQLLNVYARLGLDCQIEMTPQEV
                     FAAVMHAKTTLNLLGGYQLRRSLVMGQPRLELIGASGAVLPALKAMGCFTEVIQWKTR
                     VFIPVDGTDVLARVLSEHPVGTSAAGTAA"
     gene            56643..57689
                     /locus_tag="MED193_00285"
     CDS             56643..57689
                     /locus_tag="MED193_00285"
                     /note="COG0358 DNA primase (bacterial type)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNARRSIADLSADVADRAESFCRQYFPEGRRQGNYWQVGDTSGA
                     KGQSLAIRLQAQGGRKAGSWQDFATGEYGDLIDLLHERLGSVTLKETLREARSFLGEA
                     PCPAVPHATRNPEPPDAASGKRIARARKLFAVGKPVLGTLAATYLQARGITRLGPALR
                     YHPRIFLWRGEDDSDPPQSAPALLAKITDNRGQITGCARFYLDPSTGGLAAIESPKRI
                     LGQLHGHAIRFWSGKARSDLIVGEGLENTLSVGTALPEFDLASCLTATHLGLFIPPPG
                     IKRIWIARDDDEAGRNASQKLRNHWESLGIACGDLVPTMGDFNDDLRALGKDALRRSL
                     LGAMKAQSLEIEDR"
     gene            58001..58912
                     /locus_tag="MED193_00290"
     CDS             58001..58912
                     /locus_tag="MED193_00290"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPHQTDIQEETGATSAILDHLALHGATPGPGETDHRPLPQPDEV
                     DLAMATLFETTIGLLNGSQLEDNLEEMLWSLTSIFHRRLTHIQKLLDDNEFEVRESLA
                     VQDGSEVASVELERLQMIGLKLWDHRDAFEQMRDLAVDHFSAATGSPWLPRTGSKVSH
                     RGLTSAVVDSRAYLSAKRRKETEVHCPEGTRIAFSGGDYQAYDLIWSVLDATHAKYPD
                     MVLLHGGTPKGAEMIAARWADTRGVTQVVFKPDWKSHGKAAPFKRNDKMLETMPQGLI
                     ATPGSGITENIVDKARKLGIRIKRIGA"
     gene            complement(58921..59214)
                     /locus_tag="MED193_00295"
     CDS             complement(58921..59214)
                     /locus_tag="MED193_00295"
                     /note="COG2944 Predicted transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, XRE family"
                     /db_xref="CDD:12292"
                     /translation="MSAFESVSKGLEEALAFANGDLANAKVHEVSVAEVDVAQVRQRT
                     GLSQAEFAKSIGVAKGTLLNWEHGRRQPTGPAQVLLALIAKKPSVVQDLLRGA"
     gene            complement(59211..59603)
                     /locus_tag="MED193_00300"
     CDS             complement(59211..59603)
                     /locus_tag="MED193_00300"
                     /note="COG4737 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="RelE-like Cytotoxic translational repressor of
                     toxin-antitoxinstability system"
                     /db_xref="CDD:13877"
                     /translation="MLYVIDTYAAETYMELHMTRLQTVVELPEFQRRAKAIMSDQERE
                     AAINFIAANPEAGISLGGGLRKVRIPRERSGKSGGFRTVYVFGGTHMPIFLITVFAKN
                     EKANLSKTEQAAAVEMSKALVAKYGDAT"
     gene            60190..60528
                     /locus_tag="MED193_00305"
     CDS             60190..60528
                     /locus_tag="MED193_00305"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:17661"
                     /translation="MTTNCIKFTSTDIETAKGTGSISTLTFDLDITVEPVASTNPMAP
                     THRVLGRSPRGKLVECGGIWKKQNKETGADYYTLTIRDHGFNANLGKAANQDDPSLQA
                     VIPWGPKDVA"
     gene            60737..62092
                     /locus_tag="MED193_00310"
     CDS             60737..62092
                     /locus_tag="MED193_00310"
                     /note="COG1192 ATPases involved in chromosome
                     partitioning"
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein a"
                     /db_xref="CDD:10910"
                     /translation="MSGSLEQFLTDLSRGLERTMVAVNKELTLRQRIKRTWSMRQCAR
                     FLNVSIQYLTKFANSSDDFPAGEYVGRERVFTLSELMHMRALLAASAKRPYDYLAWRK
                     PDAPLPVISFASQKGGTAKSLSAAHFAQYLSLHYGMRVGVMDADPQSTITLYFVGGEG
                     LPQMPDENTASMVDFAGLFQSEDAPYTDHDAQTLDSFFLKTSWPGLRLLPAHGETSEG
                     EIQIARLVREAPSGKSFYRYLRDAIDRWKAGHPPKTLPNELVVEGKVDQQRLDAALTE
                     TLDVIIIDYQPALTLFQLNNVIASTSLVIPQTMKGFDIATLSTFVTGLLGMLQHILAH
                     ERIEIGTGANMLLPTIVQRSNAQDLNHIGNLLEHCPTEILPVFYLRSDAISNASDVYQ
                     SVYEYEPDTPGKRKGINRFIMNADAVNDAIVSRLWPGLERGYADAWMDEFYEDDGEGE
                     A"
     gene            62089..63111
                     /locus_tag="MED193_00315"
     CDS             62089..63111
                     /locus_tag="MED193_00315"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:424"
                     /translation="MKRSIPRSLVSKATNPDASKERTPGSEGRAEPGDAVSTPFKGAG
                     SAWKSGALAQSQAAVERSRAELCSDILNGRHEISLSPDQISDPMGTDRRQDWMSQEAF
                     RSLVSSIASNGQDTPILVWPEDPDWQPDPLEPSNVTGVPFVMLTGRRRLAAASELGLP
                     LRAILASPDARNAENSKFEMLFLRFRENEERENLSPFERLVSIGEMYETLASGEDKLT
                     AVAFAKKIGVHESLVSRARSVFAAQDQILNAFKNVYDMSFRDLQGALASLERVNTSKP
                     KPKAKPSKLTVKRKVGKRNLSATSVDGNLSIKVAGVPIDQERLEKLGDLVADYLSAEG
                     SGKDSD"
     gene            63338..64618
                     /locus_tag="MED193_00320"
     CDS             63338..64618
                     /locus_tag="MED193_00320"
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein C"
                     /translation="MKHTGWRKPTPGLGVAEQLAQAGERVAVPKTRAFVALKRVGAHI
                     GLKAGDMMLLDTLGAFTQAQDWDEGQRPIVWASNAYLMEQTGFSRSALKRHARRLAEI
                     GVISFQDSPNGKRWGRRDAEGRIVEAYGFDLSPLSARVEEFEELHADLQAERELCQRL
                     KRQITVARRMIRARIEAALSSALRGPWSQFTGLFEELLDRLPRRHEASEQLVRLLTWF
                     KELQERVEAAYLKATGAVKPVENTGNNDIQVMEKTQKMNPREVNSEPHILITKQLNPV
                     ISNSSEREEAAGVVPNAQPEERVDRELEDWVAEVRKKRTALDLPTIMQACPEFASWAR
                     NMGGFLKDWGDLHRVAGQLRPMIGISEHAWNVAQDRLGTQVATAAFALVFEKHSAGEV
                     ASPGGYLRGMVEKAGAGELHLERSFYGRLSEQAA"
     gene            complement(64733..65863)
                     /locus_tag="MED193_00325"
     CDS             complement(64733..65863)
                     /locus_tag="MED193_00325"
                     /note="COG0582 Integrase"
                     /codon_start=1
                     /transl_table=11
                     /product="yld, resembles DNA integrases; possible role in
                     plasmid maitenance"
                     /db_xref="CDD:27720"
                     /translation="MEQERQSENNEKSISKPPNGPSVSENNERDHPSSEALSLPSFVA
                     GSGTLDRLVDTARDYARAAASENTLKAYAKDWANFARWCRMKGAEPLPPSPEMIGLYL
                     ADLASGSGPFPTQSASRPLSVSTIERRLSGLAWNYAQRGFALDRKNRHIATVLAGIKR
                     RHARPPVQKEAILAEDILAMVATLPYDLRGLRDRAILLLGYAGGLRRSEIVSLDVHKD
                     DTPDSGGWIEIFDKGALLTLNAKTGWREVEIGRGSKDQTCPVHALEQWLHFAKIDFGP
                     IFVGTSRDGKRASETRLNDKHVARLIKRTVLDAGIRSDLPEKDRLALFSGHSLRAGLA
                     SSAEVDERYVQKQLGHASAEMTRRYQRRRDRFRVNLTKAAGL"
     gene            65968..67614
                     /locus_tag="MED193_00330"
     CDS             65968..67614
                     /locus_tag="MED193_00330"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:25582"
                     /translation="MVDRSDINAVDDAAWEQAVAREAVIRRLASKTPPNRAEFLKACR
                     DLGLKRSRLYELISAYKARPVASSLLAAQVGTPTGSRRLPDEIEAVISGAIEEFYKSL
                     QKPSINALQKEVRRRCSQRGLRPPCWTTLRDRVAAIDPAELTAAREGAKASRQRHHPV
                     PGSYQVERAYEVVQIDHTLVDVIVVDRVHRKPLQRPWLTLAIDVASRMVAGFYLTLEP
                     PSVLSVALAIQHLVQPKLDWLEGLGIDADWPAEGLPETIHVDNAKEFRSKAMKRGAEE
                     HGISLQYRPIGAPHYGGHIERLIGTMMGAVHLLPGSTFSSIKDRGDYDSVSKSAMTLD
                     ELEHWLALEITRYHAERHRALGIPPVAAWNEAYERREAPLRRPYDPEGFRVDFLPSTE
                     RMVRRDGIHLFGLRYWDDVLSLWAGRQDRQLRVSYDPRDLSTIFVLGPEGQRYPVRFS
                     DLRHPSITLAEHRRAQAILRERGRALEDEDLIFAVIEEQRALVDAASSRTREARRFSE
                     RRDRALDGVGAYEALDAGPEPRESESVLRDHPGFEVEEWS"
     gene            67605..68543
                     /locus_tag="MED193_00335"
     CDS             67605..68543
                     /locus_tag="MED193_00335"
                     /note="COG1474 Cdc6-related protein, AAA superfamily
                     ATPase"
                     /codon_start=1
                     /transl_table=11
                     /product="TniB"
                     /db_xref="CDD:23845"
                     /translation="MVVNEGTAFAHLDPTYRRFAALPDDERIAWIRADRWIGFDQSGA
                     ALARLENLLTYPPRDRMPCLLIYGDTGMGKTKIVRKFERDHPPKFSQITGVDHRPVVV
                     AQVPSEPIERDLYRELLASMGAPAMTGGTLAREKDICRSLLRTVGAKMIILDEVNGML
                     AGTFRQQRIFLNAIRFLANDLRIPLVCAGTDLARQALLTDAQLAERFEAFYLKPWQND
                     AAFAGLLKSFERILPLREASDLISGEARERIHKLTSGVTARIFRLIETAAEDAVRSGK
                     ERLDADSFGDNLVLPLVSMTQTARRRGKPVQQRVGA"
     gene            68540..69667
                     /locus_tag="MED193_00340"
     CDS             68540..69667
                     /locus_tag="MED193_00340"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:26639"
                     /translation="MMVSARLPVAPRPFMDELLSSWMARVAARYGSEALELVVYLAGQ
                     GGRNAGARQVDDVAPDMELLRLWAKACRVDPERLCRRSLASRYPDRPQDWFLTETVPV
                     CLACFDADVAARRDAYLRGHWRLAEQVVCPPHRTMLLDRCPACLGRLRLSFRMLNGLL
                     RPFCRKCDAILTGGGGETEDPLKADFAAGVLDLQSQISRIVRGNPGRFDRLEHAIRTL
                     WAPLDRDGAARPVLALWYDESGWNCPYEARAAVGRSAPLQHLSVSWRALTLVILHDLF
                     GADLVPGAVLPEAALVLFQRAAPLPWLTDGPDLRTGKGKRTIDAGAERVHRLSKRRVH
                     RLNGNFEGERRFRPNPPMKLKRQEFFWEPIALCPIMQTYWT"
     gene            69742..70626
                     /locus_tag="MED193_00345"
     CDS             69742..70626
                     /locus_tag="MED193_00345"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKPELEIHKATSDTLPRMPSWVTSIRAETLEDVAFLSGAALATL
                     HLVVRRKDVPQTLLRERLALSSAEACVLLSGRPERARELRDEVHLLRHDDVPGPAGKV
                     YQCWRRAVERPVSLKALHRAIPAQDPSQIAAWLDVGQGSSVNRAALVIEAVLSDVPRA
                     EEVALILADAALAQAMGWEHLVPLLAANLTARDLRMTGDALRRSCHRSLVVSATAAVQ
                     LAHDLARRTARLEAVVPKLRAKGAGEAVQMFLMRDAVMPAALPLSDRGARRLCDRLVE
                     LGVVRELTGRDMFRLYAV"
     gene            70629..71225
                     /locus_tag="MED193_00350"
     CDS             70629..71225
                     /locus_tag="MED193_00350"
                     /note="COG1386 Predicted transcriptional regulator
                     containing the HTH domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:26185"
                     /translation="MATRPEPDFDRDLDDLPAELRWREWMRRIEAVLFASATPVPRED
                     LARVVGQQASVELLIEDLGADLADRPYELAAVSGSWMLRTRSSYAPAIRAAADVGEQL
                     LDLNEFDVAVLAAVAYNQPVTRDGLKDIFGKEISRDLIGRLFVSDLITTGPRAPRRGA
                     PYTFVTTEKFLVAFGLESLRDLPDREQLDDAGMTRFAS"
     gene            complement(71222..72580)
                     /locus_tag="MED193_00355"
     CDS             complement(71222..72580)
                     /locus_tag="MED193_00355"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIMTQLDRRRFEALAGYTRHPMITLITKELDWFSDPLERVLGTL
                     VWDRVDGDYSWAVFARDAVKKFRAIQANTSYSTSQEAYNALMAAMVENSRKPDEAFHQ
                     NDEDGPAVDFFTPAVDEARFHPSFQILLEDQRYSPAREIIEAMMRYHEDVDGNFVQKF
                     QTAGWDALLWELYLYATFNELRFIRVGTGPTPDFVLRGNEGGLAVEATSVNPSNVGPN
                     DVPEDSEAFKAYLENYVPIRLSNALRSKLNHKPPYWKQEGAEDVPFCIAVQDYHLQGS
                     MRYLTSAATEYVFGVRHWMDSGEHKIARIGTHRYGKKRAQSGFFDLKGAENVSAVIIN
                     PQGTLTKFNRLGIAAGFGDPRVKMVRMGMKRNDTNSQAPFPTPFEEEVGPQSSETWVE
                     GMVVLHNPNARIPLDPDIIPGAAHEFLQRDGSIMSLLPDFHPFVSQSIVTIEDDEKNG
                     TD"
     gene            complement(72836..73474)
                     /locus_tag="MED193_00360"
     CDS             complement(72836..73474)
                     /locus_tag="MED193_00360"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MEPEIVVLGFSKGPTQTGAMASSPHDEIAYKGSRMAVGKILVHI
                     GVVPQPENSDYRGMVDRLISDRNGRFHFGSLVRCTVERFDEKTRNWKGSGGGMLDKFM
                     GTQFGNEVATNCASQFLGALPTKTRLVIMFGLGSKLNYISAARKLVEAARPGNWRMLN
                     EVTYSDGNLTFVHVEHFASQGALIPNWLGINDHPRSEYGRKSREAVQAALAD"
     gene            complement(73823..77008)
                     /locus_tag="MED193_00365"
     CDS             complement(73823..77008)
                     /locus_tag="MED193_00365"
                     /note="COG0553 Superfamily II DNA/RNA helicases, SNF2
                     family"
                     /codon_start=1
                     /transl_table=11
                     /product="DEAD/DEAH box helicase:Helicase, C-terminal"
                     /db_xref="CDD:24402"
                     /translation="MIERFEAAPALRSLKAFQRATVDYVSRRLLIDEDAVRHFLVADE
                     VGLGKTMVARGVIARTIEALQDTVKRIDIVYICSNAAIARQNVARLNVMGEAHAKVLP
                     TRLTMLALELARAGGIKEEGVNFFSLTPGTSLDLKQGGGMKQERALILRLIWDQLKDR
                     KAVAKMLQGYAGAQGWRETRRWIDAQPIEPQIAMQFQSAIAARPALLEDLENCAHAYK
                     GQRLNNTELNRRRDSLVGELRTILARESAEALEPDLIVLDEFQRFTELLHGDSEAAEL
                     ARRLFDATDPDGNQAKVLLLSATPYRILSLRDDAADAGDHYKEFLDVLGFLFGEEHGA
                     KARQELEMEMRRMRNALQMLPSSFEQAKDIKMGIERQLKQVIARTERVSETAERDAMV
                     RDMSAPITLKSQDLLEARAIARVAEAAEAPGTVEYWKSAPYLLSFLRDYKLGQKLEAQ
                     KDSPSETLLAAIRGAGTAQVDVAAVKAYRPIHLSNGRMRALQDIASLNGLDRRLWMPP
                     SLPYFGARIAASKVLVFSQWAMVPDSIAALLSYESERRMGMGDQWGSYTATHSQRLNF
                     RRAKGRLTGLRVLSLVIPSPTLATAVDPLEIFQSVRAMPDANAMRSVVKERLKNFADD
                     LALRFTAAKPSGFLERFRNNADDGADERVANWDWACAASMDISHKRFGTWLAEGRGLD
                     TIVREDGLEAWNEHLAALHEAASEKHLFGSPDRSQVLDHLTDLALGSPANCALRALAR
                     VAPDLGFDHPNMLSAATRIGMAFRGLFNQPESIALLRGSSDEFYWQAVLQYCAEHDLQ
                     SVMDEYVHMLLESEGLSDADPCNAVTRIAEAIDEALSLKPAQIDIKSYKAKRGRIEIQ
                     SNLRMRGRFATRLLQKSQEDGQMQRTDNVRGAFNSPFRPFVLATTSVGQEGLDFHYYC
                     HRLVHWNLPTNPVDLEQREGRVHRFKNHAVRLNVSEKYANDMRLSESESDPWKQMFSA
                     ALSQAKRGGELEPFWLFDGEISIERYALSLPFSREISLMAWLKRSVAIYRLAFGQPRQ
                     DDLMSFLEKAGSELSNDDLAELQINLRPPEI"
     gene            complement(77001..78848)
                     /locus_tag="MED193_00370"
     CDS             complement(77001..78848)
                     /locus_tag="MED193_00370"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTNKTALDPENRALYGEILRAPAGYELDQALATTYTLDFETALV
                     IPATLAFHAAESRQQTLDTPLALLEGLERLAKRIAIFCEAGRIKAMPSGANRLTALLE
                     DTVTEVIAPRGGAFHPKLWALRFKPVTRKGPARLRIALLSRNLTTDTSWDLSLCLDGQ
                     LGQFTNAANDPLVALLLALPNLTPGRNTPRRASQIAQSIAADLATAIWEHPEHIRKIS
                     FAVNGLSQRVWHPRIGSTLGVISPFVTDAALLKLGHKVSNENAYLLGRGEELAKLKSD
                     TLQTFGNVMILDELAETEDGDETEDQGRNVVPARGLHAKAFLTERYSSTEITLGSGNA
                     TTAALINGSNVEVFATLSGYTRDLGTVQQQLSEGSLGRYLCEFSPYELPDSDKEDAAE
                     KRLDGVRRQLAEAGLKLSCYVDNEGRIELSLSAKVPVELSDGIKLHVWPLVTGQKNGT
                     LLSTITKKPKLIGRAALKDVTRWLGVELQDAATGFKRVFTLGTDLIDLPETRTAEILR
                     SIIENQDAFLNYLRLLLGDVSDAAKALFVAGSGGTYSGLFGSMQDAPLLEDMVKALSG
                     DGRQLHDIERLIERLTNPKTGKSDVIPEDFLTLWETFRTVLPKERSRRD"
     gene            complement(78838..80004)
                     /locus_tag="MED193_00375"
     CDS             complement(78838..80004)
                     /locus_tag="MED193_00375"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSFFAWVDFDQADRDRTRRIMDLFDQKDSRDELGLGSVRDALSD
                     LLFPGTSTIQTRLRYMLFVPWIYRMAGATVGTSSARQDKARAYEIRLIDALVRGGETI
                     NVIGSEARDTLKRLPSDVYWAGMLTFGIRRFQGSRTACLELAPGEADALWAAGIPDAP
                     IGFLENGSKIDFTLRPEEADFIRDRLAQQAPDSLLTWLSRQNDAAECNMIWEHPQSSE
                     WPNDIKVLVDHAERFSSLMHGASLLYNLMLSERAAQMQATEESVWHERIEDYTSRLSK
                     WASDTPLETFEAWDMNDLWDQSQRTIHSVKPKTKRFVEDWRLAVANSKGDVAKDFSAR
                     SLVRDREKRLKGLKSRFRNDGALTRWGGASGLTPLSYRWQPVVMNHVRDLTRDK"
     gene            complement(80004..83156)
                     /locus_tag="MED193_00380"
     CDS             complement(80004..83156)
                     /locus_tag="MED193_00380"
                     /note="COG1074 ATP-dependent exoDNAse (exonuclease V) beta
                     subunit (contains helicase and exonuclease domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10797"
                     /translation="MTQLSIVPAGAGAGKTYHIQKTLADWVQDGSVAPGRILAVTFTE
                     AAASELRGRVQAELMKRDRISDALEIDHAYVGTIHALGQRLLTEHAFAAGRSPRNRLL
                     SEPERDLLIRMELAKCVGLRPLMENLARFGYRWNFLTGASAEDAFRSDVLRTVDLIRG
                     LGDRGSDPEILAPAIAALKKGYGPCAPDGAALSAALRRTVVALLDMFPESLGTILECN
                     ATAKKAFISDHQNLRKAAQNETLETDWALWQKLRGLRKSMRGSPTPEGYDELAEAVTV
                     SADELLRHPRPLADACAKVNALVIGAQEVLEAYQAAKRKAGLIDYADMIVETETLLRT
                     QPDILAAVLGEIDCVVIDEFQDTNPVQFALLWQLAQGAKRALIVGDTKQSIMGFQGAD
                     ARLSQALQDFHASAVTPLDRNWRSDPRIMGFVNALGPVLFPQGYNALTPVREETGEPA
                     LEVINLPGGRSDSTAGCVADRIARILAGNTHVFDKVTKAMRPAKASDIAVLCYTGSKC
                     EAVAAAIEAHGHPVRLQQSGWLGSLAMRVARAALAYIADPSDRLAALTWLTLGPPRMP
                     IEDALRNAVDRVLDTHTALVPLAALHEAEQQRPVVDTVAEMLRSTNLREWAAGIDGPA
                     QALADLARLEAEAQTFDSLATDLRSAAGFHGYGMQIFLGWINAQTDKAWDKHPDPDGW
                     SSSGIEISTWHSAKGREWPITIIAGLDRAFAERPGTLSAEFDGFKDLGNVLSHANLGY
                     LPKFDAPETQAVFAEAHQEQDEQEAARELYVALTRARDRLILALPREKTKARDSAERM
                     VDLLRDRGGLQSGAGFLEVCGEQFVANVTDGASDVPEVEPTSASLGYPRFGTSRQNVD
                     APHTPWRQSPSTQEPIASQAPAVIDTVKLGAAIDTSDAVFASAADRGTILHLAFRVLT
                     NQPNLSERLIAATGLAPKVIDEIATQAKILRNRLAAEGYDQLHFELPVQDIRPDGSQT
                     NAIIDCLAEGPDGFLILDHKSGPCPDPEARFHAYLPQLKSYAQLMALTRRDKPVRGLA
                     INWIDEGRLSLCSVDTMEFI"
     gene            complement(83156..85747)
                     /locus_tag="MED193_00385"
     CDS             complement(83156..85747)
                     /locus_tag="MED193_00385"
                     /note="COG2887 RecB family exonuclease"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12238"
                     /translation="MRIDPLLTASPVTDAVRHLTDDLLKEIYLAPLGKPLALQDLLTG
                     NNAPWSESFSAAPAETIAAVEDGLLTVMRATRTLDPNEINLSTLPEGRARTHLTALID
                     LWHKLDGLPAPFSTWAHVLRSNASDALEALPILDYVQCPFADPAETALAEALQAHHGT
                     APLEAALAWRNLAAAHDAFANGALGAIQAGLGKTASEVSPDETIEIFGLRDPREEAEF
                     AAARVQSLLDAGIVESPAQVGLLVPDDASYQRALEEAFDRVGLPLSGKPIEPALRDTV
                     GELMILLLALLERPAPRTAIASLYISPTMPWAKETGLRMAREQMDYGWSRTAAGLDGP
                     ARELLDALRPCSTPEQLFGRLTAIAKAAPEAGLWPKLQAIRTAVVDQIDWPLLRSIAL
                     PRPSEPSGHNRFVEGVSLFAETALPWRPVRQLIVLGLAGRTWPRPPASNPFFTESEIV
                     LIREKTGLYLAGRQQKMARGVELFRRQLCAASEAATFLVPSCTLGGEKLASSTGLSLI
                     THMMGFESSEKAIRDIHAEDQSLWPVAAEAPLPIASGGKPSVPAIGLLHLGSDLLRLR
                     EDDETGHAPQSPSRLETLIVSPLAWLLDELGAKDRTWAPETLDVMALGTLLHHVMEVV
                     FPEGTKMPDQTIIANAVPAAVDDAIRRYAAWLSNDAWDTERQSLLREAYNVTSNWVVF
                     LHETQAEVLHNEIRLAGDHGGLLLRGNADCLLKLPDGRILIIDHKRSSSGGRRDRMAK
                     GWDLQVALYQAMLERPSIQTALTDLVAQGADIVTAYHTMLDGTVLSDAAGAGLPRVEH
                     ASIDASKQAMDHLAQVVAEVGGGTIRLNHEDDAAALKKDRGITAYALEDNAFVSAFLT
                     SNDEGDQ"
     gene            complement(85781..86506)
                     /locus_tag="MED193_00390"
     CDS             complement(85781..86506)
                     /locus_tag="MED193_00390"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAEWNLPEMMSSLHNGIQNELHTARKALAHPGTKGDASEQVWLE
                     LLQTYLPKRYQVESAHVVDSEGNFSDQMDVVVFDRQYSPFIFNFKAAKIVPAESVYAV
                     FEAKQTMDAGLLKYAKDKISTVRQLKRTSLPIPHAGGEYSAKPPIHILGGMLSLESEW
                     SPPLGGSMVKNLGDPTAIGHLDLGCIASHGYFGLDRKSQDYEIHPGAKPATGFLFHLI
                     SELQFSGTVPMIDIKAYARWLNV"
     gene            complement(86578..87516)
                     /locus_tag="MED193_00395"
     CDS             complement(86578..87516)
                     /locus_tag="MED193_00395"
                     /note="COG1223 Predicted ATPase (AAA+ superfamily)"
                     /codon_start=1
                     /transl_table=11
                     /product="ATPases of the AAA+ class"
                     /db_xref="CDD:25355"
                     /translation="MNAQGQNIALFERTMLLPDPEAQERLSRLVGLDDQKLRLSKMLG
                     TLINSAGLVAWASRFHPGAEDFVSDILRRPPLVVLSGDVGSGKTELAETIGDMVARQE
                     DIEITLLPMSLSTRGQGRVGEMTQMVTAAFDHAVQEASKLVSSQGKARGGVILLIDEA
                     DALAQSRESSQMHHEDKAGVNAFIRGIDRLANGSLPAAVIMCTNRLSALDPAVKRRAA
                     EILVFGRPELEQRNLVLSSALTPFGLTAVEIEALVDATGETNERNHGFAFSDLTQRLI
                     PSIILDAYPSSKVTASRALKIARQTIPTPPFQDGVS"
     gene            complement(87513..88031)
                     /locus_tag="MED193_00400"
     CDS             complement(87513..88031)
                     /locus_tag="MED193_00400"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTMSFTHTESQTFTITHARHMASKMATDLKRIQRFYNDPSDREI
                     DDYEGELTALLKAGYLREVTYGFQRNGNWIEPTVTYTALDLNGWNGVDDDPGKIRPRA
                     NVSGASFTSFLTYSSAWSQLTENQKTDFKRGLPITRGYGDVPGVSGYLEQDRSYSAGG
                     RALNRSSVRSWT"
     gene            complement(88041..89006)
                     /locus_tag="MED193_00405"
     CDS             complement(88041..89006)
                     /locus_tag="MED193_00405"
                     /note="COG1746 tRNA nucleotidyltransferase (CCA-adding
                     enzyme)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11457"
                     /translation="MSRDHIGHAEIAKFGTDKINLPKDKADKFRMQARNLRDKLEGYL
                     KDHPDFALRKMLLSGSLAKGTGLRTLNDIDVGCYISGSDVPSDIDALMEYLAERLRKA
                     FPNFKPEQVQPKTYCVTVSFLGSGLDVDIVPILYDGDPDWYGNLVNQEDGSFLRTCVP
                     RHLEFIRKRKTLADKDFAQVIRLVKYWVRKEKREKDGFRFKSFMAEMVLSKMLDEGQD
                     FSDYPEALQAFFSYIANSGLNERIIFDDYYPKSTAKVFGTPVEIIDPVNAENNVSQLY
                     TQAQADDIVDAALDAGDAIETALRCPTKQDTIRHWQRVFGSAFQG"
     gene            89152..90084
                     /locus_tag="MED193_00410"
     CDS             89152..90084
                     /locus_tag="MED193_00410"
                     /note="COG2378 Predicted transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12050"
                     /translation="MGEIDGAKALKKAKWNVKKRLEFIEFRLFWDAKLNRKDLVDTFG
                     ISAQQASADIATYEEMGPQNLAYDSAQKTYLRTDRFSPKLIGAWTHRYLLQLVAIENG
                     WMDAEDTWFEEEQPVEIKTLTRKRVDSQVLMSVLDAIRGHKSLEMFYRSMTGSTASDR
                     LIEPHALSYNSGRWYVRAWSAEHNDFRDYNLNRIERAKAGVPASIDRALDFQWHHTID
                     LIIVPNPKLPKERQAAVEYEYEMSNGRIEVNCRLSVSFYLMSEHNLDVEPGVLDPLKQ
                     QLVLENKDEVLQTRKVARKLSKDALKRIGGSGHL"
     gene            90081..90761
                     /locus_tag="MED193_00415"
     CDS             90081..90761
                     /locus_tag="MED193_00415"
                     /note="COG1708 Predicted nucleotidyltransferases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:25840"
                     /translation="MILDALLLFGSRARGDHSASSDIDLLAVTDNKKPTVSGSADASL
                     FHYSFDWLRDKASAGDLFVWHLVTEAIAIYDPADNLSALGQEFRFKDDYRKQITHASD
                     VGWLISLLGDEMSAKEANRWLAWAVRTISIAHAATIQKPAFSGSALAEVLGYSDIEVL
                     VRQKDRKTFDDAARRLLKKFLGALGSGEPIHPPHSIDRFRSHFEATENEVGLTILNGR
                     LLGPPYHS"
     gene            90727..91068
                     /locus_tag="MED193_00420"
     CDS             90727..91068
                     /locus_tag="MED193_00420"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGGCSDHPTTVKCTSILAVWDAFVFSKFNDGELKDIEYIASKLG
                     QIFDLSDVKLKDQNYGSFQTLSLEVQLLKDPPFFNQKRSTGLDHHSIGSVLFTRLMAS
                     FTLLSGFGSAK"
     gene            complement(91979..92959)
                     /locus_tag="MED193_00425"
     CDS             complement(91979..92959)
                     /locus_tag="MED193_00425"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MQNDIDLHAFEIEASCTYRGEDYCVRDNGAVLRRARAAKRKRPL
                     DETWTFGTPSPSDGYMAVSAHKVHRIVATAFNGEPPSKGHVVDHIDTNRRNNRPNNLR
                     WVTRLENILLNPISAKRVEFLYGSIEEFLADPRNPKNGTLTKDFEWMRAVSPSEAATS
                     RKRMLDWAQSDRPSGSGTLGDWIFGRDATPEEEPTEQLVTSKTPGAVQRNWRVPAEFP
                     LCPDTTEEMPLDTYYRRLKEGSVAVVTPFDQTIVGKAAKSADCTALFILGAHGEGAIK
                     PWSLAQVTFEDNTFVHESLGTFFTKEGAEKEFTLAQGLPWEGGETFDDFC"
     gene            93006..93152
                     /locus_tag="MED193_00430"
     CDS             93006..93152
                     /locus_tag="MED193_00430"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIALVGLDCFYLFLPALQFKGMSQIFLYTSFAEAAADPHNLQGF
                     KSLL"
     gene            93625..93963
                     /locus_tag="MED193_00435"
     CDS             93625..93963
                     /locus_tag="MED193_00435"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:17661"
                     /translation="MTTNCIKFTSDDIETAKGVGSISTLNFDIDITVEPIASSNPMAP
                     THRVLGRSPRGKLVECGGIWKKQNKDTGSDYFTLTVRDHAFNANLGKAASQDDMSLQA
                     IIPWGPKEAA"
     gene            94103..94765
                     /locus_tag="MED193_00440"
     CDS             94103..94765
                     /locus_tag="MED193_00440"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTDDAQPKTLPDLLRARINDAPRQVWTPADFADIGARAAVDKAL
                     QRMVASGQLRRIERGLYDKPAQNALTGKSTVPDYRAVIDAIARRDQVRWLIDGMTAAN
                     TLGLTNAVPAKIEVLVDARLKPVTLGNQKIVFKHAAPSRLYWAGRPGMYLVQALHWLH
                     DVMSNDVEGAVVRKTVRRLLADKKSGSGLADDLKAGLSAMPIWMQDILRAPLFDAAEG
                     DQ"
     gene            94765..95805
                     /locus_tag="MED193_00445"
     CDS             94765..95805
                     /locus_tag="MED193_00445"
                     /note="COG2253 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11959"
                     /translation="MSTAGFQKIIAASAADRADLFLTTANRLGAPLINIEKDFWVCWT
                     LNALYHRLPAGGPRLLFKGGTSVSKAYGLIDRFSEDIDVTVFRDDLGHGASPEELAAL
                     SGKKRKAAIEAIQNDCQAYITGPLLEALSQLIAEDTVGEGRIEIDPDDGTGQTLLVWY
                     PRVDGSDTGYVQATVKIESGAKSALDPNSPQLIRPYISDDLDGIDLDVPDVRTIDAER
                     TFWDKVVILHGLRNWFDTRGELKQDGQRISRHYYDLHCMLETETGKAAVADIELGADC
                     VAHAKTFFNRPDFNLATAEPGTFSLLPSDDMATRLIGDYKNTEAMIFGEAPPFDAILA
                     SIGSLEDQLNQP"
     gene            complement(95828..96088)
                     /locus_tag="MED193_00450"
     CDS             complement(95828..96088)
                     /locus_tag="MED193_00450"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MEHATGDVCCAQSARRQPSRNLAQALQTARLRASDLMGQQVNGK
                     GHNGMIDRTSSTSFPALDRGPFYALKREVAANHTQAKPPRNI"
     gene            96124..96357
                     /locus_tag="MED193_00455"
     CDS             96124..96357
                     /locus_tag="MED193_00455"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPPVFSTIRPTTINGKDHNMTYEQSLDLAELQADMAFETYLSAF
                     EEGDHPEVIDSLATEALIAQDRCADLRSHDLAH"
     gene            96869..97591
                     /locus_tag="MED193_00460"
     CDS             96869..97591
                     /locus_tag="MED193_00460"
                     /note="COG0183 Acetyl-CoA acetyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKTGRPKRLKLEQRIELARRYHAGETPKVLAEAYGVSRRHVTRL
                     AKEEQGEGLAVRDPSERVSFRASASELAAFDAEWQTRGFANRSQALNAVLRGRCGLLD
                     VPRDLVAEFCASWRQAKDVSDAGLALAKAVHRGKISVSLEDRALLVDLLDLAQSMSRE
                     LGQIKDAAQVRRKQDWPLKEEGDAALRAHPEEPARAASGLRLVAGEGGREGARVSVAL
                     APAGGVASKASDAVVDRNISNG"
     gene            97584..99512
                     /locus_tag="MED193_00465"
     CDS             97584..99512
                     /locus_tag="MED193_00465"
                     /note="COG3843 Type IV secretory pathway, VirD2 components
                     (relaxase)"
                     /codon_start=1
                     /transl_table=11
                     /product="T-DNA border endonuclease"
                     /db_xref="CDD:26076"
                     /translation="MADPLALYSSVMGKLWEDERIRGKAAARIDARIAGRRQGRSFGR
                     VGSMSARNVAKAASGQSRAAVFKRIRAGGCKTQASLGNQLAYINDKAVYTYSTMTNAL
                     TEDAVLSEDQKADIIEAWSETWRGSTKLGFTSHMLLSFPTDVTVDQVRDIAVDWTEHF
                     FESGEYGDQWDYVLAVHDDRAHKHAHIILNNRGLDQGTWFSCWAEGVMSPQLMREKQA
                     EIAEGYGVMLDATTRLERGIFEKPAGLAEIYRAKEEARLPREIIMTAEQSAVAQAQVV
                     GFAKDYTEFADLLDRMDQRHLARAVRGMANNLGTVTPWKFTEGEIDMKDIKTVGDAID
                     YSERTIEALRLKAEELDVTERAAFEAKAAPVIADLSQMVPDPELRTRFGKQLEEPYPP
                     GAGSEVLIAALQSGNGDGLKDVLAQADEAGMDGDELVARITAGGTKNYGMAQDWVERD
                     MNAVLSKDGLTVESASDEQLDRALERVDGVMEALTERAKELGVAIGLGLAEEEAADLP
                     LIDEDDRSPNTYLQDLADMLRDGQLSEAQEETVERTLQAELFKELGEEGLGELRRGNY
                     EVLDDVLPSKIDQITVTQEFLEMTFEETGDQVFTDRASSLQQDKATEVAQLKGQQEAQ
                     ALGKDLGRDRGLDDDMEF"
     gene            99528..101441
                     /locus_tag="MED193_00470"
     CDS             99528..101441
                     /locus_tag="MED193_00470"
                     /note="COG3505 Type IV secretory pathway, VirD4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system coupling protein"
                     /db_xref="CDD:12833"
                     /translation="MNKAFPLWAALPFGAICGAILGTIVASFYLTLALRTGFGNFDML
                     AVWNASTGLRAAHPEAFKVAYGAVGFGSLGLGGLALAWTWKKERDDYGSAHWQTKAEL
                     MKNDMLHEPGEGFVCGKLGLPRSKGGFISSAAIPHVMMVAPTRAGKGVGFVIPNLMAF
                     AGSVVVLDVKGENFEKTSRLRALNGDEVYRFSPFDWSNATHRYNPLSRIAKAPTFAQR
                     FTEVSILADLFLDKDNKTLDTFSEAGKSIFVAACLLAIQRGTANLGEVNKIVAGGEYK
                     NAQYKTYADEAEEAILRELWTNAASASSRLLTSNIQALMTAGLKQWDNPAVRSATQDS
                     DFDFATFRKTPQSLYIAVSEDHIATLAPLLRLMFADLIASIRLKEPGPDEPWPVMMMI
                     DEFQQMGAMPYLERAIHSLASYGGRVAMIAQSLASLDRIYGSEGRESLENGAGLKLYI
                     TPRDQRTVKEVSAAVGSTTREAVTRMYGRNKGILGATSTSARLEERPLLSETEARLMD
                     PDEVIILASPQHPIKAQRVKYFDDPVFKAMDAKQKDMPFPYPPSVEGVGPWGVGSDED
                     RAQGANDTAGHPPARERAERREARGMRVMAEGVEMEQQPTPETLEREADVPKAWERTL
                     DMREEMIEEMLGE"
     gene            complement(101950..102840)
                     /locus_tag="MED193_00475"
     CDS             complement(101950..102840)
                     /locus_tag="MED193_00475"
                     /note="COG1802 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11512"
                     /translation="MNAKASKSDLQVRLARQLLQLVADGEIKPGHHLREVELSEQFGV
                     SRTPIRATLNFLVGLGAVEKLANRGFFVVAPASVALKTIKQLPKEDDEKLKEQIAKDW
                     FNGKVPKEVSEGEIRTRYDLGKMTASRVLGTLAEEGLVSRMPGYGWQFEPTLNSASAH
                     DESFDFRAMVEPAALLSPEFRYDADRAESLRTRHERVLGGRRQHNLAEIIRLDEDFHE
                     FLAKCSNNRFVVQAVAHQNRLRRLMEYQSLIDAGRLTDSCLEHIGILDNLDRKDLVGA
                     SAALRDHLTRAKQAGPEFND"
     gene            complement(102900..105128)
                     /locus_tag="MED193_00480"
     CDS             complement(102900..105128)
                     /locus_tag="MED193_00480"
                     /codon_start=1
                     /transl_table=11
                     /product="large subunit of N,N-dimethylformamidase"
                     /translation="MLPIVGYTNKLTVEPGETIDVMVSSFGAKSYRPDFRQIIQGDTN
                     PDGPGYKDKLIDLDLGGARDAIAKPFLPGSCVLIPDLDALGQIDEFTLAAVVKPSLLD
                     GRRRSIIALPGLAEIGIDEKGRLTGVAGGACLTSATPLSTEHWHIVSLSYSKSDGLLS
                     LAMSQDHDAASEPPRAEVISAPLDRTGETAKECIIAATRGPDGALTGFLDGRVDRPAL
                     FNTVVAPETLRNLLGDFALLRRQRSLLGAWDFSHKMTTQTICDISPYQLHGQIHNAPT
                     RAMTGWLWKGQELDWKLRPDLYSAIHFHSTDMYDAGWDVDFSLTIPKDLKSGVYSVRL
                     VPDGDEDNAYYCVFAVRPPRNKPSGNKVAFLFPTCSYLAYANHRLGMDVPGTEIGMGR
                     AVELDHHHMFLQDNPGIGFSVYETHDDEMGVFHSSRLRPIVDLQPKVKSFLGGFGSNI
                     WQFNADTHILGWLDAIEQDYDVITDEDMHEDGLRLLQRYNVILTGTHPEYYTRNMVEA
                     LQGFTDRGGRLMYLGGNGFYWVVSFNEDMPGIMECRRSEAGIRPWEPGHGQFYHGFTG
                     EYGGLWRRNDHPPNHLCGVGMTSQGFDVSEPYVLSPEATNPRVAFIFDGIEGPKIGDF
                     GLAGGGAAGLEVDRADAVQGTPGHALVLASSTRHTDIYLMTPEDLLDPTPDWSGTQAD
                     IIRADLTFFETIGGGAVFSTGSIAWAGAMAWNSYDNEIARMTANVLRRFNDETPFDML
                     PQ"
     gene            complement(105140..105466)
                     /locus_tag="MED193_00485"
     CDS             complement(105140..105466)
                     /locus_tag="MED193_00485"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MARYQISDSDHPFAREFLAQPIGYHSPGLQRVLNRMRGADWAFK
                     YILVIEERHSKWRLGKLPKARGSKVEMVEGVVYFDLLEAERDIFKRRWMDLTGQDVDA
                     LLSQTG"
     gene            complement(105583..106524)
                     /locus_tag="MED193_00490"
     CDS             complement(105583..106524)
                     /locus_tag="MED193_00490"
                     /note="COG4608 ABC-type oligopeptide transport system,
                     ATPase component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13764"
                     /translation="MSSVISVRNADVQFSSGPPWAKSVVHALQDVSIDIEPGQIFGLV
                     GESGSGKTTLGRACLGLQGLTNGEIEFAGTPFNQLGRKQLKGQLAAVLQNPRSSLNPA
                     LKVATSVEEPLKINQHAHGPEARKQVDRMLERVGLASGVGDRFPNELSGGQRQRVSIA
                     RALITKPRFILFDEAVSALDVSVQAQILNLIKELQASVGFAALFISHDLAATRYVCDR
                     VVVLYHGRIMEDCGRRLLYGRARHPYTRGLQAASGLIDDDTVHLEVDDKGASPTGCPL
                     AGRCPERMAMCGETLPQAYSAGGGKVFCHLYDEVSER"
     gene            complement(106521..107486)
                     /locus_tag="MED193_00495"
     CDS             complement(106521..107486)
                     /locus_tag="MED193_00495"
                     /note="COG0444 ABC-type dipeptide/oligopeptide/nickel
                     transport system, ATPase component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative ABC transport ATP-binding subunit"
                     /db_xref="CDD:10318"
                     /translation="MSDLLTVENLTVSYHTKTREVTALLDVSLSLAPGEVFGIVGESG
                     CGKSTFSSVIGHLLGPAGQVESGLVEVAGHNVLALSGKTLRAYRSNDIAYVFQDPMSV
                     LDPTKTLGKQYRRLLGSSDWKQKAIDALNHVGLGDHQRVLSSFPHQLSGGMAQRVVIA
                     MALMRMPKLLIADEPTAALDASIRSGVMELLTKWCSEIGAAMLIISHDIPIISRFCDR
                     IGVMYAGRFVEIGPAAEFITSPLHPYPIALLASEPGHEGEDGVLQSLEGAPPLSISRD
                     RACAFADRCAHRDDVCTSDFPAPVKVGSSTVSCCRIDAIHAEATR"
     gene            complement(107491..108351)
                     /locus_tag="MED193_00500"
     CDS             complement(107491..108351)
                     /locus_tag="MED193_00500"
                     /note="COG1173 ABC-type dipeptide/oligopeptide/nickel
                     transport systems, permease components"
                     /codon_start=1
                     /transl_table=11
                     /product="oligopeptide ABC transporter permease protein"
                     /db_xref="CDD:10891"
                     /translation="MNLRPLIHHWLEFHRADRLAGFASLTMATLILAALLAPLLPIDP
                     PDQVAAYPRLSPPSADIVFGSDNLGRNMLSRVLQGIQVTILLATTAVLCSALAGIVIG
                     LIAAYSGKVLDEIISRLSDIVFSFPAVLMGLLITAIIGPGEFAAICAIILVTLPPMVR
                     VVRAAAMDVTGADFVTISKLSGASPARQLLVHILPNIAVPVVTQVAYSISVGMLVESA
                     LSFLGLGSQPPAASLGSLLREGSLYITFAPWLVFAPALFLVLAIWSVNLIGEGMRVFF
                     DPVRARSLED"
     gene            complement(108356..109309)
                     /locus_tag="MED193_00505"
     CDS             complement(108356..109309)
                     /locus_tag="MED193_00505"
                     /note="COG0601 ABC-type dipeptide/oligopeptide/nickel
                     transport systems, permease components"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC-transport protein, inner membrane component"
                     /db_xref="CDD:10471"
                     /translation="MTQLLKFIAFRVGSALLTLIGVSIFIFLAIHMLPGSFEDVLAPR
                     GPEELRQQIAEKFGLNQPLPIQYAKWLGSVATGDLGISLITQDPIVDSFASRVPVTIE
                     LALLATFTSAVIGIPLGLWSGLAHRRAGVSGIARVLGSFIMSVPDFVIASVFLFVFSR
                     YSLGLTVGQWVPFQEDFGGHIRSIILPAVTLSAVGIGLFITTTRNAVIGILSKDYIMA
                     ALARGEEPREIVQGHVLRNISNPLVTTLSIYLGYLIGGAIIVEYVYSVPGMGRFLVQG
                     LLNRDYPIVQATVLVIACAVVFINMTADIAYGLIDPRLRKG"
     gene            complement(109313..110917)
                     /locus_tag="MED193_00510"
     CDS             complement(109313..110917)
                     /locus_tag="MED193_00510"
                     /note="COG0747 ABC-type dipeptide transport system,
                     periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transport protein, solute binding component"
                     /db_xref="CDD:10615"
                     /translation="MTNEHHSADLSAEDLRSALTRRSFLRTAAMTGLAAASATGVPGA
                     LYAQGASTMTWAKPLETTMLDPHTAILGSSWQMLHLVYDSLIDVDEELNPIPAIAESW
                     EQESPTSYLFTIRSGVKFSNGADLTIADVVGSLKRVQDPATGSWWVRPMGMIDDVVAV
                     GDNQVRVTLQEPHTPLIAALAATMCSILPMSLVESGELDVSKDMLGSGPYKIVSHEQD
                     DNWVLERNPHYYQQGLPKIDRIVVKIVPSDNTRIAQLRDGSIDIASFEASPDAGLLLR
                     GVANVEVNVEDVTNYYILGLNAVAEDSPFKDIKLRQAVALTLDRELIANIALGGGGQP
                     TAVMAPAHKACDTSKLPLFGQDLDRARQLLAESGNEDLSFELLVRNIPADIQMAQVIA
                     QGVAKIGLTANIAVVDEGIWVQRAWIDNPSKFEAMITWYAGYADPAISTLWWNPGVAG
                     FTAGHVENNDDINAAIDAAYQTGGEARGAVLQNLCAKIDESANVIPLVTRQDTIAYRS
                     DKLKAKLAHLEGYVHTLRNVETFELM"
     gene            complement(110944..112044)
                     /locus_tag="MED193_00515"
     CDS             complement(110944..112044)
                     /locus_tag="MED193_00515"
                     /note="COG0123 Deacetylases, including yeast histone
                     deacetylase and acetoin utilization protein"
                     /codon_start=1
                     /transl_table=11
                     /product="histone deacetylase/AcuC/AphA family protein"
                     /db_xref="CDD:24480"
                     /translation="MATGLVYHEICMWHDAGNVSSFVPAGLDVQPDRHAEEPETKRRI
                     RNLLDVSGLLDQLILIKPEPAEISQIARVHPDSYISGIEEASKSGGAEVGLNTFIGNE
                     GFDIARVSTGGSIAIMDGVLNGQMKNGYALVRPPGHHARPTEAMGFCIFANASIAIRE
                     MQEKYQLDRVAIVDWDAHHGNGAEEIFYEDPSVLTISLHQDNLFPLDSGAMSSIGEGR
                     GEGNNINVPLPPGSGRGAYQAAFDRVVIPALQAYKPQLIVVCSGFDACGLDPLARLML
                     HSSVYANLTKQLMECADDLCQGRIAMLHEGGYSRALAPYCGLAVMETLSGIKTNITDP
                     FDEYVSAFGGQDLQPHQEAVVNEARGLVDNLR"
     gene            complement(112155..113129)
                     /locus_tag="MED193_00520"
     CDS             complement(112155..113129)
                     /locus_tag="MED193_00520"
                     /note="COG2207 AraC-type DNA-binding domain-containing
                     proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, AraC family"
                     /db_xref="CDD:14970"
                     /translation="MGAMPIHADLIYCTSEFSKASRLEEWRASMSDAYYALDIVEDDR
                     HALDAKIEIVTLSNVCISKFRSTTAKGFRTRKSIAHDTTEHFVFVFVTEGEMFFNQLA
                     RWGTLSAGQYVMLRSGEPYELSCLSPSNAITLHLPVSDVEDRYKLAHLHCAKAIESDA
                     VLFPMAASVMQSVGSVPVSARKAMSHDLRRQVIDTILLLLRAERIQANVDGNDGHLGR
                     LIDYIEQNYANTDLSARTAAQDMGMSVSHVHRAFGSFNLTFGSTLRDTRLAQSYELLR
                     SSEGQNSNIGEIAFKVGFLDHSHFSKSFRTAFGISPTEVQQGASRPGK"
     gene            complement(113357..114751)
                     /locus_tag="MED193_00525"
     CDS             complement(113357..114751)
                     /locus_tag="MED193_00525"
                     /note="COG1012 NAD-dependent aldehyde dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="succinate semialdehyde dehydrogenase"
                     /db_xref="CDD:10741"
                     /translation="MSNAIKCISPVDGSVYAERPATSVTQARSVFAAAKQAQAKWSAL
                     SLEDRCALLHRAVDHFVSHASDIAIEISWQMGRPVSQAAGEIGGLEERARYMIDIAPE
                     ALHQDALPQSGLALRTIRREALGTVFVIAPWNFPFLTATNAVFPALAAGNSVVLKHSA
                     QTLVCGERFAQAFAAAGLPEGVFQQIMPTNADTTTLIEEGHHDHIVFTGSVGVGRYLQ
                     QVNAVNFSGIDLELGGKDPAYVRSDANIGFAAESLVDGAFFNSGQSCCGIERIYVHKD
                     VFQSFVDKVVEHVNAYRLGNPTLPETTLGPVVNTTAADFVRGQVAEAVASGARMLIDP
                     THFPTDQPGSPYLAPQVLVDVTHDMRVMTEESFGPVVGIIAVEDDAQAIALMNDSDFG
                     LTTSIWTSDLDAAEALSAQLATGTCFANRCDYLDPGLAWTGVKDTGRGCSLSSHAYGH
                     LTRLKSYHFRAQPQ"
     gene            complement(114799..116169)
                     /locus_tag="MED193_00530"
     CDS             complement(114799..116169)
                     /locus_tag="MED193_00530"
                     /note="COG0174 Glutamine synthetase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:22916"
                     /translation="MGKQLHLKTVEEVRQYVSEKDPKHIKVGFFDVDGVFRGKFMAQG
                     KFLSALQDGYGFCDAVLGWDVADTLYDNSKFTGWHTGFPDATLRIIPESGVILPFDNE
                     TLFFSSEFSGRAESICPRGVLRRVLQRAHDMGFIAKAAMEFEFFMFQETPDSLEEKGF
                     RDLKNLSPGNMSYSALRSIVQEDLYQDILDTFGSIGIELEGLHAETGPGVVETALAVD
                     GALAMADKASIFKAFMKILAQKRGLMATFMAKWNQNLSGQSGHTHMSLWSLDGAPRFY
                     DANGDHRMSQTMRHFLGGQLAYLREFAAMIAPNINSYARLTPGHWAPTSATWGVDNRT
                     VGIRVIPESEKSHRLEYRIPGSDVNPYLSMAAAIGSGLLGIEQGIEPGDAATGNAYDL
                     DVPTTRQLPTNLESAGILFGASQAANAMFGKAFVEHFSASRIFEAREFGRAVTDWELR
                     RYFEVL"
     gene            116098..116265
                     /locus_tag="MED193_00535"
     CDS             116098..116265
                     /locus_tag="MED193_00535"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLGILLGYILPNLFDSLQVELFTHHVPVPELEIVVFGKCPERLR
                     QQGGPNSDLPF"
     gene            complement(116188..117012)
                     /locus_tag="MED193_00540"
     CDS             complement(116188..117012)
                     /locus_tag="MED193_00540"
                     /note="COG3931 Predicted N-formylglutamate amidohydrolase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative N-formylglutamate amidohydrolase"
                     /db_xref="CDD:13238"
                     /translation="MSVFDQHPWDIGFQEGSVPRRPLLGAKEPTPAKVLNGSGKGPFV
                     FGCEHAGNRIPKSLGTLGLTKAERSRHIAWDIGAAHLTEKLSEKLDSPAVLQRYSRLV
                     FDCNRTASHPGAFVVEADGSNVSGNENLGKEEKLEREEAIYRPFHNTLSEITDRRRWM
                     GERIAYVAVHSFNDQVHGETRPWHVGFLYNQRSGMSRFMIDWFQSNTEYEVGDNQPYS
                     PLDAVDHTLRNQAETRGLPYTMVEIRNDLLRSERQIAVWAALLTQALRAFAKDHNL"
     gene            complement(116999..118369)
                     /locus_tag="MED193_00545"
     CDS             complement(116999..118369)
                     /locus_tag="MED193_00545"
                     /note="COG0161 Adenosylmethionine-8-amino-7-oxononanoate
                     aminotransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminotransferase protein"
                     /db_xref="CDD:10036"
                     /translation="MNKQASNSWEQRDMTNVFHGFTDLGTLNSNGPVVLSHGEGIYVF
                     DVHGKSYMDANSGLWNNVAGFNHQGLIDTICEQARRFPGYHAFFGRIADTTVALSEKL
                     IDVSPFDAGKVYYTNSGSEANDTMVKMLWMLHRRNGQPQRRKIITRLNAYHGVTVASA
                     SMTGKSYNAEFGLPLPGFLHADCPHYWRYGLGGESELEFSQRLARNLEELIIKEGPDT
                     IAGMFAEPVMGAGGVIPPSEGYFEAIRPILRKYSIPFVADEVICGFGRTGAMWGSVKY
                     NMEPDAIIASKCITAGYFPMGAIILGKEFSDELLRVSENAEEFPHGFTAGGNPLGSAV
                     ALKALDVLENEGLLENVNLVSPRFLERLHKLGAHKYAGEARGVGLMGAVELVANKDTK
                     EALPGEMQVSERIANKALEKGLICRPLGASIVLGPPFIITEDQIDEMFDILEETMAEV
                     FADVGL"
     gene            complement(118842..119792)
                     /locus_tag="MED193_00550"
     CDS             complement(118842..119792)
                     /locus_tag="MED193_00550"
                     /note="COG0630 Type IV secretory pathway, VirB11
                     components, and related ATPases involved in archaeal
                     flagella biosynthesis"
                     /codon_start=1
                     /transl_table=11
                     /product="VirB11 protein"
                     /db_xref="CDD:14094"
                     /translation="MERYLEPFRELLLRDDIVEIAINPDGKVWIEAAGDAAMRHEGQI
                     VDRATAFNLAQTIVGDANARVSEKNPLVSGKVEYGGRPLRVQVAVPPAIEQGASITIR
                     LFATAGVTGYTPSYLFGKAVSLDQLRAEKMKGIANQAEENLEAALEALVHQRLNVLIS
                     GGTSTGKTTFARHLLTHVDDGERLITIEDAFELFPSQPNTVALLASRGTGTQRSSNAL
                     LQASLRMRPDRIIVGELRGDEALTYLEAINTGHGGSVSTIHAETAELAIDRLAIMVLQ
                     AGTPLNFAEVRQYIQKSIDVIVQLVRVDGRRGIAEFYLPN"
     gene            complement(119819..121249)
                     /locus_tag="MED193_00555"
     CDS             complement(119819..121249)
                     /locus_tag="MED193_00555"
                     /note="COG2948 Type IV secretory pathway, VirB10
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein B10, putative"
                     /db_xref="CDD:8701"
                     /translation="MADENTPDLRDRLSTFSQKNKTKRRGGNIGVGALAIALALGGGG
                     AAYLLATNLQEGTTGLETSDVETFQDQRTGNGGRLEFPPDEAEQQVNDALIAVEEALD
                     VPSPVPAAEPSAAVLEEIAKLREALAASQSARNAEIQEAVSDLREAFQVQTDALEASI
                     AAKDTEIENAQRQSEARLAGLQAMLDAERAQREGLEAEMARDGLIADQRLLEERQRQE
                     EEQRQREVEQAAQELLNAQIVSPSVVYADGPRSTSAGGTNPTAALAGADGPTLSENEQ
                     YLRQGARPLDVQEASQMAFPERTLSQGSVIQAALQTAINSDLPGSVVAVVSEPVPAFS
                     GDQILIPRGSRLFGQYRSGIELNQKRILILWTRVLTPDGTSIEIASVGGDQLGRSGLT
                     GIVDTKFAERFGGAALISLIGAAPAVAANSTDNEIASEVLEGVSGDLEDAVGSVIAEQ
                     VSISPTIYIDQGASVTVLVDRDVVIY"
     gene            complement(121252..121983)
                     /locus_tag="MED193_00560"
     CDS             complement(121252..121983)
                     /locus_tag="MED193_00560"
                     /note="COG3504 Type IV secretory pathway, VirB9
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein, trbG"
                     /db_xref="CDD:15554"
                     /translation="MNTAACLICAAALLSASPAMSETVPRSGPLDNRVRTATYVENQV
                     FVIETDLRHSTTIHFGQGERFDVVIVGDTESFQVDPIPELGNVLTIKPHVQGASTNMT
                     VITNRRTYSFHLREGAIPGRSGMFFEVRFRYPEDERRAAAASTQPKGFEAPRNYSYRV
                     AGEGDFRPTHIYDDGRYTYFTFPENGRQPAVFKADEQGRERTVNWTQQGNTVRVLGVN
                     EFWTLRIGDEAICALRDDSAIYVSN"
     gene            complement(121988..122659)
                     /locus_tag="MED193_00565"
     CDS             complement(121988..122659)
                     /locus_tag="MED193_00565"
                     /note="COG3736 Type IV secretory pathway, component VirB8"
                     /codon_start=1
                     /transl_table=11
                     /product="VirB8 type IV secretion protein"
                     /db_xref="CDD:13056"
                     /translation="MKSQTSQDQSDAFAVDFIYGPRRRERFAYFVAAAGVLVGLAGIV
                     AGASLFPLKSIETFVVVVDKETGQMDRVAAVQALSLSESDAIIQANLVAYVDDRETYD
                     LTDGEQRINSVLERSDGDAARTLRDLWTSSNEDYPIAVYGRDAVIEVVIKSVNQIEPG
                     VAQVRFTRTLRRARDTRSVTRSYVATVGYAFEPETRQRLQDVWANPMGFVVTSYRVDA
                     ETLEN"
     gene            complement(122679..123692)
                     /locus_tag="MED193_00570"
     CDS             complement(122679..123692)
                     /locus_tag="MED193_00570"
                     /note="COG3704 Type IV secretory pathway, VirB6
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:15907"
                     /translation="MGIIRDILDQVDAAVDSVAQEGFISSAAAVGDVITAGAILLLIL
                     LGINVVMQLRPMTFGSAFAFGIKISLVAIFAQSWDNFSVIYGIATQVPDSVGASILAL
                     TGSGDEAGVYESLDNMVARITAYGDTIGDQAGWVFGAVLGAIFFVLSALFAAVTAGII
                     AFAKIVFALMIVIAPFMIITSLFKPTQSLFEAWSRATIGYALMPVAAAGAAGIIVAIA
                     EAIGDASADPVDVETVSLILPFLVILLLSAGIMASVPYIASNLTGVMGIASNAVGLTG
                     LARRGIVNTSDYGTGSATRFATGKSPQELQQAVNSGVVKTGEAIRRTPATALNTVKSF
                     RAP"
     gene            complement(123696..123992)
                     /locus_tag="MED193_00575"
     CDS             complement(123696..123992)
                     /locus_tag="MED193_00575"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAVAPDAEEFCRVPRPPAGLAETAYLRNGYRAILRILVAERQLE
                     TETCDCPLSDFTWDMALAELPRFQTTDNPRLPFKVLDLYAMADALEAEHAEGCS"
     gene            complement(124112..124852)
                     /locus_tag="MED193_00580"
     CDS             complement(124112..124852)
                     /locus_tag="MED193_00580"
                     /note="COG0840 Methyl-accepting chemotaxis protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MITTLGVSSPAKAQGVPTFDGSQLGQLVAQLEHMAEDLNVQLQQ
                     LATMRLELETQLSQLLNLEAQLTSLIEGSGLSGLFASIEEFRALRGKLVAPLNTARAL
                     ADGDFLSGFNPGAELEASVERVLSGSGFTSETLSTLSSSPEPADNRIATSAGASAMLS
                     VAAQESHAEAGQSLERLETMVGLIDDQDGLKAAVDLNTRVTAELGIILTQIWRLEAAQ
                     GVSAGQLGVVDAATLADERRFRSMAVDP"
     gene            complement(124876..125946)
                     /locus_tag="MED193_00585"
     CDS             complement(124876..125946)
                     /locus_tag="MED193_00585"
                     /note="COG0741 Soluble lytic murein transglycosylase and
                     related regulatory proteins (some contain LysM/invasin
                     domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:27995"
                     /translation="MHATSGFAQGVPTQDNAAIGQTIARVTALVQDLGTQGDKEAERS
                     SIADVQADQLRTLEAISAAMTGPGFDISALEGNADFGVASVYPNIDTSPMNSRLFGEG
                     RETVEMMIVRVAGEYAGAPGVARAGLSATQWRCLFQALIKQESRFNITAESHVGAYGL
                     TQLMPGTASDLGVNPYDPMDNLRGGARYITTQLNRFGNIPHALAAYNAGPGRVIEYGG
                     VPPFTETQGYVRNISKFYNEYLAVVGGADALGTLSSSDFALAEYANISDAGVYYAASS
                     HATTMQVINRLRAIILQIDAQPNAKAAWELNTYAKAEIARILNLRVRLMAANQQREAT
                     HAQHLVADRLSEREFMQMGVPN"
     gene            complement(126188..128578)
                     /locus_tag="MED193_00590"
     CDS             complement(126188..128578)
                     /locus_tag="MED193_00590"
                     /note="COG3451 Type IV secretory pathway, VirB4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein B4, putative"
                     /db_xref="CDD:12779"
                     /translation="MGVTALALDGGTLSGIGPAVREAGGTGFARESYLAEHLPYFALA
                     TDDVMVLREGDLLATLRLDGLNPMTTEDDRLDALKRAVAAIVAQTGNTFGFYIHRVSV
                     PQNLDLKPVEGDTFASQVDARWAAHIKGLRPSKRQMYLSVIRRPNLAARIPFLRALAR
                     KAWVKDRAARVQELNEVMGFFAVALSSANPVRLTKTGGEWLGYLNTLNAGSFSPIAFG
                     QSPLPLSHTISDCRATFDGDVATITCATTGAVKYGALFSIKSYPALTDVTLLDALDLP
                     LDIVLTNSFSPIPNNIMAERIQRIIRQMHASDDAAVSLRDQLALAADDQEAGRIAFGD
                     HHLSIAVYAPDRDTLERAAAQIKRVGQEIMAVIVRENMALKATYFAQSPGNFGYRARK
                     TPISSTNFSDFAALHGSVEGRSNDESPWGQSIAVLPTVGTSGYRFNFHEAGSASKEPT
                     VGHTLVLGRTGTGKTLTTAFLTAQAQRIGARLFFFDKDRGLEMAVRALGGRYNEIRAG
                     VPTGLNPLASEIDERGRAWLSDWLATLLTRSGALSGEQSRHIQGAVTQNADAGAALQR
                     FASFETLFQSLDDDGELQSRVAEWAPGGRFGWVFDEPDRGQRLDLSGDIVGFDMTEIL
                     DMTTERMAVLSYIFRQIERVVEDRRPTIIVLDEAWKLLDDPYFGARLENWLVTLRKMN
                     CVVIMMTQYPSQLRDSRVGKTIVETVPTQILFPNDRATVADYDFLRVNSKEAALLVQP
                     TIGQRIALVRSAGDSVFVDADLCALGDLLPILGGGATGEARVPADWRSNPDFWRPQ"
     gene            complement(128553..128831)
                     /locus_tag="MED193_00595"
     CDS             complement(128553..128831)
                     /locus_tag="MED193_00595"
                     /note="COG3702 Type IV secretory pathway, VirB3
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13022"
                     /translation="MAERSPLFLGLARPPKYLGLPVGYLVVLAMGVVLPFIWTKSLIF
                     FLIGIIAYPVLWFVADKEPHFFEVLRISFGTVRPTKNRAHHGGDSFGA"
     gene            complement(128963..129211)
                     /locus_tag="MED193_00600"
     CDS             complement(128963..129211)
                     /locus_tag="MED193_00600"
                     /note="COG3838 Type IV secretory pathway, VirB2 components
                     (pilins)"
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein, trbC"
                     /db_xref="CDD:13155"
                     /translation="MVATLALLASPAFAQDLSPIQTMLETVEAALTGPIGIAVATLAV
                     IGTGFMCMMGRLNWGWFASVIIGIVLIFSAGTIVDGFT"
     gene            complement(129259..129804)
                     /locus_tag="MED193_00605"
     CDS             complement(129259..129804)
                     /locus_tag="MED193_00605"
                     /note="COG0741 Soluble lytic murein transglycosylase and
                     related regulatory proteins (some contain LysM/invasin
                     domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase SLT domain protein"
                     /db_xref="CDD:27995"
                     /translation="MEAQPVAVAPIAPAAGASAQVLSLIRQTASRHQNNRAIAQAGLS
                     TRDWHVLFQAMIEAESSYNPTAISPKGAYGLGQLMPATARELGVDPRDISQNLDGAAR
                     YLLTQLAEFRSVELALAAYNAGPHRVEQYSGVPPFSETRAYIARIHDIRERLSGGTSQ
                     PAPIRVANTAPTRAPVIIELN"
     gene            complement(129896..130210)
                     /locus_tag="MED193_00610"
     CDS             complement(129896..130210)
                     /locus_tag="MED193_00610"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPIARNQILITLDGVKDLQKREVAFRCRYELVGFTDDGKPRYQC
                     IYLREGEPEAILVSTRITPLGPEARYFNIWPGLFKHHLEFGDGRDLRFGADYNITLEG
                     NG"
     gene            130343..130921
                     /locus_tag="MED193_00615"
     CDS             130343..130921
                     /locus_tag="MED193_00615"
                     /note="COG0047 Phosphoribosylformylglycinamidine (FGAM)
                     synthase, glutamine amidotransferase domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKRLILSAIFGVLMTFGAPKKAQAYDIDCAIMLCMAGGFPPSAV
                     CARAYRTMIRRITPWPSRPPFGICTFAAVPIELGGPGGEGEVDTDLPEYEWLNRTHVI
                     WFTGRSYTPRDDPRQWDWSIRSCDRENRTCRYIARVYGSHTRWPSSFVSESGQTILLP
                     VGRGFGNFYSRDIMVEYGDYGGNMGHSDWFSY"
     gene            complement(130939..131250)
                     /locus_tag="MED193_00620"
     CDS             complement(130939..131250)
                     /locus_tag="MED193_00620"
                     /note="COG0685 5,10-methylenetetrahydrofolate reductase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MATVQKLAFALEVDPIELIEPVLITRGKKSGTADHETSDDQKVS
                     GGSQLLAVPFQEGFEKRQDDLTLVLIDYRWNDGSTVRRWLVDPKKVKQSAIVVKPCIL
                     L"
     gene            131546..131800
                     /locus_tag="MED193_00625"
     CDS             131546..131800
                     /locus_tag="MED193_00625"
                     /codon_start=1
                     /transl_table=11
                     /product="hicA protein"
                     /translation="MNSKHRKTLAVVFADPVSGTVEWSAVERLLVAAGAQVIEGRGSR
                     VRFEKDGEVETFHRPHPAKEAKRYQVRAARAFLERIGVTP"
     gene            131797..132129
                     /locus_tag="MED193_00630"
     CDS             131797..132129
                     /locus_tag="MED193_00630"
                     /note="COG4226 Uncharacterized protein encoded in
                     hypervariable junctions of pilus gene clusters"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23758"
                     /translation="MTNTMTYKGYSARIEYDDEDGIFTGRLAGISDGVGFHADTVEAL
                     RDAFQEAVEDYVETCAKVGKEPQKAFSGQVMFRVDPEVHRKAALAAELSGKSLNQWAE
                     EVLGRAAE"
     gene            132273..133868
                     /locus_tag="MED193_00635"
     CDS             132273..133868
                     /locus_tag="MED193_00635"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MERVKLDNGNQKRPPLSARAASATGRSALFLAKVAGKAGWAIAK
                     PVGRQTGKLAAKGGKAVKDHAAVKFAEFELRHTKYTPENFFEKGAISLEDLVDALLIE
                     KRGTSARIVTALSGKLAAAGTTASLFSIASILGTASTGTAISSLSGAAFNSAALAWIG
                     GSVVTGGWIVLGVAAAGGAAAYFGSRKLVGKWTGVRRKKKSLDPQEMRFVETCLMLAT
                     AFRERANQNAVLDPLTAETLQQNLKHDLLEQLDVCIAKVSDWPDLPLMRLEDRKVDLV
                     ELLDALPMAHVQNPSIRRKSTAAAPVVTGVVSATILKLMSDTSPSFTEDEELVLQALR
                     RSNNSLADASELELSEYVQSLSVEQISGLKNNVKGIYHELAFQRQENLDGDEYIVELF
                     GDTNHAGADVRIINVETGDVSEVQLKATNYASYVREHNEKYENIDVLVTSEVAGSSPD
                     WSSSEFSNADLTADTSSALQKLGHEADVDIVHSMGVAAMVALATNAKSMLKGDALSTE
                     AKQKIIQDGVVAASVAGMVQLII"
     gene            complement(134001..134159)
                     /locus_tag="MED193_00640"
     CDS             complement(134001..134159)
                     /locus_tag="MED193_00640"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLVTARSRMAGEISIREFKTVTGIVSFLTDCGFTKISFPVIEGD
                     TVRLPLDT"
     gene            complement(134475..135749)
                     /locus_tag="MED193_00645"
     CDS             complement(134475..135749)
                     /locus_tag="MED193_00645"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MDNRFAYMRKYLGFSQKDASNIFSTRLDTIKKWDSGKLLVPGPV
                     LEELYDYIRFSNDMVVEFCDERQAEDEDEGIDEIYLRTFTVEGLAEQGLPPSLGWQDQ
                     VIGAIIGRLASIHVYGADTLPEHHDPDYHWYEYWGFEPVKKPTEFFTIQDEALFANEL
                     AKAVEGNFWQVDFDPDENYYLIGFRTKSVSKVTRHIWIRAVRAGRGSELVERFAGEPL
                     RYCDSFGEGAPYIEGPNKAKIPVGFASGHDDDTVDPHTLAETLFAALATSYPTEGAMR
                     EACRDRYAALVGADEGYTADFMNDWDVKDTRFVSHNFIAALFFETQKQTGLTLHPEAM
                     VELCSILAKSEPSIRSMDHEVVVIDMGEMVFTITLDLRDVLSQSGDGRDFHTEASKAL
                     DVIQASIGNDGLTRIEPFSTIEIEFTSDDAEG"
     gene            complement(135742..135876)
                     /locus_tag="MED193_00650"
     CDS             complement(135742..135876)
                     /locus_tag="MED193_00650"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MQMALEPLAPSTEDNYASKQPEDWSTGFWFQVQFQQQMEDYRYG
                     "
     gene            136207..136986
                     /locus_tag="MED193_00655"
     CDS             136207..136986
                     /locus_tag="MED193_00655"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MALCASYRAGRGWLDIQRPSGRFFPLQPHFGVNRIATWAPSSGT
                     TVNTNGMPRTAVGTVATPTLATTKLSTSMRRWRVASAASADAAAEERSAGWGCWRGNA
                     EGLGGFTYVNRLSLVTLQATGMGFFGLYGSTAALTTTLTLSAVVNCIGIGFQRGTHTN
                     WQLVQNDASGAPTLTDLGASFPVASTTSVLTLTLLAAPNSSEIGVRMVEEVSGAVVEF
                     TLDTDIPVATQLLSPRNSMNNGGTAAAVGYDCSGVYVETDY"
     gene            complement(136980..138089)
                     /locus_tag="MED193_00660"
     CDS             complement(136980..138089)
                     /locus_tag="MED193_00660"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSDDFSVRWVRVTGREGTMMPRLTFSGLLVPYLHFTDMTLVWSD
                     PSQIGFQNLFLRDAVIQGAFSTISATRLEKITGVPAQFWRPSLLALESAGLLAVVDDE
                     PQDATAGGVTYRLVDGAKADPAALDEWDHISTRIRVIRDVLVFPETGELMVSTGNPNH
                     PVDRFMAFFLQTDPKKTFDWFSSVLPRVDSAESLKSYLTALGAASPPVGVPEQVTNLD
                     FRITGGRPRVAPVRAVSGIFDTTRTDLQPFLTRVLQENEKGLWFLPPGAMTIPEGAQS
                     IENLHGLPAMLRRRLDQCQSDEVISAARRRAPKAFPQLSALALTDPYCWTIDGTTTSP
                     YVLEVHFSEVRIRIGIPNSTAEAIDAVPASAEAVQ"
     gene            complement(138082..142326)
                     /locus_tag="MED193_00665"
     CDS             complement(138082..142326)
                     /locus_tag="MED193_00665"
                     /note="COG1112 Superfamily I DNA and RNA helicases and
                     helicase subunits"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10834"
                     /translation="MTRPEQKKLIAAVQSLQAWQAHIQDRGSLRLQVSLSCLLRSRYR
                     PFSISVREFQKQVSNGVLLRRDDTAPDEAVDTSAQPTRAHFRLVTNQHAFSVTSALDP
                     IDGMGMLHARDYLWTRKPITFGMAVSAAPIKVAPIITLHLLPWTRLPTDWQDWVRSLE
                     TEGLLVPFNPKTKELDTGSRHVWHSGPFVFEVQLLAAEGEEPANAVVNWVGRRKNGKN
                     LPSRGSKAVLHLDADSLRLETSLPLVLPPTLLGSNVFPRTRSPRHFKSLGLDKARDLR
                     RPEETEIEDLSPLPEDTRFSNDDIAPLMQNGVVALDFATGRNRFSLFARPTVSPLTGR
                     PYLAVVGAKRTPKKTGTGHRNAETATLRNDCLRPVSAFALELKKPALERLWKGAAPPP
                     TPQAVFSDLDHGFNLLNFASEPVDGGGIKLNSTQFYLIVRPEQGQPREPIPGVRVHIA
                     THIQPNDWPLRVCFQADLIPVNRIEPLFPDELLIERSNDSTRRTLDAHYHFSSHFAQL
                     LNIRDAGTFHYSPRPSWRAPVNVLGVQDRTRRVFPNVPERIAQVLGSVRPRVLLRLNA
                     PPGRGLFLDGSAVGLVDDQGNVSPFRIEVISGQHVLLRAVRRPVGPDKEPPIDQYECP
                     FSPGDKAWIFRRHAVDRADLEQQIRDLRAGKYFVASQEVFARVVSQPDALSGAFEPNA
                     PVEQLMARNTRKRACANPLNARQKEAVSKAARTPHAFFIKGPPGTGKTEVIRELVEIL
                     AARGERILLTSAQNKPLADATERCMNSYGVVPTRITGRRPDLNPSEASCLWASLVERL
                     TAAFDKDDGFGDRLDAEEHRLHALWQSRIALGGLDAAARDARIEDLVRQLLSSVNLYV
                     INIDALAGRIGSLRARLERATAGPRPDDEPDGGPIHAGITSVAATQSARNSPTITPDF
                     EAEFDTLIIDEASRVNDSAFVTAALRCRRWILVGDERQLPPFLADTDASFFHALCALY
                     LVEGRMIGALAQKGIQKHQVPTLDAYLTDTATSDTELRDAVERVGNLWLMKDDRRPIQ
                     SDQVQDIAAALLWQGAFAGRTATANPEEEDAQPRQSTIGKKFDKIIQGQARHHAQPRR
                     PSLQAPQTEWQAYQDMLASYFDAVIDGVQNNFDKFFVRSFFERGYATGNTTEDDNGQA
                     EGFRATLVEQFRMVPEIANLVSERVYDGEYVTPETPPVCPLHLPSFPHQVHFVDLSLL
                     GRISPATQIGTSWANPDEAEHVIEIIRKISAELPGGTTVSVMVLSLFAAQTEFIRARA
                     TEVFGSSGAAPALKGISRLDFGNVDAVQGGEADIVVMSFVRVATGGMPEPGMALFLQD
                     MRRLNVAITRARRKIIFVGHGTTIENLSGTAKAADFLAWMASAESGTVRDMPLRLPYE
                     QLVAGRRALRRFAGSDRTLAQDAEADGIPDEEAADE"
     gene            complement(142323..147248)
                     /locus_tag="MED193_00670"
     CDS             complement(142323..147248)
                     /locus_tag="MED193_00670"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKSDSVTQRELSDRLDRAFSEASGKAPTGPYVFVLQSPALSGKS
                     EAVARYLQRRIQHGPEGRETAGHHWVALRTHHETQRELNLSKARARPTKYVPDFFWFC
                     TGARRHRSFSRDENARIDSPLWDLAEQVADKEVRKKLSPGARAVDFLENIQDRFSLKG
                     LMINAGNAILGTSMEAFAPGMAEAQPFIQRSIDTVAEQMSQVWAETNGEDIRRTLRSI
                     DRALGDAFFDNLRDFSQSISGKPTFLVLDDFDEMSEMAQAIILKNMSTDGFERLIVIL
                     TLQEGTAQANSLAEELGRGDLARNTVLLTLSAPTGVELLSQLQEDFGAAVSRELVDHL
                     SNRSGGSNPVIIREIIQALLGWYGGRPYLVIDGQADERTLTFTSNVTLEDINSEFFSV
                     GSKSSDELSDILGNIWGDAIRRLDDLDQFILAAIAFGGNEVSEDFIVAALQQDTGFTS
                     TAVTEVAHWRERVRDLAARLSFLVSDAENIFRFDGAYTRFAILKVTERIWAPRRAVLL
                     AAAVVDAFRLGHALQQSAAFGSTCAELVLSVADGNQPLCRMRVSGSSLHAFGESSLER
                     VESLRSGLASIVISSLPDDRQTEADISERADKILSAAAEHFYVQSLSGRDRSAQDRLR
                     FLASALRASGYPDFPHARARASVLQLRLALNRRPLTSGGLQNVIKLSEIERKAAREHL
                     DEMKPEENWRLALLAIEMDILHAEAVLGAIKSGQAKSGTSNRDREEARQQVFRSLREA
                     VERLSRDPGTEADRNGEKNRLLDRLLSGEIDKMAYLDLLSEVEKSESTTNFAWPKGAK
                     AEVDFQLVRARERLVFLLEFHASPDDDRSQLEETRAELSRSLEDYVKMGPQPHLQARF
                     AWATRKLGLILRDQACDTQGDLGTASPETINISERAVQFLSISYDQSKAPNVAMELLR
                     AIEFHVGLVGDTRSLTRLRDRLLDLGRELVTAPLASRTIVGVAEIESRICARLGDGAD
                     VSPPSLWAGYVAGDTEALFVETAFTDFARIPSRNDRYWVLSRLFSEPELAETNVLERL
                     LASGRDIGGLSIAAIVDTLDVFEQQRFEAVPDKTPLTDQASSELLRALDQIGPKIQTV
                     APPTRVALDMLRFRVLAQKAIVAISHSNDSASVFEANKSVETLARSIGDLAQALRDEK
                     SAKKLIGYAKQIGDAFLARAASMEDRAFHFALRDAALAWYQLATTTLQTCPDLKISVS
                     ILRSHAGFHRDHGNFSEARLLNNACARLERYRKWGNDLGGTVYAATDAILTASAESQE
                     RGARLLLLAVLKAEIVDPQIIARMPAFEAERRQLRTRLAAVLWQSLRSRQPKQVSASM
                     SLAPPIDAVRKFAEPSSAPDTGERPGRANSLVGDILSFWAAEPPPAPTPGTLVVARIS
                     AVLPNGIELLDLRGQRFRIDDNLLPSSYYQFLKYAVGRDGSDLAASLRKKKLAAMLPI
                     IVLAGDGEAGLGDGVLPATARGLAYLGDLIGCLLPGLSRGLVVGGSNSVVALRLAQPD
                     FEPFRVGGWTLHKQIAAELLCVKRLILAPAPYVPQAPNSMYDRHALLQQELADFARAT
                     WSALSLVSLRQDLSEATFEIAIDAPVSPQTERTTRSLLRKAFPDVHLIRFLGGALEEE
                     AFSDITGDTATDTGQATGETTSPNAQSGAVL"
     gene            147634..149034
                     /locus_tag="MED193_00675"
     CDS             147634..149034
                     /locus_tag="MED193_00675"
                     /note="COG3505 Type IV secretory pathway, VirD4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12833"
                     /translation="MEDVHPEPLPYGFSYGPRPRPTYPEDWDPILQSGEGHLMTIAPT
                     GAGKGVSAVIPTLLRYPGQAVVIDPKGENYHVTAAARRAMGQRVVLLDPFDVCGTGET
                     DRLDPLDLMRAGLIPANTAQRTGKGLPADEEKAREFLGDTARQIARALVPDIPQLRDP
                     FWENSARRMVGALLAYIMAESPKALTNFAELVYTLSQSDKDLGLTVKDMARSKHPFVQ
                     SAASGAFPAEPKVRASVVSTALAAVEFLQGKALEVTQKSTFHLSDVLEGEPMTIYMVL
                     PPEKLASQGRLLRLWMTTLISTLSQRRRLPETPTLFLMDEAAQLGRMDEFLSAVTLMR
                     GYGVKVWSFWQDLSQITAHYPSEWRTILNNTHALQMFGLWNTHMRKDAMNITGFDDLW
                     ELRDMDRNEQLLVLSGDDPVITRRANYLDDPAFDGLAAPNPYYRGSEGEAERLRPIVE
                     PRSYARGPSTDGEAPA"
     gene            149031..149837
                     /locus_tag="MED193_00680"
     CDS             149031..149837
                     /locus_tag="MED193_00680"
                     /note="COG1253 Hemolysins and related proteins containing
                     CBS domains"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSLVWDEPEYPTARVVEHVQQSLPVRLIMVPRSQIQTCAMGDTA
                     ADVAKRNIDDFSYVPVADDAGEIVGLYHAAQWFNRAAPDHTIDLGVAPLSDEMFIDVQ
                     ASILDFILGADRAPTLLVRNRDRISGLVCVSDLQKLPVRMALFGLITGLEMAWAQAIE
                     LHWNGGDGWMHHLSSNRQAKLRDRMAYLRRTDAFVDALETTQLSDKFTILLRENLLPG
                     TERQLRGQYDRIEELRNDLAHANGYAETPARARGLSQTARDILRLQDHAL"
     gene            complement(150095..151603)
                     /locus_tag="MED193_00685"
     CDS             complement(150095..151603)
                     /locus_tag="MED193_00685"
                     /note="COG3436 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:3544"
                     /translation="MLEMPQTLPSDPDELSALTAQLRDLDRAQALKIEKLEHQLAGHR
                     KARFGSKSESLDQLAFDLHEDADIAAAAATQQEEDGQDGEGKRRHSRAPLPDHLERQS
                     EVLSPGETCADCGGTLRALGEDVTQELEYIPGRFVVREIVRPRMACNCCEAFAQVPLP
                     SRPIERGRAGPGLLAHVLVGKYCDHLPLYRQSEIYAREKVDLHRSTLTDWVGRSTALL
                     APLADYIGKQVRAGPALFADDTPVKMQIGGKTGKAQTARMWSYVRDERPWCGQAPPCA
                     WYQFSVDRKGKHPAAHLAAYKGTVHADGFTGFNGLFGEGLASEQACMVHVRRKFVDVF
                     ERNGSTIAKETIERISRLYAVEKDARYKPPEERVALRQTKAKPIFDDLETWLKSQLPK
                     ISGKTKLAEAIRYALSRMPKARAYLENGQLELDNNICERSIRPLTLGRKNYLFMGSEG
                     GGKAAAIAYTLIETARMNRVDPEAWLTWVLTHIADHKINRIDELAPWNWQPS"
     gene            complement(151642..152013)
                     /locus_tag="MED193_00690"
     CDS             complement(151642..152013)
                     /locus_tag="MED193_00690"
                     /note="COG3436 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="70 kDa peroxisomal membrane protein"
                     /db_xref="CDD:23941"
                     /translation="MIPVPSNTRVWLAAGVTDMRRGFNTLAAQTEKVLAEDPYSGHLF
                     VFRGRRGDLLKIIWWDVQGACLFSKRLERGRFVWPAAKEGKISLSPSQLSMLLEGIDW
                     RMPQKTWRPLTTGNLPENPAP"
     gene            151696..152028
                     /locus_tag="MED193_00695"
     CDS             151696..152028
                     /locus_tag="MED193_00695"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRHAPVNPLQEHRQLRRAEADFALLGGRPDEAPAFQAFREQTGA
                     LHVPPDDFQQVSPAPAEHEQVARIRILRQHLFRLRGERVEAAPHVRDPGSQPDPRVAG
                     HRDQVISP"
     gene            complement(152010..152417)
                     /locus_tag="MED193_00700"
     CDS             complement(152010..152417)
                     /locus_tag="MED193_00700"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23225"
                     /translation="MAGKKGQKKRFWSDEEKRSICNQTQVPGVSVAQVARRYSMNSNL
                     IFTWLRDPRYAPGPKEESCGPDGGDVFLPVEVSGPTLEDRTDAARVETVGLYNGTVLA
                     NRIDITLSDGRRIVVEGPTALSAVVRLVQGLIT"
     gene            152694..154046
                     /locus_tag="MED193_00705"
     CDS             152694..154046
                     /locus_tag="MED193_00705"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MASKTTLNAKNLAALGAERLADLLLEVTKGNAGAKRRLRLELAK
                     EAGSGNVAREIRKRLSTIARSRSFVDWQGRNAFAADLDMQRRAIVSQVGPVDPTGAFD
                     LIWRFVALANGVYERCDDSTGKVQSIFYEACEDLIDLAEVAAPDPLVLADQLLEALAD
                     DDYGHYPTLISGLASVLGSEGLQHLKAGITTSGIDLSNNYALRMALEQIADVEGDVDA
                     YIDQQSDLARKAPQVAAEIARRLLEAGRVEDARGAINAPDGKDRGWIPYEWEAIRISV
                     MRAMGEPEAARDFMWACYARSLNQDHLRAWLGGLPDFEDVEAETRAMEHALGFESFTT
                     ALHFLMTWPEIEQAAVLITNRASEIDGHHYELLGPASDALEDRHPLAATLLKRGLIDF
                     ALQNSRVKRYRHAARHLRECKNLAVRIDDFAQFETHEAYLDGLKQSHGKKTSFWGAVV
                     "
     gene            complement(154151..154594)
                     /locus_tag="MED193_00710"
     CDS             complement(154151..154594)
                     /locus_tag="MED193_00710"
                     /note="COG1846 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulatory protein"
                     /db_xref="CDD:15281"
                     /translation="MNVYYMPGHLIRRLNQMSTQVFSHHVQVAGYDLTPVQFAAMDAV
                     RANPGLDQAGIAALIAYDRATIGGVIDRLEQKGLVTRSISKRDRRAREVALSDMGHKV
                     YQDVLPTIVRVQGEILEGLTDDEQKQFLRLAEKALRSASNSYSKT"
     gene            complement(154713..155318)
                     /locus_tag="MED193_00715"
     CDS             complement(154713..155318)
                     /locus_tag="MED193_00715"
                     /note="COG1961 Site-specific recombinases, DNA invertase
                     Pin homologs"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA integration/recombination/invertion protein"
                     /db_xref="CDD:11669"
                     /translation="MGQRAAIYARVSTSDQSCERQLRELTEFAERGGYEVMGVFKETA
                     SGTKSNRAERSKIMELAQARKIDAVLVTELSRWGRSTQDLLDTLNKLSGWKVSVVAMS
                     GMTFELDTPHGRMMATMLAGIAQFERDLISERVKSGLAAARARGKKLGRQPGQRPKSD
                     KLAPDVLAAVEEGRSYRWIARDLGVSKNTVLSIVKRHRENA"
     gene            155412..158300
                     /locus_tag="MED193_00720"
     CDS             155412..158300
                     /locus_tag="MED193_00720"
                     /note="COG4644 Transposase and inactivated derivatives,
                     TnpA family"
                     /codon_start=1
                     /transl_table=11
                     /product="Transposase"
                     /db_xref="CDD:6485"
                     /translation="MPRRNILTERQRAALFDLASDEPSLLRHYTLSDEDLEHINLRRR
                     PENRLGFALQLCALRYPGRALTPGELIPHDVLAFIGAQLGLTGEALLSYAARRQTRQE
                     HMEALRNLYGYRAFSGRGARDLKAWLDEEAEISISNEDIARRFVDECRRAQTILPAIT
                     TVERLCADALVAAERRIETRIAQRLSDDLCGQLDALLSERIDDRLTRFVWLRQFEVGN
                     NSAGANRLLDRLGFLQDIELPPDLIDGVPDHRVTRLRRQGERYFADGLRDLPGDRRLA
                     ILAVCALEWRAAISDAIVETHDRIVGKTWREGQRLCAARVENARSAVQQTVRFFRDLG
                     AALLEAKEDGASLEKAVEGSLGWDRLPDLVAIAARLSDTLSSDPVAHVVQGHNRFRRY
                     FPRMLRLLNMEGAKVASPLIEATALIQSGAKHDQPRDFLRRTSKWHRHLDSQETGDKR
                     LWEVAACFHLRDAFRSGDVWLKKSRRYGDLKQVLVPATVAAENGRLAVPLDPEAWLAD
                     RHAQMEIGLQQLSKAAKNGAIPGGVIKDGVLSLSRLPTKTPSDAADLLFDLYKRVPET
                     RITDIMLEVDEATGFTDAFTHLRTGAPPKDKIGLMNVLLAEGLNLGLSKMAEASNSHG
                     FWELMRISRWHIESEAYGRALASVVDGQGNLPMARFWGMGLTASSDGQFFPTTRQGEA
                     MNLINAKYGNEPGLKVYTHVSDQFAPFASQTIPATVSEAPYILDGLLNNDVGKRIKEQ
                     YADTGGFTDHVFAVTSILGHRFIPRIRDLPSKRFYVLDPGGTPPNLKGMVGGKIREEL
                     IASNWPDILRIAATMTAGTIAPSQILRKLASYPRQNDLAVALREVGRVERTLFMMDWV
                     LNTDMQRRVQIGLNKGEAHHALKNALRIGRQGEIRDRTAEGQHYRMAALNLLAAIVIY
                     WNTARLGEAVAERQDAGLPVPPELLAHTSPLGWAHILLTGEYKWPKKR"
     gene            complement(158671..160194)
                     /locus_tag="MED193_00725"
     CDS             complement(158671..160194)
                     /locus_tag="MED193_00725"
                     /note="COG1012 NAD-dependent aldehyde dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="chloroacetaldehyde dehydrogenase"
                     /db_xref="CDD:25427"
                     /translation="MKDLTHTEAGTYTSPFKTKYGNFIGGAFVEPVNGRYFENVTPIT
                     NEKINDIPRSDAADVELALDAAHAAKEAWGKTSATDRANLLMKVADAIEDNLDLLAQA
                     ETWDNGKPIRETVNADIPLAADHFRYFASILRGQEGHMSEIDADTVAYHYHEPLGVVG
                     QIIPWNFSILMAAWKLAPALAAGNCIVLKPAEQTPAAILVLAEIINPILPAGVLNIVN
                     GYGAEVGAALATSKRIAKIAFTGSTATGRTIMKAATENLIPVTLELGGKSPNVFFSDI
                     MAEDDAFFDKAIEGFVLFAFNQGEVCTCPSRALVQEDIYEPFMERVIERVKAIKHGDP
                     RDPETMVGAQASVAQQEKILSYFTIGREEGAEVLIGGEAAKFDGELAGGNYIQPTIFK
                     GDNSMRVFQEEIFGPVVSVTTFKDEAEALAIANDTMYGLGAGVWSRDMNTCYRMGRAI
                     EAGRVWVNNYHAYPAHAAFGGYKQSGIGRENHKMMLDHYQQTKNMLVSYNPNKLGFF"
     gene            complement(160321..161277)
                     /locus_tag="MED193_00730"
     CDS             complement(160321..161277)
                     /locus_tag="MED193_00730"
                     /note="COG3284 Transcriptional activator of
                     acetoin/glycerol metabolism"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulatory protein"
                     /db_xref="CDD:12619"
                     /translation="MGRTRHADKIIEVTQSSSAAARSQVAASWHRSALKYGLDPDETR
                     APERVEQADLENRRAALERFMIVASPRLDTLFSLVGQSGCAVLLTDAEGIVLDQRMSD
                     GDTSAFEAWGLAAGSNWSEAHQGTNGIGTCLTENRRVIVDRDEHFFARNTGMSCIDAP
                     IYGADGSLVAALDVSSARADQTEAFNRLISAQVGQTARAIEEAYFRAAYTSSRIIVAD
                     GDDCEAAVLLAVDRDDLVVGATRAARSIFGLQRTGTISARPAADILGREDGPTGFQKA
                     ERAAVVRALARADGNVSQAARQLGVGRATLYRRMKRLGLNES"
     gene            complement(161277..161456)
                     /locus_tag="MED193_00735"
     CDS             complement(161277..161456)
                     /locus_tag="MED193_00735"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MMQLAPMTALLDLPITRQHPTRSAKKTAPFCGYHFHDFRMVQSA
                     EGFAMVQTCLRKVFK"
     gene            161802..162824
                     /locus_tag="MED193_00740"
     CDS             161802..162824
                     /locus_tag="MED193_00740"
                     /note="COG2207 AraC-type DNA-binding domain-containing
                     proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transcriptional regulator"
                     /db_xref="CDD:14970"
                     /translation="MLEHALVLDSLGAPIRHRQKTHSADWDEVEDFCRSVYMRYRVRP
                     LDRLSLPDATMISAKAGCVTMTRFAYGTGIHLDRFDPDAGNILVLNTLRGALDHQTDG
                     GSIATAAGESFVVDCSRAEYWLEGDPDHMQLNLTIPHQAMVDTAERWFGFVPDDRLWT
                     SRVKIGGPNSAWPALLDYATRALTRAGEVSSDAVLVRHIEEMLCVELLRQWASAAGLS
                     LETGARCAAPGYVRAAEEIMEAEAREAPSIGDVAKRVGVSARTLSGGFQKFRGISPRA
                     FLVARRLDGFRRDLETLPANVTVTVIAADWGFSNFGALAGRYRERFGETPSQTRGRVA
                     RRVRPH"
     gene            162921..164120
                     /locus_tag="MED193_00745"
     CDS             162921..164120
                     /locus_tag="MED193_00745"
                     /note="COG1680 Beta-lactamase class C and other penicillin
                     binding proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="probable 1,4-butanediol diacrylate esterase"
                     /db_xref="CDD:25413"
                     /translation="MKDINPNDLKIRCDAVLNGLGTGPSRVPGVVAMATDRNGDIYAG
                     AAGERRLDGDAMTEDTVFAIFSTTKAIAGTTALQCVEEGLLDLDAPAKNYAPAIGELK
                     VIDGFDADGTPRLRAPKSDVTTRQLMLHTAGFGYDFFNETYKRLAEEQGQPSVVTGSR
                     ACIETPLLFDPGTKWEYGTNIDWVGQVVEGIRGKRLGEVMKERIFDQLGMQDIAFTRT
                     PDMKERTATIHARGEDGGLTPMDDFALPDDPEVHMGGHGLYATVPEYMKFIRMWLNDG
                     AGPNGRVLKPETVEWAVQGALVPPQKVTMLPGVIPSLSNDAEFFPGIPKDWSYTFMVN
                     TEDASTGRPAGAIGWAGLANSYYWIDRKNGIGGYWATQILPFADGVSFPGYMDFESAV
                     YAALSGQ"
     gene            complement(164356..164589)
                     /locus_tag="MED193_00750"
     CDS             complement(164356..164589)
                     /locus_tag="MED193_00750"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTDRLSQIINPRWLLRAEPDQATCADQVSAGSQTTNPPSPAGSA
                     WRLGWEARICSLVQKAKRPAETAVVSIVSELYP"
     gene            complement(164586..165785)
                     /locus_tag="MED193_00755"
     CDS             complement(164586..165785)
                     /locus_tag="MED193_00755"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:26317"
                     /translation="MPRTELEIADIFRTHGPAWRLANAGHVSLSQLKVMSSIEACRTE
                     ALGGHVAGCAKCGHHHIAYNSCKNRHCPKCQGPAARDWMEARAEDLLPVEYFHVVFTL
                     PAEIAQIAYWNKKAIYGLLFKASAKTVMTIAADRKRMGVRVGMTSVLHTWGSALTHHP
                     HIHMIVPGGGLSPDGTKWVASKPGFFLHVRVLSRLFRRLFLDGLVALHQAGDLAFYGD
                     LERLALTDAFTTWLTPFRKSEWVVYSKPPFGGPEAVLAYLSRYTHRVAISNHRLVSAD
                     ADTVAFRWKDYRLKNGDRQKIMRLATPEFIRRFLIHVLPDGFHRIRHYGLLASSARKA
                     NLTKIRKLLCVQPPDQADVQDAEPDVTPLTLREPCPCCGGPMRIIEIFRRGQKPMSRA
                     PPREQAA"
     gene            complement(165798..>166719)
                     /locus_tag="MED193_00760"
     CDS             complement(165798..>166719)
                     /locus_tag="MED193_00760"
                     /note="COG0582 Integrase"
                     /codon_start=2
                     /transl_table=11
                     /product="integrase/recombinase"
                     /db_xref="CDD:27734"
                     /translation="GAFSINRQEVPMTEERVTPLRQRMIDDMRIRGMGEKAQKSHIRA
                     IKDFAAFLGRPPDTATPEDLRAYQLHMTDSGVTPSTFNVRIVALRFFFSMTCGREEMK
                     RYMQFRTEPRKLPVVFSVEEVSDILMAAPGPGLKYRAALSISYGAGLRASEVCNLKIS
                     DIDSDRMLIHVELGKGQKDRKVMLSPGLLELLRAWWREARPEGWLFPGKPKINPISPR
                     QLSRAFTSAKHMAGVKKPATLHTLRHSFATHLLEANTDVRVIQVLLGHAKLTTTARYT
                     HVATKTIRDTVSPYEMLAKLQDQTVKRSLE"
     gene            <166920..166989
                     /locus_tag="MED193_00765"
     CDS             <166920..166989
                     /locus_tag="MED193_00765"
                     /codon_start=2
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="HSEMSLVAQSRNVTKGRDMSKA"
     gene            complement(166986..167261)
                     /locus_tag="MED193_00770"
     CDS             complement(166986..167261)
                     /locus_tag="MED193_00770"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKQIKLRVVSDDGVEATISTDGSQGGVEDYYAVVSVDGFIKEKK
                     VYGIDPVQSFVLGLKLIEELTTDKRIGDDDDVAITPGASWRIEVVED"
     gene            complement(167230..168579)
                     /locus_tag="MED193_00775"
     CDS             complement(167230..168579)
                     /locus_tag="MED193_00775"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="probable transposase protein, Y4bF"
                     /db_xref="CDD:25582"
                     /translation="MGWLMMSERELNRVEVLAQVDDGQLSVDNAANMLDLTRRQIFRL
                     LKRYRQDGAAAIRHKSRGRTPNNQIHLAKRDYALTVIKEQYPDFGPTLAAEMLAENHG
                     FKVSRETLRKWMAEDGIWLSRKQRRQFHQPRLRRECIGELIQIDGSDHRWFEDRGPPC
                     TLLVFIDDATSTLMELRFVKSESTFSYFEALESYLRQHGRPVAFYSDKHTVFRVAKED
                     AKGGARMTQFGRALNQLNVEILCANSSQAKGRVERANRTLQDRLVKELRLADICDMDA
                     GNAYLQGFKERHNAKFAKAPAKPDNLHRALNVEPDRLDDVLCWRENRYVGKQLTFSYD
                     RKRIMLEESDVTRGLVGKYVDTYAFVDGRFEVRSKGRSLPYKIFDMDQRVTHAAITDN
                     KRLGAVLEHIKEIQDAAPPKYPVRTNSEKMGYKPQGRPSGSKAKRQRDETNQATRSI"
     gene            complement(168734..169600)
                     /locus_tag="MED193_00780"
     CDS             complement(168734..169600)
                     /locus_tag="MED193_00780"
                     /note="COG1846 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MQSPDFESPEFSNFCHACFAVRRFKPTLTIAQLRTALTVSASTR
                     PMGFREVANSAEIKYGQATHQIAQLADGKGSDLGLKLLVRQKAEGRRSSFVKPSRTGK
                     AIACCYALPEERDPALTLDGVKRSEMLAKHLKQSILPAFNEVTSRTQGLSLGSFCVLL
                     HVTLKQFEIAFEGRPLHEVSSSIGISNVPRHISFLSEGTPKRKGLGLIELTRNPEDRR
                     LTLPKPSEAGIELMTAICSRLLQRPAAQLRRPKPTSIEALDAPVDAATLKKDDFDYID
                     PGTLMRPEDKKS"
     gene            169839..169952
                     /locus_tag="MED193_00785"
     CDS             169839..169952
                     /locus_tag="MED193_00785"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTNFDCFRNLLVELSANPKMAWFSDLRIRTETLAAAT"
     gene            169949..171973
                     /locus_tag="MED193_00790"
     CDS             169949..171973
                     /locus_tag="MED193_00790"
                     /codon_start=1
                     /transl_table=11
                     /product="putative RepA protein"
                     /db_xref="CDD:26019"
                     /translation="MKHFQSANLRDLNQIARPEPQQQECPSVSNAQANCTCQYQARIC
                     CRLKRGLISWKDLSLPEFLCLGNQRPGRPALSEAKRARVFGQYWEQIRTREAHAHKGW
                     KTVYTNRFPPKNTLLREERLPHVGQYAVIDENNKIQGRIDAERFVLMQMAYLPLDREG
                     RFDVLVIDVDCNFDLNLLKTAGLPMPRYFVSRRKEAVDPPSFLRRPHLVYWLRTPVKR
                     SMNGGQTRAELFYHAIRKTLIMRLQDLGLTVDQKLIDLSKNPHADNWDHVQGDYRDWS
                     LDELREAIGPLEPAKKYYRRALSKQNTLASGTQTNKLAESLPALSETRLSQDKQLLQG
                     YAGRNDFIFNRTRLAAYRKKTRSPEGFDMRAWIETRAHQLNQDQFAQFSKGPLPRSEI
                     NVIVNSVSNFVINIYAPSSDSKDRGACHRAHLIDASMTQSFKQGVGGRYGARKNAEKT
                     RQRVLDALEALSRHEGQPTITAISKQAGISRPTARKWMTQIAAELIKSTEQTVENTVH
                     IRKGDKKHLYTQRWVDLDGAYGVSTLGPILGLIEVFGDTAALTSALGPANIPYQPLRK
                     RGHGTDSDKVYRHPFNARLVLTQEGEAIGIHNIAAGIHSIECAPMTVLDRGGFLGDPA
                     DEYAPPIGETDHDGSVKYTEDYYAPTRVGLATKEWTAEEVDKYLDEVLSA"
     gene            172660..173337
                     /locus_tag="MED193_00795"
     CDS             172660..173337
                     /locus_tag="MED193_00795"
                     /note="COG0419 ATPase involved in DNA repair"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:26184"
                     /translation="MARTKVTSRKIDGQIAKLQNQINKLSMKRSDIIRRIEHLEQKFQ
                     ECPNDNQPRDPKFQADLKSALRSRSLLDDQLENFREQQRHLETSLMNPLVEKLDLVNG
                     KAQAHTLSASNVVFLARETEELLMNKGFTQKNIIGAEVSLRPAGKKASNAYAAKASSS
                     ITTRVRLRRVTDGWRLIEAKRDHCYVNQSEAKSVHVHPAAHADILRIATRGILVSPQP
                     EQGTSVS"
     gene            173490..173597
                     /locus_tag="MED193_00800"
     CDS             173490..173597
                     /locus_tag="MED193_00800"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLSKIQTQFHRIHEIAVVIYVAKFVTEVVGGSYFS"
     gene            173835..175946
                     /locus_tag="MED193_00805"
     CDS             173835..175946
                     /locus_tag="MED193_00805"
                     /note="COG0464 ATPases of the AAA+ class"
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-dependent Zn proteases"
                     /db_xref="CDD:10338"
                     /translation="MSPSRPAFTPILSDWFPDALTRLNTLWELPDFDPDEAVDQGPSS
                     AWRKITANYDIPTVAALIRLCSALPQSNNALVSEIYNPFKITVITTQDTRLIEPTVDA
                     IKRGLLPEIESKHDHLPKMKVHYEKTLGARSNPVKNKDDFKKELFQVLQNQSPAVIVV
                     DTINQLPANIRQAISNEIVLAPLCRKSLLKLHAVIHNSASTGQFARTFQELPFDTALG
                     RLDPQDVSIAARHREPLEMARAVSLLIEQNHTSANPEALNQVKGLGPTSSPIKQLAQD
                     MRAWRANELEWSEIPRGVLLSGPPGTGKTFTASKLAEAVGGHFIATSYADWQREGHLG
                     DFLAAMYRCFQEARDNAPSVLFIDEIDSFTDRAKASGDNATYIRSTVNALLEQLDGTA
                     KSAGVLVVGACNDISALDPALTRSGRFDQKVSLYLPDKQAIAEILKSHVPDSVSVADI
                     ERTAAHLVGQSGADAAAVVRQAQSLSRYHRRSITGEDLWTAAQQTTPTASVEDLKRAA
                     THEAGHAVVGFLLGKGVPLNAEIGSTGGFVQFRHLTAFPTQKQLERDLATLLAGRAAE
                     SLYCEAPSAAAGGGMTSDLAQATLLAARLEFQFGLGSEGLIWRHVTESSLPELLKDVE
                     TRSRMNKFLKDAEQIATRILKEHGLMVKSIVVDLLSKRQLTAVELASLLQPPPGPASG
                     HPKAADAPFSKVPVASLCQSS"
     gene            complement(175953..176651)
                     /locus_tag="MED193_00810"
     CDS             complement(175953..176651)
                     /locus_tag="MED193_00810"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIIKSSRISRGRTKALSSYFSSKGDNQSVCWRYGGVSDIAWMAL
                     PAQITGQVFQVRHVIIAPEMELSMTDLAAATKAVCDEYGVSHLARGQVCIVEHAKATD
                     GQVKAIPHFHLLLPEYDMGRERVMDSRFTHMRDEKLSRMLELRFEHPSRAGQFNKEVY
                     SGLQEEFPGLCLIPFQQALKQMSVEAGLSARDWLSFRAKAPAPAKSWMARRKDAKTMA
                     LLEVVNGLHMPRFL"
     gene            complement(176648..177058)
                     /locus_tag="MED193_00815"
     CDS             complement(176648..177058)
                     /locus_tag="MED193_00815"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MMTKEIGLVAKRQLGIKISTAAYGVLEGRARDRGMSPTTFARWL
                     LLDRLGYEGEVVFRGARRKKVIKPLSSEYRAALSLLQELQLIKMRLDQISPPRKKRKQ
                     TPAIIVDPEEIAKTLHDAQALFRRVLASMSKAEK"
     gene            177408..178241
                     /locus_tag="MED193_00820"
     CDS             177408..178241
                     /locus_tag="MED193_00820"
                     /note="COG0640 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator/arsenate reductase"
                     /db_xref="CDD:10268"
                     /translation="MEEMIPLRLSILGHPQRLAVFRLLMRRYPDQVPAGEIGAALDIK
                     ASTLSSYLSALMQADLVSKTRTGTWLRYQINMQTTRETLDSLFLDCCRGRPDLCRSYP
                     DPVTSEENQMTDRKYNVLFICTGNSARSIFAEAILNSKGQDRFQVFSAGTQPQSHLNP
                     IAIEMLKAKGHDISTLRSKNVAEFIGEGAPEFDFVFTVCDQAANEECPTWDGQPISAH
                     WGMPDPVKATGTEAEKSLAFQQAYGVLNHRLQGFAALPIEQLDRISLQSAVDEIARTS
                     E"
     gene            178250..179251
                     /locus_tag="MED193_00825"
     CDS             178250..179251
                     /locus_tag="MED193_00825"
                     /note="COG0057 Glyceraldehyde-3-phosphate
                     dehydrogenase/erythrose-4-phosphate dehydrogenase"
                     /codon_start=1
                     /transl_table=11
                     /product="glyceraldehyde-3-phosphate dehydrogenase, type
                     I"
                     /db_xref="CDD:9932"
                     /translation="MTTYALNGLGRMGKLALKPLLDSGAEIAWINDAVGTPEMHAHLL
                     EFDSVHGRWNAEFSHDDKSITINGTRLPTHRETRLEDLPLESVDVVIDCTGVFKTEAK
                     LAPYFDAGVKKVVVSAPVKDGDAANIVVGVNDDIYQPEQHRIVTAASCTTNCLAPVVK
                     VIHENLGIKHGSITTIHDVTNTQTIVDRPAKDLRRARSALTNLIPTTTGSATAITLIY
                     PELTGKLNGHAVRVPLLNASITDCVFEVEQETTAEEVNALFKAASETGSLKGILGYET
                     RPLVSADYTNDQRSSIIDAPSTMVVNGTQVKIYAWYDNEMGYAYRLVDVARMVGDQL"
     gene            179248..180516
                     /locus_tag="MED193_00830"
     CDS             179248..180516
                     /locus_tag="MED193_00830"
                     /note="COG0477 Permeases of the major facilitator
                     superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein, putative"
                     /translation="MTQQPGLAAYIAVTASYWAFMLTDGALRMLVLLHFHTLGFSPVQ
                     LAYLFVLYEIAGMVTNLSAGWIAVRFGLTATLYAGLSLQVVALLLLTQLDTSWQISTS
                     VIFVMMVQGLSGVAKDLAKMSSKSAVKLLAPSEGDGLFRWVAVLTGSKNAVKGFGFLL
                     GAALLASVGFTWAVLGMALILAIILAAVLLAMPKGLPVGRKGAKFSEVFSKSRNVNWL
                     SAARVFLFGARDIWFVVGIPVYFYAVFSDGSEEGNRAAFFLIGSFMAIWTIFYGVIQA
                     SAPRILKAATRTEAELIAAARNWALLLAIVPAVLALAVLLTGEPALWLTVSLVAGLLA
                     FGAIFAVNSSLHSYLILAFTKAERVTMDVGFYYMANAAGRLIGTLLSGLTYQLGGLAA
                     CLGTAAVMVALSALAAARLQDKPATAPARS"
     gene            complement(180562..181521)
                     /locus_tag="MED193_00835"
     CDS             complement(180562..181521)
                     /locus_tag="MED193_00835"
                     /note="COG2423 Predicted ornithine cyclodeaminase,
                     mu-crystallin homolog"
                     /codon_start=1
                     /transl_table=11
                     /product="ornithine cyclodeaminase/mu-crystallin family
                     protein"
                     /db_xref="CDD:12077"
                     /translation="MISPAMFSAADIHAALEIPDLLGPLKTAMIAVSNQTAGHPPRFA
                     APINAQGRMGIMYGHLQDPPVHGAKVLSLFPGAPAMGLSSHQGFVMLFDSQNGRPLAI
                     CDADALTALRTSAMSMLATQTLARSDPQEITVCGAGEQAEWHIRGSLACFPKAKIRIW
                     ARRFDAAQQLAKRFCDHSSQVVAISDLPEAVRGADVIHTVTASKEAFFCGAWFESGQH
                     INLVGASLADTRELDDAGVARVSMFTDSCESSSREAGEILGAKHAGLICEDYTVTEIG
                     QVLSNRHVGRQSDAEITAYKSHGVIVQDLVAAYEVLKRKECGL"
     gene            complement(181518..182012)
                     /locus_tag="MED193_00840"
     CDS             complement(181518..182012)
                     /locus_tag="MED193_00840"
                     /note="COG3090 TRAP-type C4-dicarboxylate transport
                     system, small permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="C4-dicarboxylate transport system (permease
                     small protein)"
                     /db_xref="CDD:12429"
                     /translation="MTGFLHQASAQVDRACLLLAKLALIGMALTVLLQIWARYGFDYP
                     FSWTEELARYLMIWAGLLGATCAFKRRLDPTVVQVNPEDQSTWHRVVFALTVLIFLSP
                     ILYYCFFGPNMNFERGFLWRSSNRMSQGMGVNMAMVGAIVPLSCSILLLHLAALLTTK
                     KAAT"
     gene            complement(182009..182986)
                     /locus_tag="MED193_00845"
     CDS             complement(182009..182986)
                     /locus_tag="MED193_00845"
                     /note="COG1638 TRAP-type C4-dicarboxylate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter, DctP subunit"
                     /db_xref="CDD:11350"
                     /translation="MKHALFAAAATLLTAAPLWAEEIKIAVGCPPVNACSDYVYAEDL
                     AAGLREQGLEASVFAGGALGKDPEVVDQLSQGLVQFGMTNFVMIKEVDPRILGFIAPY
                     MFDDMEHFFRATQDTQSDLLEEIKASMEGQGVKIAGLPGLGGTMGVFNVKTPVAKVED
                     MADLRLRAIDATQIELFKNWGVQGAVVDMPEFAGAVQQGVVDGYYNPPVVALIFRHTE
                     FLKHYTDIGAGTPFRSALMSADWYGDLDDADRAKVDQAVDQANAKNRVWTAKAAAGEL
                     AGLQKSGVTISTMSPEALADLKARSEEAWAGLMPADSVEAFRALAAKTR"
     gene            complement(183009..184328)
                     /locus_tag="MED193_00850"
     CDS             complement(183009..184328)
                     /locus_tag="MED193_00850"
                     /note="COG1593 TRAP-type C4-dicarboxylate transport
                     system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="probable transporter"
                     /db_xref="CDD:11306"
                     /translation="MIWILLIIFALAAVLSGVAISYVAGAAAVLAFVLTDHAAYLGIL
                     PQRIFSQIDVFTFLAMPLFILAGETMTKGGVTRVLIDLAMLLVGRLKGGLGYVNIASS
                     VFLAGISGSAVADAAATTNTLVPAMRERGYRTDFAAALTAASCVIGPIIPPSIVMIFY
                     AALMNVSVAALFAGGIVPGLMMAVFLGAYNFWIARKEDHPGGNSETLPPVKPTVLRAL
                     PALLIPITIVSGIVFGVVTPTEAAGLAVAITLCLVFLYAYWDRQGLVGAFKISANLAS
                     GAVERTVMLTGSIFMILFAAAVFGYLMGILKVPDQIGAAVQSLGLNSTYYFLLASGVM
                     FLAGMVMDISMALVLLVPVLIPAAIAGGADPVHVGVVSCLNLTLGLISPPFGGCLMVI
                     SSASGVNYMRLSLAILPFLAVQIALLILLIFYPEITLTLPRVLGLIQ"
     gene            184338..185039
                     /locus_tag="MED193_00855"
     CDS             184338..185039
                     /locus_tag="MED193_00855"
                     /note="COG1396 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="probable transcriptional regulator"
                     /db_xref="CDD:16530"
                     /translation="MFGRKFDDRKKVNKIFVSENIMSKTETSEEFQDKRAAFGAMVQS
                     LRRAQKLTLKQVSEASGLALSTISKIENSNLSPTYDVMLKLAAGLDTDIVSILDGASA
                     QVPKTSPTGRLSVARRSELPRLEAANYIFEPIATQLKNRLIDATYATVTARDITEFSA
                     PIRHGGEELVIVLSGAVELHSDLYEPVRLESGDSVYYDAAMAHAYVSVSEEDAVILNI
                     VSGANMTQEFLNAKS"
     gene            185026..186450
                     /locus_tag="MED193_00860"
     CDS             185026..186450
                     /locus_tag="MED193_00860"
                     /note="COG0154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A
                     subunit and related amidases"
                     /codon_start=1
                     /transl_table=11
                     /product="putative amidase"
                     /db_xref="CDD:15348"
                     /translation="MLNRDEWLKQDLVGLAELAETGEISRRDILLSAIAQIEAQNPAI
                     NAVVLTQFEEALDALEKTAETSRFTGLPYLLKDLHAPAKGMPLSNGSEMFRGTDMGFD
                     STTVSRLRAAGFGLLGRTASPEFGLTITTESKAWGKTRNPWNTGLSAGGSSGGAAAAV
                     ASGMVPAAHATDSAGSIRIPAAYNGLVGLKPTRGVNAIGPHRGDPNFGMSHEHAVTRT
                     VRDCAALLDVTSGPDQGCPYFTATPEGGFEALLQRPPGKLRIGFLTDRFDGKAIHPAS
                     AEAVTQTAQKLSALGHTVEEARPDFDFAELTSQAFRLLVGSLAGFFSPEFAAGPMQGF
                     EPMTQRTMRYAAGVSLHDYLARYAAVNSQVRKMCAFFESYDILLTAATNGPAHPLGLT
                     SLDQDLEFDPFVDRLLDLSPFSVPFNASGQPAMTLPVHQTADGLPIGVQLVSGFGQDG
                     CLIQLAAQLEEASDWCTIAPGALG"
     gene            186702..187106
                     /locus_tag="MED193_00865"
     CDS             186702..187106
                     /locus_tag="MED193_00865"
                     /note="COG3232 5-carboxymethyl-2-hydroxymuconate
                     isomerase"
                     /codon_start=1
                     /transl_table=11
                     /product="5-carboxymethyl-2-hydroxymuconate delta
                     isomerase"
                     /db_xref="CDD:12569"
                     /translation="MPHFQIEYSGNLDQIVDITALCEHIRATAVEIDTFPLAGVRVRA
                     TRVDHYAIADGDPKHGFVDISIRLRAGRTPEVKQEATQRIFDAAQSFLSPAIAKHSIA
                     LSLEMRDIDPDLSPKTGSIRDHLGRPSQEVSS"
     gene            187103..188611
                     /locus_tag="MED193_00870"
     CDS             187103..188611
                     /locus_tag="MED193_00870"
                     /note="COG1012 NAD-dependent aldehyde dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="5-carboxy-2-hydroxymuconate semialdehyde
                     dehydrogenase"
                     /db_xref="CDD:25427"
                     /translation="MTALNDNITKLSGFLARFQETGIQNRIAGEDHPGSAGKFQSISP
                     VDKSVICDVARGSESDINMAAEAAKTAFPTWRDMPAIERKKILIRVAEGIEARAEEIA
                     LCECWDTGQTLKFMSKAALRGAENFRYFADQVVQARDGQHLQSPTLMNITTRKPIGPV
                     GVITPWNTPFMLSTWKIAPALAAGCTVVHKPAEDSPLTARLLVEIAEEAGLPPGVLNT
                     VNGYGHDAGKRLTEHPAIKAVAFVGESRTGSIITKQGADTLKRMHLELGGKNPVIVFD
                     DADLDRALDAVIFMIYSINGERCTSSSRLLVQDTIRAEFEAKLVERVNKIKVGHPLDP
                     ASEIGPLISEEHYNKVTSYFQIATEDGATVAAGGTKLGDEGYFVRPTLFTEANNQMRI
                     AQEEIFGPVLTSIPFSTEEEALELANDTQYGLTGYLWTSDLTRALRFTDQLEAGMIWV
                     NSENVRHLPTPFGGVKASGIGRDGGDWSFDFYMEQKHIGFATGQHKITRLGA"
     gene            188730..189581
                     /locus_tag="MED193_00875"
     CDS             188730..189581
                     /locus_tag="MED193_00875"
                     /note="COG3384 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="3,4-dihydroxyphenylacetate 2,3-dioxygenase"
                     /db_xref="CDD:12716"
                     /translation="MGEIVLAAKMTHVPTMLMSEQEGPVKGKRQAAIDGHREIARRAK
                     TLGATTVVICDTHWVINAGFHINANKHFEGLFTSNEFPQFIQNLPYAYDGNPELGEAI
                     AKAATDRGAYTLCHQLDSLELEYGTLVPMRFMSREHDMKVVSVAAWATVHDHDESRIV
                     GEAIREAIEATDEKVLLVASGSLSHKIWANKDYAANNGTFTISSEFNRQMDLHVLEMW
                     KQGDHATFLKMLGEYAQFCCGEGSMHDTAMLYGALGWDNYDGKCEVLTEYFPSSGTGQ
                     TNVIFPV"
     gene            189646..190503
                     /locus_tag="MED193_00880"
     CDS             189646..190503
                     /locus_tag="MED193_00880"
                     /note="COG0179 2-keto-4-pentenoate
                     hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase
                     (catechol pathway)"
                     /codon_start=1
                     /transl_table=11
                     /product="fumarylacetoacetate hydrolase family protein"
                     /db_xref="CDD:10054"
                     /translation="MRFATYTAEGNTFFGAVTEVGMIALNEACPQWATLYDVIAAGGL
                     AELEKLAADKPVSHTDFIYEMVLPNAPRILCVGVNFPDRNAEYKDGSAQPKYMSLFPR
                     FASGFTGHGRNLVRPPENHTLDYEGEVAIVIGKGGRRIAQDDAYDHIAALTLCNEGTI
                     RDWVRHAKFNVTQGKNWDSSGSIGPWLVPFTDAKQLDDARIITRVNGEVRQDDVLSRM
                     MFPIRREIEYISTFMTLQPGDIIITGTPTGAGARFDPPRYLKPGDVVEVEVEGIGTLR
                     NGVEDEVPA"
     gene            190500..191300
                     /locus_tag="MED193_00885"
     CDS             190500..191300
                     /locus_tag="MED193_00885"
                     /note="COG3971 2-keto-4-pentenoate hydratase"
                     /codon_start=1
                     /transl_table=11
                     /product="2-oxo-hepta-3-ene-1,7-dioic acid hydratase,
                     putative"
                     /db_xref="CDD:13277"
                     /translation="MTPQDHAQAAADLLNAETTGQQIGLLTKRHPEMGMDDAYAVQNA
                     IYRAKLEADQKVIGWKIGLTSKAMQYALNIDIPDSGILFDDMLFETGETVPAGRFIQP
                     RIEAEIAFVMKTSIGGGDVSRDDVIAATDYVTPSIEILDTRIQRADPETGQTRSVFDT
                     ISDNAANAGIVLGRERHAVDAHDLRWVGAITSRNGEVEETGLGAGVLNDPVESVVWLA
                     RRMAQYGQSIEPGQVILSGSFIRPVECPSGADIHADFGAFGSVDIRFA"
     gene            191344..192402
                     /locus_tag="MED193_00890"
     CDS             191344..192402
                     /locus_tag="MED193_00890"
                     /note="COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid
                     aldolase"
                     /codon_start=1
                     /transl_table=11
                     /product="2,4-dihydroxyhept-2-ene-1, 7-dioic acid
                     aldolase, hypothetical"
                     /db_xref="CDD:13153"
                     /translation="MPAPHNPFKAALKAGKPQMGCWLGLADPYVAQISAGAGFDWLLI
                     DAEHAPNDLRSITAQMQVLAGFDSHAIVRPTIGETWMIKQYLDAGAQTLLIPMVESAE
                     QARELVRAVTYPPHGVRGVGSALARASNFSAIPDYLQTADAEICLLVQVENRAGIKAL
                     DEILEVEGVDGVFIGPSDLAADMGFIGNAGAPEVKAAVMEAMGKIVASGKAGGILTLD
                     PEMQRACLDAGATFVATNIDVTLFAAAMRNTAKAALALLPDQITTGTAKTENASRYLQ
                     QLCKHWSHKGTAEFDADKGSVSFATGNRVEMSALGEELSITATTGPRGDLERWKKVIS
                     DHLVRFAFREEFEITWAE"
     gene            complement(192661..193017)
                     /locus_tag="MED193_00895"
     CDS             complement(192661..193017)
                     /locus_tag="MED193_00895"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLSKERHQTVTGPTTSFIADNESGPYCDVVPQRRSIPWVLFSTM
                     ETVRARFPEIADSPNYEDWYRYILQTEPIQSNEWKAELDGALHAYAAQTGTEEELKRA
                     YVPKKIEAGGLWDKLR"
     gene            193042..193317
                     /locus_tag="MED193_00900"
     CDS             193042..193317
                     /locus_tag="MED193_00900"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23225"
                     /translation="MGLKRTDEFRQDAVRIALTSGLTRKQVADDLGVGMSTLNKWITA
                     HRDTDVVSKEDLSLAQENDRLRRENRLLKEEREILKKATQFFAGLKQ"
     gene            193512..194171
                     /locus_tag="MED193_00905"
     CDS             193512..194171
                     /locus_tag="MED193_00905"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family element, transposase orfB"
                     /db_xref="CDD:25582"
                     /translation="MTEELKEIGLNVGHRRVGRLMRQNGISVVRTRKHKVTTDSDHKF
                     NIAPNLLDRNFSADLPNQKWAGDISYVWTREGWLYLAVILDLHSRRVIGWAVSNRMKR
                     DLAIRALNMAIAFRQPPKGCIHHTDRGSQYCSHDYQKILRQNGFKVSMSGKGNCYDNA
                     AVETFFKTIKAELIWRHPWETRRKAEMAIFEYINGFYNPRRRHSALGWKSPVAFERKV
                     A"
     gene            complement(194168..194725)
                     /locus_tag="MED193_00910"
     CDS             complement(194168..194725)
                     /locus_tag="MED193_00910"
                     /note="COG0463 Glycosyltransferases involved in cell wall
                     biogenesis"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRANFEFALRSSTGDFVSVIGDDDGYLPAQFPALRSILEKHQPD
                     CLYWDLPAYTWPAKGESGLVKLRRRSAFGLPKAIEADVFRENLLEARIEQTNSAPSVY
                     HGVASRSCLERIACPDGTCFAGSIPDIYFSYRSLFAGGNMLRAAHPFSIAGQSNASNG
                     AAHNRQKESDITWTCRVLVPPQVLV"
     gene            complement(195113..195469)
                     /locus_tag="MED193_00915"
     CDS             complement(195113..195469)
                     /locus_tag="MED193_00915"
                     /note="COG3668 Plasmid stabilization system protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAWTIEVSAEAERDIDLLFDHLADSYVEFGETRSVAAAQAVDRV
                     GRILDMMERIATAPYRGEIHDDLLPGLRHLTLERAIYWFQVEEKAEIVRVLAIFYGGQ
                     DHVRQMLLRLLSSPAA"
     gene            complement(195453..195728)
                     /locus_tag="MED193_00920"
     CDS             complement(195453..195728)
                     /locus_tag="MED193_00920"
                     /note="COG3609 Predicted transcriptional regulators
                     containing the CopG/Arc/MetJ DNA-binding domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12933"
                     /translation="MTIKTSISLPDAQAEFAKDLVEQGLFSSLSAVAQHGIELVRQRQ
                     EAERVDTEALRAVLQERAKGPFVDAKTFRSRMAKRLEDKRRAYGLDH"
     gene            complement(195778..195915)
                     /locus_tag="MED193_00925"
     CDS             complement(195778..195915)
                     /locus_tag="MED193_00925"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MFYIADPAGLLAIYVNIHESPAGQLLAFPNLKVKRIEPALRVVA
                     F"
     gene            195929..196393
                     /locus_tag="MED193_00930"
     CDS             195929..196393
                     /locus_tag="MED193_00930"
                     /note="COG3316 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="putative transposase"
                     /db_xref="CDD:12650"
                     /translation="MRKFGAQMANWVRAARRKPSDKLHLDEVVIMIRGVKHWLWRAMD
                     SEGQVLDILVQSRRNARAAKRFISRLVARWGVPRVIITDRLRSYGAALRKLALGVDHR
                     AHKGLNIRIEGTHRPTRKREKIQGRFKSARQAQRFLVVHDEAANLFRPCRHK"
     gene            complement(196559..196696)
                     /locus_tag="MED193_00935"
     CDS             complement(196559..196696)
                     /locus_tag="MED193_00935"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAAHLRGHFLGNICSPMAKVFMGAILEGTRSKSAVNTRLANLRS
                     N"
     gene            complement(196717..196860)
                     /locus_tag="MED193_00940"
     CDS             complement(196717..196860)
                     /locus_tag="MED193_00940"
                     /note="COG2113 ABC-type proline/glycine betaine transport
                     systems, periplasmic components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11821"
                     /translation="MLKNVQFTGDEINGWIVEMFENKRDPQEVAEEWIEDNAEIVSSW
                     ING"
     gene            complement(196929..198128)
                     /locus_tag="MED193_00945"
     CDS             complement(196929..198128)
                     /locus_tag="MED193_00945"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix, Fis-type"
                     /db_xref="CDD:25582"
                     /translation="MRQTPKSPSEKIVKDIKRATRKQYSSEEKIRIVLDGLRGEDSIA
                     ELCRREGISQGVYYKWSKDFMEAGKKRLAGDTARAATTDEVKELRREARDLKEVVAEQ
                     TLELRLLKKKHGRGWGRPRMRYPASVKLEIIRLVEDSHLSARRTLAKLGIPRTTFYRW
                     YDLYLQRGAAGLEDQSPKPKHVWNRVPEEVKRKVVSFAVKETELSPRELAVTFTDQER
                     YFVSESTVYRTLKAYDLITSPAFIVLKAANEFEHKTTAINQLWQTDFTYLKVLGLGWF
                     YLSTILDDYSRDIISWKLCTTMRAEDVTGTLDLALQASGCDQVHVVHKPRLLSDNGSS
                     YVSADLAEWLQDNGMKQSRGAPYHPQTQGKIEQWHQTLKNLNVLMGARMLILKPRTGW
                     KCQSSNA"
     gene            198992..199516
                     /locus_tag="MED193_00950"
     CDS             198992..199516
                     /locus_tag="MED193_00950"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRDLLKGIIPTAKRKVAHRVNASYGNLAKAIVTAAAITMALFST
                     TSSATAAGQAPYVVGSDRGGFVRDRLIELRELRSSGRRVEIRGRVCYSTCTMLLGLPN
                     TCISPRTTFGFHGPSKSGQRLSAEKFDHYSRIIASTYPQKLNSWYMQTGRMRIDGVYK
                     IRGSELIRMGVRAC"
     gene            complement(199653..200375)
                     /locus_tag="MED193_00955"
     CDS             complement(199653..200375)
                     /locus_tag="MED193_00955"
                     /note="COG0631 Serine/threonine protein phosphatase"
                     /codon_start=1
                     /transl_table=11
                     /product="Ser/Thr protein phosphatase, putative"
                     /db_xref="CDD:10501"
                     /translation="MTDVRTYRYAAQTHVGLKRKVNEDAILALPEHHIWLVSDGMGGH
                     QAGDFASSLIVDSVASLPVSLDPTEKMHGLRDKIQGAHRAIQAETAARGGGTIGATVA
                     ALVLANGHFLCLWAGDSRIYRLRDGIIEMLTCDHSAVADYVLAGKMDWDEAEQHPHSN
                     AITRAVGVGEELELDKVRGIVETGDRFLICSDGLTKYATFPILQDVLSNTPLETVGDR
                     LLQIALDGGGADNISHIVVDVI"
     gene            complement(200372..201058)
                     /locus_tag="MED193_00960"
     CDS             complement(200372..201058)
                     /locus_tag="MED193_00960"
                     /note="COG3913 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13224"
                     /translation="MAAGGGAFGKMPEVGDFFRLNVASSFVRVWDNWLQQLIMEGQAL
                     YGAGFDAHYMSAPLWRFTLTADLAGPSKIMGVLMPSVDRVGRRFPLTLVMPLESPGPP
                     ALDHLREGSLFEALENIALSTLEDGMTKDRLEEDLQSLATAGSEDCPPLRQDGDTLVL
                     TGSREDGSGVAPQLAGALLAKQTPRCCLWSTYLDSGPRMLITADLPLGRAGSGLFDLA
                     APIWREAQPI"
     gene            complement(201058..204630)
                     /locus_tag="MED193_00965"
     CDS             complement(201058..204630)
                     /locus_tag="MED193_00965"
                     /note="COG3523 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12851"
                     /translation="MIRRYFLPLFKSLYSALILLAIALSACTWFFAPYIGGADWRPFD
                     SVQARVITIVVIWVIILFIIGLVFFLRRRRDRAMADDMVEAVDTGEDDDATLEEIGEL
                     RGKFKQAMAELRKSKNGRRHLNVLPWYVIIGPPGSGKTTAIVNSGLQFPLADKLGKAA
                     IGGVGGTRNCDWWFTNEAVLIDTAGRYTTQESDAEADNAAWLGFLGLLKKYRKRQPIN
                     GALVAISLSDLSLQDEVTQKSHAQAVRRRLSELRERLGVRFPVYVLFTKADLIAGFQE
                     YFDALGKEEREQVWGFTLPLVKSKKEAAAIEHFDDEFAGLLGQMNAQLLEKMQSETDH
                     QRRALVAGFPSQVASMRSVAKEFLSEVFQDNRYEQRQMLRGVYFTSGTQEGTPIDRLM
                     LGMAQTFGIGRQAIGTGQGTGRSFFLTRLFEGVLFPEAGLVSADDKVERRYRWTRRLA
                     ITATILVAFAMGGLWVNSYFQNAEFIRAAEAKVVDYQARAATLPPSPVGDTDLVPVAA
                     ALNLLRDMPGNPVLSDPKPERAMTYGLYQGEVIGTQTAQTYRAALNQRLLPRLLVRLE
                     EQIEGNVNNPDVLYEALKIYLMLGLQGPMNPDLVKEWMRLDWELVAYPGASRGQLRSD
                     LTDHLSALLSQPMEEIALNGPLVEQAQNILSEMPLAQRVYNGIINSNQATSLPKWRLT
                     EIGGPSVKRVLVRSSGKPLNEGVEGIFTYDGFNNVFLPEAVSVSERVQNEAWVLGERA
                     GDGQSDAALLALSRDVLDLYYNDYISRYDQVLGDVDIVPLESLSHAVEVTNVLSGPTS
                     PIMNILTEISRETRLAEDRSALDSESLNEGVSQIVGIETRSGLSIQGQILLEALMKSA
                     ANAPGEAPKPPGSYVQERFQWLHDLVVRLEGQPSRLDDLMGSLQLVYQELNKMSFSGV
                     ASGESGQALLQFQQTASRIDGPIQRWATQISAGSSGITSEGTRASINARWQSSVLPFC
                     QKALDNRYPFNRRARADVAMVDFAKLFAPGGLIDGFFDENLLKYVDTRTRPWTWKRVN
                     DVDLGISQAVLQQMQYAAEIRDAFFNGAATPSVQFQITPKALDPKAKEVLLEIDGTKV
                     SYNHRMGQPTPVAVNWPGSVGLARITLLPQRRGNENTMSRDGPWAWFRLLDAAEVRRT
                     NVSDRRRVNFRVGGRLALFELQSGSVVNPFALPAMAKFRCPKSM"
     gene            complement(204627..206060)
                     /locus_tag="MED193_00970"
     CDS             complement(204627..206060)
                     /locus_tag="MED193_00970"
                     /note="COG3455 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12783"
                     /translation="MGDYDDPFAEPGDTDKTVIRPNPGGRRPATPPSPSVAAPEAGQG
                     GASGLGEDAFGVPQAASTTGQSNQTAGGAAGKAAPMALTGMNPLAACASTLFALISRI
                     RNRAQHMDPDGLRKNVVAEVRAFENRALQAGIAAQTVKVARYALCATLDDVVLNTPWG
                     GQSSWGLQSMVGTFHRETVGGDRFYDLLARLEKEPGANIDMLEFLYMCMSLGFEGRLR
                     IEQGGPEKHLQIRAALARILRNQRGPVERDLSPHWEGVVRPFKVLSAWRLVWIALVVT
                     SVLLVAQFLGLSWVLSNQTGNVVGQLSIVDSGPAVELERRAPPPPPPPPIQTLEEQVA
                     KVADFLGPEIDEGIVQVFQKGNTLIIRLAGSGMFGSGSDQLSKAFKTPVARVAEALND
                     EKGQVIVAGHSDNVPIRSSRFPSNMALSLARAKSVMSGMAQVFDDPDRLSAEGRAEKE
                     PIADNGTKAGRAKNRRIEILLVQEVDQ"
     gene            complement(206130..207470)
                     /locus_tag="MED193_00975"
     CDS             complement(206130..207470)
                     /locus_tag="MED193_00975"
                     /note="COG3522 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:24809"
                     /translation="MSWDSKVLWTEGLFLQPHHFQQSDRYTEGLVTGLARRLGPYAWG
                     VNALEIDHEALKIGQFALKSCEGLTQDGCIFRVPMADPHPPALEVPTTIKDCVVYLTV
                     PQRRQGAIEVDLSGAERSASRLRPSSQEVTDVTSTERKPVPLNVGKMRLQFALGVDDM
                     ADMLAIPVARIIEVRSDKEIILDQAFIPSCLDARAASVLRDFLRELEGLLAHRMEALS
                     GRLAEAGTARGVADVSDFMLLSVVNRMLPMIRHLRQIENLHPERLYMLCAGLAGELSG
                     YMAADKQAPELPSYTHDDLMGCFAPLIRVLRQYLSSVLEQTAIAIKLEERKYGISVGV
                     IADRKLLGNAGFVLAVSADLPAEDVRRHFAGQAKIGPVEEIRQLVNSALPGITLRPLP
                     VAPRQIPYHSGVVYFEMDSDSPYWRKMTTSGGVAVHVSGQYPGLKMELWAIRNS"
     gene            complement(207512..209047)
                     /locus_tag="MED193_00980"
     CDS             complement(207512..209047)
                     /locus_tag="MED193_00980"
                     /note="COG3456 Uncharacterized conserved protein, contains
                     FHA domain"
                     /codon_start=1
                     /transl_table=11
                     /product="FHA domain protein, putative"
                     /db_xref="CDD:12784"
                     /translation="MAVTLKFQNSGAMPGNAAPVSMLGPSLTIGRGDSNDMVLPDPDQ
                     MLSRNHCAIEDHNGNVVVVDLSANGTFLNYSKIPLGRTPTPLNNGDVLCVGNYELLVE
                     IHSKSAAHMIPDPLSDAPASHGVADNAPDPLALLDDAGPAGDFLDDLLGASGPTGPSQ
                     LNPVDPIDDLLPPLGEEEDPFFQKPSDGREGVGASLPSHSASAADSFAAPSAHISTIP
                     DDWDDDFLSGIGEPAAPEPAPTPAAAPVEPVAAPPEPVPVQSTAPVSPAVDAASSDPF
                     AEPSDTAATTLEAPVAAPAAQPAVKETPTQPEPEPAAQPGSSSAATSAFLRGLGVEED
                     ALGDEDPVKSMGRMGRVLQTLVTGIREILMTRTSIKSEFRIEQTMISAGGNNPLKFSI
                     TPEQAIEAMLKPATKGYLSPETAAEEALKDIKAHEVAMVTGMEAALKGVLTRLDPKAL
                     EAQIEDKGGLSGLLRGKKARYWDVYERLFSEISDQAENDFHDLFSREFARAYKAQLDK
                     LKD"
     gene            complement(209055..209354)
                     /locus_tag="MED193_00985"
     CDS             complement(209055..209354)
                     /locus_tag="MED193_00985"
                     /note="COG4104 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13386"
                     /translation="MGMPQARLLDLHACMLPSIPPPPALPVPTPIMPPCAVTVLVGKL
                     PAARLSDMCTAAPPHPIVKGSATVLINKLPAARITDNAACGGLIIKGEFTVLVGG"
     gene            complement(209356..209985)
                     /locus_tag="MED193_00990"
     CDS             complement(209356..209985)
                     /locus_tag="MED193_00990"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MMSENFENLVKLPADPVAKLLSHANVLLKTPLTAPPTATAGVVL
                     RELYEKEALVDLLRLLGVLLPPRERVWWACMAARDYIGPRSDKDPASLSCSEAWVRDP
                     SEENRDAARLTLDHAYIDDDTVNCALSVLYAPGTLGPGDLNQYPAPAGASEAAAFAMN
                     MVALSQLSDKFEEHGRVLVARALDIARGGNGQGKAKQADPDPGNEKEEA"
     gene            complement(209992..212103)
                     /locus_tag="MED193_00995"
     CDS             complement(209992..212103)
                     /locus_tag="MED193_00995"
                     /note="COG3501 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12829"
                     /translation="MVESKAHDSDMVWMSGSYSVRDLLLKRAIVREGLSKLTETTIEF
                     QSKNKAIKLEDIVGQTMNLHVQTEDQTDQKFSGLCISVENMGFRDGYGLYVAEVRPWF
                     WLLTRTTDSRVFQELSAVDVIKQIFSENGFSDFRDRLSESYEARDYCLQYRETDYDFI
                     CRLMEEEGIYFYFDSTSDKNAAEKLVLCDGMSGHSPVNGKSQIEFHARDDRDRRREDH
                     ISEWAHEEVLTTGKVTLNDFDFLSPAADLKVKNAIPKGSHSHKDYEFYDYQGHYRKDT
                     GLGNKRVRVQMEAEAIRHKRWRGAGSLRTLGTGYTFQLKNHPDKPANGEYLVVDAVHY
                     LQVAGDYNEREKRTTSAAEAGEMRHDIKPRNMDFPEEIKGDAYASTFGAIEKHEQYRA
                     PLATQWPQVPGLQTATVVGPSGEEILTDKHGRIKIQFHWDREGKADEKSSCFVRVVTP
                     WSGKNWGMVAVPRIGQEVVVQFEDGNPDRPICTGMLYNADTMPPYTYPDDQTQLGIKT
                     NSSKGGGGYNELMFDDKKGEELMRVQAEKDHQMLIKDRSAVTIGLDAPEPDAPGTDEK
                     SYALTIKQHMDEVVKSGNRTEVVETGDKAETIQKGNMTLDVDTGNLTETIAKGNHDET
                     VSLGNISVDATAGKIKMTAGQEILLQVGPTSVKIDNSGVTIKGPMIKVEGSAMVEAKA
                     PMTTVKGDAMLTLKGGLTMIN"
     gene            complement(212179..216096)
                     /locus_tag="MED193_01000"
     CDS             complement(212179..216096)
                     /locus_tag="MED193_01000"
                     /note="COG3516 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23815"
                     /translation="MADSSQKFIGRNRAPRVQIEYDVELYGAEKKVQLPFVMGVMSDL
                     VGKSKAPQPAIGDRKFLEIDVDNFDKRMKSMVPRAAFTVPNTLTGEGNLAIDLTFESM
                     KDFSPGAIASKVDSLRPLLEARTQLQTLMAYMDGKSGAEDLIEKILHNPALLSTLAQG
                     NAASAADQESALDSLRGVALPEAEQDQSDDVLADLAARAPTEAEHDDGVEGALAALAS
                     TAPEDAPNQDDAQADAALAALAAAAPEEAIQTEDMGEEALASLRAVAPAPEEIPEGSA
                     DILGDLARAGEDLLPSEVPSNDGILDDLAAQELPETDAPDPLADILSDLEASAPTPQE
                     DGDDLSDVLGALQELTPPAEESETAQEASKAILDGLATQEGAADPEDNDLSALLDELS
                     ASAPTEEDSEEADLSDILGALDEGAQEEQSEDQVDDILADVLSAAPGEPEDAPEEDPL
                     ADILGGLDVEEEPGAVEESVDLQGLLGELSTGEQDSPDSSAALDEVLAGLDGAEDPSE
                     PDSSSDLEAVLSDLATESEEDSAQSEGDLSLEGLLSDLDLGQDAAGDTVDVDSILSDL
                     EITDEAESRDDSEASLTELLGTTDAAEADLDDLLGFSDEGAEADDLNLDDLLGDLTSD
                     PAEETEQEAPSPTEAADESDGLDDLLADLDSEEAADPAAAETALDLSDDLSDLEALLG
                     DLESDAPQTDVEEVAEPQAAAPDAEKQVTTAEPEFAYGTISAERPEAEQLTRKRFRIA
                     LFGDFSGRAARGQVETGAALAQRQGILLDPDTVEEIIEGFASELVLPIGQDEGGIAVK
                     LKEFDDLHPDELFENVALFSELVSLRDQLQSGVTVDHASRSLATWAAQYGTPVRVPKR
                     SSPSNSIPADRRLSAFQQLIGDTENSLREASPVDEMLARVVGPYIRALPNPEVPAMQA
                     AVDAALSDAMRLVLHHPEFQALEAQWRSLDLIARSVEVDDSLEVVLYDVSAEELAADL
                     AAQDDLSGSGFTRLLSEEPMDPELGRGGYSALIGMYGFEETPPHAELLGRIARVAAHV
                     DAPFFTSLSPEFLKTEKKDRPAVVANAWDTLQQMPEAGHLALASPRFLLRRPYGAKSN
                     PVDAFDFEEFSEAEGLKGMLWGNPVVLVTILLARSFKENGASMQLGSIMSLGGMPYHT
                     VNDRFGDQVALPCTERNIDLDKIAMANERGVMALSAVKGRDELRLTSFSSVAGGEVLG
                     PWSGVPAPAPSPADPREKTGIAAAKPAEPAMEPDSEADDLDLSDLGLDDLDLGDGDTG
                     AATADEADLDDLDALLAGFGEETDTEEDDDEMDAELAALLADL"
     gene            complement(216089..216943)
                     /locus_tag="MED193_01005"
     CDS             complement(216089..216943)
                     /locus_tag="MED193_01005"
                     /note="COG1226 Kef-type K+ transport systems, predicted
                     NAD-binding component"
                     /codon_start=1
                     /transl_table=11
                     /product="voltage-gated sodium channel"
                     /db_xref="CDD:25532"
                     /translation="MTESAQTQPSLQDRARVFVERPVVTNSILGIIIFNAITLGLSTS
                     AAVNEQVGGLLGVVDKLVLAVFVAELALKFFAYRLKFFSSAWNIFDLLVVSVGLLPDK
                     QGLSALRGLRVIRALRLLSVVPQMRKVVQALLDALPGMGAVIVMISIVFYVFGVMATL
                     MYGSAFDEWFGTLGRSLYSLFQIMTLESWSMGIVRPVMEVYPMAWSFFVPFIVVTAFS
                     VLNLFIGLLVNTMQTAVEAEAEAEFEQLRDLVRKETDLVDAHVLELHAEIKALRQELG
                     ALKGGDNG"
     gene            complement(217025..218254)
                     /locus_tag="MED193_01010"
     CDS             complement(217025..218254)
                     /locus_tag="MED193_01010"
                     /note="COG1196 Chromosome segregation ATPases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MDFKNLDIKVSGLEMVEPPKLSFKVVIDLDKKMEKGADKDPLLQ
                     QEFQAAASDVLEQTKETIEKKCKIFDKLFGQMVNKGASEKEMEKQLKGLNDAIKNDVK
                     VAEKGAELAAAKAWSDLQKKRKEWSKFKIKIGVSIVGTLAGLAVSIAAMATSPFSGGA
                     GAAFAIIGFIKSGVSLAQDVGKLAINIDQSKAILVKNLALVEKAASNPALNATNEVSA
                     AIFQEFLGVSQPSVKTVEDAADTLKAKYAQMVVKMHDLSKTLAKILKEQDKLKKEFLT
                     EVSKRLKKHPVKDKKAQLVMISKALDTALAKNYDAVQSAIDKIQFMYGDARKWADNIK
                     DLMKRVKALTIKDPKALKVFREALKFAALGLSPIDGNSIATGTKDLALGVGGAAGGYV
                     YDKLASKALDGTVFDAA"
     gene            complement(218308..221031)
                     /locus_tag="MED193_01015"
     CDS             complement(218308..221031)
                     /locus_tag="MED193_01015"
                     /note="COG0542 ATPases with chaperone activity,
                     ATP-binding subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="probable ClpA/B-type chaperone"
                     /db_xref="CDD:10413"
                     /translation="MTEISRVALFGKLNKLGYQAVEGATVFCKMRGNPYVELVHWMHQ
                     LLAQQDSDMHRIIAHYDLDTGKIASEMTRALDMLPRGASAISDLSDHLMDAMERGWVW
                     GSLLYSASQVRSGYLLLGMLKTPALRNILASMSPELASIGADDLADNFAEATDGSPEA
                     TMSAQDGSSVTGGGAEPGEASGAMAPGAMGKGEALEQFCTDLTEQARNGEIDPIVGRD
                     EEIRQIVDILMRRRQNNPILTGEAGVGKTAVVEGFALRIARGDVPPALQNVRLLALDI
                     GLLQAGASMKGEFENRLRQVIDEVQASAQPIVMFVDETHTLVGAGGAAGTGDAANLLK
                     PALARGTLRTIGATTWAEYKKYIEKDPALTRRFQVVKIDEPSVPKAILMMRGIASMLE
                     NHHRVQVLDEGIEAAVSLSARYIPARQLPDKSVSLLDTACARVAVSQHAVPAEVDDSQ
                     RRIEALTTELEIIGRDETAGYDVADRREAVTAAKTTEEERLAGLTTRWDKEKAVVQEI
                     LDLRAKLREGAAPVDAAVDTGEEGAEGAMTSPLSPEDRADLMQQLKDKNAELEELQGD
                     SALILPIVDHQAIASVVGDWTGIPVGRMVKDEIDTILHLEEHLAKRVIGQDHAMKMIA
                     KRIQTSRAGLDNPNKPIGVFMLAGTSGVGKTETALALAEVLYGGEQNVITINMSEYQE
                     AHTVSSLKGAPPGYVGYGEGGVLTEAVRRKPYSVVLLDEVEKAHPDVHEIFFQVFDKG
                     VMEDGEGRVIDFKNTLILLTSNAGSDMIMDMCADPDLMPAPEGIAKALRDPLLKIFPA
                     ALLGRLVTIPYYPLSPDMIGKITRLQLGRIKKRVEEAHGVPFSYTDAVVDKIVDQCQE
                     LESGGRMIDAIVTNSMLPDISNEFLRRLMAGEEVASVAIDVADGEFTYSFD"
     gene            complement(221057..222094)
                     /locus_tag="MED193_01020"
     CDS             complement(221057..222094)
                     /locus_tag="MED193_01020"
                     /note="COG3520 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:27103"
                     /translation="MASAKGSGPNDLSLFDRLVEAPEEHHVFQALRVLEAHYSDAPRL
                     GESRRPRQDPLRLGQEAELAFPPSSIADFTPATKEGPARLTNRFFGLFGPQGPLPLHL
                     TEYARDRKRNHRDPTMVGFADMLTHRMMSLLYRAWAEGAPAVSFDRDEDPLADRVAAL
                     AGYHGKGLQNRDDMPDLAKLHFTGILGQGTKTPAGLVAILSDFFQVPVQLEEFVGSWL
                     QLEPDDRWQMGRGQGGLGQSTSLGEKVWSRSAKFRLRIGPLNLQDYERLLPGGAALDR
                     LRAIVRSYVGDFLDWDVNLVLAGDAVPRASLGGTTRLGHTSWIRSRPDPDIDQPDVED
                     LFLYPGSSSGN"
     gene            complement(222058..223935)
                     /locus_tag="MED193_01025"
     CDS             complement(222058..223935)
                     /locus_tag="MED193_01025"
                     /note="COG3519 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:24820"
                     /translation="MDTRLLGHYENELNYLRDMGAEFAAAYPKIASRLGMEGVEVLDP
                     YVERLLEGVAFLSARVQLELELQYPNFTSNLLEIIYPHYLAPTPSMMIAHFEPDPTNS
                     AVKSGYVMPRNSVLRSRLNEGEQTPCEFRTAADLTLWPVEISEAQYIDGRGDLVAAGV
                     ATGYEARAGIRLRLKRSDGEALRDLDMDRLQIYLGSAAGNSWPLLELLCTQVQGIVAR
                     STDRRADWHLPLPEGRIVQKGFSRDEALLPVPARVFDGYRLLQEFFAMPERFRFVELQ
                     GLRPALQKAEGSELDLYIPLREGMRDIAPVVMPEVFQLNCIPAVNLFEKRCDRVRMTV
                     RNTEHQVVPNRTAGLDFEIYALKKVTGISGEGADDVVFRPFYSADDFTAAGETHPAYY
                     TLKRRMRERSEKERLRGVRSSYLGSEVYLTLVDRSQAPYGPDLEQLAVQALCTNRDLP
                     LLLATGNENVFHLPEGGPVRQINLPISPTRPHPSLGQGDTAWRLISHLSLNYVSIADS
                     GRGNAAEALRELVGLYAPLGNRVTEKQLEGIVSVSSRPIVRRMSDEILSTAVRGMEIS
                     IGFDESFFEGSNIYALGAVLERFFHGYASINSFTETVLTTEKRGEIARWRPQKGLGRM
                     I"
     gene            complement(223938..224435)
                     /locus_tag="MED193_01030"
     CDS             complement(223938..224435)
                     /locus_tag="MED193_01030"
                     /note="COG3518 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12846"
                     /translation="MADKMLAERLQPSLLDRLTDNNPTDRKETRDSRVIDLNRLREII
                     QRDLSWLLNTQNAGHQIDADRYPMAAASVLNFGLSEVTGEFSTTEKAEKIRRAIEQAV
                     TSFEPRIIEGTVDVQLIGDVDVAGMTIGLDIRADMWAQPLPLELYLRSKVDVTTGEVK
                     MERGL"
     gene            complement(224428..225231)
                     /locus_tag="MED193_01035"
     CDS             complement(224428..225231)
                     /locus_tag="MED193_01035"
                     /note="COG4455 Protein of avirulence locus involved in
                     temperature-dependent protein secretion"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:27131"
                     /translation="MTPEEHLRAGDPEQALAALQEQVRADPSNAKLRIFLFQLLCILG
                     DWKRAVAQLRLSAELDAGATVMAQAYREAILCEVYREKVFKGEKDPLILGEPEAWLAQ
                     LIEAQKMLAQGNTDQATALREAAYEAAPTTAGTVNGTAFDWIADADMRLGPVLEVILN
                     GRYFWLPFTQIQSLEIDAPSDLRDTVWMAGTLTLANEGALAVLIPTRYPGSEKADAGA
                     KLARATNWQELDGGTYTGLGQRLLTIGEKDFPLMDIRQLKIGTQDEPDG"
     gene            complement(225314..225805)
                     /locus_tag="MED193_01040"
     CDS             complement(225314..225805)
                     /locus_tag="MED193_01040"
                     /note="COG3157 Hemolysin-coregulated protein
                     (uncharacterized)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23862"
                     /translation="MFVEISDIEGDATEDKHKKWIVIQSANWNVERAVEMTDLGSTQR
                     MHANSNFGKIELTSQMGKASNELAKSVANGTVRPEIIMHWCRSGDAQAEGLLEYSIWK
                     LKDVVIDSYSISASEDGIPEETWSLAYAAIEHTYKSTNQKTGKLENPIVFQWNVQTGK
                     FEY"
     gene            complement(225873..227369)
                     /locus_tag="MED193_01045"
     CDS             complement(225873..227369)
                     /locus_tag="MED193_01045"
                     /note="COG3517 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:24816"
                     /translation="MADEALQTEAAPAEAAFGSSEFANLLQKEFRPKSDQAKTAVESA
                     VKTLAEQALANTGLISDDALRSIESIVAEIDKKLTEQVNLILHNKEFQQLESAWRGLH
                     YLVNNTETDEMLKIRVIPITKKELGKSLAKYKGTAMDQSPIFKKLYTEEFSQLGGEPY
                     GSLVADFHFDHSPPDIELLGEMSKIAAAAHAPLITGAEPSLFQMDSWSELSNPRDLTK
                     IFQTPEYAAWRSLRESEDSKYVGLAMPRFLGRMPYGSKTDPVDEFAFEEDTTGAESDK
                     YSWVNAAYGMATNITRSFKSYGWCSRIRGVESGGTLEQLPSHTFPTTDGGVDQKCPTE
                     IAIDDRREAELAKNGMMPLLHRKNTDVATFMGAQSLHKPTEYDDPDATANANLGARLP
                     YLFATCRFAHYLKCMVRDKVGSFKSRQDMESWLQNWINNYVDFNADISSENEKARKPL
                     AAAEVVVEEVEGNPGYYSSKFFLRPHYQLEGLSVSLRLVSKLPSEKGG"
     gene            complement(227381..227899)
                     /locus_tag="MED193_01050"
     CDS             complement(227381..227899)
                     /locus_tag="MED193_01050"
                     /note="COG3516 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23815"
                     /translation="MAGSAQKFVGRNRAPRVQIEYDVELYGAEKKVQLPFVMGVLADL
                     TGKSEVEQPSVADRKFLEIDVDNFDKRMKSMAPRAAFTVPNTLTGEGNMAVDITFESM
                     DDFKPAAIAAKVAPLKELLDARTQLSNLMTYMDGKTGAEDLITKIMQDPSLLKTLAAQ
                     PKPGGDAGGETE"
     gene            complement(227983..229026)
                     /locus_tag="MED193_01055"
     CDS             complement(227983..229026)
                     /locus_tag="MED193_01055"
                     /note="COG3515 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:26920"
                     /translation="MDLAVLLQSMEEDAPSGDNLVYDPAFAEMERAAQPSKDDSGQTN
                     PPDYPTVEEKALEVLERSHELRAAVFLAEALLLRGELVSFADVTSYMRGCLEQFWETC
                     HPELDEDDGDPIMRINAVQGLCGQPDGMAGPSAVYSAVRRVHLSDSRNFGRFSVRDIE
                     IAEGQMSAPEDMDTIPDQASIAAAFQDSDDDFIAARLAAVELAEENIRAISDVFSEQT
                     PGQGPELDPLVKLLRQMAKRLRDYGNLGDSSVAEDSDAAEETEAVEAAPAAGGVARVA
                     APGAINSPTDVANTLDRIIAYYQREEPSSPLPLLLERAKRLVGADFLTIVNDMAPRGL
                     ENVQLIGGLEDDD"
     gene            229242..230051
                     /locus_tag="MED193_01060"
     CDS             229242..230051
                     /locus_tag="MED193_01060"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MVREGTKRRTSFAFCLDPLKDPLMMIQPGSKPETLRAPLKQAGG
                     KPPVLWGTYVVQGDQMEMTCEQAPTQMLLQLKRFMKANRPKVNVLFLDDGGNTLDSLK
                     PDSATDAAAQNADASDISAPGIDASAIEPLKRRLKRIQPRIALAPGPLELKLNRALGK
                     SVSLINAGRLQEAETLVLVIERALAALGKDREDEETTLKRGQRESDQRSLGAQVKRAQ
                     GLQAHVARAPGPARDRLTQAIHKAARLLKQRDLNGARDAMDKIEKALTSLV"
     gene            230132..230575
                     /locus_tag="MED193_01065"
     CDS             230132..230575
                     /locus_tag="MED193_01065"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPFTSSFLSVMSRSLAIVLLVMLPQFSRAETGPLLVELNKMEEI
                     DSGGCRAFFLFRNQTGKSFAGFEMSLAILDGQGVIDRLLSVDASPLPVQRTTLKLFEV
                     PEISCSNISEILLHDVTACQPQNEAEMDCFAILTLGSRASAKLVK"
     gene            230578..231195
                     /locus_tag="MED193_01070"
     CDS             230578..231195
                     /locus_tag="MED193_01070"
                     /note="COG0811 Biopolymer transport proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="MotA/TolQ/ExbB proton channel family domain
                     protein"
                     /db_xref="CDD:10678"
                     /translation="MGAILQNLTTGGPIIALLAVISLLSLTLIAVKLAQLWPVTSGKD
                     QRQAAIELWRGGDKHGAQAKVASGKSPADRILHFAMSAMQGGLKGPVLTSELERRGNE
                     EIQGMNGLIRLLELIAMVSPLLGLLGTVLGMIQSFQELELAQGAANASVLAGGIWQAL
                     LTTAAGLVVAIPAAIAAGLFSARIDHAAMLIESAVGQLMLADHAR"
     gene            231214..231624
                     /locus_tag="MED193_01075"
     CDS             231214..231624
                     /locus_tag="MED193_01075"
                     /note="COG0848 Biopolymer transport protein"
                     /codon_start=1
                     /transl_table=11
                     /product="probable biopolymer transport exbd-related
                     transmembrane protein"
                     /db_xref="CDD:10714"
                     /translation="MVLNRRARPQALISLVPMIDVMLILLVFFMVTSTYLNLDMIPAL
                     RPGEGSARSDSAPDVRLMIRIQADGQPSLRGETLSPRDLNRVLDQALAKDPLTQLVIL
                     PSGAASTQALITVMDLAATAGMQNMRVLRLEARQ"
     gene            231621..232046
                     /locus_tag="MED193_01080"
     CDS             231621..232046
                     /locus_tag="MED193_01080"
                     /note="COG0848 Biopolymer transport protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:2982"
                     /translation="MKLKRASTRPQSETIIALIDVVFFLLVFFMLIGRMDATAPFDVA
                     PPHAQTGRDMPAGGVTLAISPMGDLALDGRAIAAETLASKLTVELVKDPDLRLRINAH
                     RDTDLRHVLPFVSQAEGLGILDVILVVTPERSAASGGRP"
     gene            232043..233641
                     /locus_tag="MED193_01085"
     CDS             232043..233641
                     /locus_tag="MED193_01085"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:24828"
                     /translation="MKPAAHSLDPENRSPGVSLWALGIAASASAHLGVLAGLIPFLAP
                     DPVVQQPSPESALTMESQQVARSRAQEQRANPERGKQISAQGDSLGAGAVQETSARPS
                     SPALLPVTAAPSQGDQIASRAPQGVTTSSQIPKPQPAVARVASGEPAPVRLAPSQPVS
                     ARPALAQPVPTRPVEAQPLSERPAAAQTLQAQRPELPAALVQTPASNVVTAAAQNPTD
                     ASATSPQALAHVTQTSIAPTQPLAEAATAPQHAPESQPQAEAITAALAFQGDATKDLD
                     PASIAAFQSFTRPGDPTSQAAGLRDGVAGLLAAVPCSRLQVVFDPETATLELRGHLPE
                     DALRQPILAALQGQMGRDIALSDKMRLLPRPQCGALSGISSVGLPQSTDQITNPLLLG
                     PDAQARVLGYSGGEQLYFDLTAPDYPAYLYVDYFDAAGDVIHLSPNAHIPLKLAAPKS
                     PQRVGAKTPEDPGLRITVGPPYGQEIAVAFAASTPLYEGLRPLSEPAAPYLDFLRRKV
                     AEKRGEDADFKGEWVYFLVETQAN"
     gene            complement(233796..235307)
                     /locus_tag="MED193_01090"
     CDS             complement(233796..235307)
                     /locus_tag="MED193_01090"
                     /note="COG4249 Uncharacterized protein containing caspase
                     domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13497"
                     /translation="MTGFWASCLFRIVVLVALLTGAARASEDDARLALVIGNASYGSV
                     SALDNPVNDAQMISQTLQGLGFSVTMAVDLGQTKMKRAIAQFGRDLRAAGSEATGLFY
                     YAGHGVQSFGNNYLLPVDVALADAADLDLMAVEAQTVLRQMASARNRTNLVILDACRN
                     NPFENVPELNESGLAEMKAPTGTFLAYATAPGGVALDGQGENSPFTQAVVEQIVVPGQ
                     PIEQAFKEVRRAVLAQSGGQQTPWDTSSLVSDFMFVEAPESPILTVAETEELQLWRSV
                     RSARDPVQLMLFLRGYPDGSFADEARRLLADVMAEELSVGSAAPKETTSAPAAPDATE
                     TALFKAAQEDGSLAGYEAYLQSYPTGTYAEIATTEIAALQAGQSTDPVGEGVENDTAV
                     ATPEPEAVPRHKEAGPVTFVSPLESDLETISGRSLAELIEQTPLFPPVEGLPESYWKT
                     QTCSSCHQWTQERLCTQANTYLSLNMQRSLSKQHPFGGVMKRSLKSWAAGGCQ"
     gene            235489..236532
                     /locus_tag="MED193_01095"
     CDS             235489..236532
                     /locus_tag="MED193_01095"
                     /note="COG2885 Outer membrane protein and related
                     peptidoglycan-associated (lipo)proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12236"
                     /translation="MVRQFLRPLLVLFYFIAQPALAADPFEHGWQLDPEASAITFLSV
                     KKDTIAETSQFAAISGQITERGVAQLIIALDSVDTKIDLRNVRMRFLFFETFTFPEAT
                     VTAVLDPVPLQDLPSLRRKVINLPVTLSLHGVEVELEAEVAVTLISNDRINISTLNPV
                     ILQLEDFNLMGGRDKLQEAANVTITPLGIVNLNLAFDRRAPGTPVLAAVPAVSGATAA
                     LETAGDFSREACIGRFDILSQSRSVNFAPGTSRLDQRSTSFLDSLFDIISRCPAMVIE
                     VGGHTDDKGSAAANTRLSQKRASSVVRYLSDKGIARDRLQSVGYGESTPLVPNNSAQN
                     RAKNRRIAFKVLN"
     gene            complement(236687..238006)
                     /locus_tag="MED193_01100"
     CDS             complement(236687..238006)
                     /locus_tag="MED193_01100"
                     /note="COG0174 Glutamine synthetase"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamine synthetase III"
                     /db_xref="CDD:22916"
                     /translation="MTDLAAFAQEKGIKYFMISFTDLFGGQRAKLVPAQAIADMQEDG
                     AGFAGFATWLDMTPAHPDMLAVPDPETVIQLPWKPEVAWVAANPVMEGADVAQAPRNV
                     LRKLVAEAAELGLNVKTGIEAEFFLLTPEGDKISDPADTAEKPCYDQQAVMRRYDVIA
                     EVCDYMLELGWGPYQNDHEDANGQFEMNWEFDDALKTADKHSFFKFMVKSVAEKHGLR
                     ATFMPKPVEGLTGNGCHAHISVWDLAGKTNVFATDKGTGQTGELGLSEQGAAFLGGIM
                     KHASALAAITNPTVNSYKRINAPRTMSGATWAPNTVTWTGNNRTHMVRVPGPGRFELR
                     LPDGAANPYLLQAVIIAAGLSGIKTKADPGPRYDIDMYAEGHTVTDAPKLPLNLLDAI
                     RWFDEDAALKAKLGEEFSASYIKMKMQEWTSFVTHFSQWERDTTLDI"
     gene            complement(238064..239389)
                     /locus_tag="MED193_01105"
     CDS             complement(238064..239389)
                     /locus_tag="MED193_01105"
                     /note="COG0069 Glutamate synthase domain 2"
                     /codon_start=1
                     /transl_table=11
                     /product="glutamate synthase family protein"
                     /db_xref="CDD:9944"
                     /translation="MENTPNTLPRQSWTFSNDTNSEIRRAADTGIYDIRGGGAKRRVP
                     HFDDLLFLGASMSRYPLEGYREKCTTSVTLGTRFAKKPIELDIPITIAGMSFGSLSGP
                     AKEALGRGATMAGTSTTTGDGGMTEEERGHSEKLVYQYLPSRYGMNPDDLRRADAIEV
                     VVGQGAKPGGGGMLLGQKITERVAGMRCLPEGIDQRSACRHPDWTGPDDLEIKILELR
                     EITNWEKPIYVKIGGARPYYDTALAVKAGADVVVLDGMQGGTAATQDVFIEHVGQPTL
                     ACIRPAVQALQDLGMHREVQLVVSGGIRTGADVAKALALGADAVSIGTAALVALGDND
                     PKWEAEYQKLGSTTGAYDDWHEGRDPAGITTQDADLMARLDPTEAGRRLRNYLNVLTL
                     ECQTLARACGKSHVHNLEPEDLCALTMEAAAMAQVPLAGTNWYPGKPGF"
     gene            complement(239402..240070)
                     /locus_tag="MED193_01110"
     CDS             complement(239402..240070)
                     /locus_tag="MED193_01110"
                     /note="COG0070 Glutamate synthase domain 3"
                     /codon_start=1
                     /transl_table=11
                     /product="FwdC/FmdC family protein"
                     /db_xref="CDD:9945"
                     /translation="MAQLDLRAVNTSLQAAAKAQANDEFVIENPRGSHAMACGLDGAI
                     RVTVNGSTGYYCAGMNQEAEITVTGSAGPGVAENMMSGIVTIEGDASQYAGATGHGGL
                     LNIKGNASSRCGISMKGIDIVVHGNIGHMSAFMAQKGNLVVLGDAGDALGDSLYEACL
                     FVRGEVKSLGADCIEKEMRPEHIELLTDLLARAGADAQPQEFKRYGSARRLYNFNIDH
                     AGEY"
     gene            complement(240092..240982)
                     /locus_tag="MED193_01115"
     CDS             complement(240092..240982)
                     /locus_tag="MED193_01115"
                     /note="COG0067 Glutamate synthase domain 1"
                     /codon_start=1
                     /transl_table=11
                     /product="amidophosphoribosyl transferase-like protein"
                     /db_xref="CDD:28304"
                     /translation="MCGIVGLFLKKEELRPQLGDMLTEMLITMTDRGPDSAGIAIYGD
                     ETEGVIKITIQSDTPNEAFLGLDGRLSAAINKPVGIKVISTHAVLTVPADTETAAIAF
                     LEENGLRIMGSGQSMEIYKEVGLPEDVAARFDLRGMGGSHGIGHTRMATESAVTTMGA
                     HPFSTADDQCLVHNGSLSNHNQMRRTLARKGVFTRSENDTEVGAAYISSRVAEGATLG
                     EALEGTLEDLDGFFTFVAGTKDGFGVVRDPIACKPAVMAETDDYVAFASEYRAFADLP
                     GIDGARVWEPEPATVYFWER"
     gene            complement(241167..241832)
                     /locus_tag="MED193_01120"
     CDS             complement(241167..241832)
                     /locus_tag="MED193_01120"
                     /note="COG1396 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein, putative"
                     /db_xref="CDD:16530"
                     /translation="MAKNSPKTSTASAGRAALSQNPHAVREVREKNLEVAIGRQVREL
                     RKRQRLTGANLAELTGLSVGMLSKIENGVISPSLNTLQVLADALRVPLMQLFSGFEEA
                     RGAMHVKAGQGAEIERAGTRAGHQYQLLGHIGSNNSGVVIEPYLIELTTESDRFPTFQ
                     HEGLELLYMLEGAVDYRHGDQIYHLEPGDSLLFDADAPHGPENLVSLPARYLSVITYP
                     QQR"
     gene            242140..244035
                     /locus_tag="MED193_01125"
     CDS             242140..244035
                     /locus_tag="MED193_01125"
                     /EC_number="2.3.1.86"
                     /note="COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid
                     ligases II"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA synthase"
                     /db_xref="CDD:10192"
                     /translation="MCWEHMMADFGTHPIKSQSDLLRFETEMSLEARLPEQSILDVFI
                     NSAARSPDATAMTMLMTGAPDETPRQVSYQDLLGQIRRAANLFAQIGGTAPGVAFMLP
                     ALVETHATLWGAETVGYAVPINFLLQPESIVELLRAAEVKILVALGPHPQLDIWEKAL
                     VIQAQMPELQLVRLSPPGAAADDGIIDFATAMAEQPDDHLTFGDARSGDDLAAYFHTG
                     GTTGVPKLVAHTHRSQLVAAFGGAVMCGYTPDDVLTATFPLFHVAGTIVAGLSGFMAG
                     IELLVITPAGLRNPAVVANFWQLVADHKVTLVAGVPTALGAVLQTPLGDNDISTVRAG
                     MTGASLLPPAVANSFKDVTGCTLYEILGMTEASGLISIDPPFGKGTSGSVGWALPYTQ
                     VDVLKLNADGSLGGVCDVEEIGVIAIRGDHISPGYRDPAHNDGVFAQGVLNSGDLGYK
                     DANGCLYVAGRSKDLIIRSGHNIDPTMIENALSTHPDVALAAAVGLPDAYAGELPMCY
                     VQLHPEASVSIAELMAHAQKTIDERPAWPKIIEVIDAIPLTSVGKIFKPSLRCDAAKL
                     VVSKVLTEEFNLPNAQVDAATGGPRGLCVTVTLPSDAQASAQAVEAALANYLFETDIE
                     IAPAVPG"
     gene            complement(244091..244777)
                     /locus_tag="MED193_01130"
     CDS             complement(244091..244777)
                     /locus_tag="MED193_01130"
                     /note="COG0693 Putative intracellular protease/amidase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10562"
                     /translation="MTNSVLVVVTSHDKLGDTGEPTGFWLEELAAPYYLLQDAGVKIT
                     LASPKGGQPPLDPKSDDPAAETEATRRFKADAAANAALSETAKLSEVKAEDYDAVFYP
                     GGHGPMWDLVTDTNSIALIEAFWATNKPVAAVCHAPIVLANTKDANGAYIVKDRAVTG
                     FTNSEEDAVGLTDIVPLLVEDTLIDRGGKFSKGADWAPFASQDGNLITGQNPASSEKV
                     AELLLQQLRA"
     gene            244901..245776
                     /locus_tag="MED193_01135"
     CDS             244901..245776
                     /locus_tag="MED193_01135"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="Transcriptional regulator"
                     /db_xref="CDD:10453"
                     /translation="MFEGILEFATVAECGSFTKAAQRLRVSTSHVSRQVSALEDRLGV
                     KLLNRTTRVVQLSDIGQRYHQQVQRVIEGLQEANQTAISTHADLAGPIRMSGAGPFVE
                     EQVAPLLVQFAAQHPKITLEMDFETRLVDLVDQGFDFAIRYGVLAESGMIARKLSSRP
                     LVCAASPAYLDRHPAPHHPRTLRDHSCLVINNDLWRFSDPDQKTNIELRVSGRVRANS
                     IVAAREAAVQGLGVIYTPASNVVSQIQAGTLVEILPEFVDTTRSHWLVYPERQHMPTR
                     VRAAIDHLIAGLDNK"
     gene            246021..247190
                     /locus_tag="MED193_01140"
     CDS             246021..247190
                     /locus_tag="MED193_01140"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNAKPSVLITGARAPVALHLARLLNDAGHGVSLLDHVKHPLAAA
                     SQMNIPYYRIPPFSTEPEAAGDALHDIIEERGITLVIPTCEEVLHLGALWQRRPPNAR
                     LFAPKLAKLSQVHNKYHFIRLCEGLGLPTPQTQLVTTQRELALHVQNAQNLVFKPVWS
                     RFGSQVLIKPKAPKLQRLRPTAQNPWVAQEYVDGTELCIYAIARAGHLVALSAYRGLV
                     RAGVGAAVCFTPEETAPLRAFVERIVSATNWTGQISFDVVQTAHGRLLPLECNPRATS
                     GLHFFSKGTAFCEALFGENHEVEPDVTAPLTLPLALWLYGLPMMLNPDQRPVFLNALR
                     SAGDVMRWPSDRVGYGAQLSALAEFAGIALRHKISLERASTWGIEWNGAEQSVLS"
     gene            complement(247208..248329)
                     /locus_tag="MED193_01145"
     CDS             complement(247208..248329)
                     /locus_tag="MED193_01145"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSRPIGKAVMEQPSQPLDAFVECFARHPSEALIRNLQTRVARLD
                     VRGQAFPITVNDGGLPGNCYICNPVTGYIDYALEETRNFAPNPLLRKSLITMIRAAAV
                     VVRASGLDRAVHVNNWLFSTNPAPVVTRDMAAALRDQLAAQFPGHAILLRSLNTYSDQ
                     SALTALVQEGFQLLPSRQIYLFDATAPMGLNPDMEKDLALLRKTPFEEVDNEGFTQAD
                     YPACIGLYEQLYLEKYTPLNPQYTPAFLEMAHQSGILRLKGLRDADGQLVAIGGRFQY
                     GRTLTQPLVGYDTRRPQKEGLYRMITAMAKRDALAEGLLFNMSAGAAGFKRNRGAIPA
                     IEYSAVYTRHLSRRRRIATGIIGSVLSRVGVPLLKRFEL"
     gene            complement(248302..249567)
                     /locus_tag="MED193_01150"
     CDS             complement(248302..249567)
                     /locus_tag="MED193_01150"
                     /note="COG1541 Coenzyme F390 synthetase"
                     /codon_start=1
                     /transl_table=11
                     /product="probable coenzyme F390 synthetase"
                     /db_xref="CDD:11255"
                     /translation="MIARLNAPISFLSTRYLSRPGLTRARFLQHQERALGKWLHRAVP
                     KVPAFVDAPPHLSILPVMDKAQLMANFAQYNSQGISADQVRGALKSGDQIGALTVGAS
                     TGTSGNQGLFVISDAERFRWLGSILAKTMADLLWHKQRVAILLPRGTGLYDSANQIQR
                     LQLRFFDVTRGPDAWRAELEAFDPTVIVAAPKVLRAMAEEKFSLRPLRVFSAAETLDP
                     LDRPVIEAAFGRGLGQIYMATEGLLGTTCRHGRLHLAEDSVHFEFEPVGDGLVTPLIS
                     SFRRGTQILARYRMNDLLRLDPEPCSCGTPLQAVTEIVGRMDDCFHLHGARGLQMLTP
                     DVLRNAVVMADHRISDFRVIQTGPRTVELALPADLPPGAGLAARHGLQSLFDARGLHA
                     KIALTYGPLPLDVSRKLRRVECRAQSVKP"
     gene            complement(249564..250388)
                     /locus_tag="MED193_01155"
     CDS             complement(249564..250388)
                     /locus_tag="MED193_01155"
                     /note="COG0491 Zn-dependent hydrolases, including
                     glyoxylases"
                     /codon_start=1
                     /transl_table=11
                     /product="metallo-beta-lactamase protein"
                     /db_xref="CDD:10952"
                     /translation="MRPVFANSAWVAAPERLILRNGRWRRRWLQVRYGLFIHPKAGPT
                     LIDTGYTSHSLNTSSRTLALRSYAGILAPRLVVQEQAGPFLTQFGLTAVDISRVIVTH
                     FHADHVSGLAAFPNARFIASGAAWAQVQGNSALQNLRHGVFAELIPGDFGTRLEVVEK
                     CASQKIAHLPDGHDIFGDGSVLAVPLPGHAHGHFGLLFGQLEVPFLYATDTQWVGEAL
                     LPGGRPRLFPRLISDSFSEVVRSSEQVSAFQKAGGEVLLCHDTAPSQFDFAQGAEL"
     gene            complement(250385..251359)
                     /locus_tag="MED193_01160"
     CDS             complement(250385..251359)
                     /locus_tag="MED193_01160"
                     /note="COG0451 Nucleoside-diphosphate-sugar epimerases"
                     /codon_start=1
                     /transl_table=11
                     /product="3-beta hydroxysteroid dehydrogenase/isomerase
                     family protein,putative"
                     /db_xref="CDD:10325"
                     /translation="MAARVLVTGATGFLGGAVLRRLGDNGVGQGRNPSHCAALDAAGI
                     NVVNWTLPGAAPQSPQLAQVDTIVHCAGLSSPFGRAEAFHAANVLGTASVLNFARLQG
                     VKRFVFISSPSIYFALSDQLDVPEDMPLPPAFTPYAQSKIAAEQLVRAAPEVGPIILR
                     PRGIYGRGDSALLPRLLKATTTRALPRFRQGQARIDLTYIDDVVDAVMSAISAKQLQE
                     GRAFNISGGEVLPISEIVESVCERAGIVPRWRDMPLAPTLFAARVAETLALMRRDPRE
                     PVVSRYSLGLFAYQQSLDISRARDGLGWAPRVAFAEGLDRVFDQGEAG"
     gene            complement(251361..252347)
                     /locus_tag="MED193_01165"
     CDS             complement(251361..252347)
                     /locus_tag="MED193_01165"
                     /note="COG0332 3-oxoacyl-[acyl-carrier-protein] synthase
                     III"
                     /codon_start=1
                     /transl_table=11
                     /product="GumO"
                     /db_xref="CDD:27985"
                     /translation="MNTFILGTGRALPLHCAQSTDLDIKWSAGGRIAASGVRRRHHCT
                     DESQIDLAVLACQRALENAGCKIGEIDLIISGASVAYQPIPAMAPLIMRGLGMEDGSA
                     AAFDVNSTCLSFVTGLDMAARMICGGAAKTALVVSSEIASRALPWSTQPETAAFFGDG
                     AGAAVIGAASSGSAAAIKAIRLRSYPSAYEACGIGAGGTRFDFNIDREAFAEHSKFNM
                     DGKALFRLTTQHFNGFVDALLREAGWDHSDVDLIVPHQASPGALDHMIRQTGWPREKV
                     VRIVEDYGNQIAASIPFAFDIAREQGRVPAGSKVLFLGTSAGVSLGGAAVVT"
     gene            252760..253023
                     /locus_tag="MED193_01170"
     CDS             252760..253023
                     /locus_tag="MED193_01170"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPPNDPFSAMSRSLTSPATEHFAIVPTDGVDLPTRPRVLRVVSS
                     GDISMRDAKGVVITYSVSAGETLQFSAIGIEATGTTATVVGWL"
     gene            253023..254375
                     /locus_tag="MED193_01175"
     CDS             253023..254375
                     /locus_tag="MED193_01175"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPGLGLGLGVRGMQPALLARYSLGGKAPAVIADTVAGVYGVGGR
                     SVGFDGLFTFSRLSAAWKLNALGHWVKVLAGEPRTGHHVWRDGKLAPAGIAVCSEVRT
                     NLASYSDDLRSWSLDNNITVTPQGTLGGSPSFALSDQTDTFGQISQNIGAIGDGEFCC
                     QVKVAKSRTKVNAFGIRATYSAGGVTQFNGISFNAETGGGIIGMWGSTIIERKVQDCG
                     DYWLAWFSFDATGIGLNEAKIQVFPAHNGVNGNGGPHWTGDHRCTAIQVNAGRCPKNY
                     IKTETAPVSTASESLQINPSLLSSAFGGVMPEALTFVMKGTMSYADVGLNPQVRMLLW
                     QADSIDRIRLQLNTVDARTGQFIAFTQKDGVANSALSAPDAYSPGVEVPFSVAAVLTA
                     TDIEGFYNGVSTGKVAHGGLPSLMAAPMEFFSPGTGTITEFCLWPEALTSSTLLEATA
                     "
     gene            complement(254465..255313)
                     /locus_tag="MED193_01180"
     CDS             complement(254465..255313)
                     /locus_tag="MED193_01180"
                     /note="COG2017 Galactose mutarotase and related enzymes"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11725"
                     /translation="MTNEALSLAVAPLGAEMQYLRTGSGEDLLWHGDAAFWSGRAPVL
                     FPIVGRAVDDLIAVGDHTAAMPQHGFARRQVFALEEQTETSCRHVLKESPESLALYPF
                     SFVLQVTHELDGNRLHVTAEVQNTDQRVMPFGFGFHPAFCWPLPKSDQKTHSISLASG
                     GNPNRVGLQDGLLRPQPVAGPFSDGELELHEALFKDGALVFPHGAESLRYGPPDGPSL
                     EFQFHNLPDLALWRPPGAPFLCIEPWHGTASYLGDGPQIARRPNSIDLQPGLAVQFGY
                     SVTVHV"
     gene            complement(255507..256556)
                     /locus_tag="MED193_01185"
     CDS             complement(255507..256556)
                     /locus_tag="MED193_01185"
                     /note="COG1004 Predicted UDP-glucose 6-dehydrogenase"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide sugar dehydrogenase"
                     /db_xref="CDD:10733"
                     /translation="MKIAVLLAQNHQVTAVDVAKERVDMINALKCPIVDAELETFLSD
                     KPLKLRATLDAEAAYSDAEFVIIATPTDYDTDTNYFDTSSVEAVIDQVSAVNPAATIV
                     IKSTIPVGFVQRLRAERGINTLMFSPEFLREGQALYDNLHPSRIIVGSQSEAEAIKLF
                     ANTYLAMRVAFFNELDSYAMAGGMEARQIIAGTGHDPRIGNHYNNPFFGYGGYCLPKD
                     TKQLLANYSEVPQNLIRAIVDANHTRKDFLADQIIAKAPNVVGIYRLVMKAGSDNFRR
                     SSIQGIMKRIKAKGIKVVVFEPVLQQDDFFGSAVVRDLETFKQVSDVIVANRLTDEIR
                     DVESKIFTRDLSGTD"
     gene            256932..257417
                     /locus_tag="MED193_01190"
     CDS             256932..257417
                     /locus_tag="MED193_01190"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSFLNSAVSKPSLRKIVTVATLGLSALLLPLETAKAAQRATYVV
                     GNDRGGYLHDRLIELGNLQRNGTRVQIRGNICYSTCTMFLGLSGTCVNPNTTFGFHGP
                     SKSGRRLAPQKFEYFSQVMANHYPTQLRDWFMREGRHRISGVYKIKGSELIRMGVKSC
                     A"
     gene            257825..259261
                     /locus_tag="MED193_01195"
     CDS             257825..259261
                     /locus_tag="MED193_01195"
                     /note="COG0836 Mannose-1-phosphate guanylyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="Mannose-6-phosphate isomerase, type II"
                     /db_xref="CDD:10703"
                     /translation="MTDIIPILLCGGSGTRLWPLSRKSYPKQFVPLMGEETLFQASAK
                     RLTDQGHGVGFTAPMVLTNSDFRFIVTEQLQAVGIDPGAILIEPEGRNTAPAVLAAAL
                     NAQAQDPEAILLVAPSDHVVPDVAAFHAALNQGLQAVAEGQLVTFGITPTHPETAYGY
                     LELAEMPDATGRPVRLKQFVEKPDTLRASDMLAAGNFKWNAGIFLFAAKDIIAAFQAH
                     ATELMAPVEAALDQAQTDLGFLRLAPNPWSQADDISVDYAVMEHAQNLSVVPFDAAWS
                     DLGGWDAVWREAGPDENGVVTSGEATAIDCTDSLLRSDSDRLEVVGIGLDGIMAVAMN
                     DAVLVADKSRAQDVKLAVAALKEKGAAQATAFPKDHRPWGWFESLVVGDRFQVKRILV
                     HPGASLSLQSHFHRSEHWIVVEGTARVTIDDEVKLVTENQSVYLPLGCVHRMENPGKV
                     PMVLIEVQTGAYVGEDDIVRYEDKYARS"
     gene            259425..260591
                     /locus_tag="MED193_01200"
     CDS             259425..260591
                     /locus_tag="MED193_01200"
                     /note="COG1004 Predicted UDP-glucose 6-dehydrogenase"
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotide sugar dehydrogenase"
                     /db_xref="CDD:10733"
                     /translation="MKIAVAGIGYVGLSNAVLLAQRHAVVSVDIDEGRVAMVNSNQSP
                     IVDQELEDFLATRDLQLSATTNSAEAYGGADYVIVATPTNYDAQTNSFDTSSVEAVVA
                     EVIQINPQATIVIKSTIPVGYVRDLRARLGTDQVIFSPEFLREGKALYDNLHPSRIIV
                     GERSERARVFAELLLDGAEDEDVEILFTDPNEAEAIKLFANTYLAMRVAFFNELDSYA
                     MAGSMDSRQIIQGISLDPRIGDHYNNPSFGYGGYCLPKDTKQLLANYNHVPQNLIRAI
                     VDANRTRKDFLSDQILMRGPKVVGIHRLVMKAGSDNFRQSSIQGIMKRLKAKGIEVII
                     YEPVMEEDHFFHSRVIRDLSTFKSQSDLIVANRMTDEIQDVAAKVFTRDLFGGD"
     gene            260669..261895
                     /locus_tag="MED193_01205"
     CDS             260669..261895
                     /locus_tag="MED193_01205"
                     /note="COG0438 Glycosyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="Glycosyl transferase, group 1"
                     /db_xref="CDD:10312"
                     /translation="MTRKKKNILYLSPYFWPEEIGSAPYSRELAQYLSHKGYDVSALT
                     FRPHYPSIEPFKAWAGGERDFETHEKIKIERVAVSPRGKGGFKDRLKNDLRYLKSCLT
                     HAIKGSYSDAEAIYAYIPSVLTLYGAKVLKMRSGAPLIAIVHDIESGLAHSLGITSKP
                     IMLKIMRMVERIGLNFADHVIVLTEGMKNEIIDIGCRKPIDVLPIWSQVADIAPIDDA
                     GPVRVMYSGNFGKKQNLDQLLPLLSHISSTLPAVEIVMRGGGSERPRIEEEVQKRGIT
                     SAQFLELAPSDAFMASLQSANVHLVPQALNVANYALPSKLFSVMSAGRPFVCIAEKNS
                     PLDVLAQDSGAGICVYPEDEAKLCQEVEALLSDIPRQQKMGESGRQFVQKNMNRETIL
                     SRYEQIMLSKAHQRAA"
     gene            261917..263035
                     /locus_tag="MED193_01210"
     CDS             261917..263035
                     /locus_tag="MED193_01210"
                     /note="COG1089 GDP-D-mannose dehydratase"
                     /codon_start=1
                     /transl_table=11
                     /product="NAD-dependent epimerase/dehydratase"
                     /db_xref="CDD:10811"
                     /translation="MKKALITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTQRVD
                     HIYQDPHVDHANFKLHYGDLTDTSNLTRILQEVEPDEVYNLGAQSHVAVSFESPEYTA
                     DVDAMGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEIPQRETTPFHPRSPYAVAK
                     MYAYWITVNYREAYGMYACNGILFNHESPRRGETFVTRKITRGLANIAQGLEDCLYMG
                     NIDALRDWGHAKDYVRMQWMMLQQDAPDDFVIATGVQYSVRQFITWSAAELGISLEFS
                     GTGLDEIATVAAIEGDMAPALKPGDVVLRIDPRYFRPAEVETLLGDPTKAKEKLGWVP
                     EITTEEMCAEMVREDLKTARRHALLKEHGMDLPVSVEG"
     gene            263041..264015
                     /locus_tag="MED193_01215"
     CDS             263041..264015
                     /locus_tag="MED193_01215"
                     /note="COG0451 Nucleoside-diphosphate-sugar epimerases"
                     /codon_start=1
                     /transl_table=11
                     /product="putative nucleotide di-P-sugar epimerase or
                     dehydratase"
                     /db_xref="CDD:10325"
                     /translation="MKIYVAGHRGMVGGAILRQLEARRAGGEDLQLVTRTSAELDLTN
                     QQQVQSFMQAEGPDQVILAAAKVGGIVANNSYPAQFIYENLMMECNVIHAAYEAGVKQ
                     LLQLGSSCIYPKLAAQPMAEDALLTGVLEPTNEPYAIAKIAGIKLCESYNRQYGVDYR
                     SVMPTNLYGPGDNFHPDNSHVLPALIRRFHLAKLNGDASVTIWGSGAPRREFLHVDDM
                     AAAALFVLDLPQATYASETQEMLSHINVGCGTDISILELAQLVAQVTGFEGEILTDPS
                     KPDGTPRKLMDVTRLERLGWKASIELNDGIAETYQWFLKQDTKNLRSK"
     gene            complement(264064..265977)
                     /locus_tag="MED193_01220"
     CDS             complement(264064..265977)
                     /locus_tag="MED193_01220"
                     /EC_number="1.14.13.7"
                     /note="COG0654 2-polyprenyl-6-methoxyphenol hydroxylase
                     and related FAD-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="phenol 2-monooxygenase"
                     /db_xref="CDD:10524"
                     /translation="MQFYKEGFRGGDPDVKSAVPGWRVRDSFAALPSEVDVLIAGCGP
                     AGLCLAAQLAQFPEIKTMIVEPKPGPIEKGQADGINTRTMEMFQAFGFGETVKRESYW
                     VNQTAFWAPDPQNQGHISRIGRVQDVPEGSSEMPHALINQARVHELFLDVMKNAPTRL
                     EPDYSWGVKDLVIDPSTEDHPVTVTLENTGINAGETKTVRANYVVGCDGARSKVRTAI
                     GGELHGDAAHQAWGVMDILANTDFPDVRQKCLISSATEGNILILPREGGYLFRMYVEL
                     DKLNPNERVSSRNFTADHMIAAANRIMQPYAIDVKEVVWWSIYEIGHRLTDRFDDVAE
                     GMDRNPRVFTAGDACHTHSPKAGQGMNVSMQDSFNLGWKLVQVLQGRSDPHLLRSYSA
                     ERWKEAKRLIETDHQWARIMSAPPGESELDSGDMPRFQKQFIENLEFTGGLAVKYLPS
                     ALTGPDQFQALAPRFEIGRRFHSAPVVRVADAMQMQLGHVAEADGRWRIYAFAGEDSA
                     AGSDLYRLCTWLMEDPDSVVQKYRGQDEDIDAVIDLRAIFQQSFDALLDQELPEILKP
                     RTGKLGLQDHEKVFGVDHKDAGDIFEIRGVDRKKGCMVVVRPDQYVAHVLPLTAHEAL
                     SSFFEGVFKPRSD"
     gene            266146..266586
                     /locus_tag="MED193_01225"
     CDS             266146..266586
                     /locus_tag="MED193_01225"
                     /note="COG1846 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulatory protein"
                     /db_xref="CDD:15281"
                     /translation="MKVQNMAGHLIRRLNQASTHIFAKRMQETGVDLTPVQFAAMDAI
                     ASYPGIDQAGVAARIAYDRATIGGVIDRLEQKGYVRRSVSTRDRRAREVHLTDQGLAL
                     FQDVLPLVEHMQGEMLEMLTGEERSAFLSLARKALGKVATDDAS"
     gene            complement(266623..267267)
                     /locus_tag="MED193_01230"
     CDS             complement(266623..267267)
                     /locus_tag="MED193_01230"
                     /note="COG0235 Ribulose-5-phosphate 4-epimerase and
                     related epimerases and aldolases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10110"
                     /translation="MSEETRAREDICRIAKSMFDRGLTCGASGNISQRLSDGTYLVTP
                     TGSSMGFLDPGRISHMDAQMRHIGGDQPTKEIPLHSAFYETRAQTGAVVHLHSTHSVA
                     LSMLPDTDPDNVLPPMTPYGIMRLGKVQLLPFFLPGDDRMGEAVRGLAGKRSAVLLAN
                     HGPVVAGKDLWAAAHAIEELEETAKLALLTQGLQPKMLSDAQVQAIVKKFDVDW"
     gene            complement(267264..268493)
                     /locus_tag="MED193_01235"
     CDS             complement(267264..268493)
                     /locus_tag="MED193_01235"
                     /note="COG3395 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="ygbK domain protein"
                     /db_xref="CDD:12727"
                     /translation="MKLGVIADDFTGASDIALTIAEAGLSVAQFIGVPGAPAPADLGA
                     GVVALKSRTAPVAEAIQSSLAACEWLLAQGAEQIIFKVCSTFDSTPKGNIGPVLQALA
                     ERLGAQSVIVCPAFPENGRSVYQGHLFVNDVLLSESGMQDHPLTPMTDPDLRRVLAVQ
                     TDWQVSHIPSKVVMQGGGAIRAALPALPRMVVVDAITEADLLQIGAAAKGAKLLCGGS
                     GIALGLPLNFGAKPAQPDWTPITGGGVVISGSCSQATRRQVAAYAADNPCFEVSAEAI
                     VNGEITVAGLAEWVLGQRCAPLVYSSANPIVVRQAQEGLGAELAASAIEGLFAELAAE
                     LAARGIARIVVAGGETSGAVVKGLKARALVIGPRIAAGVPLLRMSDQSVALALKSGNF
                     GGEAFFGDALAQMEGKA"
     gene            complement(268490..269308)
                     /locus_tag="MED193_01240"
     CDS             complement(268490..269308)
                     /locus_tag="MED193_01240"
                     /note="COG0491 Zn-dependent hydrolases, including
                     glyoxylases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:25604"
                     /translation="MTGLMIGALTWEVHAIKYADRNARRRADSFLFDDNHDAPHAMDF
                     FMWLLRCGDRVILVDTGYDHAEAAQRGRPIRLDPREALDPLGITPEDITEVIVTHLHY
                     DHAGGLALFPNAHLHLQEAEMAFATGPCMCHDTLKAPFTASHICEAVTRLYRGKLSFH
                     AGDSQIADGVTVHCIGGHSRGLQCVRVRTAAGWLVLASDAAHYYENVTARKPFPIVVD
                     LQNMLDGFARLEQLASSPNLIIPGHDPLVRQLFPRGVADHITRLDQGPISEISS"
     gene            complement(269305..269586)
                     /locus_tag="MED193_01245"
     CDS             complement(269305..269586)
                     /locus_tag="MED193_01245"
                     /note="COG1359 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11075"
                     /translation="MYAVCVTFKIRPGQMDQFLPQMVENARTSRALEPGCQQFDICRA
                     GDMIFLYEIYDDHAAFEAHLASPHFRRFEVGTADMIAEKQVQFFDEVIR"
     gene            complement(269586..271097)
                     /locus_tag="MED193_01250"
     CDS             complement(269586..271097)
                     /locus_tag="MED193_01250"
                     /note="COG3333 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12667"
                     /translation="MEFVFSQLAGFGGAFAALVADPWTYVYLVTSVFLGITIGALPGL
                     TATLAVTILTGFFGNKIPLDYSLIALLGAYVGAIYGGSYPSILLNIPGTAASAATAMD
                     GHPLAKAGRGGEALGLTTTASFIGTLIGTAALLIFVWVLLLVSKNIASPEKALLALFG
                     ILLSGTLMSEDLVIKGWIAGLIGLAMAMVGMDPLLSEPRYTFGWSYMLSGFQVVPVLM
                     GAFAVPQIIEGLRHIEVGKIVALQGRILPNLATVRRHMPTITRSGVIGTGIGALPGVG
                     EDVAGWVSYGVGKTVSKDGKNFGKGSLEGLLSSETANNACIGGALIPLLVLGIPGSPP
                     AAALMGAFKINNIIPGPTIDPNIILRVVAIMVLASLTMWILGLFTARVFIKILRIPQT
                     VFLPVVMVLTAIGSFSVGGGINDLYLMLGVGFVAYFMNLMKYPIAPLVIGVILGGLFD
                     ETFRRSLFLADGSLAGFVSRPGAATLLSLNIALITAQFPAMRRIFARLRRKET"
     gene            complement(271097..271975)
                     /locus_tag="MED193_01255"
     CDS             complement(271097..271975)
                     /locus_tag="MED193_01255"
                     /note="COG5013 Nitrate reductase alpha subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGFEQVKDGNATVVKDNSENEIKPALSRAKPQAPDRVSDGVVGI
                     EAEQLAVLRARDFWASLALLLLSLFFLWRTSLIPLWGENRAGVQGGDWYNSAALVPLG
                     IFSALLVLSLVLMRIAVTAGGAKRALSSVGIGWNRTEALRFTTISVVLFFYIAGLVPR
                     VDFVIGSGLLITALIYGYHGGHPRRMIVAAGVVALAGGYAMMMHLPRAEWRLHDDDWL
                     TLALWLGLTLWVLILGRGDPVARAIPAIALVAPLVLVCAMAFGFRQNVPNRGGLIFKT
                     IEYHYYVTLKPLWSRT"
     gene            complement(272042..273061)
                     /locus_tag="MED193_01260"
     CDS             complement(272042..273061)
                     /locus_tag="MED193_01260"
                     /note="COG3181 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12519"
                     /translation="MELKFGRTLGLAALLGGYAVGLAGGVSAQDYPYRDITAAVVWGA
                     GGGTDTINRMIMAEMEKHLPVSINVTNQTGGVAGSNGMVYVMNQPDDGYTLVGLSESN
                     VTAAVQGGWDKKFDYWYPFIVGGSPDLISVPATSPYSTIQELVDAAKAAPGTIPAAAS
                     GAGSIHHLNLLAIQNGAGVEFKFVPYKGSAPGQEAAIAGEVQLVVTSLAEQAALIQGG
                     QLKPLAMLTPESAQIAGMTVPSAFSSYEGLDKYLPLKQAIGFAVHSSASADVKAALGA
                     AFEKAMSGDAVAEWAAANNYDVGGQYGDEASKIFSTLEANFAYTLKDLGATTVDPASL
                     GIEKP"
     gene            273194..274291
                     /locus_tag="MED193_01265"
     CDS             273194..274291
                     /locus_tag="MED193_01265"
                     /note="COG0473 Isocitrate/isopropylmalate dehydrogenase"
                     /codon_start=1
                     /transl_table=11
                     /product="3-isopropylmalate dehydrogenase"
                     /db_xref="CDD:10346"
                     /translation="MANTFEIAVFSGDGIGPEITGPTVKILRLMSEVSTGYDLSFAEA
                     PAGAAHYAKTGESLPETSMRIAQNADAILLSAMGLPDVRYEDGTEISPQIDLRKALTL
                     FAGVRPVTVRPGQLTPLKMPAGKEIDFVLVRESTEGLFHTQGCGEVTKDEARETLLIT
                     REISEKLFEFSFNLAKQRQTAGRGQGRVTCVDKANVFRAFAFFREIYDAEAAKHPDLT
                     ADHAYVDATALWMVQKPWDFDVLVTENMFGDILSDLGAGLMGGLGLAPSADIGLDHAV
                     FQPCHGSAPDIAGQGVANPFAMILSAAMMLEWLGIKHDNDALRTDGQRLREAVESVVA
                     SGQILTRDLGGSASTKDAASAVEALLAMAPA"
     gene            274288..275319
                     /locus_tag="MED193_01270"
     CDS             274288..275319
                     /locus_tag="MED193_01270"
                     /note="COG0673 Predicted dehydrogenases and related
                     proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="probable NADH-dependent dyhydrogenase"
                     /db_xref="CDD:10542"
                     /translation="MTSASPIKVACVGAGYFSQFHYASWARMENVTLVGSCNRGIEKA
                     RATGLAAYDDLAQMLVETAPDLLDIILPPVAHAACIRMALAAGVKTMICQKPFCRDLS
                     EAREMVSLAKAQGARIIVHENFRFQPWYRAMKQALMRSDIGTVQQLTFRLRPGDGQGP
                     KAYLARQPYFQTMERFLVHETAVHWIDTFRYLLGDPIAIYADLRQVNPVIAGEDAGYI
                     LSEHPGGVRALFDGNRSLDHAAENHRRTMGEALLEGTEGSITLTGDGALHLRRFGAQN
                     QICLLAPDTWDGFGGDCVHHLQSHVISGLLGAGDFENEAASYLRVIEIEEAVYHSAQT
                     GRKISLETE"
     gene            275316..275993
                     /locus_tag="MED193_01275"
     CDS             275316..275993
                     /locus_tag="MED193_01275"
                     /note="COG1802 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, GntR family"
                     /db_xref="CDD:11512"
                     /translation="MTPLSEKPPSNSQRAYQALRDMIFSGELAPGSDHLESEMASRLG
                     VSRTPVREAALMLESQGLLELRPRKGVRILPVSPDDMAEIYDVLTELECLAARSAAEK
                     RLTDKSLQTLTNAIESMELAVSAGDLEQWAQSDDAFHRELVRLGGNSRVTAIFEMMND
                     QVRRARAVTLFMRDMPVQSNEDHRQVYEAIKAGDAKRAGEVHRSHRQNAKQMMLDLLQ
                     KHRLLSV"
     gene            complement(276082..277305)
                     /locus_tag="MED193_01280"
     CDS             complement(276082..277305)
                     /locus_tag="MED193_01280"
                     /EC_number="1.6.5.-"
                     /note="COG2871 Na+-transporting NADH:ubiquinone
                     oxidoreductase, subunit NqrF"
                     /codon_start=1
                     /transl_table=11
                     /product="Na(+)-translocating NADH-quinone reductase
                     subunit F"
                     /db_xref="CDD:12223"
                     /translation="MATFGLGIVLFTLIVLALVSIIIAARSKLVSTGNVNITINGEKT
                     ISVPAGGKLLQTLAAEKLFVPSACGGGGTCAQCRVKVHSGGGSILPTEEGHITKREAS
                     CGDRLSCQVAVKQDMEVEVPEEVFGVKKWECTVRSNENVATFIKALVLDLPEGEDVNF
                     RAGGYIQIEAPAHALKYTDFDIEEEYREDWDRFNLWQYESVVDEPVERAYSMANYPDE
                     KGMIMLNVRVASPPPGSEGIPAGLMSSYIFNLKPGDKVTISGPFGEFFARDTQKEMVF
                     IGGGAGMAPMRSHIFDQLKRLENRDRKISFWYGARSKKEMFFVEDFDTLAKEFDNFDW
                     HVALSDAMPEDDWEGYTGFIHNVLFEEYLKNHPAPEDCEFYMCGPPIMNQSVINMLVD
                     LGVDREDIMLDDFGG"
     gene            complement(277319..277927)
                     /locus_tag="MED193_01285"
     CDS             complement(277319..277927)
                     /locus_tag="MED193_01285"
                     /EC_number="1.6.5.-"
                     /note="COG2209 Na+-transporting NADH:ubiquinone
                     oxidoreductase, subunit NqrE"
                     /codon_start=1
                     /transl_table=11
                     /product="Na(+)-translocating NADH-quinone reductase
                     subunit E"
                     /db_xref="CDD:11916"
                     /translation="MEALLSLAVKAIFVENLALSFFLGMCTFIAVSKKISTAIGLGIS
                     VMIVQAITVPANNLILTYLLAPGALAWAGFPDVDLTFLGLISYIGVIAALVQILEMVL
                     DKYFPPLYNALGIFLPLITVNCAILGGSLFMVERDYGFAEAATYGLSSGFGWALAITA
                     MAGVREKLKYSDIPDGLQGLGITFITAGLMALAFMSFSGVKL"
     gene            complement(277927..278580)
                     /locus_tag="MED193_01290"
     CDS             complement(277927..278580)
                     /locus_tag="MED193_01290"
                     /EC_number="1.6.5.3"
                     /note="COG1347 Na+-transporting NADH:ubiquinone
                     oxidoreductase, subunit NqrD"
                     /codon_start=1
                     /transl_table=11
                     /product="NADH-ubiquinone oxidoreductase"
                     /db_xref="CDD:11063"
                     /translation="MSQTRREMLLDPLVDNNPITLQVLGICSALAVTSSLKVALVMTI
                     AVTLVTAFSSMFISVLRNQIPSSIRIIVQMVIIASLVILVDQVLKAYAFEISKTLSVF
                     VGLIITNCIVMGRAEAFAMKNPPVASFIDGIGNGLGYGLILMLVGFVRELFGSGSLFG
                     VTILETVNNGGWYVPNGMLLLPPSAFFIIGLLIWAFRTWKPDQVEEREHKIQVVEAH"
     gene            complement(278580..279386)
                     /locus_tag="MED193_01295"
     CDS             complement(278580..279386)
                     /locus_tag="MED193_01295"
                     /EC_number="1.6.5.-"
                     /note="COG2869 Na+-transporting NADH:ubiquinone
                     oxidoreductase, subunit NqrC"
                     /codon_start=1
                     /transl_table=11
                     /product="Na(+)-translocating NADH-quinone reductase
                     subunit C"
                     /db_xref="CDD:12221"
                     /translation="MSEQTKKGALQRFLEASPDSTGKTLFVAVALCLCASMIVSAAAV
                     ALRPTQEANKLKDKQINILQVAGLYEPGVNVTEAFNASFEPRILELATGQFNDDFDVA
                     SFDDRASADDPATSIALEDDPASIGRQSKYMTVYLLKDDAGEIDKVILPLHGYGLWST
                     LYGFIAVEENANDIFGLQFYSHAETPGLGAEVDNPRWKALWNGKRLTDEAGELQITVA
                     KTTTAAGKEFHVDALSGATLTSVGVDNLVRFWMGETGYAPFLANLKAGDI"
     gene            complement(279379..280578)
                     /locus_tag="MED193_01300"
     CDS             complement(279379..280578)
                     /locus_tag="MED193_01300"
                     /EC_number="1.6.5.-"
                     /note="COG1805 Na+-transporting NADH:ubiquinone
                     oxidoreductase, subunit NqrB"
                     /codon_start=1
                     /transl_table=11
                     /product="Na(+)-translocating NADH-quinone reductase
                     subunit B"
                     /db_xref="CDD:11515"
                     /translation="MGLRNFFDRIEPNFTKGGKWEKLFPIYEMVESFLYTPKTVTTAA
                     PHARSYIDMKRIMTYVVIATIPCILFGLYNTGLQVNTAIGTYGASGWRAAVIEALGIG
                     FNPENPLGNMLHGLLYFLPIYITTLVVGGIFEVIFATVRGHEVNEGFLVTSMLYALIV
                     PVSIPLWQVGLGIAFGVVIGKEVFGGTGKNFLNPALTGRAFLYFAYPAYMSGDSIWTP
                     VDGFSGATALSVSASQGFDQLAANGIEWMDAFVGTIQGSFGETSTIACLIGLAFLLIT
                     KIANWRLIVGCMAGMVGFSLLLNTIGSDSNPMFAMPWYWHLVTGGFAFGMVFMVTEPV
                     SASHTNLGRYIYGALIGFMVVMIRVINPAFPEGMMLAILFGNVFAPLIDYFVVQANIK
                     RRAKRHV"
     gene            complement(280583..281920)
                     /locus_tag="MED193_01305"
     CDS             complement(280583..281920)
                     /locus_tag="MED193_01305"
                     /EC_number="1.6.5.-"
                     /note="COG1726 Na+-transporting NADH:ubiquinone
                     oxidoreductase, subunit NqrA"
                     /codon_start=1
                     /transl_table=11
                     /product="Na(+)-translocating NADH-quinone reductase
                     subunit A"
                     /db_xref="CDD:24120"
                     /translation="MRHYKLRKGLELPVAGAPAQEIHDGPAVRTVALLGSDYLGLKPR
                     LAVQEGDVIAAGAPVFAHKDTADVQVVSPVSGRVKAVNRGARRVLVSVEIEVDATAAE
                     PVDFSSVGDVSTAEGLAERLCAAGLWTSFRTRPYSKVPASDTRPAAIYVTAMESEPLA
                     ADASVIINQAADEFAAGLKAIAVLSEGKTYLCQSGDASIPSADGVEVVGFDGPHPAGL
                     AGTHMHFIEPPTATKTVWSIGYQDVIAIGRLLKTGVVSGERIVALTGPLVSKPRLVRT
                     SVGASMAELLAGELDSAAAPRMISGSILSGRAGEGADGYLGRYARQITVIEEDHKQIP
                     MGWIRPMASKYAVQPVLGSLFSKKLYALTSNLNGGRRAMVPTGTFEQLMPQDYLPTQL
                     LRALLVMDTDQAQALGALELDEEDLGLVGFACPAKYEYGLALRDSLTKIEKEG"
     gene            282129..283154
                     /locus_tag="MED193_01310"
     CDS             282129..283154
                     /locus_tag="MED193_01310"
                     /note="COG1477 Membrane-associated lipoprotein involved in
                     thiamine biosynthesis"
                     /codon_start=1
                     /transl_table=11
                     /product="thiamin biosynthesis lipoprotein ApbE"
                     /db_xref="CDD:8297"
                     /translation="MARFFVVALMFILAACKSDPLTLKFSGETMGTTYNIVAIDKTAD
                     LSPETLQADITAALAKVNSQMSNWDPNSEISQFNSAPTTDPVAISPELARVVAAANEI
                     HRKSEGLFDVTLGPLIEIWGFGARTADSPVPADEEIAAALKVVGQGKILSLSQDDLTL
                     RKNLPETSVYLAAIAKGYGVDQVAAVLAEAGITDYMVEIGGDLVTAGLNPNGEAWRIG
                     IERPDSASQTIEEIVDVSGLGMATSGDYRNYFEQDGTRYSHIIDGVTGRPITHGTASV
                     TVLAENAMMADGWATALLALGQERGLKIAEAEGLAVLFIARQPDSGETGFETTTSTQF
                     SKLQSKQ"
     gene            283166..283414
                     /locus_tag="MED193_01315"
     CDS             283166..283414
                     /locus_tag="MED193_01315"
                     /note="COG2991 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MATFLFTFGFLALIMLGMSLGVLLMGKTIKGSCGGLNAISGADK
                     CVVCSKDIDPDSPLRDKLQCKRARKMVEQMEAEMRAES"
     gene            283632..284090
                     /locus_tag="MED193_01320"
     CDS             283632..284090
                     /locus_tag="MED193_01320"
                     /note="COG0665 Glycine/D-amino acid oxidases
                     (deaminating)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10534"
                     /translation="MTTNRLAATAPASSDRRDIYWCDGLPAAPATPRDPLPQVDVAII
                     GSGYTGLNAALVTARAGRSTLVLDAGAPGWGCSTKNGGQISTSIKPTLKMLTSRYGAQ
                     KARAIRQEGIDALNWIDGFIQSEALDCDFARCGRYQAAHSPKHFDALLMF"
     gene            284174..284278
                     /locus_tag="MED193_01325"
     CDS             284174..284278
                     /locus_tag="MED193_01325"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MVFPHHASLDPAKYHRALLNTAIEAGVHVTGNCA"
     gene            complement(284396..284578)
                     /locus_tag="MED193_01330"
     CDS             complement(284396..284578)
                     /locus_tag="MED193_01330"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLASQITLTPLIATILIFLAVLAGNRYRRVWKAEGPRWQLWLFG
                     LIAAASLLTLAFVPMP"
     gene            284702..285223
                     /locus_tag="MED193_01335"
     CDS             284702..285223
                     /locus_tag="MED193_01335"
                     /note="COG0517 FOG: CBS domain"
                     /codon_start=1
                     /transl_table=11
                     /product="CBS domain protein"
                     /db_xref="CDD:10388"
                     /translation="MPSSYQAPSRGDQAKKTTHSQSAQSNISHETAIVGQLISKKGGT
                     TYTITSSDTLSTAVTVLRDRRIGALLVTGEGGALEGILSERDIVRKLAETPGQTLPQT
                     VGENMTSKVETCSPSDPLVAVLRRMNEGRFRHMPVVDDGKLCGMLTIGDVVNYRLNEL
                     EYEALQLKQMIVG"
     gene            complement(285273..286067)
                     /locus_tag="MED193_01340"
     CDS             complement(285273..286067)
                     /locus_tag="MED193_01340"
                     /note="COG1414 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="regulatory protein, IclR"
                     /db_xref="CDD:11129"
                     /translation="MPDLKDDKRFANTLARGLNVLRAFGPNDDGLGNLEISERTGLPR
                     STVSRLTFTLCALGYLTHGHHHDKYRLGPAALALGNIAGASFGFVETAGPIMQKLADA
                     TKTLIGVAIQDDGKMLIVKTWRPRNSTTTWLNVGYRMPMLQSSSGAAFLGALARSELA
                     KLTQAMSAEDQALYQDFGGKAQSSLLSDGYAFVRGEQRFNATINAIAAPYRPSEFGEP
                     VAFLSGARKSDLTDEQVTESVGPALVTAVQELLHITGRRFPIMSDD"
     gene            complement(286135..287475)
                     /locus_tag="MED193_01345"
     CDS             complement(286135..287475)
                     /locus_tag="MED193_01345"
                     /note="COG1593 TRAP-type C4-dicarboxylate transport
                     system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter, DctM subunit"
                     /db_xref="CDD:11306"
                     /translation="MDPATIGLVAFGLMLVLLAMRVPIAFALIGVATLAAFTIFAFRT
                     GTFMPERAIRATSSLVFSNSFDLVHSFDLSMIPLFVALGNIAYRAGITTAVYNSAKVW
                     LVRQRGGLAVASVMGCGGFSAITGSSLACASTMGKICTPEMLRLGYDPRLATASVAAG
                     GTLGSLIPPSILFIIYAIFTETSVSKLFLAGVLPGLLTLAGFVLVIWVWIRVNPKLVP
                     EQGAAASWSEKMAAVREAWPAALIFLIIVIGIYGGFFTATAAAAVSVVVTTLIGFAQR
                     RLTLQGLWEAVRETCVQTSAIFVVAAGAKIFVAAIALTGMAPALVQSVADAQLSPVVL
                     LICICAVYLMLGMFLDPIGIMVLTLPLVVPLVESYGMNLIWFGVVVVKLLEIGLITPP
                     VGLNVFVLSNVVGKAAPIGTVFAGIWRFLCVDVVVLALIVGFPSISLVLSMTAK"
     gene            complement(287595..288098)
                     /locus_tag="MED193_01350"
     CDS             complement(287595..288098)
                     /locus_tag="MED193_01350"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:9849"
                     /translation="MLDRIEKLFIDVATAAIILLALMIFADVVALNLFKASVPDAVII
                     VRELMVLAIIMPLAAATTQRAHISVEFLTNMLPPKVVEYFVVFGTLFGVFALSPLIYS
                     GAKELMHQINTGSAFYGDLNLPQWPGRLAFVIGISLCWLRLLIMALGDMRTVWRGKTL
                     NFEPTGH"
     gene            complement(288184..289248)
                     /locus_tag="MED193_01355"
     CDS             complement(288184..289248)
                     /locus_tag="MED193_01355"
                     /note="COG1638 TRAP-type C4-dicarboxylate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter, DctP subunit,
                     putative"
                     /db_xref="CDD:11350"
                     /translation="MSVIKTTLGAAAVALSFGTVAAAQTTIFYGHSGPARGTVPAALK
                     WFDGRIGELSEGDLKLDVQWGGALFKASASVQSIGDGVADAGSIISAYFQKEMAAYSL
                     ADLPLGGPNPWVGLRATDHLMRTMPEITENLARQNLVYIGTFTASDVNVACKGAEINS
                     IQDIAGLKVRGAGVYGKVFGELGATMVNLSVYDAYQGLDTGLIDCTQGYSYIIPALKW
                     HEVIDSYTVLNWGQIGGYGMFMNKQSYDALSDEQKAVMTQAGTELADKFAQIVIGANS
                     KALNAMRADEYERPVKVLEVSAEERAALNAATEPFLADWKENAASVGLNPDKMIEVYT
                     QAVADYTAEFEAKGYPWERN"
     gene            complement(289328..290791)
                     /locus_tag="MED193_01360"
     CDS             complement(289328..290791)
                     /locus_tag="MED193_01360"
                     /note="COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid
                     ligases II"
                     /codon_start=1
                     /transl_table=11
                     /product="long-chain-fatty-acid--CoA ligase, putative"
                     /db_xref="CDD:10192"
                     /translation="MIDYADGKFTWSDLAEATAAAREVLLAQGVKPGDRVVMVFENCL
                     AVCAFIFATSQLDAISVPLNARLTHAELDRLITHSDPSVVVFCNDASESAVIHGKAFS
                     AKAAIGRYGTVGLFQRRGSQPEPCFEDGAEQVALLLYTSGTTGVPKAAMLTHNNLLCA
                     AVASAKVRGMQDDDMTYLALPLSHIFGFVTFVSICGAQGAMRLEARFAVERLYKALQM
                     DVTLLPAVPQMHALLFHYARAQKNPRYDVGLLRFVSSGGAPLDPVWKREAEAFYGIPL
                     QNGYGLTEGTAGVCATASPLGDPDVSVGHPMQDSLFRLDFEAEGATPDEGIGEILVGG
                     PQIMNGYFRDPEQSAKVLTEDGFFRTGDLGRFDDAGRLHIVGRSKELIIRSGFNVYPV
                     EVEGALTDHPEVIMAGVVGRQVSGNEEVLAFVKVAADCSLSEADLSAFVKDKLAPYKR
                     PTRIVLAQDLPAAPTGKILKAKLISTFADQLMPETTH"
     gene            291236..292321
                     /locus_tag="MED193_01365"
     CDS             291236..292321
                     /locus_tag="MED193_01365"
                     /note="COG4663 TRAP-type mannitol/chloroaromatic compound
                     transport system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="TRAP dicarboxylate transporter- DctP subunit"
                     /db_xref="CDD:13806"
                     /translation="MKRRDFIKIGAAGAAASSLAAPATAQGIRQWNMVTAWPKNLPGP
                     GVAAQMLADRITTLSGGRIEVKLHAAGELVPGRGVFDAVSEGTAELYHAVPAYWGSKS
                     KGMLLFGSQPFGLRADEQFGWLYHGGGQALYDEIYGRFNLKPFLCGNSGPQWQGWFRD
                     EIHSLDDLKGLKFRTTGLASEMCSKIGMAVQAMGPRDMFQALQTGALDAGEFIGPWTD
                     SAVGFYQVAKNYYWPGVGEPSSAEECAVNATAYAELPDDLKQAVSFACESLYNPVWTE
                     YTTKHAQALKQMVENEGVQVKMLPDDVVAAMAAAAAEVMAELAEDEDELVRRITASFT
                     AYRDSVGSYMSYADNGQMNARAKALGY"
     gene            292349..292894
                     /locus_tag="MED193_01370"
     CDS             292349..292894
                     /locus_tag="MED193_01370"
                     /note="COG4665 TRAP-type mannitol/chloroaromatic compound
                     transport system, small permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="Tripartite ATP-independent periplasmic
                     transporter, DctQ component"
                     /db_xref="CDD:13808"
                     /translation="MRGLSRRFSGFEAQMQRILSVLDGISRTTGNLVRWLALAMLLAQ
                     FLIVIARYVFGYSSIAAQESVLYMHATLFMLGAGYTLLNDGHVRVDIFYDRLSTSGKN
                     RIDLAGHLLLLMPAMVMVIYWSWPAVTNAWKILEGPISVGGIKAVFLLKSLIPAFCIL
                     VLLQSLSCVLRILFQSETRDG"
     gene            292887..294437
                     /locus_tag="MED193_01375"
     CDS             292887..294437
                     /locus_tag="MED193_01375"
                     /note="COG4664 TRAP-type mannitol/chloroaromatic compound
                     transport system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical permease component of C4
                     dicarboxylatetransporter"
                     /db_xref="CDD:13807"
                     /translation="MAEYLDILMFGALVVAILSGFPVAFSIAGTAILFAILGWSLGVM
                     NINLLGAMSQRIFGLLTNNVLIAIPLFVLMGAILEKSRIAEDMLDTMGRSFGQLRGGL
                     GISVILVGMLLAASTGIVGATVVAMGMIALPTMLRAGYDPRVASGLVCSAGTLGQIIP
                     PSTLLIILSDVVSNAYQQAQYEQGKFTIDTISVGQIFASALLPGLTLVGLYILYVLLR
                     GWIRPQDMPPAPADMARPPLSEVAKAILPAILLILAVLGAILSGIASPTEAASVGGIG
                     AALMAAVKSGANRRVILIGTLSLVLLAIGAGLFPVRLQRSDLGLGSYALGAVYVGLTV
                     AGLVAIALALRSMVTQKVLQPTLNSTLTMTAMIFATILSAGIFSLVFIGLGGEDRVQE
                     LLAAMPGGATGALIFSMLFIFVLGFFLDFVEISVIVLPLVMPTLIIMGHDPVWLSVLI
                     AINLQTSFLTPPFGFSLFYLRGAAPKEISTGQIYAGVTPFILIQIIAVALIWFLPEIA
                     TYLPSVMF"
     gene            complement(294495..295679)
                     /locus_tag="MED193_01380"
     CDS             complement(294495..295679)
                     /locus_tag="MED193_01380"
                     /note="COG2951 Membrane-bound lytic murein
                     transglycosylase B"
                     /codon_start=1
                     /transl_table=11
                     /product="peptidoglycan-binding protein, putative"
                     /db_xref="CDD:12298"
                     /translation="MSFSKKVTTQVSRRAFGFGFAAFGLVACGNVTSANQRVNSASRP
                     VAKPGLPADLQPTPNAGYDKWVEGFYTRAQAKGITEATLRTGFRNAGYLPGVVKRDRN
                     QTEFKRTLEDYLSIAVSDERVSKGRAAYQKHRKTLLALEAKYGVDASIIAAIWGLESF
                     YGERRGDLPVVSATSTLAYDGRRGAFFEKQLIAALKILQNGDISANKMTGSWAGAMGH
                     TQFIPTSYQAFAVDFTGDGRRDIWSEDPTDALASTAAYLARNGWTRGQSWGREVTGAA
                     AAGALQPQAGGPSFAVTGNFKAIKRYNNSDAYAIGVGHLADRIAGGPPLRGKFPPDAN
                     GLTKDDRVALQTRLTAKGFDTGGADGVLGPKSQAAISAYQTSIGQPATGTPSQDLLRS
                     LK"
     gene            295861..297261
                     /locus_tag="MED193_01385"
     CDS             295861..297261
                     /locus_tag="MED193_01385"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKNEEQTMTGEYIIRGLPASLERDGWWLSCDSADEAPTDSPTEQ
                     RNWADLSRKGSSGLLALVVLVALADWLFWGYAPGISVALFSWALFGAAALLSTPNMRH
                     IKPALLFLLLTSLPVIEHYQALSMGFQLLGLITAVAWLQLSSKDHLATLPAAAMQLLR
                     ALPLSALRAFLKALLPSPIDTGAKDTQKSKKSTPTKAAKPEERRSFSFGLNAGSVLRA
                     LVMFNLILAVQSVMDLSILIGGAALPEGMSLATYAHRGAYPLLATAMLAGGFALAARP
                     YLGSHASLKPLMMLWLGQNALLGLSSVLRLDLYVASFGLTYLRLYAMIWIGLVVVGLM
                     LTAWQILKVRSNRWLLLRCAGLGLGTLYICAFVNFASVIATQNLSMKSTQMLDLYYLC
                     TLGPNASGGIHTALQANPDLKIPSGYHSCWEISAEQDNWREWGFRSWRVSSYAGLNFD
                     GASADKAKSDENPIGR"
     gene            297239..297913
                     /locus_tag="MED193_01390"
     CDS             297239..297913
                     /locus_tag="MED193_01390"
                     /note="COG0745 Response regulators consisting of a
                     CheY-like receiver domain and a winged-helix DNA-binding
                     domain"
                     /codon_start=1
                     /transl_table=11
                     /product="two-component response regulator"
                     /db_xref="CDD:10613"
                     /translation="MKILLVDDDPRLRDLVRIALERAGWQVVTAADGQEALLHASRED
                     PDFIVLDIGLPELDGFEVCRRIRQRSEVPILFLTARDDEVDCILGLELGADDYVTKPF
                     SPRELVARIRTIMKRSQKAQASTSLTHGELSLDPRAHRCQINGQEIALTAREQGILAL
                     LLQDPAQIRSRAELISQIWGAGSQVSDRTLDSHLRNLRAKLEQAGGNDLIETVHAVGI
                     RLRGLS"
     gene            297913..298908
                     /locus_tag="MED193_01395"
     CDS             297913..298908
                     /locus_tag="MED193_01395"
                     /note="COG0642 Signal transduction histidine kinase"
                     /codon_start=1
                     /transl_table=11
                     /product="two-component hybrid sensor and regulator"
                     /db_xref="CDD:10512"
                     /translation="MRAQLVQKWRPSLALVLGGGLAGTLVLSLIGLVALRYLGPEIGF
                     RNAAALLGSLILLATAFLGWLLVRLLLSPIRALNAYAAQTRSQPGQTLDPPDQSGTAE
                     LHEMARNVVDMADHLRNREMTIRSFTDHVSHEIKTPVSAIRAASELIEDSGTLAPDDQ
                     KLLAQIDGAARQIEDQLTALREVARAREMTHQGSARLDTLRTWLREDFADLGLSFSGA
                     ALSLPIGESGLRVILTQLLNNAREQGAQSVVIAAQGSPSGLELSVSDDGKGISPGNAA
                     QIFDPFFTTKRDQGGTGMGLTILRNMLSVHGGEISLRPGESGACFVVAFTPVPTR"
     gene            298992..300233
                     /locus_tag="MED193_01400"
     CDS             298992..300233
                     /locus_tag="MED193_01400"
                     /note="COG2951 Membrane-bound lytic murein
                     transglycosylase B"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical transglycosylase"
                     /db_xref="CDD:12298"
                     /translation="MVTRFLILLMALWLLPLPAPAQNRAKVERQFQNWLQQEIWPEAK
                     AAGVSRKTFKSAFSGVALDWDLPDLVPPGSTPQVPRQQRQAEFGVPAKYFNRGGLNGA
                     TSTGRQMLQRHADTLARVEAKTGVPGRIVIAIWGRESAHGRAKIPHNVFRVLGTKAFM
                     STRADYFSQELIAALQIAQAGHVQASTMKSSWAGALGQPQFMPSSFLKYAADGTGDGR
                     ADIWGSEADTLMSIGHFLAEHGWQKGRDWGFEVKVPASVSCSLEGPDQGRSIADWEAL
                     GITRVSGRPFPAAERPGQGFLMMPAGRYGPAFIVTPNFYVLKDYNKSDLYALFVGHVG
                     DRIQYGVGDFTAPWQGLDKLYRSEVAAMQRGLEALDHDVGGADGLVGFKTRRSIGLWQ
                     ESQGKEPRCFPDSSIKSLTSN"
     gene            300347..301360
                     /locus_tag="MED193_01405"
     CDS             300347..301360
                     /locus_tag="MED193_01405"
                     /note="COG0451 Nucleoside-diphosphate-sugar epimerases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23188"
                     /translation="MKRVLVTGTAGFIGFHLAKLLLDEGFRVHGFDGMTEYYDVALKQ
                     RRHAMLLQHPNFSATEAMLEDTQAFDAMADEFAPQVIIHLAGQAGVRYSLENPRSYLE
                     TNVMGTFNVMEAARRLKVEHLLMASSSSVYGGNDVMPFTELDRTDAPLTIYAASKKAN
                     ESMGHSYAHLWDLPTTMFRFFTVYGPWGRPDLAFYKFGDAILEERPIDIYNHGEMYRD
                     FTYVDDLVRGIRLLIDVVPQRPASKEEIEEGDSLSPVAPYRVVNIGNSEKVRLLDFID
                     AIEISLGKKAIRNYMEMQIGDVPATWADATLLKKLTGYQPQTNFREGIDRFVTWFRDY
                     YQK"
     gene            complement(301391..302458)
                     /locus_tag="MED193_01410"
     CDS             complement(301391..302458)
                     /locus_tag="MED193_01410"
                     /note="COG1475 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="ParB-like nuclease"
                     /db_xref="CDD:2710"
                     /translation="MAKRRRLIAPDASELQELEEGFATKPSANPFETKSAVPPIAQVA
                     AEAASLNSMAGVTDRVALAHDQSDAARWRAAEKDGLVVQMLALSDIDQDFIRRDRLVE
                     DAEAMAELQASIKENGLRAPIEVAKTSTGYGLISGFRRLQAYRALAGGDERFAQIPAF
                     VREADAGQAAYVSMVEENEVRANLSHYERGRIAVLAKGQEVFPSIEAAVDALFAAASK
                     AKRSKVRSFALVHEALGDLLQYPTGLTEKAGLALATALRDGRQGQLRAALAEAKSQDA
                     KSEWALLQKTLKDASAAPRDRSRGGRPQEITRLPSRDLPKGGALSAEVSSDGLRIELK
                     GRVINADTAEQILKLIARQIG"
     gene            complement(302451..303836)
                     /locus_tag="MED193_01415"
     CDS             complement(302451..303836)
                     /locus_tag="MED193_01415"
                     /note="COG1192 ATPases involved in chromosome
                     partitioning"
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family ATPase"
                     /db_xref="CDD:10910"
                     /translation="MSKPTSPALPPYLNLDPEAAAKKLPPPIGTARFAKAAAFCTKGR
                     EDLARRGYAPDGQKRLRKFSTWEITKYLIPVAPAHLRRVLKANPDLPQGEGEGGSKWF
                     TLEEVLALRQHFDSEGVSTKEYVPYRPKGLPAKVVSVANFKGGVGKTSTAAHLAMSAA
                     LDGYKVLVIDLDSQGSMTSIMGGKVADEWQTVFPLVAKDYAKAVTAENEVRAAAGQPE
                     IPLDETLQEALKTTPQDVIQKTHWPNIDLIGAQLNLYWAEFQIPVWRMGLRSWPLWDG
                     LTNFLQDEDILEQYDVVFLDTPPALGYLTINALAAADILLVPLGASYLEFDSTGRFFD
                     MLYTTFASIEDGENSAQRAAGLPEIKFEWDVVRAIVTRFDASQQTDMANVIQAYFGDF
                     MNAYRQDYTALVGQAGEQVNGIYEADYRDFNRDTYVRGRETFDRTYAEFKELLIGCWW
                     RDANMGDEQNG"
     gene            304435..305697
                     /locus_tag="MED193_01420"
     CDS             304435..305697
                     /locus_tag="MED193_01420"
                     /note="COG5527 Protein involved in initiation of plasmid
                     replication"
                     /codon_start=1
                     /transl_table=11
                     /product="Plasmid replication initiation protein"
                     /db_xref="CDD:25678"
                     /translation="MSDSQIDMDSLSGPLRRETVKKNVAAIHISGKLSLLQRKLSNVL
                     LLNAYDALTTAQSHTIDARTLATIVGYNSNDFDTLRASLRALAETVAEWDMLDEKGRQ
                     EWGVSSLLSFAKLKNGVCEYAYSPALAQKLHDPKIYALINVHIQRNFSSGHGLALYEN
                     CYRFVRTRSTGWWSLETFRKLMGVDGSSYYESFKHLNAKIIKPAVAEVNKSSDIIITP
                     EFQKKGRAVTEIRFLIKSNPQMAMFQIDDSDGMRNLSTYKALRGQGVSDRLARQWITE
                     HGEDYVKQKLSLMGEQAQVKSSVGYLSAALRDDYQPQKTPAKVEPSPEAIEAARLRDQ
                     QRAQEEAEYAARQAERAGRARLLDLVEDLVSRRNPTQRDADKQLFMASLDEDLERENF
                     RAHGWRSALNASAIIAFWQEMEPEAFEV"
     gene            305911..306093
                     /locus_tag="MED193_01425"
     CDS             305911..306093
                     /locus_tag="MED193_01425"
                     /EC_number="1.2.7.8"
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate ferredoxin oxidoreductase"
                     /translation="MKHVPKETTDDALIQEFLNKGGTVSVGKTKPMPSELGLSNNVWN
                     NKMTKEEKAARDGPKK"
     gene            complement(306162..307337)
                     /locus_tag="MED193_01430"
     CDS             complement(306162..307337)
                     /locus_tag="MED193_01430"
                     /note="COG1014 Pyruvate:ferredoxin oxidoreductase and
                     related 2-oxoacid:ferredoxin oxidoreductases, gamma
                     subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="indolepyruvate oxidoreductase, IorB subunit,
                     putative"
                     /translation="MAPGDGIASSDEVRAAAEIAADHLILFDMDRLAVENGSVISSAL
                     FGALAGSGALPFPRAAFEEAIRASGKGVEASLRAFGAAYARAQAKSDETAPSRPVAPI
                     TQTQPAQGPARQVQHWQELAAQAEALPGADMALRGLRRVVAFQDLAYGREYLSHLTAF
                     ARQDSGDGRLAEAAAKHIANAMCYDDIIRVADLKTRKSRFDRIQTEMKAEEKPVLLTE
                     FFHPRGEEIISLLPARLGAWIESRPKLAAWIDRRLNKGRRIRTHRLRGFVLLYLIAGL
                     RRTRRYSLRHKIEQAHLQNWLSLCQQTLPQKYDLAIEILLCRRLIKGYSDTHSRGLSK
                     FSRIMETLPLLAHRDDAAEWVARLRTAALQDAEGKDLEGAIETVISFSSTVPATPPP"
     gene            307362..309944
                     /locus_tag="MED193_01435"
     CDS             307362..309944
                     /locus_tag="MED193_01435"
                     /note="COG1020 Non-ribosomal peptide synthetase modules
                     and related proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="non-ribosomal peptide synthetase"
                     /db_xref="CDD:25528"
                     /translation="MAGGNQGGAVRRDKATHDGAAAGQNIAIFAPRGAAQVLAMAAVL
                     ECGGVLMTLDPDLPEDRRAVMLEQGRVKRILYGGGLTASQMNWLKGLELPRLPITQAV
                     SRREVQTFSANRFAPPCGARDPAYLVFTSGSTGTPKAILGTAGGLAHFLSWQRDSFEI
                     GPGDRAAQFTGLSFDVLLRDVFVPLISGATLVIPPEGTGPAQPGALGWMDQAEITLLH
                     SVPSLLQSWVSTELSVSKLPHLRLAFIAGEPLEGALLRRWRHRFGQAVRLVNLYGPTE
                     TTLAKFAFEPGPDVFEAGQPVGYALPQTRAVIVTARGKPAASGELGEIAIATPFMSLG
                     YVNDPSLTKARFIPSPDAGDRDRGKEDFIYLTGDLGWLDPAGRLHVAGRIDDQVKIRG
                     IRVEPLEISALLEQHPAVAASAVVARRNAAGEMELDAYYVMAHANLNNTQTTEPQMRA
                     QLRSYLRARLPAALVPNGPLLLPELPLTPNHKLDRRQLPPIVPLQNSPSGQAPSSAVE
                     GQMLQIWEEVLEKSDLGVNDDFFDVGGHSLLALRLVLLIEQRMGVKIPLAELFKSATI
                     AHLAEVAQTRETGDGLVPLWLRGEGPPLWIVHTGGGMLWNYQPLVRALAADFPIYGFE
                     AKGLFDGAEPQDSIAAMASSFIQNMRHHQPQGPYRLAGHSFGGLVAWEMACQLQAAGE
                     EVSGVYLFDSSLTRPDDAWHADHSAARVAARDLSVAVQVYARFTQSDLSLEEGALSDL
                     SLEEQLGRAADVMAASIGSKPAARKLVEGVLRISNSHRAARLAYHPGRHTAPVVLFQA
                     EDDRKADPDWAQFWRETAGGAFETQVVPGDHVTMMAQPHVEVLAQALKASLDQREVSR
                     SSAV"
     gene            complement(309933..311651)
                     /locus_tag="MED193_01440"
     CDS             complement(309933..311651)
                     /locus_tag="MED193_01440"
                     /note="COG1524 Uncharacterized proteins of the AP
                     superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="putative alkaline phosphatase"
                     /db_xref="CDD:11238"
                     /translation="MRLIFLVSLLLGTSTLLSAQGRDLPPKLIVQITVDQLRADLLLR
                     YSTGFTEGGFQRLMTKGTWFRDAEHRHANTETVVGHTTLSTGADPAVHGLIGNNYLDT
                     QLPSSDVNTTGSDTQGIVLDVSDALHFATQDSSAPLLYPDGSLSAPEAGRSPRDLLVT
                     TIGDEIRLSRGAKAKIFGVSMKDRAAIGATGHAGTAYWYNTEKSTFLSSTFYVEAYPQ
                     WHQNWTDRQLPESYAGSGWELLYDIANYVFAAFDDQPWEKDYPGWGITFPEHQYPDPS
                     DGFYQAFLETSPAADELTLSFAKALIAGEQLGTDEVTDYLAVSLNSVDYVGHTFGPSS
                     LEAEDTLKRLDAQLAAFFDHLERVVGLENTLVVLSADHGATEVPDYMNARLRTNLDLF
                     DYDQVEQAPAIQAFKAKYGINDPISSYTSPWIYLDHDLLRFTRAGAAEAEALIIATLR
                     GLPGLAWVFERDHIAQGSLPDTHIGRAVTANFMPSRSGDLYPILSPGWFMKDPDPLAG
                     ASQHGSPYAYDRHVPIFFMGPGIPAQVVHRKVQTVDVAPTIAGYAGTRLPSGTTGRML
                     PEILDR"
     gene            complement(311881..312537)
                     /locus_tag="MED193_01445"
     CDS             complement(311881..312537)
                     /locus_tag="MED193_01445"
                     /note="COG1802 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="regulatory protein GntR, HTH:GntR, C-terminal"
                     /db_xref="CDD:11512"
                     /translation="MEKRHADLIAEQLEERIFDGTHSDGDRLDEVRLAEHFGVSRTPL
                     REALQRLARSGLVELIPRRGAFVRQPGPVELLEMFEVMAEMEAACGRLAAKRISDAAL
                     AELHSANEKCQAAVSAQNTDDYYAENEKFHKIIYQEAGNGFLAKETGNLHRRLQPFRR
                     QQLRFRGRMAQSMSEHKAILEALEAGDSEAAAHALRGHVAIQGEKFHSLMAGLKNAAE
                     "
     gene            312643..313662
                     /locus_tag="MED193_01450"
     CDS             312643..313662
                     /locus_tag="MED193_01450"
                     /note="COG1638 TRAP-type C4-dicarboxylate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11350"
                     /translation="MFRVGFFWEEDMTSILKTAVATLALASFGTLAGATELRLSHQWS
                     TKDIRHQVAQIVADEVAAADVDLDIKIFGSKSLFKPREQYKPLSRGQLDMTVLPLSYA
                     GGQQPAYNLTLMPGLVKNHDHAARLSNSPFMEALEAKMAEDDVMVLVHGYLAGGFAGK
                     DKCITSPEDVKGLQTRAAGKSFEQMLAGADASIASMASSEIYNAMQTGVLQAANTSSS
                     SFVSYRIYEQVSCYTPAGDVALWFMYQPLLMNKRTFEGLNEAQQNALLAASEKAEAYY
                     LEEARKQDAASAKVFADAGVEIAHMSSEDFAAWRQLAMETSYQKFVEEVADGQELLDL
                     ALAVE"
     gene            313666..314292
                     /locus_tag="MED193_01455"
     CDS             313666..314292
                     /locus_tag="MED193_01455"
                     /note="COG3090 TRAP-type C4-dicarboxylate transport
                     system, small permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12429"
                     /translation="MGGAGFVSRALPPLFLFLHSYQQEVQMAGHSSAVASHTGNNLFL
                     RVVAALSTVAGWCSAAMIVSAVAITCQMIVVRFVLNKSTIWQTEAVIYLVIAATLIGL
                     PYVQRLRGHVNVDLIPISLPPRPRFFMAIVTSLLSITIVSIMLFYGYEYWHFAWQRGW
                     KSDTVWGVRLWIPYLAIPVGFGLLLLQLIADLFAVLIGIDKPFGLEDT"
     gene            314293..315609
                     /locus_tag="MED193_01460"
     CDS             314293..315609
                     /locus_tag="MED193_01460"
                     /note="COG1593 TRAP-type C4-dicarboxylate transport
                     system, large permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11306"
                     /translation="MDPLLLGAIVAIATILVLFSGVSVALGLLIVSAAFLLIFDGARS
                     LELMPELLFGKLDNFALLSIPMFIIMGSSIASTRAGADLYEALERWLTRVPGGLVVSN
                     LGACALFAAMSGSSPATCAAIGKMGIPEMRKRGYPDGVAAGSIAAGGTLGILIPPSVT
                     MIVYGIATETSIGRLFLAGVIPGLMLVGLFMAWSLYSTWKSGNAAQLGAGSYTWAERF
                     EILPRVLPFLGIILGVLYAMYGGIATPSETAAVGALLCLLIAMVIYKLWNPKDLWVVL
                     RDSTKESVMILFIIAAAGVFSYMLSSLFITQSIAEWIGTLEVNRWVLMGVVNVFLLIA
                     GFFLPPVAVILMAAPILLPIIDTAGFDPIWFAVVLTINMEIGLISPPVGLNLYVINGI
                     APDISLKTILTGSLPFVGCMVLAIVLLCLFPSLATWLPDLVMGATR"
     gene            315606..316877
                     /locus_tag="MED193_01465"
     CDS             315606..316877
                     /locus_tag="MED193_01465"
                     /codon_start=1
                     /transl_table=11
                     /product="putative decarboxylase"
                     /db_xref="CDD:17669"
                     /translation="MTLLADLLSTVFERRYRRDASELVEDGRPLIELATDLVGSTGET
                     SGLALARQILSRFADLDDAQKLSFFCDIATTMNIDPEEVRSALDAYEQAPSKATYRAF
                     SEAAEPARQELVRRLNSVPGATGALVNMRADLLRLGRRDPELEALDLDFRHLFASWFN
                     RGFLVLRPINWESPAHILEKIIAYEAVHAIDSWEDLRRRLEPADRRCFAFFHPSMPDE
                     PLIFVEVALTRGIPGSVQALLAEDRDAMAAGDADTAVFYSISNCQAGLASISFGNSLI
                     KQVASDLSAELSKLNTFVTLSPIPGLTKWLDQVGLSWDVEAPEAMQALAAHYLLNAKS
                     RGTLPFDPVARFHLGNGAIVHAVHADADTSEKGRSQSGGTMVNYLYDLSKVGQNHENF
                     ATTREVVAASPVKALAASVAVPTTQERTSHG"
     gene            316870..318381
                     /locus_tag="MED193_01470"
     CDS             316870..318381
                     /locus_tag="MED193_01470"
                     /note="COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid
                     ligases II"
                     /codon_start=1
                     /transl_table=11
                     /product="malonyl-CoA synthase"
                     /db_xref="CDD:10192"
                     /translation="MANPLYDGLFGIHAEKTTAFLYLPNGQVITHRDFLAKSAQIAHV
                     TAQIGLKPGDRVAVQVEKSAEALALYAACAQAGLVFLPLNTAYTVDELSYFIENSGAS
                     LIVCDGGSADQLGIVAKDLNAKIETLNSDGGGSLMEQAREMATSFATVERDGDDLAAF
                     LYTSGTTGRSKGAMLTQNNLLSNAQTLVEEWRFTSADVLLHALPIFHTHGLFVATNVT
                     LAAGGSMIFLPKFDLDQVLDRLPEATTMMGVPTFYTRLLGDARFTKELSAHMRLFVSG
                     SAPLLAETHVQFEHRTGHRILERYGMTETNMNTSNPYEGERRAGTVGFPLPGVEVRIC
                     DAEGTAMPQGEIGEIEVRGPNVFRGYWQMPEKTAAELRENGFFITGDLGRIDQDGYVQ
                     IVGRNKDLIISGGYNIYPKEIELVLDDQPGVLESAVIGVPHPDFGETVLGVIVPENGV
                     TPDVESIEKAVSQSLARFKHPRKLVMLEELPRNTMGKVQKNILREQYQGMFTS"
     gene            318801..319985
                     /locus_tag="MED193_01475"
     CDS             318801..319985
                     /locus_tag="MED193_01475"
                     /note="COG0436 Aspartate/tyrosine/aromatic
                     aminotransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate aminotransferase, putative"
                     /db_xref="CDD:10310"
                     /translation="MKTTDVTKRLASFGGAKWDLHLAARDRIAAGADIVEMTIGEPDV
                     PVPAELMERSISSMRAGRTGYSDGRGEINLRRALAESYSASRGREFEPDNFLCFPGTQ
                     TALFAAMMGVAQHGDEVLVGDPMYATYEGVVAATGATLVPVPLSPENGFRMQAADVAD
                     RITPRTRALLLTSPHNPTGAILGRSELLELCELARVHDFWIISDEVYEQLVFEGSEFA
                     SPLSLAEYADRVIAVSSISKSHASPGFRSGWCVGSKAFCDALLPFSETMLFGNQPFIA
                     DMTELAIREGSSVSAGMCARFSRRARLLSERVEAETALQVHRPEAGMFAMINVAATGM
                     TGDDYAWDLLDHGVAVMPGSAFSESLTSWVRVALTIDDAEFETALTRLISHAQKLAKG
                     AA"
     gene            319982..321589
                     /locus_tag="MED193_01480"
     CDS             319982..321589
                     /locus_tag="MED193_01480"
                     /note="COG0028 Thiamine pyrophosphate-requiring enzymes
                     [acetolactate synthase, pyruvate dehydrogenase
                     (cytochrome), glyoxylate carboligase, phosphonopyruvate
                     decarboxylase]"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:9904"
                     /translation="MSEAVKTIGEALVDGLKAREVSCVFGIPGVHTVELYRGVAASGL
                     RHVTPRHEQGAGFMADGYARVSGKPGVAFVITGPGLTNVLTPMAQARADSVPMLVVSG
                     VNAQASLGKGMGHLHELPNQHALAQTVALTSEHIAKAEALDPALNKAFAPFTSGRPGP
                     THIQIPLDVAGDAATDLSMPAVAEPAPVKAAQLQEAARLLAQAKHPVILAGGGAKRAA
                     EALQALAERLDAPVVQTANGRGLMHQHALGVPASPSLVSVRALIEGADVVLALGTEFG
                     PTDYDMYATGEWPQIQQLIRVDICDQQLSRHPALVPVQADAVAFATDLLAVLPADCAG
                     TDGEIRAAETRAAALQEIGADYRGQVAVLGAMRDAVPGSLMVGDSTQPIYAGNLYYDH
                     DRPGGWFNAATGYGALGYGIPAAIGAAIAAPDTPVICIVGDGGAQFSLPEIMTAVDEN
                     LSITFVIWNNQGYREIATSMEDVGVEVIGCDPTPPSFAGTAQSFGIPHVTVTTDPAEI
                     SAAITKNQGQGPRIVEITAPVFAPAKD"
     gene            321594..322376
                     /locus_tag="MED193_01485"
     CDS             321594..322376
                     /locus_tag="MED193_01485"
                     /note="COG1834 N-Dimethylarginine dimethylaminohydrolase"
                     /codon_start=1
                     /transl_table=11
                     /product="NG,NG-dimethylarginine dimethylaminohydrolase,
                     putative"
                     /db_xref="CDD:11544"
                     /translation="MKNPSFEFSRAITRRPASSIVDGLRATDMGTPSLTGMLAAHAQY
                     VAALKSTGAEVIELEPLEAFPDAVFVEDTALCLPQGAVLMRPGAPSRMGEVAEMAPTL
                     RQCYADVREISGPGHIEGGDILVTGREVLVGRSDRTDAAGVAELAEIVAEWGHSLREV
                     FTPPGVLHFKTDCSLMDGETILSTKRLSASGCFEGYRILDVAEGEEAAANAIRFNNLV
                     LCPAGFPRTVEMLDKAGFEVVQIDNADCAKLDGGMSCLSLRF"
     gene            complement(322401..323357)
                     /locus_tag="MED193_01490"
     CDS             complement(322401..323357)
                     /locus_tag="MED193_01490"
                     /note="COG1737 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain protein"
                     /db_xref="CDD:11448"
                     /translation="MFWISHEEIICFYHTMDPHLDPKQTARLIAALKDQIVQMPTKLA
                     QAAKYIIDNPGSFALDPVRDTARKAQISANSFVRLADRLGYDSFEALRRPFRDALITT
                     NESNLGADWIAQMAEAGPTAAQQARMVQSELNMVSRSLRQMGADRTQAIVKTLRQAKH
                     CYVTGSRASYALAYYFHYVARMALPTIDLVPRHIGTTLDDLIGLGAEDCLIAITFAPY
                     SASTIKALRQARRLGAQIVLISDSEVIAPGVDVDHVLPVTTASAHPFGAYGGAMAVLD
                     CLLSHLIEAGGAEARQRIEAYEALRQDSGAYWTGSKLPQIRS"
     gene            323637..324527
                     /locus_tag="MED193_01495"
     CDS             323637..324527
                     /locus_tag="MED193_01495"
                     /note="COG3221 ABC-type phosphate/phosphonate transport
                     system, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12559"
                     /translation="MKQTESSVSSAALKCRRICGTVLLIALMLLTIGLSEARAEISLT
                     FGTYAADKPTETVRQYRPFLAFLEERLSQRLGKPVTIKMSISKQYVEAVRQLAEGKID
                     LARFGPASYVRAKQLNPGIRIVAIETKKGKKRFTGVIVVHRDSPIQSLEELAGLTFAF
                     GDQLSTTGRYLAQAQLLGAGITSVDLRGFSYLGRHDLVGEAVGARKFAAGALKQSTFR
                     TLVAKGVPIRVLVSFENVTNPWLASADLDLEILQAIRDVMLAPQNVEIIRNISNNGFL
                     PSDDADFNLIREAIEQSRSF"
     gene            324546..326837
                     /locus_tag="MED193_01500"
     CDS             324546..326837
                     /locus_tag="MED193_01500"
                     /note="COG0642 Signal transduction histidine kinase"
                     /codon_start=1
                     /transl_table=11
                     /product="Hybrid sensory histidine kinase"
                     /db_xref="CDD:10512"
                     /translation="MKRHGILFQIVLSLSLAAFLVAMVVGAVARRYESDRSREELTEQ
                     AGLTISLVGGLMLESIIVEDVPVLETGLYETLARVPKILSIQILNNDGLVIASANRRQ
                     ILAEEDTVTYEQPVELAGFTFGTMVVQWSLREGKALVQDRVQFTIMWTVLAVVGLSAV
                     MLVLLNMLALQPLKTIHDRMSDALSGVQGQVRKLPWYASREFWALNFSVGVLEDTFVE
                     RDEREAALERACEDADIANQAKSDFLANMSHEIRTPMNGVIGMAELIMETDLDEDQQI
                     YAETISKSGTALLTIINDILNFSKIEAGKVELNLAPFNLLTAIEDVVTLLSPRANAKG
                     VEIILRYDPNLPEFFEGDVGRVRQVITNIIGNAVKFTDVGYVHVDVSGGKNSENYSLT
                     IKVADTGIGIPANRLEAVFSAFEQVDSGATRSFEGTGLGLAISARLLALMGGEVAVAS
                     KAGEGSIFTVQLPLPRAERVGEIKVNTTAFQGLTGLIVDDLELNRSVLTERLRAWGVD
                     CLEAGSAIQALERISDLRREGRSVDFFILDYQMPETDGCELAQRIRAIPAYATSPIVV
                     LSAVDHALDRSDPNALQDFEIAQKPLRVAQLKQVLRRALHLEKQPLSVPQSSQATYQT
                     SNLVKLLIAEDNRTNQLVVTRMLKDAGFDITIAANGVEAVERFKEVQPDIILMDMMMP
                     VMDGVAATVKIREIERAARSRGCHIIALTANAMESHRNKCMRAGMDDFLSKPINKKAL
                     IATIQKWVEVDEDAPVDIRTRRN"
     gene            complement(326869..327681)
                     /locus_tag="MED193_01505"
     CDS             complement(326869..327681)
                     /locus_tag="MED193_01505"
                     /note="COG1108 ABC-type Mn2+/Zn2+ transport systems,
                     permease components"
                     /codon_start=1
                     /transl_table=11
                     /product="high-affinity zinc uptake system membrane
                     protein ZnuB"
                     /db_xref="CDD:4391"
                     /translation="MITLLDSFLLRAALAGTGVAVAAAPLGCFVVWRRMAYFGDATAH
                     ASILGVALALGFQVPIFAGVLIIALLMATAVSGLSGRGFAMDTLLGVLAHSSLAFGLV
                     AVSFLQGIRIDLMAYLFGDILAVSRIDLAVIWGGASLVLLLLWARWSALLTATLSPDL
                     AYAAGINPKREQLVLTIALALVVAVAIKVVGVLLISALLLVPAAAARPFAATPERMAA
                     IAAGIGALSALAGLQLSFMLDTPTGPTIVCVAAVLFALTNLGGTIYRQITAA"
     gene            complement(327678..328463)
                     /locus_tag="MED193_01510"
     CDS             complement(327678..328463)
                     /locus_tag="MED193_01510"
                     /note="COG1121 ABC-type Mn/Zn transport systems, ATPase
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter, ATP-binding protein"
                     /db_xref="CDD:10843"
                     /translation="MQLISLQDLSVSYGGNTVLSHVTVGISPGEIVTIVGPNGSGKST
                     LLRSVIGAQLPSQGKVIRSPGLRIGYVPQKLHIDPTLPMTVRRFLSLPIKVSDKQAKE
                     ALEQAGAGQLSNRQMVDLSGGQFQRVLLARALLCKPQLLILDEATQGLDQPGSAAFYQ
                     QIEILRQTLGCAILMVSHELHVVMAASDRVICLNGHICCEGEPEHVASAPEYRALFGS
                     GTQGALALYRHEHNHSHDHSCGHDHGKEHPGSHSPDVIQEARG"
     gene            complement(328454..328942)
                     /locus_tag="MED193_01515"
     CDS             complement(328454..328942)
                     /locus_tag="MED193_01515"
                     /note="COG0735 Fe2+/Zn2+ uptake regulation proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="zinc uptake regulation protein"
                     /db_xref="CDD:10603"
                     /translation="MDSIGFETHDHASCIADCIETADAQCKAQGLQFTPVRKRVLEIL
                     LQEHRALGAYEILDRLREEGLGSQPPIAYRALDFLVSNGFAHKIERLNAFIACTHPGE
                     DHAPVFMICRMCKSVAEAQAVPTNGQLGQAARDAGFQIERTVVEAEGLCPKCQESANK
                     CN"
     gene            329097..330170
                     /locus_tag="MED193_01520"
     CDS             329097..330170
                     /locus_tag="MED193_01520"
                     /note="COG4531 ABC-type Zn2+ transport system, periplasmic
                     component/surface adhesin"
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ABC transporter, periplasmic zinc-binding
                     protein"
                     /db_xref="CDD:27835"
                     /translation="MGLAGVSLADVPKVATDITPVHGLVARVMQGLGEPSLVVPAGAS
                     PHQHSMRPSEALALSQADVVFWMGEALTPWLEGAVDELAKDAHVIELLELEGGLALPF
                     REGVGFEAHDHGDHDDHGDHEDHEGHDHGDHDDHGGHDHDDHGNHEGHDHAGHAEAGH
                     AHEDEHEEGHDEDHVGHDHEGHEGHAHEGVDPHAWLAPENAMLWLDVIAAELSEHDAE
                     NAATYAANAAAGKLEIKEAKAEIMASLGEVRDGGFVVFHDAYQYFEHSFGLQAAGAIS
                     LGDSSDPSPARIAEIQQVVKEKQVSCVFSEPQFNPELVATVLEGSGAQTVVIDPLGTG
                     LELGANFYPALLKELGAAMAACH"
     gene            complement(330237..331511)
                     /locus_tag="MED193_01525"
     CDS             complement(330237..331511)
                     /locus_tag="MED193_01525"
                     /note="COG0665 Glycine/D-amino acid oxidases
                     (deaminating)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10534"
                     /translation="MTSDLTTSLWHQTCQENPASSVLTGEVTADLVVIGGGYTGCSAA
                     LKAAEMGASVCLIEAEVFGHGGSGRNVGLVNAGLWLPPEDINTRLGPVKGNALSQELG
                     KAPDLVYGLIERHGISCEPVRNGTLHCAHAPSGMQDLQRRADQLQSIGAPVLLLDAAQ
                     AQSRVGSEAIHGALFDPRAGTIQPLGFARGLARAAIKAGAQLHDQTPATAINRNKGHW
                     QVTTPKGSIRAKYLVMATNGYARAMTGYSAPAIVPVHYFQGATAPLSPAQQAQILPGL
                     EGCWDSALVMSSWRMDQQGRLIIGAMGALDHFGSSIHQSWLTRKMAAVFPALTGAKFE
                     SEWFGRIAMTQEYLPKIGKLEDGYVSFGYSGRGIGPGTLFGHKIAEALISGDEGLLPL
                     PASTDHKLPFARLRGAYYEAGATLTHLVNDRI"
     gene            complement(331501..333003)
                     /locus_tag="MED193_01530"
     CDS             complement(331501..333003)
                     /locus_tag="MED193_01530"
                     /note="COG1012 NAD-dependent aldehyde dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase family protein"
                     /db_xref="CDD:25427"
                     /translation="MPHTQILAAAGFTKDALTGGSLSVKTPVDGSEIACIPMHSLTDA
                     EAQIAKAKDAFKSWRLVPAPRRGELVRLLGEELRREKENLGRLVTLECGKIYREGLGE
                     VQEMIDICDFAVGLSRQLYGLTIASERPGHAMRETWHPMGTCGVITAFNFPVAPWCWN
                     AALALVCGDPVIWKPSEKTPLTALAVQKICNRVTAQFGEDAPDGLIQTLIGERDLGEA
                     LTASKDVAIISATGSVPMGKAVAQDMSQRLGRTILELGGNNAMIVAPSADLEMALRAI
                     VFSAVGTAGQRCTSLRRLIVHADIYDALIPRLIKAYAGLPIGDPLVDGTLVGPLIDEQ
                     ALKTMDRALTQAKAEGGKVHGGGQALTDSHAAAAYVHPAIVEMPAQSAIMHTETFAPI
                     LYVVKYHDLDQAIELQNEVPQGLSSCIFSTDLRESEYFLSAAGSDCGIANVNIGPSGA
                     EIGGAFGGEKETGGGRESGSDAWKGYMRRQTNTVNYSRELPLAQGIKFDI"
     gene            333147..334043
                     /locus_tag="MED193_01535"
     CDS             333147..334043
                     /locus_tag="MED193_01535"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, LysR family"
                     /db_xref="CDD:10453"
                     /translation="MIAPRRFLPSISSLLALEAVDRLGSASAAAEDLNLTQSAISRQL
                     KQLEQQMEVDLIARDQMRMQLTPGGANYAKEARAILSRLAQASIKLRANPDGGSLNLS
                     ILASFGLHWLAPRLKGFVGQHPGITVNLQTHNLPFSFEAGTAQAAIHYGTRDWPGVQY
                     LPLMPKHVLPVCAPDLLPSPLHRPQDLLDYPLLHLETHPDSWEQWFGLHDVEAARLQG
                     MLFDQSSAMTQAAVHGLGIALLPTFLAEGEIAAGRLQLAISGAPVTLGEYFLVWPAEH
                     ADDYPLMQFRNWLLDQIKAEEC"
     gene            334045..334932
                     /locus_tag="MED193_01540"
     CDS             334045..334932
                     /locus_tag="MED193_01540"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, LysR family"
                     /db_xref="CDD:10453"
                     /translation="MRLPSLTHLRCFDSAARHQSFTAAGEEIGLTQSAVSKKVKELEA
                     DLGFALFQRVGRGVVLTAAGASLAADLAQDLGALRNSVQKAVAAGAGRSALRIAVLPT
                     FANRWLIPRLPDFFTRHPEIELSLSTRLEPFDFARDPFDLAIHYGRDNWPGARMVELF
                     GEQMVPIAAPELFASHDLASVNRLTDVPLVHLESRSDAWADWFLAADMRGQPRQDGRY
                     FDQYSMVIGAATAGLGAAIVPFDMVAAELDAGTLLQLPGPVLRSSKRYYLTRPHGAAP
                     EAVRKFETWITRQLRQKPG"
     gene            335096..336304
                     /locus_tag="MED193_01545"
     CDS             335096..336304
                     /locus_tag="MED193_01545"
                     /note="COG0436 Aspartate/tyrosine/aromatic
                     aminotransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="aspartate aminotransferase b protein"
                     /db_xref="CDD:10310"
                     /translation="MSEFRKASRIDAIEVSEILQIGARAAELKRQGREVIVLGAGEPD
                     FDTPDAIKQAAVDAIWTGETKYTALGGTPALKQAIRAKFARDHDLDYGLDEIIVSTGA
                     KQVLYNAFMASLEPGDEVIVPTPYWTSYVDIIALAGGKPVLVPCGAEAGFRMTPEQLQ
                     QALTPRTRWVLFNSPSNPSGAAYSAKDYAPLLELLLQHPHVWIMADDMYEHITYPGFD
                     FATPAAVEPRLKSRCLTINGVSKAYAMTGWRIGYAGGPAALIAAMAVIQGQSTSCASS
                     VSQAAAEAALNGPQEILRERRASFQARRDLVVDGLNAIDGISCPRPEGAFYTFASCAG
                     VLGCRTPQGSVLHTDADFCAYVLEHHDVAMVPGRAFGLSPYFRISYATSTAELREALA
                     RLTRAVAQLS"
     gene            complement(336318..336803)
                     /locus_tag="MED193_01550"
     CDS             complement(336318..336803)
                     /locus_tag="MED193_01550"
                     /note="COG1247 Sortase and related acyltransferases"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphinothricin N-acetyltransferase, putative"
                     /db_xref="CDD:10965"
                     /translation="MPVEIRQAQPRDATGIARIANSMIRETLFTFTTQERRPEEIALR
                     LREDPRPFLVAELDGRLLGFATYGDFRTGPGYRHTQEHSIQLLPDAQGHGLGRALMAK
                     LEDAARAREVHVLVAGISSANPKAVGFHSAIGFTQTGLMPQVGRKWDQWLDLILMQKR
                     L"
     gene            336942..338114
                     /locus_tag="MED193_01555"
     CDS             336942..338114
                     /locus_tag="MED193_01555"
                     /note="COG0626 Cystathionine beta-lyases/cystathionine
                     gamma-synthases"
                     /codon_start=1
                     /transl_table=11
                     /product="Cystathionine gamma-synthase"
                     /db_xref="CDD:10496"
                     /translation="MGQRSQGAFNMQRNDLKPATIAAQAAGTIDAASGGVVPPLQPST
                     TFVRDRDYQLVNESNVYLRSHNEAVRLGEEILSRLEGAEDTQLFPSGMAAIAAVFRTV
                     PNGGAVIVQSGIYWGTTKWIRDFCTRRDIALHEVDASDIGALQAVCAVHQAQLLFIET
                     PSNPWLKTVDIKAAKACAQTAGASLVVDSTAATPLLTRPLEMGADIVMHSATKVINGH
                     SDVLGGVLSTRLRTPLWEAICMDRNEAGAVMGPFEAWLLVRSMRTLPLRVEKMCANAM
                     AVAEFLASHPEVEDVLYPGLPSHAGHGLASQQMSGGYGFLMSFLVKGGREAALAVAGR
                     LNLFHRATSLGGVESLVEHRHTIEPHTGIPENLLRISIGIEDANDLISDLNQALLG"
     gene            complement(338197..340365)
                     /locus_tag="MED193_01560"
     CDS             complement(338197..340365)
                     /locus_tag="MED193_01560"
                     /note="COG0515 Serine/threonine protein kinase"
                     /codon_start=1
                     /transl_table=11
                     /product="Serine/Threonine protein kinase"
                     /db_xref="CDD:17776"
                     /translation="MIASHPSDLFQPGDLLNNTYRIEMLLGRGGTSNVYKARSEISGN
                     LVAIKVLKQEFSGNEDFTVLMAREENIREIRHDAVVRYSENHRTPDGHIYLLMDYIDG
                     PGLDKKLKQGPMEAADLLVICRRVAEGLKAAHARNIVHRDLSPDNIILRDGDPAQAVI
                     IDFGIAKDTNPGAETIVGNEFAGKYSYAAPEQLSGNTDARADIYSLGALLLANFRGAS
                     PQLGANPMEVVENKQKPVDTEGLPAPFKQLIERMCDPNPDSRLGSAAEVLDFLDRIES
                     DPNASVEARPVAPSDEEATIIVPSAAAAPKTSGATKGRSIKEEPSRSKAPLLALVAVL
                     ALALAGAGAFFSGLLDPLLGPSYPVAQPFTLIVEKTKPGPRRAIGNMPSEESRDALTA
                     LVDQADITLSSGAIADTWAEDVLTTLTPLSDLQQWRLTVSDNQAKLSGITSDPDLAAT
                     LNAQFEDGLPGGLDGVAIITYRLPVLAISEVRGLVGGFEDCGPLHVAPGSVGGGFGPE
                     DTVTVTGRLAGSEARVRLFDALRGLAETRKISLDLEILNPSLCVVEGALPKAPAGKFD
                     VNFSTGNDNTPNPSGRFFVGENPVIDVTIPASITSGYLTVSILDVSGNVFHLLPNISR
                     QENSITDLREGRTGQISVRVAYTLAESALNGGLAFRVDDSTLGKSRILVLHSSEPLFA
                     GLRPTSESAVGFAEALKENSANDANLILSMDSKILETALP"
     gene            complement(340492..341076)
                     /locus_tag="MED193_01565"
     CDS             complement(340492..341076)
                     /locus_tag="MED193_01565"
                     /note="COG2885 Outer membrane protein and related
                     peptidoglycan-associated (lipo)proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="OmpA/MotB domain protein"
                     /db_xref="CDD:12236"
                     /translation="MVRVSIIAAFMCSALLLPTSGLHAQASSEGQSVEEITKILQQQK
                     TRGLVIAPSSAAAPAPQASDAQETATVATANTDYSPVDRQSQINLQISFDFDSATLRP
                     DQQPKLVNMCASMQALQGTVFQIIGHTDSSGSARYNERLSLLRAQEVRRHLISNCGID
                     EDMLKAIGMGEAAPYNSANPRADENRRVEFQALG"
     gene            341253..342092
                     /locus_tag="MED193_01570"
     CDS             341253..342092
                     /locus_tag="MED193_01570"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRVLPAIIICIGLLLAPAVWIGLKWMLSEEDFQGASVDSTARIE
                     IEMLRQQIEDLQLRLTDLQTEVTRLPLGNGGQMAPAASSAEAEREIWDQTEGADLDYA
                     QVVLIADRVNVNRGLQVTGGRYLTERLGRPRETLNDTCQPMTNPELKEKLVTEQVGPI
                     RVSMLRPAIESLKVVFENIRQADPDLYNRINTAGALCVRRIRGTTNSLSTHSYGLAVD
                     LNIDGQLDNFTDGKTQLGLTIMADFFFAEGWVWGAGFRREDSMHFEISRRQLDSWIAE
                     GRL"
     gene            complement(342129..342707)
                     /locus_tag="MED193_01575"
     CDS             complement(342129..342707)
                     /locus_tag="MED193_01575"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRFALSCIGVVFLALTHPVTAQETGDSQSGYSGDPSGSPTGRSP
                     STQVASVPQLATRLSQMKNLCTATGGYVVDCLAERIETLGLDAANMNGHTELKQILRE
                     TAEELRLLARANSDKTAARARISSNDGQRSARPLVAVTPERRASAQRQAIAILQEAET
                     KLLRSSTQSAARASQYQQVAAALGSNKVLLRS"
     gene            complement(342759..344258)
                     /locus_tag="MED193_01580"
     CDS             complement(342759..344258)
                     /locus_tag="MED193_01580"
                     /note="COG4249 Uncharacterized protein containing caspase
                     domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13497"
                     /translation="MTRFFKVLTAIVCFALPQIAEAARDRIALVIGMADYQYLPPLEN
                     THNDANGMAQSLENIGFDVTLALDATAQQMVGLLDDFAFRSEVADLALVYFAGHGIEV
                     QGENFLIPIDANVTSNRDVQRQSASLKQLLAAVDRARKMRIVILDSCRDNPLGDSIAL
                     DQSNASGTASEETRGGGGGMAAVDPDRGTLVAFAARDGQVALDGTGNNSPYAQALMQK
                     MAQPGLEISLMFRQVRDLVLEKTGNLQEPHTYGSLTGVPFYLAAATQDGAEAVPAGTS
                     EAWSAIKPDQEEQLLALAEQGDTRSMLGLAYMRLNPNAGRFDPVAAVDFLQRAADAGA
                     PEAQFELAKLYERGTGVPANPQKALELYQAAAAQNFADAINDLGFLHHQGGLGLQANP
                     QKAYGFFQRAAELRHPQAQFNFAALIDDGLVPGKGPTEAAHFLYAALRSGSADVLDLL
                     SKRPNMFTLNTRRALQDKLKENKFYQGSIDGDFGPGTQRGIRRAYGLDG"
     gene            complement(344399..344725)
                     /locus_tag="MED193_01585"
     CDS             complement(344399..344725)
                     /locus_tag="MED193_01585"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MEGQHQTISGLSAISAREMRQLYSKVQTLEDVVHDIFDRGTKPT
                     RQETQSLQDFDLVMQTLAGMASFFEKVETQIMDTGEADIQAATETVTLQKLRERLREI
                     GSFVAN"
     gene            complement(344728..345087)
                     /locus_tag="MED193_01590"
     CDS             complement(344728..345087)
                     /locus_tag="MED193_01590"
                     /note="COG0784 FOG: CheY-like receiver"
                     /codon_start=1
                     /transl_table=11
                     /product="Chemotaxis response regulator,"
                     /db_xref="CDD:5334"
                     /translation="MVVDDMSTSRGIITQCLDELGIKNYMVENNGQSAFQKLTTTPVH
                     LVLSDYNMPGMDGLGLLQAVRGHQVTQRLGFILVTGKPTPEIIEVGKKLGLNNIIRKP
                     FTVATMKQAIEQVVGRL"
     gene            complement(345151..346014)
                     /locus_tag="MED193_01595"
     CDS             complement(345151..346014)
                     /locus_tag="MED193_01595"
                     /note="COG1352 Methylase of chemotaxis methyl-accepting
                     proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="Putative MCP methyltransferase,"
                     /db_xref="CDD:24209"
                     /translation="MMAAGSIEPNNDGFTLTDQDFEAIADFAYKHFGLAMSSSKKPLV
                     SARLARQLRQQKVVNFKEYLARLNGKNSEQERSKLLSLLTTNVTHFFREPHHFETLRK
                     DVLPPLIEKARNGGRVRIWSAGCSKGPEPFTMAMIIHNMCPDIGRYDFKILGTDIDPQ
                     VVQFAKAAKYPQEELDQIPAEYRSLVPKMEAGGRMPENLRSMITFGVLNLIEPFPFKG
                     KFDAIFCRNVAIYFDTPTQQKVWQAFQRSLNPGGYLFIGHSERMSGPAEAKLTTSGIT
                     TYINTPPGGAA"
     gene            complement(346014..346493)
                     /locus_tag="MED193_01600"
     CDS             complement(346014..346493)
                     /locus_tag="MED193_01600"
                     /note="COG0835 Chemotaxis signal transduction protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10702"
                     /translation="MQAEVKSNDQEVKHAQFSEFVSFTVAGQAFCLKITQIREIRRWS
                     PVTILPHAPSDVLGVMNLRGAVIPIYDLSARFGLETTEASERNVVIVVSSAGKPVGLL
                     AESVSEIISINPEEIQETPPVDSRNTKEYIQGIISHDETMVRIINLDAVISVPEQVL"
     gene            complement(346483..348648)
                     /locus_tag="MED193_01605"
     CDS             complement(346483..348648)
                     /locus_tag="MED193_01605"
                     /note="COG0643 Chemotaxis protein histidine kinase and
                     related kinases"
                     /codon_start=1
                     /transl_table=11
                     /product="Chemotaxis histidine protein kinase,"
                     /db_xref="CDD:10513"
                     /translation="MSGSIQDTFFEECEELLEATDEGLSAIEGGDHNPEVVNAVFRAV
                     HSIKGGAGAFGLDELVAFAHRFETVFDEVRANRMELDEPLIQLLLRSCDHLYNLVAVA
                     RDGGETDQAHHDMLIEALDKYIPEEEEDLTFEPMGLGGPMDVSAIDIPAAPTEETYQI
                     HFRPLKDMYSTGNEPIFLFQALQEMGELSIELDVMELPGFDSIDPEESYLSWNLTLVT
                     TEARSTVEAVFEFVEGLCELSIEGAGDAEADAAALAALEAAFGGAPADPTPVSEPAAM
                     VEETPAAPFEQPAPAPTPEAKPEASGGKPAAPKAENAKSEQRGPNPTLRVDLERVDRL
                     INAVGELIINHSMLAQQIANLDVADVRDVETELEGFKNLARDIQEGVMSIRAQPVKPL
                     FQRMARIVREASSATGKTCKLVTEGENTEVDKTVIERLADPLTHILRNAVDHGIEKPE
                     DREGTNKDRVGEIRLTASHRSGSVCIEVKDDGAGVNRPRVKQIAIEKGLIPENAELTD
                     SEIDNLLFAPGFSTAKEVSNLSGRGVGMDVVKNAVTGLGGRINISSSPGKGSTFTIIL
                     PLTLAVMDGMVVSVADQTMVVPITSIVETMRGNDDMINNLGADGTLLSIRGSFVPICD
                     VAGALGLEKKDDQPPGVYLLVETETGQRSALAVDDIHDQRQVVIKSLDGVCGEIAGVA
                     AATILGDGKIAMILDPESILATSPAVGAFDTERRMSNAS"
     gene            complement(348650..349024)
                     /locus_tag="MED193_01610"
     CDS             complement(348650..349024)
                     /locus_tag="MED193_01610"
                     /note="COG0784 FOG: CheY-like receiver"
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis regulator protein"
                     /db_xref="CDD:5334"
                     /translation="MKTKVLAIDDSRTIRNLLAATLEEAGFEYVSAVDGREGVDMYDD
                     VAPDVVITDINMPNLDGFGVIEELRGTDINSKVPILVLTTESAPEMKARARNAGATGW
                     ITKPFDDASLIFALKRVTGAAA"
     gene            complement(349021..349308)
                     /locus_tag="MED193_01615"
     CDS             complement(349021..349308)
                     /locus_tag="MED193_01615"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11082"
                     /translation="MTTETQKHLLELPNAFAELSPLTAFLSGARSAAVEIDCSNVAAM
                     PSRCLQLLLSAEQQWRSEELGFAVTHINDSCRKSLTLLGLEPNRFEDEVTA"
     gene            349757..352129
                     /locus_tag="MED193_01620"
     CDS             349757..352129
                     /locus_tag="MED193_01620"
                     /note="COG0840 Methyl-accepting chemotaxis protein"
                     /codon_start=1
                     /transl_table=11
                     /product="methyl-accepting chemotaxis protein McpC"
                     /db_xref="CDD:24241"
                     /translation="MQGLKSLKIAHKLPLFVVGFGVLLTAIIVTISTINFQKSAFQQA
                     ENQFESLIAGRKTAFQALLRGVNADLLTLASTPSTATAIQRLSAAWSNLGAEASDIAR
                     QTYIAENPFPAGERHMLDRGKQTIPYNIHHSKFHPSFRTLLTAKGYYDAFLISMPGDV
                     IYSVFKEDDYGTNLMNGAYKDSDLAVLFREALEAEAGRAVFSDVAPFAPSGNAPAAFA
                     ATKIVAPSGQTVGVVVLQISMNMINSIMNDDQGIGDSVDIFLAGPDLTARSSSRFEDG
                     HAVLDQLPASDYLTQALEGNGHFTTEATGLRGQPVAAYAESIPLERGTWVIAIEQDRQ
                     ELLAPVVRDRNILAIASLLGAAVMSVFGWLFAGRITRPLARICRNMDAVSSGNLDTDV
                     PDANRGDEIGEIGKTLVSMQEDLQQARIAEEHRAELQQEQQIVVENLSAGLVRLSEGD
                     FSLPIEQVFSGEHEKLRLNYNQTIETLSGTVSQVIDSSSSIRNGATEISRASDDLSNR
                     TESQAATLEETAAALDELTASVKSAADGARSVEATMDEAKKEAENTGEVVQSAVSAMT
                     EIEQSSNHIGQIISVIDDIAFQTNLLALNAGVEAARAGEAGKGFAVVASEVRALAQRS
                     SDAAMEIKTLISDSSKQVERGVDLVGKAGDALNNIVERVSHISKLVSGIAEGAVEQST
                     GLNEINTGVTQLDQVTQQNAAMVEQATAAGHLLSADSTQLAQLVSRFSIKDGAKVVQM
                     KTEDSLPAAQDQIPSAHGNDDWDLDEATPAPSPVAAQTGGNAAEDLWQDF"
     gene            352280..353218
                     /locus_tag="MED193_01625"
     CDS             352280..353218
                     /locus_tag="MED193_01625"
                     /EC_number="3.1.1.61"
                     /note="COG2201 Chemotaxis response regulator containing a
                     CheY-like receiver domain and a methylesterase domain"
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis-specific methylesterase"
                     /db_xref="CDD:11908"
                     /translation="MESTYPGMKVLLANNLMMAYNQAEAAGPVFAFVEDGFTKLPEFE
                     MMLALFSALDTRWVAVMDSLGATPARKSSPLLNVGAGIFELTKTDSPVQFSQYFDMMV
                     KAPRRDQTRAGKRNGAAGSATDFKKIILIGSSTGGVEALRSVLVGFPAQCPPTLIVQH
                     TGKNFGQGLVSLLDRICAAKVLPADDNMTLEPGHVYVAAGQRRHMGMTQRKPMRVRLK
                     EGPPISGHMPSVDALFTSAVPYGKEVVATILTGMGQDGAKGLLALRKAGATTFAQDEK
                     SSVVYGMPRVAWETGAAEKQVSLARMAGALLQAAKA"
     gene            353242..353805
                     /locus_tag="MED193_01630"
     CDS             353242..353805
                     /locus_tag="MED193_01630"
                     /note="COG1871 Chemotaxis protein; stimulates methylation
                     of MCP proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="chemotaxis protein CheD"
                     /db_xref="CDD:11580"
                     /translation="MTTVFANTTSVTVLQGEYRVTTDPKVMFSTVLGSCIAACIYDAE
                     NGVGGMNHFLLANANGNGVSARYGIHAMELLINGIMKKGAQRSNLKAKVFGGAKMSVN
                     LSDIGASNSAFVQQFLQDEGIPVISSSVGGTSARRVRFHAVSGSAQQTRVANDRRLGE
                     QELAAARPAPKPAPTPAAADPGGLTLF"
     gene            354038..354772
                     /locus_tag="MED193_01635"
     CDS             354038..354772
                     /locus_tag="MED193_01635"
                     /note="COG0725 ABC-type molybdate transport system,
                     periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter, periplasmic
                     molybdate-binding protein"
                     /db_xref="CDD:10594"
                     /translation="MSGFGSAAPALAADVTVFAAASLKTALDEISAKFEADTGHSTAL
                     SLAGSSLLARQIALGAPADIYLPASPEWMDYLQTQDRIVPGSRLNLLGNKLVLVAPKQ
                     SARAITGFEDPVLFEQLGQGKLAMAMVEAVPAGIYGKSALETLGLWQDLAPHIAQTDN
                     VRAALALVAAGAAPLGVVYASDAIADPRVTVLAVFPAYAHDPIRYPLARVRGAGGPAA
                     AAFHAYLQSPKAREAFVAAGFDVIAE"
     gene            354779..355471
                     /gene="modB"
                     /locus_tag="MED193_01640"
     CDS             354779..355471
                     /gene="modB"
                     /locus_tag="MED193_01640"
                     /note="COG4149 ABC-type molybdate transport system,
                     permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate transport permease protein"
                     /db_xref="CDD:13426"
                     /translation="MTWLGPEEWQAVALSLKVSIWASLVTLPFGIFTAYALARWQFPG
                     KQVVNGLVHLPLILPPVVTGYLLLLTFGPQAGLGGFLQQFGISFAFRWTGAALAAAIM
                     GFPLMVRAIRLSIEAVDPKLEQAAATLGANPFWAFATVTLPLILPGILAGVILAFAKA
                     MGEFGATITFVSNIPGQTQTLPSAIYAFLQVPGGESAALRLVGISVAVAMGALILSEV
                     LARRAARRLGGL"
     gene            355471..356568
                     /locus_tag="MED193_01645"
     CDS             355471..356568
                     /locus_tag="MED193_01645"
                     /note="COG4148 ABC-type molybdate transport system, ATPase
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="molybdate ABC transporter, ATP-binding protein"
                     /db_xref="CDD:13425"
                     /translation="MLEVSLRQPLDGFTLDLSFEAPAGVTVLFGGSGAGKTTVINAVA
                     GLKRPESGRVALNGRVLFDLGKGLWVPPHRRRLGYIFQEARLFPHLTVRQNLLFGRWF
                     APRGAVREDLDRIVAMLGIGALMQRHPVALSGGEKQRVAIGRALLSSPDLILADEPLA
                     ALDEARKEEILPYFERLRDELKVPMLYVSHSAAEVARLATSVVVLKDGQVQRQGNAAE
                     VLGDDRVMPTGVRAAGALLEARLLRHHPDGLSELDAGGVSLFLPQVQQVPGSLLRVRI
                     LAQDVILSRHRPEGLSALNILPAEVEQIRSGSGPGAMVSLKTDAGRVLARITRRSAQA
                     LELSSGTQCYAVVKSVAIARSDVGGAVPVDD"
     gene            complement(356639..357658)
                     /locus_tag="MED193_01650"
     CDS             complement(356639..357658)
                     /locus_tag="MED193_01650"
                     /note="COG1652 Uncharacterized protein containing LysM
                     domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:25526"
                     /translation="MLKKLSLSLALVLGFLSPATAWAICDVDYRVQPGDTLFSIAEHH
                     YGDRGRWTLIYYGNQSRLTGPVAEPGKVLHIPCAKGVSAPDATPLRRDDAEMKLLTGG
                     GFAPFTDQDLPGQGLITELVNAAMELTPSPVSYSITWENDWSKHLFPKLDDKEFDMGF
                     PWFKPDCETTPQDKRCVNFHFSEPLITIPIMLFARADAGFSYEQDSDLEGKTLCRPKG
                     YFTHDLDRPGRRWLTEEKITLVQADTPAACFHLVNEGRVDAATVNLFLGANTLIEEGL
                     RNSILPVERPLSEEGLHVVISKRHWRGTSHLYRINAGLKALKKEGRFEEVVARHLELF
                     WAQLQ"
     gene            complement(357670..358752)
                     /locus_tag="MED193_01655"
     CDS             complement(357670..358752)
                     /locus_tag="MED193_01655"
                     /note="COG1652 Uncharacterized protein containing LysM
                     domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:3750"
                     /translation="MKNKLLAATLAVAGLFSAQTLAAETCGGYYKVRSGDSLSVIADR
                     LYKDVGTWSTIHSQNIDAIGPKPNAIRVGMKLRMPCINGLPTGLEGGTKAASTTPIAA
                     APVKVTPGNASVRQKINLLTGDDYAPFTSKASHNGGLITDVMDAVMTSAAPKEGYAIH
                     WVNDWGSHFDPLLSNALLDVGFPWYRPDCDSMPDSYRCVNFLFSDSMFETLMLLFVDK
                     SRPFTFEDDADILGKTLCRPNGYLTFDLDGSGRRWIADNKITLKSPHTVKDCFDMVAK
                     GEADAVAINEFTGRSVMKEHGLGDQFNVLPQPLSVLGIHAVVHKTHPRAEEMMALVSQ
                     GLKDVRDNGTYQRIIEDHLSRIWAEF"
     gene            complement(358922..359788)
                     /locus_tag="MED193_01660"
     CDS             complement(358922..359788)
                     /locus_tag="MED193_01660"
                     /EC_number="3.8.1.8"
                     /note="COG0098 Ribosomal protein S5"
                     /codon_start=1
                     /transl_table=11
                     /product="atrazine chlorohydrolase"
                     /translation="MLQSLDFPTDDSPSPAPAAKPFRLNTVVTKGHIRVVSESGLQVV
                     SPQVSDATSPDLAIDAVDLGEPENTETNGAENAFVSTVEPATPSASAPWNEGFTERAH
                     DTTPIDSVILPPPGLSMKMIKLIAAASVLGIAAIALTFLQFSGSDSEIQGGGLAGASG
                     YSPVIAAADAGTLSTIPVAQLATASDANNADIVAQITAGTLAALRNGTSKSPAAALPE
                     TAAPTSVNMGEVSGLYAMVLTALEQGQSRQYIDQMVNDAHRTQKVAVPALLLTSSGEV
                     NTDALLTLFGGQ"
     gene            complement(360211..361581)
                     /locus_tag="MED193_01665"
     CDS             complement(360211..361581)
                     /locus_tag="MED193_01665"
                     /note="COG0402 Cytosine deaminase and related
                     metal-dependent hydrolases"
                     /codon_start=1
                     /transl_table=11
                     /product="formiminoglutamate deiminase"
                     /db_xref="CDD:28174"
                     /translation="MTTIFAKRALLTTGWAEQVRLTLHGGKISEICVNTQPEPSDCHV
                     NSLLPALGNLHSHSFQRAMAGMTEYRLAGRDSFWTWRELMYRFTAHLSPDQIEAIAAL
                     VFMEMQEAGYASVGEFHYLHHQKDGQTYDNLAEHSDRIMAAAVETGIGLTHLPVLYSY
                     AGVGKRPLEPGQLRFGNDVDQFCRLVELARSAVSNLPADCQVGIAPHSLRATAPDDLA
                     RVLQTQAEDCLVHIHIAEQPKEVQEVLAGLGARPVEWLMANAPVSQNWCLIHATHMTQ
                     DETIAMARSGAVAGLCPITEANLGDGPFNGATYLEANGAFGVGSDSNVLISLTEELRT
                     LEYSQRLRDLARNVLVRGEGSVGHALYTGAAKGSAQALGRGTGEIAEGQWADLLAIET
                     SHPSLCALTNDQLLDGLVFAAKDSVITDLWSAGRHTVQAGRHIARDPVVARYRKAMSD
                     LLSEIG"
     gene            361665..362876
                     /locus_tag="MED193_01670"
     CDS             361665..362876
                     /locus_tag="MED193_01670"
                     /note="COG1228 Imidazolonepropionase and related
                     amidohydrolases"
                     /codon_start=1
                     /transl_table=11
                     /product="imidazolonepropionase"
                     /db_xref="CDD:28157"
                     /translation="MTTEGHVFTELRAATLVAGAGPYGLVDAAAIAVVEGEIAWVGPE
                     SELPAAFEGCPKTSLGNRLVTPGLIDCHTHVVHGGNRAAEFEMRLNGASYEELARAGG
                     GIVSTVTATRAATVEALVAQALPRIDAMLAEGVTTVEVKSGYGLDQETELNMLRAARA
                     LPEHRAIRVVTSFLGAHAVPAEYSGNADGYIAEVCIPTLRAAHREGLVDAVDGFCEGI
                     AFSPTQIAQVFDEARRLGLPVKLHAEQLSNLGGAKLAASYGALSADHIEYLDGDGVAA
                     MAEAGTVAVILPGAFYTLRETQMPPLDLLRAAGVPMALATDCNPGSAPMTSLLLAMNM
                     GCTLFRMTPEEALCGVTSHGAQALGLSDRGCLAVGQLADLAVWDVAHPAELAYRIGFN
                     PLYARIIGGSL"
     gene            362873..364423
                     /locus_tag="MED193_01675"
     CDS             362873..364423
                     /locus_tag="MED193_01675"
                     /note="COG2986 Histidine ammonia-lyase"
                     /codon_start=1
                     /transl_table=11
                     /product="histidine ammonia-lyase"
                     /db_xref="CDD:27885"
                     /translation="MTNQTLTLTLTPGAVSLSELERVFREECPVRLDASCRPDIERAH
                     SHIAAAAAGEAAVYGVNTGFGKLASVKIAAEDTATLQRNLILSHCCGVGPAIPRAHAR
                     LMMVLKLLSLGRGASGVRLEVIDLLEAMLEKGVTPVIPAQGSVGASGDLAPLSHMAAV
                     MMGAAEAEYDGRILSGEAALAAAGLAPIEFGPKEGLALINGTQFSTAFGLVGLFGAWQ
                     AAQSALVTSALTTDAIMGSTAPLQPEIHSLRGHRGQVEAAATMRLLLAGSVIRESHRD
                     DDARVQDPYCIRCQPQVVGAAMDVLRQAAQTLEIEANAATDNPLVLVGADLIVSGGNF
                     HAEPVGFAADMIALAIAEIGAIAQRRIALIVDPVLSHDLPPFLTPNPGLNSGYMIAEV
                     TTAALMSENKHLANPCVTDSTPTSANQEDHVSMAAHGARRLGQMLVNLERILGVELLC
                     ASQGVEFRAPLPTSDALQHVIAKLRNAVPPLEEDRYTAPDIEAASALIVSGEIARCSQ
                     IAMPELGA"
     gene            364420..365223
                     /locus_tag="MED193_01680"
     CDS             364420..365223
                     /locus_tag="MED193_01680"
                     /note="COG3741 N-formylglutamate amidohydrolase"
                     /codon_start=1
                     /transl_table=11
                     /product="N-formylglutamate deformylase"
                     /db_xref="CDD:13061"
                     /translation="MISAVDVTRGDSPLVLGLPHTGTYVPAEVAAKLNARGRGLDDTD
                     WHIDRLYEGLLPDVTSVRAVFHRYVIDANRDPSGVSLYPGQNTTTLVPLTDFDGHPIW
                     DQEPDAAEIDSRCREFHAPYHRALEAELARVKAIHGFAILYDCHSIRSTIPFLFEGVL
                     PDFNTGTNMGRTCDPALEEIVVSACTRAKNYRSVVNGRFKGGWTTRHYGRPDEGLHAI
                     QMELAQSTYLTREAAPWIYDQTKANRLREHLHTILTRLADWAPQTGGNT"
     gene            365220..366902
                     /locus_tag="MED193_01685"
     CDS             365220..366902
                     /locus_tag="MED193_01685"
                     /EC_number="4.2.1.49"
                     /note="COG2987 Urocanate hydratase"
                     /codon_start=1
                     /transl_table=11
                     /product="urocanate hydratase"
                     /db_xref="CDD:1724"
                     /translation="MTDPRKNTRDVFPTTGSEITAKSWLTEAPMRMLMNNLHPDVAEN
                     PHELVVYGGIGRAARTWEDFDLIVDSLKDLEADETLLVQSGKPVAIVKTHEDAPRVLI
                     ANSNLVPHWANWDHFNELDKKGLMMYGQMTAGSWIYIGTQGIVQGTYETFAEAGRQHY
                     GGDLSGKWILTGGLGGMGGAQPLAAVMAGACCLAVECNPDSIDFRLRTKYLDEKAETL
                     DEALAMIAKWTAAGEAKSVGLLGNAADVFPELLVRAESGGMRPDIVTDQTSAHDPVNG
                     YLPLGWTMGEWKARRESDPKAVETAARASMRVQVDAMCKFHAMGVPTVDYGNNIRQMA
                     LEEGLENAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPEDIRKTDAKMKELFPENTH
                     LHNWLDMAQERIAFQGLPARICWIGLGDRHKAGLAFNEMVKNGELSAPVVIGRDHLDS
                     GSVASPNRETEAMMDGSDAVSDWPLLNALTNTASGATWVSLHHGGGVGMGFSQHSGVV
                     ICADGTDAAAKRLERVLWNDPASGVMRHADAGYEEAKECARVHNLRLPGILK"
     gene            complement(366920..367642)
                     /locus_tag="MED193_01690"
     CDS             complement(366920..367642)
                     /locus_tag="MED193_01690"
                     /note="COG2188 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="histidine utilization repressor"
                     /db_xref="CDD:11896"
                     /translation="MIALNDKGAEIMKATFRHVKADIMGKITSGEWAPGGLLPNEMDL
                     AESYGCARATVNRAMRELADEGVVERRRKAGTRVRQAPLRQARFSIPIVRAEIEEQNA
                     AYRYTLISRAVQAAPHWLCARLSLDQGTQVLHLTCMHYADGLPYQFEDRWISLSILPQ
                     AEEADFSTLGPNEWLVSTVPFSDAEIAFSATAATPELAEYLGCAQDEALFTVERSTWL
                     KEEAITFVRQTFRPGHRMTTRY"
     gene            367908..370244
                     /locus_tag="MED193_01695"
     CDS             367908..370244
                     /locus_tag="MED193_01695"
                     /note="COG2202 FOG: PAS/PAC domain"
                     /codon_start=1
                     /transl_table=11
                     /product="two-component hybrid sensor and regulator"
                     /db_xref="CDD:10512"
                     /translation="MDSFHTASRFETRDSLGHFEQLATPIWVFDVDNHKIWWANAAGI
                     LFWEAPSLDDLLKRDFSTDSDMVRTRLRQIIGNGPGQKRIQDTWTLYPNDAPKNVILS
                     FLPIIIEQDTNAVLIEVKQFVGSMVDAESLRILEATRASALMVSTFSADGELLAQNPA
                     ALCCYGPPRPGLSGNEMASRLKDPNVAEQLLETAINGKSLDLEQLVWTQNGSRVHRLL
                     ARRGRDPITGAFAVIISEEDVTKQNALRLQMQRLNAQLERKVEERTRRLDASEERYAL
                     ATQSVAVWDWDIEQNHLYFSPSFLEALDLEPDTKIDTLVGENGEGLLQRILHPDDIES
                     YLEELTRHLKEPDEPFSHEHRLKTGLGRYRWFHARGKAISGPDGRAARSVGILTDITE
                     RKELEASLLAAHRAEAIGQLSGGIAHDFNNLLTVILGNAELLEMADGSNHELIGAIKK
                     AALRGADLTRHLLAYSCKQTLNPGPMALSQLITSIRKPLLANLGAGIEVEIKIPGGLW
                     PVYADAAQVESAILHLASNARDAMPEGGKLKISCQNHLVTEAQPLPGGEHSLKPGEYV
                     EILIRDTGEGMTPDTLNRACEPFFTTRKPGQTSGLGLSMVFGFAQQSGGGFALHSELG
                     QGTSASLFLPRSLQNPEASKAPNLATPIPGNGENIHLLEDDRAVQSTLRSILESLNYR
                     VTQSSDAASAMQVISQGPRPALILADIVLPGGESGLEFVDRLGGRFPEIKAVLMSGYM
                     QDEATLEALSLRGHIFLQKPMNKARLSHILQTALENKT"
     gene            complement(370301..370750)
                     /locus_tag="MED193_01700"
     CDS             complement(370301..370750)
                     /locus_tag="MED193_01700"
                     /note="COG1522 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, AsnC family"
                     /db_xref="CDD:11236"
                     /translation="MDDKDLEILKLMQGNARLTADALSLEVGLSPPAVQKRVKRLRDS
                     GVIHSEIAVLSPAKLGREMTAIVEVVLERESRMHLDAFKQRMRAAPEVQQCYYATGAA
                     DFILIVVTKDLKEYEAFTQEYFFDESNVSRFNTSVVMDRVKVSLDIL"
     gene            complement(370818..371987)
                     /locus_tag="MED193_01705"
     CDS             complement(370818..371987)
                     /locus_tag="MED193_01705"
                     /note="COG0006 Xaa-Pro aminopeptidase"
                     /codon_start=1
                     /transl_table=11
                     /product="metallopeptidase, family M24"
                     /db_xref="CDD:9882"
                     /translation="MQRKAPARGFEQAEFQARTQKAQALMAQQGLEGLLLMTEPDVRY
                     FSGFHTLFWQSPTRPWFLFIPASGKPVAVIPEIGAALMRQTWIEDIRSWSAPAPQDDG
                     ISLLHELLAPLARRGARLGILKGHETSLRMPLGDWERLVRALPGLQLTDATGLIQGLR
                     MVKSAAEIEKLAHICTIGSATFDQVPKQISQGMPLEEVFRAFRREALAQGADDTPYLV
                     GGAGPGGYADVISPPSRRPLQAGDILMLDTGATWDGYFCDFDRNFAIETADDAARRAY
                     DVLWRATEAGLAAAQPGNSCQDLFQAMQGVIAELDDQSGDIGRLGHGLGMQLTEQPSH
                     ADFDCTRLQEGMVLTLEPSLGYGDGLIMVHEENIVIRADGAELLTRRAPPELPVI"
     gene            complement(371977..373170)
                     /locus_tag="MED193_01710"
     CDS             complement(371977..373170)
                     /locus_tag="MED193_01710"
                     /EC_number="4.3.1.15"
                     /note="COG1171 Threonine dehydratase"
                     /codon_start=1
                     /transl_table=11
                     /product="diaminopropionate ammonia-lyase"
                     /db_xref="CDD:10889"
                     /translation="MFDFLTLPKLGHVAAKKRKGDAVERVLSRQDFATSRAEITQWQG
                     YAPTPLVSLRALADKIGVAEVLYKDEGPRFGLGSFKALGGSYAAQRVLQRQLAANLGH
                     EVSLEDIREGKYKAEAAKITLVSATDGNHGRSLAWGCQRFGALCRIYIHAEVSEGRAA
                     AMRDLGADVIRIAGDYDDSVLLAKQEAEENGWFVVSDTSWEGYSEPPRDVMAGYGVMT
                     QEICDSLEQAPTHVFLQGGVGGLAAGVVAGLRQHWAAKGPRVVIVEPELAACLFESGR
                     AGAATSVAIQEETMMAGLSCGEPSEMAWEILAEEVSDFLTIPDSLVAPTVRLLARPLE
                     GDPSIEAGESAIAGLAALIAARQDGALSQKLELDAGSRVLLIGSEGITDPTIFARIMG
                     DLDAA"
     gene            complement(373163..374317)
                     /locus_tag="MED193_01715"
     CDS             complement(373163..374317)
                     /locus_tag="MED193_01715"
                     /note="COG1473 Metal-dependent
                     amidase/aminoacylase/carboxypeptidase"
                     /codon_start=1
                     /transl_table=11
                     /product="amidohydrolase family protein"
                     /db_xref="CDD:11187"
                     /translation="MDEFHKRLTALRQQFHQDPELGFEEHRTKARVAERLRQLGLEVH
                     EGVGVIGVLKSGGGNRAIGLRADMDALPIHEATDQDYKSQNTGVMHACGHDGHMAMLL
                     GAAEVLAQSRDFDGTVVFIFQPNEEHGLGAQAMIAEGLLERFELEEIYAIHNLPGDPL
                     GQVSTRQGQICASESLFEITLRGQGGHASMPHVGVDAITVGAELVLALQTIVSRKLAP
                     SSGAVVSVTEFITDGQRNVLPGLARLKGDVRARAPEDRLALERFMRQITSGIAAAHGV
                     TATMSFDTEFIETLNATDPTEAVVRVAQAMQIATLADRPPMSFSEDFAHFSAAVPGCF
                     LLLGNGVSGAHGQPLHSADYDFNDALLPIGAALWAELVRDRLPNRKTTDV"
     gene            374667..375341
                     /locus_tag="MED193_01720"
     CDS             374667..375341
                     /locus_tag="MED193_01720"
                     /note="COG0639 Diadenosine tetraphosphatase and related
                     serine/threonine protein phosphatases"
                     /codon_start=1
                     /transl_table=11
                     /product="serine/threonine protein phosphatase"
                     /db_xref="CDD:14907"
                     /translation="MSPGGPFCAIGDIHGRFDLLTRLLTKLEPELQVICVGDYVDRGE
                     HSAEVLRFLQAHPEITCLMGNHEQMLLSFLDDPKAAGPRWLRYGGLQTLASFGVAGVS
                     DTSQGTDLEKACEALTVAMGEDLITWLRRLPLSWQSGNIFVTHAGCDPAVPVDEQSAS
                     HLLWGHPEFFKMPLQDRNWVLHGHTIVDAPSAEAGRISIDTGAFATGRLTAAVVKGQA
                     VEFLQA"
     gene            complement(375488..376747)
                     /locus_tag="MED193_01725"
     CDS             complement(375488..376747)
                     /locus_tag="MED193_01725"
                     /note="COG0677 UDP-N-acetyl-D-mannosaminuronate
                     dehydrogenase"
                     /codon_start=1
                     /transl_table=11
                     /product="polysaccharide biosynthesis protein"
                     /db_xref="CDD:10546"
                     /translation="MPDQICIIGLGYVGLPLAVAFGRHRATLGFDIDGARIAELRAGA
                     DQTREISPQELSEASHLALTSNPDEISDARIYIVTVPTPVDASHRPDLRPLLAASKTV
                     GAVLKPGDLVIYESTVYPGATEEDCVPVLEAESGLRFNQDFHVGYSPERINPGDKNRR
                     LPDITKVTSGSTPAVAAQVDALYKEVVTAGTHLAPSIRVAEAAKVIENSQRDINIALV
                     NELAMIFNRMGIDTEAVLKAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKAESLGYHP
                     DILLAGRRLNDGMGTYVAQQMIKALVKRGKPMRRVLIMGLTFKENCPDLRNTRVIDVL
                     RGLEDYGLSVDVHDPHADPAAAKASLGVELVAEPAQQAYDGIILAVAHSAFIQMQESD
                     FRAFGGEDAVLYDLKYILPPDASDLRL"
     gene            376991..378652
                     /locus_tag="MED193_01730"
     CDS             376991..378652
                     /locus_tag="MED193_01730"
                     /note="COG4425 Predicted membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13646"
                     /translation="MFRIGTLVPRFSLPCLLLGVLLFAASLTPSLIPRGPAVQGILGG
                     VLISLGYLFGRAADLIWRAADMPRLQGKLAASLNLALLGITVSVTVLTIWFHLDWQNE
                     LRQKMGLEPAEAQYLTTILVSALITFAIAFVMGILISGVFRWVRAAFYRIMPVRRANI
                     LGVITVILLLFVVTRDGLFDRAVTGLDESYEAAQKLFENAPPRPTAEHKAGSAASLID
                     WAAMGQPGRDFVMTGPDAKAIAAFSGKPALEPIRVYVGRANGDTATERAELALAELKR
                     LKAFDRKVLIVASPTGTGWMDPGSHDPVEYMHNGDIATVSAQYSYLQSPLALVLETKT
                     GLDQATALLETVHEYWKTLPQDSRPRLYAHGLSLGAWSSMYATNLFRLVGDPIDGAFW
                     VGPPFPSRFWQYVQHSRRPGSSWWLPTIGDGSLVRYASHISDASQAKAEWGSMRIVFL
                     QYSSDPIVFYDPYSLWRAPPWMNDPPAHDVSTRLKFIPIVTQFQLAFDLALAFDAPAG
                     HGHAYYAQDYIAPWAEVTAPENWTREDSRRLKERCNLGVQQGCKN"
     gene            379334..380236
                     /locus_tag="MED193_01735"
     CDS             379334..380236
                     /locus_tag="MED193_01735"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="regulatory protein, LysR:LysR,
                     substrate-binding"
                     /db_xref="CDD:10453"
                     /translation="MDDKLTSTFLQVCREGSIRAVAVSLEQEPSTISRRLTALEEQLS
                     IQLLERHKKGVKPTEAGNLLLRHLRGQAAEFEALTAEFDALRGMRRGCVSLAVGEGFV
                     SDLIKNALPSFKTTYPEITFTLRSGSTEAVVQDIHNDAAHLGFVFNAKPDRQSKVLVH
                     MAQPLRLLAAPTSDWAKTATPVSISSLAAMPSAVLSSGSGIGAMVREVETIYGVRLNR
                     ALEANSLAAIRNFVREGLGVTVLPAFVVAQEIADGTIVDLPLDVSEFSRGEVSLIARS
                     GRRLPEVAVKLANHAMRSMQAFQV"
     gene            380294..381196
                     /locus_tag="MED193_01740"
     CDS             380294..381196
                     /locus_tag="MED193_01740"
                     /note="COG2084 3-hydroxyisobutyrate dehydrogenase and
                     related beta-hydroxyacid dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="3-hydroxyisobutyrate dehydrogenase family
                     protein"
                     /db_xref="CDD:11792"
                     /translation="MPDVGLLSLKHREIFMIGLVGLGAMGGGYLSRLMAQNCDLMCFD
                     AMPEARARAAAAGAKVADSLADFSACDTVILSLPKAAIVSAVMEELGPYLKKGSIVVD
                     TSTSEPDTTKRLAAAAESNGYTFLDGPVSGGPLGARTGTMTMVVGGDEAGFTKVRPLL
                     EKMTGKLVHIGPSGAGHTVKIANNLLCAANLVLMSEMAQMAERAGISLTELLTGINAG
                     SGRSGVSEVNFPKWITNEAYDSGFTMGLMRKDVGLATGLAERLGIDLPATREIAAIWE
                     NSREILDDSADFNEIYKYRKRSNV"
     gene            381189..382703
                     /locus_tag="MED193_01745"
     CDS             381189..382703
                     /locus_tag="MED193_01745"
                     /note="COG1012 NAD-dependent aldehyde dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="aldehyde dehydrogenase family protein"
                     /db_xref="CDD:10741"
                     /translation="MFDRIAYYKSRCAELDLSEVPQSYVGGEFVSGTGAMIALEDPYS
                     RTVLAEYPDCGAETANRACEAAAVAQKVWMTDFTAAGRGIVMQKIAALVDERQETLAQ
                     VEAVVSGKPLRDCRVEVAKVSEMFRYYAGYTDKLHGQVIPVPSGHLNYTIREPLGVIF
                     QITPWNAPMFTAGWQIAPAMACGNGVVLKPSELTPVTSIALATICEDAGTPAGLINVL
                     AGLGPTAGEAAIAHDATRKVVFVGSPATGRVVATSAGKALKPVVLELGGKSANIVFED
                     ADLKAACKGAQAAIFATAGQSCVAGSRLLVQASIKDKFVKMVADGMEQLKVGDPLDEA
                     TEIGPISNRRQFDHVTAMVDQAAKNGAKVLSGDRTKGDALIVPPTILTDLPPEADAAQ
                     TEIFGPVVAALSFVDEADAVRIANSTDFGLAGAVWTNNVSLAHRMAGNVRAGTFWVNG
                     YKAIHVSTPFGGSRSSGFGRSSGTDVLMEYTEPKSVWVETAEVPRVAFGYAPSE"
     gene            382687..383439
                     /locus_tag="MED193_01750"
     CDS             382687..383439
                     /locus_tag="MED193_01750"
                     /note="COG1045 Serine acetyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="serine acetyltransferase"
                     /db_xref="CDD:10772"
                     /translation="MPQASDMTLIEDTAQLFHEEPALAALYGFTPDEVQNDADLLAAV
                     LAGLVPDAQARHRIRDLVGEAFAADAGSVAFALEDLVATAERDLSTDAARVLLFAPGY
                     QGLLSYRASHALLMSGRDTAAAAIKAMLGRQLSVDIAPEAQIGRRVWLDHGLGVVIGR
                     TAVIEDDVSIWHGVTLGSNFVSMGDRRHPLIGKGAVLGGHSVILGGIDIGENAVVAAG
                     AIVTKSIPAGKTVYGPKATIRDRKPGSFSGFT"
     gene            383449..384321
                     /locus_tag="MED193_01755"
     CDS             383449..384321
                     /locus_tag="MED193_01755"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAFLGIDHPLIAVRDLDKAIETYRSLGFFIAPPGQHPWGTSTAL
                     ALFRHQILEIVSIGDTSLLDGYETGGFRFGRHVEAFLDKSEGVALTALFTEDADEAEA
                     ELAKHRISCTGTVNFGRDVVRADGKQDRTKTTLKVFRNDTMPRLSVFACQQHRRDLLE
                     FPDKMTHPNGAKGFAAATIVAEDKAPVMDWLARIHNVSATKDAEGFDSIETANGHWRI
                     VGPGQFRSFYGAELPADYLSDGPRIAALDVRVKNLEEVKGDSVVDLRKVDNRLVASDM
                     SKLGGIVMCFLQDA"
     gene            complement(384475..385329)
                     /locus_tag="MED193_01760"
     CDS             complement(384475..385329)
                     /locus_tag="MED193_01760"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:25582"
                     /translation="MSLSERREMIRKDNTDLSLTRQCKLLKISRSSIYYTPVGFDQAT
                     IDLMHEIDRIFTKYPFFGSRQIAAYLPQSGFSAGRHRVRRLMGIMGLQAIYKGPNTSK
                     KHPQHKIWPYLLRKLSITRPNHVWCSDITYIPVKNGFLYLVAIMDWATRKVLSWRLSN
                     TLDASFCVEALDEAIAKYGKPEIMNTDQGSQYTGADWIKTLTKADIKISMDGRGRYLD
                     NIFIERLWRSLKQEAVYLHEITNGFQAKRIIDDWIGFYNAERPHTALDKRTPDAAYFE
                     QSETRKAA"
     gene            complement(385326..385604)
                     /locus_tag="MED193_01765"
     CDS             complement(385326..385604)
                     /locus_tag="MED193_01765"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase (class V)"
                     /db_xref="CDD:23225"
                     /translation="MTKRRNFSDKFKATVALEALRGDKTVQEIASKRQLHPTQVSTWK
                     RQAIDGMVNVFSDKVKKAENKDGEIKELHAKIGQLAVENDFLSQGLKR"
     gene            complement(386012..386701)
                     /locus_tag="MED193_01770"
     CDS             complement(386012..386701)
                     /locus_tag="MED193_01770"
                     /note="COG3484 Predicted proteasome-type protease"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12812"
                     /translation="MSDTRTNAGVDNFSVTRKMFTWEVPGDRVITLMTSGNLATTQSL
                     ISLLEERSKVTTERSPSILELPTMFQIARLVGSTLREVIADSHTEGQQASSKFKASVI
                     VGGQIKGGAPTMFLIYPEGNFIEITEDNPFFQIGEAKYGKPILVRAYDPDMSFEDAVK
                     LLIVSFDSTIKANLSVGLPLDLHIYFQDSFVATARPRIEADDAYYQAVSSSWGDALRN
                     ALAQLPSYRID"
     gene            complement(386794..387591)
                     /locus_tag="MED193_01775"
     CDS             complement(386794..387591)
                     /locus_tag="MED193_01775"
                     /note="COG1305 Transglutaminase-like enzymes, putative
                     cysteine proteases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11021"
                     /translation="MKLEISHTTQYTYDAPVSYGLQQVRLTPTSTKHQTVLDWNISIS
                     GGVQELEFQDQYQNQTLLVQADAGTTAVSVQVSGVIETHSSDGIFGKIYGKAPLWHFC
                     QSTPRTIPGRGIRKLAKHIKPKGDTLSDLHVLSKEILAAAPYGEANTFAGTSAEEALK
                     AGGGVCQDHAQIFVAAARVAGIPARYVSGYLLMDDRIDQDASHAWAEAHVEGLGWVGF
                     DVSNGISPDERYVRIATGLDSRDAAPITGIRRGALDETMIVSLQIQQ"
     gene            complement(387604..388545)
                     /locus_tag="MED193_01780"
     CDS             complement(387604..388545)
                     /locus_tag="MED193_01780"
                     /note="COG2307 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:9727"
                     /translation="MLGKTAGGLYWMFRFLERCENTARLVEAGFRIALTRSNDPASEW
                     KSVVTTAGARSNYDAKYDTYEAAYVVDFLLRDPANPSSVLSAVEKARTNARMVRTALT
                     TEVWEAVNEGWMGLKQTLKSPVKETDLPAVLGEIRRHSALVRGALHGTMLRNDIFDFT
                     QMGIALERADNTARIIDVKYYTLLPSASFVGSALDNVQWETILRSVSAHRSFRWLNDE
                     NMTPASVADFLILDPRFPRSLSFCSRILEESLGFLAKDYGTRLTCHDMISAQRDRLRG
                     HTIATVFDEGLHQFITAFIDDINAIGQQIEKDYRFIG"
     gene            complement(388550..389977)
                     /locus_tag="MED193_01785"
     CDS             complement(388550..389977)
                     /locus_tag="MED193_01785"
                     /note="COG2308 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11987"
                     /translation="MDLERRHFDEMLLGSDGVRAPYAEYQKWFANEDPTRLSKKSKEA
                     EAFFRRTGITFNVYGQAEAQERLIPFDLIPRIIANREWTKLSKGIKQRVVAINAFLHD
                     IYHRQEILRAGIVPTELISRNEAFLPQMIGLTPPGKVYTHIVGTDLVRTGEDDFYVLE
                     DNARTPSGVSYMLENRETMLQMFPELFSQIKVQRVSDYPKNLRRSLAACAPQGCSGKP
                     TVAILTPGIHNSAYFEHSFLADQMGVELVEGHDLMVVDGHIAMRTTRGYKNIDVLYRR
                     VDDDYLDPLNFNPDSMLGVPGIMDVYRAGNITIANAPGTGIADDKAIYSYMPDIIEFY
                     TGEKAILKNVETWRCSEPDSLAYVLEHLEELVVKEVHGSGAYGMLVGPAASKKELSSF
                     AAKLRKNPGNYIAQPTLSLSTVPIFAKKGLAPRHVDLRPFALVSPEGIDIAPGGLTRV
                     ALKAGSLVVNSSQGGGTKDTWVLED"
     gene            complement(390026..390805)
                     /locus_tag="MED193_01790"
     CDS             complement(390026..390805)
                     /locus_tag="MED193_01790"
                     /note="COG1305 Transglutaminase-like enzymes, putative
                     cysteine proteases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11021"
                     /translation="MLLSIQAHLIYTCAQPCDLLLQIEVAQDPEQRLEEMQFRISPDI
                     ETNIVRGEEQVGIRRWLRVADAFECLYQTKVVVDRQSVELADLQTTPLNQIPSEVTKF
                     LMPSRYCHPEDFLNAVPALFGPHSGGQLIAVMSKWIRNEFTYDNLVSNGMTTATDSFG
                     ARAGVCRDYAHVLIAMARAVGIPARFLSAYAPNVTPQDFHAVAEVYLEGKWHLVDPTG
                     MAKASEIARIGVGRDAADVSFMTSYGSMSLKKQAVNVSRII"
     gene            complement(391034..391912)
                     /locus_tag="MED193_01795"
     CDS             complement(391034..391912)
                     /locus_tag="MED193_01795"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="probable transcriptional regulator"
                     /db_xref="CDD:10453"
                     /translation="MIDLPPLNGLRAFDVSGRRLNFRAAADEMGVTQGAVAQQVRQLE
                     AHLGITLFERLPKGLALTPAGRSYHKRIAHAFAELRSATAQLKPENGKVLISVTPTFA
                     SKWLIPNLPDFSNRHPEIDLRILATEKVSSFHSDGIDLAVRQGSPPFGAALDATLLFR
                     QNLIAVVAPKLVQTARPPYSDETLAHLPKIHDTHDLWPKVLSEWGIGDQSKRGLRLSQ
                     TALAVDAAISGQGVALVSRFLVANDIAAGNLLEIGPLNAVGAQDFYLLTLRKTTSNAA
                     IDTVVSWLTSQANKTD"
     gene            392055..392714
                     /locus_tag="MED193_01800"
     CDS             392055..392714
                     /locus_tag="MED193_01800"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="putative oxidoreductase protein"
                     /db_xref="CDD:25396"
                     /translation="MGADAARRLAADGFKVGILSSSGKGEALGTELGGFGVTGSNLNG
                     DDLSTLVQGAQERWGRVDVLINSAGHGPKGPVLEISDDDWHQGMEVYLMNVIRPTRLI
                     TPLMQRQGGGAIINISTFAAFEPDPLFPTSGVFRAGLAAFCKLYSDKYASDNIRMNNV
                     LPGFIDSLPETADRKARIPMGRYGRTEEVSSIISLLASEGGGYMTGQNLRIDGGLTRA
                     V"
     gene            392704..392955
                     /locus_tag="MED193_01805"
     CDS             392704..392955
                     /locus_tag="MED193_01805"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPSDLALRRQYRERLVFMVKWAASAIQIMGYTATGFGWTPWNLY
                     LFLIGVLGWFAVGALWNDRALMLVHLVALAAMIAGMTSG"
     gene            complement(393049..393393)
                     /locus_tag="MED193_01810"
     CDS             complement(393049..393393)
                     /locus_tag="MED193_01810"
                     /note="COG0640 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulatory protein"
                     /db_xref="CDD:373"
                     /translation="MDQANALEAFTALAHPTRLEAFRLLVRIGPTGLPALEVSRRLGT
                     KPSTLSGHLSILKRAGVLTATRHQREIHYSANLASVNALVQFLIADCCGGQFENCSEI
                     VALLDMADPLQS"
     gene            393662..394522
                     /locus_tag="MED193_01815"
     CDS             393662..394522
                     /locus_tag="MED193_01815"
                     /note="COG3608 Predicted deacylase"
                     /codon_start=1
                     /transl_table=11
                     /product="succinylglutamate desuccinylase/aspartoacylase
                     family protein"
                     /db_xref="CDD:12932"
                     /translation="MAGNHGDEYEGQIAVSNLARSLDVADIRGRLILLPMVNTPAAEA
                     GLRISPIDSGNLNRSFPGSATGTPTEMIAHYIEEVLMPLADYSVDLHSGGSSLFYPPT
                     LLRGQGHSTEETKALLDLQAAFDLPYAWVFTGGGGRSSSARTAMGAANRKGAINVMAE
                     LGGSGVVTPEILQSTERGLRRILNSLGMLPDYQPDARRGTQELNVQGSVYAYSAGIFE
                     STKSIGDNVEVGETVGLIHHPETPKAEPEKVSSPYAGIVLCSRAMARVERGDAVFQIA
                     SDAEAEADKA"
     gene            394617..395282
                     /locus_tag="MED193_01820"
     CDS             394617..395282
                     /locus_tag="MED193_01820"
                     /note="COG0580 Glycerol uptake facilitator and related
                     permeases (Major Intrinsic Protein Family)"
                     /codon_start=1
                     /transl_table=11
                     /product="MIP family protein"
                     /db_xref="CDD:24161"
                     /translation="MTLERRLMAEWLGTFSLLATVIGSGIMAERLADGNVAIALLGNT
                     IPTGAILVVLITIFGPISGAHFNPAVTLCFALRREIEKRDALFYVGAQVFGGIIGVLA
                     AHVMFDHPLVDPSTTTRSGIGQWAGEFVATFGLVGTILACLKARPTAVPMAVGLYITA
                     AYWFTSSTSFANPAVTIARGFSDTFAGIAPVDVAAFIMVQVIAAVMATGFFGWLLREE
                     NHG"
     gene            395275..396453
                     /locus_tag="MED193_01825"
     CDS             395275..396453
                     /locus_tag="MED193_01825"
                     /note="COG1168 Bifunctional PLP-dependent enzyme with
                     beta-cystathionase and maltose regulon repressor
                     activities"
                     /codon_start=1
                     /transl_table=11
                     /product="putative aminotransferase"
                     /db_xref="CDD:10887"
                     /translation="MAEAFDFDEVINRRDVPALKSHRMVLGEDGMDLFPGGVADMDFR
                     APPPVRDAMAQRLSHGVFGYETVPDGLLPALTGWMKDRHSWNIVPDHILRAPNVLNSL
                     SMAANLFTNPGDGIIVQPPVFFDFADIIAENGRRLVENPLVLSAGKYDMDFEGLEACA
                     ADPRTKMLFLCNPHNPVGRVWSKEDLARLGAICRQHGVLVVADEIHGDITFAGHAYTP
                     FATVSEADALNSITCLSPAKSFNIAACCGAFTIVPEEGRRNAFKAENSRLTVNKNNAF
                     ASVAMEAAYRQGSPWLDAAVSYIEGNLALVHARLNDIPEVTLITPEGTFLLWLDFRAL
                     GLAQDDLTRFLRTEAGWAITRGIAFGEAGKGFGRLNIACPRARLDQALDGLDAAISKR
                     "
     gene            396422..397171
                     /locus_tag="MED193_01830"
     CDS             396422..397171
                     /locus_tag="MED193_01830"
                     /note="COG0431 Predicted flavoprotein"
                     /codon_start=1
                     /transl_table=11
                     /product="NADPH-dependent FMN reductase"
                     /db_xref="CDD:10305"
                     /translation="MGWMRQFQNDETNMTDTPNIEDDHFRAIDTDRLFASDDIGQPPR
                     ILLLYGSLRARSFSRLMTEEAARVLHRFGAETKTFNPSGLPLPDDTEADHPKVQELRD
                     LVAWSEGMVWCSPERHGAMTGIMKAQIDWIPLSLGAVRPTQGKTLAVMQVNGGSQSFN
                     AVNQLRILGRWMRLLTIPNQSSTPKAFLEFDDNDRMKPSPNYDRMVDVMEELVKFTLL
                     TRGRSDYLVERYSERKETGEALIRRVNQTAI"
     gene            complement(397235..398158)
                     /locus_tag="MED193_01835"
     CDS             complement(397235..398158)
                     /locus_tag="MED193_01835"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10453"
                     /translation="MDTQTLRLFVLACETLNISAAGRTLGMAPAVASTRIAKLERLVG
                     ADLLHRSTRKVSLSLEGQDFLPYAREMIAQEEAALAALGKGRTKVSGTLRFAAPSTFA
                     QLYLAPLLPTFMDKYPDLRLDLHLSDSQFDLIEGSFDLALRNAVLADSSLTARKLADD
                     TRILCASPAYLERYGTPANPKDLAKHRLIAFKDTEPKALISNNGMQALFDPKSAAHCL
                     ILNDGLTQKLTTLNGAGISVNSLWAVQEEIADGTLTRVLPDYALSTEPALWLIYPKSN
                     VVSAKVRVFMDFLIDQLGRANVAHRTPRHRS"
     gene            398257..399045
                     /locus_tag="MED193_01840"
     CDS             398257..399045
                     /locus_tag="MED193_01840"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="probable oxidoreductase"
                     /db_xref="CDD:10174"
                     /translation="MTKTILITGATDGIGLLTAQTLAAEGHRILLHGRNVAKLEAAAK
                     TVGGTTEQYIADLSNMAQVHALAAAIVAKHNQIDVVINNAGILKTPITKTKEGYDFRF
                     VVNTFAPYALTRDLLPIMAKDGRVVNLSSAAQAPVDLEALLGRKKLDDMAAYAQSKLA
                     ITIWSREMAKALPEGPVFVAVNPGSLLASKMVKEGFGIAGNDLSIGVNILREAALGTS
                     FADASGKYFDNDSGQFTQPHAAALDAAHSADVMQAIQDVLSLQP"
     gene            399739..400716
                     /locus_tag="MED193_01845"
     CDS             399739..400716
                     /locus_tag="MED193_01845"
                     /note="COG0604 NADPH:quinone reductase and related
                     Zn-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="ripening-induced protein-putative Zn-containing
                     oxidoreductase"
                     /db_xref="CDD:10474"
                     /translation="MTLTAYGEAAKFEAADLPKPEPISGHVVIRIAASSVNTVDTMIR
                     AMGRDLPLSPALPAVLGMDFAGVIEAVGEGVSAFAVGDEVYGCAGGLADLQGTLAEFM
                     LADARLIAHKPKSISMREAAAMPLVGITAYEGLERAGVRAGQKVLVQGGAGGVGHLAV
                     QLAKHFGAEVYATGTGHTQMGVIKGYGATPIDFAAEKIVDYVAKYTDGAGFDLIFDTV
                     GGANMTNSFEAAALNANIASTVGLLEIDLSPAHFKGLSLHIVFMLLPMLSNLGRENHG
                     AILAKLAKIVDQGALKPLLDESVYGLDNLAGAYDHLTSGKAIGKVVIDV"
     gene            400807..401895
                     /locus_tag="MED193_01850"
     CDS             400807..401895
                     /locus_tag="MED193_01850"
                     /note="COG1609 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="probable LacI-family transcriptional regulator"
                     /db_xref="CDD:11322"
                     /translation="MPPKAKVTIKDVALKAGCGIATASRVLNNSGPTSAEVRERVNRA
                     ALDLGFSFSAIGRALQSSKSMTVGCLVPSLANPVFAEAVQGVQNELVGTNYQLLISSS
                     NYDDKADDDAISTLVSKEVDGLIVTMVAPERSPALKLAHQRGIPASLMFHDPIEGFAT
                     SYVDNFEAAREVAQRFSEYGHRRTGFLALRLATSDRSRNRYAGFHAECRARGMPDPVL
                     IELSETDANRPEKLTAILAAHPDLTAIFASNDFLAIAVQKAARLLGWIVPRDLSVVGF
                     DGIEIGKLLDVPLTTIETMPEKMGRQAAKSLLTAMQGGVLEQLPPLPFRFRAGATLAA
                     PRAKSRDDGRVAAQPPSVPLIKTILKQG"
     gene            401900..402895
                     /locus_tag="MED193_01855"
     CDS             401900..402895
                     /locus_tag="MED193_01855"
                     /note="COG1840 ABC-type Fe3+ transport system, periplasmic
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative periplasmic solute-binding protein"
                     /db_xref="CDD:11550"
                     /translation="MKHTALAMLFATSIAAPAMAEDAICYNCPPQWADWASMLEAIDK
                     TLDIQMPHDNKNSGQTLSQLLAERASPVADVAYYGVTTGIKAGNEKVAQPYKPAGFED
                     IPEGLKDPEGNWFAIHYGTLGFFVNVDALGGADIPQCFADLTKPEYRGMVGYLDPSSA
                     FVGYAGAVAANIAFGGDLGNFDPAIKYFNDLAANDPIVPKQTSFARVVSGEIPILFDY
                     DFNAYRGKYEEDGNFEFVLPCEGSVRVPYVMSLVADAPNPELGKRVLDFILSDEGQAI
                     WTNAYLQPARPVELPAEVAEKFLPASEYERAMAVNYAEMEKAQAGFGQRYLSEVK"
     gene            402965..403768
                     /locus_tag="MED193_01860"
     CDS             402965..403768
                     /locus_tag="MED193_01860"
                     /note="COG0555 ABC-type sulfate transport system, permease
                     component"
                     /codon_start=1
                     /transl_table=11
                     /product="putative permease protein"
                     /db_xref="CDD:10426"
                     /translation="MTQRQFLLLCFLPLAIFTLAFLALPLARLILASSESEAGWAIYL
                     KILQTPRYLSTLLQTVLVSVAVTFAALAISTTAGLFLVRNTFPGRSVLLSILTLPLAF
                     PGVVVGFMIILLGGRQGLVNQLLPGHWVFAYSVLGLFLGYLYFSIPRVLLTVMAAAEK
                     IDPALEEAALTLGAPSYRITLDVLLPALASALIAAGAIAFATAMGAFGTAFTLATKID
                     VLPMVIYTEFTLSANIAMASALSVVLGLVTWALLLIARSFSGTTVAAGG"
     gene            403770..404561
                     /locus_tag="MED193_01865"
     CDS             403770..404561
                     /locus_tag="MED193_01865"
                     /note="COG1177 ABC-type spermidine/putrescine transport
                     system, permease component II"
                     /codon_start=1
                     /transl_table=11
                     /product="putative permease protein"
                     /db_xref="CDD:10895"
                     /translation="MLKSNTKLLQLSVTLAACAFLFVPTLQSVLAGVTANYFRGVSSG
                     LTLKWVGQVWELYAGSIFLSIQIALACLAATLIIGVPAAYALARNPGRMSRVLEEFIS
                     LPLAVPGLALALALLQLYGTNHGFRTHWSFILVGHVLYTLPFMVRSVMSVLAAIDLKT
                     LEEGAASLGASPQRRFFDIVVPNALPGILAGALTVVTLSIGEFNLTWMLHTPHLKTLP
                     VGLADSYASMRLEVASAYTLVFFVMIVPLLLAMQWASARAQRITQ"
     gene            404558..405592
                     /locus_tag="MED193_01870"
     CDS             404558..405592
                     /locus_tag="MED193_01870"
                     /note="COG3842 ABC-type spermidine/putrescine transport
                     systems, ATPase components"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC spermidine/putrescine transporter, ATPase
                     subunit"
                     /db_xref="CDD:13158"
                     /translation="MTLTLRNIAKTFAGGTRALLPTDLEINKGEIVSLLGPSGCGKST
                     LLRIIAGLETADPGAAIHFDGEDVTAQPVESRKVGMVFQSYALFPNMSVRGNIAYGLK
                     MQKLPKSEIKARVDEVVTLCQLEKYVSQPIASLSGGQRQRVALARAFAPRPRLLLLDE
                     PLSALDAALRTQLRDELAQLLRNFGITAIFVTHDQNEAMAIADRVAVMSHGKVAQIGT
                     PEALYRNPDTAFVARFVGDAQPLVGRIEGNMLYLQGGKLPLSRAAEGHQAFVRAEDIR
                     LEPRGPLCAKVEAVTFLGAHYRIALTGAAKETLFALYGGLNAPSPGDTVRLAIAPQSI
                     LTLPVDKEVA"
     gene            405593..406411
                     /locus_tag="MED193_01875"
     CDS             405593..406411
                     /locus_tag="MED193_01875"
                     /note="COG1409 Predicted phosphohydrolases"
                     /codon_start=1
                     /transl_table=11
                     /product="putative ICC protein"
                     /db_xref="CDD:11124"
                     /translation="MPRFVQITDTHIVVKDALVCGQSDSSKALEAAVTTLNTKLPVLG
                     EVDCVIVTGDLTDHGTPQEYAQFTAIMAGLKLPWLAVPGNHDQREAMRTSLSAASWMP
                     RSGPIQWHYDLGAFSLIGLDTLLEGAHHGELCKEGFAFLDATLTAIGTQPVIVATHHP
                     WMHSGIAAMDADNLRNGAALMDRLEAHPGPVRMISGHVHRALTTQIGRVTCQVAPATC
                     HAVDIDHRPGVSNGLILEPGAVTIHSWLTTPEPCLVSDIIPTGVFAGPWPFSDG"
     gene            406538..406909
                     /locus_tag="MED193_01880"
     CDS             406538..406909
                     /locus_tag="MED193_01880"
                     /note="COG0531 Amino acid transporters"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIGIGGLSVMTAAYMWTATQHWYDTIPGVSFTGPLNSHFAKDVA
                     LAYLTSGVALIWAGVKQDRNVGLFGAAWLALHALFHIWIWVHRGAPVDLVALVNLTGI
                     QLPAFIGLASAISLTSEKVKT"
     gene            407023..407448
                     /locus_tag="MED193_01885"
     CDS             407023..407448
                     /locus_tag="MED193_01885"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLSTYSQFRGPQKAQNVWAGAMLASTREGDCGPCVQLIVDMALE
                     AGVPTDQIARCLTGHAKSAGDVGLGFRFANAAIADAPELEMLREEIKTRFGETALVAA
                     SFAASSGRIYPVLKRSLGFGQACSLVTIQDEPVKVLRQT"
     gene            407445..408323
                     /locus_tag="MED193_01890"
     CDS             407445..408323
                     /locus_tag="MED193_01890"
                     /note="COG1595 DNA-directed RNA polymerase specialized
                     sigma subunit, sigma24 homolog"
                     /codon_start=1
                     /transl_table=11
                     /product="putative RNA polymerase sigma factor"
                     /db_xref="CDD:11308"
                     /translation="MNISVEIFEAERTKLISLCYRMLGERARAEDVVQDTWLKWAVAD
                     RGQIDNPAAWLRRVATNIAIDTLRSAHHQREVYVGPWLPEPLIQSETLEPRHPFELAQ
                     ECELALLWAMERLTERERAAFILREAFDASYAEIADTLGATEASCRQLVSRSQKKLQD
                     SGPRFDATPEEVSELSERFFLAIMSEDFDTALSLLSPSSIALSDGGAKRRAARRPLMG
                     GKEILQVFRALYEKARNEQGWTTQISTVNSKPAFLRYQFGQLDSITTLAPDYHGKIAW
                     LYIMRNPDKIQEAGHQ"
     gene            408518..409030
                     /locus_tag="MED193_01895"
     CDS             408518..409030
                     /locus_tag="MED193_01895"
                     /note="COG1292 Choline-glycine betaine transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="glycine betaine transporter"
                     /db_xref="CDD:11008"
                     /translation="MTGKARGDLVCQSVAIEPAYYVRPPHGFEHASNALGEGLASMKQ
                     PFTDLEIKKAGSGFYEGHSVEIALLSKGIIVALVIWALIWPANANGVLGSLNWRILED
                     FNAFYIIIVGFFAFFLLVVAALPQTGKRIMGRNGEAPEFSNFSWFSMMFGAGLGVGLM
                     VFATAEPLGL"
     gene            409043..410458
                     /locus_tag="MED193_01900"
     CDS             409043..410458
                     /locus_tag="MED193_01900"
                     /note="COG1292 Choline-glycine betaine transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="glycine betaine transporter"
                     /db_xref="CDD:11008"
                     /translation="MVVSGAIEGNTTEALQSGYRYTFLHYGFHAWAIYVVTGLSLAYY
                     AYTRDMPLTIRSALTPLFGKWVNGILGHVVDVLGVVATILGVSVTIGFGVSQFIDGVY
                     AITGMEWMMDMTGDAPAPGTVGLIAGLVVIMGLSIISAVSGVGRGVKYLSNLNLVLSV
                     ILLLTFVVFGSFLFAMTTYASAFVDYILNFASLSFGAYGPQSADAFAAALPEAAKPLA
                     GELKAGATNAWGSYDGFVGGLTGAAAELPAETLAVVYEAGNEGRQFGWQAGWTTFYWA
                     WWIAFSPFVGLFLARISRGRTVREFIIGCVFAPAMVCFAWMTILGGTAIDLELNGAAD
                     GVIIGASNTSKLFVTLGEMISGGFLSGITIMCVVLIMTFLVTSADSGILVMNTIMSGG
                     EQDTGIKHRIVWGVLLTFVIGALLIAGKTNGEADPMEALKSAMIIGALPFTVVMGLMC
                     LALVKALFRDGKREALSTPSN"
     gene            complement(410629..411147)
                     /locus_tag="MED193_01905"
     CDS             complement(410629..411147)
                     /locus_tag="MED193_01905"
                     /note="COG1522 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, AsnC family"
                     /db_xref="CDD:11236"
                     /translation="MVRALLLGERMPPGDRDMNTKLDAKDRQILQALQRNGRITNHAL
                     AEEVNLSPSPCLRRLRILEESGVIRGYNADIDPKQYGLSMMAFISIRLERHTKECVSH
                     FESRIKLIDEILVCYLLTGGQDYLLHVLVKDLDGYDDFIRNRLHAIGGIASIDSSLCY
                     NIVKNTPVFPDV"
     gene            411299..412501
                     /locus_tag="MED193_01910"
     CDS             411299..412501
                     /locus_tag="MED193_01910"
                     /EC_number="4.4.1.11"
                     /note="COG0626 Cystathionine beta-lyases/cystathionine
                     gamma-synthases"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine gamma-lyase"
                     /db_xref="CDD:10496"
                     /translation="MTRLTDDFATRAIHHGYDPQQNQGALTPPLHMTSTFVFETAEAG
                     GEMFAGERQGHFYSRISNPTNDLLEQRIACLEGAEAGLALASGMGGITSTLWTLLSPG
                     DELIIDKTLYGCTFAFMQHGLSKFGITVTPIDMTDPANLARAISENTRVVYFETPANP
                     NMRLVDIAAVSAIAKTSGATVVVDNTYATPFLTRPLEHGADIVVHSATKYLGGHGDLV
                     AGLVAGSAEMIQQIRLFGMKDMTGAVISPFNAMLVLRGIKTLALRMERHCQSAMTVAQ
                     MLEAHPAVREVHYPGLTSFAQHDLAKRQMDGFGGMIAFELEGGIAAGRAMMNALTMIG
                     RAVSLGDAETLIQHPASMTHSTYSPEERAEHGISDGLIRLSIGLEGVEDILADLSSAL
                     PAPQTAAA"
     gene            412528..415212
                     /locus_tag="MED193_01915"
     CDS             412528..415212
                     /locus_tag="MED193_01915"
                     /note="COG2609 Pyruvate dehydrogenase complex,
                     dehydrogenase (E1) component"
                     /codon_start=1
                     /transl_table=11
                     /product="pyruvate dehydrogenase E1 component"
                     /db_xref="CDD:12126"
                     /translation="MNMQQGFNPSAAVADTDPEETRDWVEAFLGLKNAVGADRARFIL
                     KQLEDTARLEGLNSGEQPYSSYRNTISVAQQGTYPGDLEIESRLTSIMRWNALATVVR
                     ANEAYGGLGGHIASYASAAEIFEVGFNHFFRARDDSFGGDLVYYQPHSAPGIYARAFL
                     EGRLDRTQLANYRQEVAGNGLCSYPHPWLMPDFWQFPTGSMGIGPLNAVYQARYMRYL
                     EARGLAQTQDRHVWGVFGDGEMDEPESIAGLTLAAREGLDNLTFIVNCNLQRLDGPVR
                     GNGQVIQELESLFIGAGWNVIKVLWGSEWDELFARDKDNVLLSRFAQTVDGQYQNLGA
                     KDGDYNREKFFNADPRSAALVSHMSEEEINNLKRGGHDLRKLYAAFAAAKAEKGRPTV
                     ILAKTKKGYGMGGAGESRMIAHQAKKIDTEALFQFRDRFNLPISDQDVEEMNLFEPKA
                     DSKEMIYLHAKRQALGGYMPKRERAAPKASMAAAPALEKYGKFALEADGKEMSTTMAA
                     VRMMGGLLKDKQFGPRVVPIVADEARTFGMDNLFRQIGIYAPYGQLYTPEDAGSMMYY
                     KEAENGQLLEEGITEAGALSSWVAAASSYSIHGMPMLPIYIYYSMFGFQRVGDLIWAA
                     ADQRARGFLLGATAGRTTLSGEGLQHQDGTSQLIAATIPNCRSYDPAYAYELAVIMDH
                     GTRRMMDEQIDEFYYITVMNENYAQPSLPDGAQEGILKGLYKVASQGNGPKVNLLGSG
                     TILPEVLAAAEILEQEFGIASDVFSATSYAELTREAEDCARQNRLSPRATPRQPYVQD
                     CLGSEAPVIAASDYVRAVPQMIAAYLPQRVVTLGTDGFGRSDQRAPLRAFFEIDRNSI
                     ALAAIEAMQQEGSLPQGTHATALELLQMPLEKPAPWTV"
     gene            415225..416523
                     /locus_tag="MED193_01920"
     CDS             415225..416523
                     /locus_tag="MED193_01920"
                     /EC_number="2.3.1.61"
                     /note="COG0508 Pyruvate/2-oxoglutarate dehydrogenase
                     complex, dihydrolipoamide acyltransferase (E2) component,
                     and related enzymes"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide acetyltransferase"
                     /db_xref="CDD:10379"
                     /translation="MSDIIELRVPNIGDVSDVPVIEMPLIVGDHIDLDDTVLVLESDK
                     ATLDVPATSSGKLLEVLIREGDTVSEGDIIGRVEVTGKSEGPAPEASSVQIPSPAANP
                     TEAVERAAAGTVDAGQASTSGILPSRLPEGPQSKHMVHASPSLRKLARELGLDISQVT
                     GTGPKSRITREDVTAHIKKALQTPTLAAGFGLDLPAWPDVDPAKFGPVSRTKLSRIAR
                     ISGPSLARNAIAIPHVTNFENADVTDLESFRKSVNSEGKGAKLTLLAFVVKAVVAALK
                     AHPKFNASLDGEDLVLKEYFNIGVAADTPDGLVVPVIKAADQKSLRDIAVEMADLAAD
                     ARDGRIKPADMQGGSFTISSLGGIGGTNFTPIINAPEVAILGMVRSSMQPVWDGSAFQ
                     PRLIQPMSLSWDHRVVDGVAAARFLQTVQSILQDFRRISL"
     gene            416535..418241
                     /locus_tag="MED193_01925"
     CDS             416535..418241
                     /locus_tag="MED193_01925"
                     /note="COG1249 Pyruvate/2-oxoglutarate dehydrogenase
                     complex, dihydrolipoamide dehydrogenase (E3) component,
                     and related enzymes"
                     /codon_start=1
                     /transl_table=11
                     /product="dihydrolipoamide dehydrogenase"
                     /db_xref="CDD:10966"
                     /translation="MTTLVEIPDIGDFSDVPVIEVNVAVGDRVEVDDPILMLESDKAT
                     LDIPAPLAGIVAEIRVAPGDLVNIGSVVMVISVGAGDTSPPPVGSVSQELDQQAALKS
                     GEQVPVQADVVVIGAGPGGYSAAFRAADLGLSVILIDSSDTLGGVCLNRGCIPSKALL
                     HIAKTMDEAEAAADHGLTFAAPDLDLDKLRSWKDGVVARLTGGLKSLARRRKVTLLQG
                     HARFQSPHTLSVHSLDGETQIGFQSAIVAVGSSPVSLPFLPQDPRIIDSTGALDLDDI
                     PKRLLVLGGGIIGMELGQVYQRFGAKVSVVEMMAQLIPGADADIVAPLFKRVSTRFSE
                     VMLSTRVTSVAAHETGLTVSFEKYGITHQAEYDKILVAVGRSPNGHCIAPEAAGLGVD
                     KAGFIQVNKQMRSNIPHIFAIGDVVGQPMLAHKAVHEAHVAAEVIAGHRASFDAAVIP
                     SVAYSDPEIAWVGLTETQAKAKGIKVQRGLFPWMASGRSLSMGRDDGITKLLFDPDSK
                     RLLGAGIAGQGAGDLIAELALAIEMGADAEDIALTVHPHPTLSETVGLASEAFLGTIT
                     DL"
     gene            418433..419758
                     /locus_tag="MED193_01930"
     CDS             418433..419758
                     /locus_tag="MED193_01930"
                     /note="COG0626 Cystathionine beta-lyases/cystathionine
                     gamma-synthases"
                     /codon_start=1
                     /transl_table=11
                     /product="Cystathionine beta-lyases/cystathionine
                     gamma-synthases"
                     /db_xref="CDD:10496"
                     /translation="MTTSNTTRGDASSQSPLSPGINWLSDLKRSRKPGPFFGEAQHTW
                     SGASTCAVHAGSSDDPRTGAVGTPIYQSSTFLLEDDQYNSIHDGYARDRFIYARYGNP
                     SQWAVQQKLAALEGAESAIVFSSGMAAITTAVLSFMDKGAHVVASKELYGGTYNLFNQ
                     ELPSLDMSATLVDPRDFDAIEAAIQPNTQILYFEAITNPLLTVVDIPKIVEIAKKHRL
                     RVIIDATFATPIGLRCLELGVDIVVHSASKYLNGHSDLIAGVVLGSRKLIDQVWPRML
                     TYGGSLDPHACFLLERGLKTLAIRMQAHQDSAFALATYLEQHPAIEKVFYPLLPSHPD
                     HALAQRLLDNATGNVTFVVKGGDGAALALLKALRLPKQATSLGGVESLISLPFNSSQA
                     GFTHQQRVDMGILPGTVRLSVGIEDATDLIADFKQALGQMTDKTETTHA"
     gene            419751..420296
                     /locus_tag="MED193_01935"
     CDS             419751..420296
                     /locus_tag="MED193_01935"
                     /note="COG1765 Predicted redox protein, regulator of
                     disulfide bond formation"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:25924"
                     /translation="MRNGIPAAALSEFVNEVRDTPHEAVMDYGIHITWESGTRSHVEA
                     KPMHVGGHRVSRKFSWKADEPRQLMGTNHAANPQELLLSGLGACMMVSFLAGASAKGI
                     QIETLEIDFEASLDLRGFMGIEANSAVGFPEIQYTIHVTGDASAEVFETLHRAAVAHS
                     PNAQTILNQVALKGAIVSTSI"
     gene            complement(420652..421494)
                     /locus_tag="MED193_01940"
     CDS             complement(420652..421494)
                     /locus_tag="MED193_01940"
                     /note="COG0454 Histone acetyltransferase HPA2 and related
                     acetyltransferases"
                     /codon_start=1
                     /transl_table=11
                     /product="putative acetyltransferase"
                     /db_xref="CDD:25558"
                     /translation="MKDLIFDTANLKDLETALIWAAQEGWNPGLHDAQAFLAADPDGF
                     FVARIAGEIIAAISVVNHSDTMAFLGLYLCKPDFRGQGIGFALWRHALHHAGARCVGL
                     DGVAEQEPNYAKSGFVRTGATTRLQGKAPTGTTVGTRSFDMARDFTAVAALDQLANGY
                     DRSRFLSHWVAEGAGTRKTVVSTQNGEVSGFATIRLCQNGAKVGPITAPDTATALKLL
                     RAAAASLDVADVTLDLPSSAIAFHKALEELGFVETFKTARMYSGVVPKSSPLRMAIAS
                     MELG"
     gene            complement(421491..422177)
                     /locus_tag="MED193_01945"
     CDS             complement(421491..422177)
                     /locus_tag="MED193_01945"
                     /note="COG1802 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, GntR family"
                     /db_xref="CDD:11512"
                     /translation="MTEQTSAPLTAEQLVSQLELAIHEHRLAPGTKLGEDEIASIYGV
                     SRTTVRSALQALSLQRLVEHKRNRGAYVAQPSLREAREVFEARALLEPRTAFSAAERT
                     TEEDIAKLQVHIDAEHEAMAVGNHGRALYLSGQFHIEIARIADQTTIETFIKQLISRS
                     SLIVALYWQRRTAMCESHAHDALVSALADQDGLRADELMRNHLLDLVTSLDLRNKTSA
                     PLSLKDALAQ"
     gene            422229..422393
                     /locus_tag="MED193_01950"
     CDS             422229..422393
                     /locus_tag="MED193_01950"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MMGINFVFKVVYNFAHKNQDRRSAGAQINGNLSFAVWKAAERLA
                     GGDRRNLKLV"
     gene            422409..423401
                     /locus_tag="MED193_01955"
     CDS             422409..423401
                     /locus_tag="MED193_01955"
                     /note="COG3842 ABC-type spermidine/putrescine transport
                     systems, ATPase components"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC spermidine/putrescine transporter, ATPase
                     subunit"
                     /db_xref="CDD:13158"
                     /translation="MSDGANMRGKYDLELVDLTKKFGDTLAVNKISHRFKAGSYVCLL
                     GPSGCGKSSTLRMIAGHENVTEGAILLGGFDVSHLTPAKRGTAMMFQNYALFPHLNVR
                     DNVSFSLRMKGEDKATRDARANELLELVDMTGFADRLPAQLSGGQQQRVALARALITQ
                     PKVLLLDEPLSALDPFLRIRMRAELKKLQRELGITFVHVTHGQDEALALGDELVVMNN
                     ALIEQAGSAREVWTAPRTEFVARFMGGHNVIALDGGKVALRADDVKLGDHGLPAWVTS
                     IEYQGGHVALTARIEAGEQVLALVPEAIFFQSPKNLGDLVNLAWDEGRLHRLQS"
     gene            423370..424695
                     /locus_tag="MED193_01960"
     CDS             423370..424695
                     /locus_tag="MED193_01960"
                     /note="COG0687 Spermidine/putrescine-binding periplasmic
                     protein"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC spermidine/putrescine transporter,
                     periplasmic binding protein"
                     /db_xref="CDD:10556"
                     /translation="MRGGCTASNLNQINQQGMNSMSKMRYSRRTVLKGGAAVAAASAL
                     AAPMVWAQEIKDITLRQFGTGVSNLNDVATKVKEDLGFNLEMTALDSDSVTQRAATQP
                     DSFDVADIEYWICKKVWPTGNLQAMDTSKIANYDKIVGTFRSGKLTPESVIAQGTAPH
                     TVGFVEGPGGKTFAGNETGWMTLIPTIYNADTLGIRPDLIGRPIESWTELLNPEFKGK
                     ASILDISSIGIMDMAMVCEAMGEIQYGDKGNMTKEEIDKTFAIFTEAKQNGQFRAFWK
                     SFDESVNLMASGEVVIQSMWSPAITAVKSRGIPCVYQPLKEGYRSWGGGLGLSSSLSG
                     MELDAAYEYINWYLSGWVGGYLMRQGYYSAVPETSKEFMTANEWGYWFEGKPATDVIT
                     SPTGDQLAKAGDVRDGGSFTERMGAVACWNSVMDENQYMVRKWNEFIAA"
     gene            424779..425633
                     /locus_tag="MED193_01965"
     CDS             424779..425633
                     /locus_tag="MED193_01965"
                     /note="COG1176 ABC-type spermidine/putrescine transport
                     system, permease component I"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC spermidine/putrescine transporter, inner
                     membrane subunit"
                     /db_xref="CDD:10894"
                     /translation="MGKSRDIIAYLQAAPLMAVLLAFLVVPIGMIVVVSFWGATEFSI
                     YPAFQFDNYAFLFGSPVTYKVFFATFKYAFITWIFTLSIGFTVAYFLAFHVRTQAMQT
                     ALFLLCTIPFLTSNIIRMISWIPFLGRNGIANQTLISWGLIDEPLEWLLYSDFSVILA
                     FVHLYTLFMVVPIFNTMMRIDKSLIEAAYDNGATGLQTLWHVIVPLTKPGIMIGTIFV
                     VTLVMGDFITVRFMSGSQKANVGRLISNDIALLQYPSAAATAVVLLCTVLIVIGVLLR
                     FVNIRKEL"
     gene            425635..426471
                     /locus_tag="MED193_01970"
     CDS             425635..426471
                     /locus_tag="MED193_01970"
                     /note="COG1177 ABC-type spermidine/putrescine transport
                     system, permease component II"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC spermidine/putrescine transporter, inner
                     membrane subunit"
                     /db_xref="CDD:10895"
                     /translation="MEQRPRSFYYLAAFFCLFLLFLYGPTLTIGILSFQGKGGGLTFP
                     MRGVSLNWFRELFEQQAVGDIWGSFRRSLALGLMVMVSTVVVSVMAGLAFRKKFAGST
                     VLFYLAITSLVIPSILVSLGVGLIFNQLGLKVHWTSSGFGSQLTWTLPFGLLIIFAVF
                     NRFDKSYEEAARDQGATSWQTIRHVILPIIAPSLIGVALFGFTLSYDEFARTLLTAGS
                     YNTLPLEIFGMTTNVTTPVIYALGTLTTLFSLAIIGVFLAVVWIVGKRRSRVGSDAGK
                     AV"
     gene            426471..427136
                     /locus_tag="MED193_01975"
     CDS             426471..427136
                     /locus_tag="MED193_01975"
                     /note="COG4126 Hydantoin racemase"
                     /codon_start=1
                     /transl_table=11
                     /product="HyuE hydantoin racemase"
                     /db_xref="CDD:13408"
                     /translation="MHLVYINPNSTEAMTQSVVAVAARNAPQVQVTGLTNTKGPAAIE
                     GPEDGDAAIPGVLQLVAEAQLLGADAIVIACFDDTGLSQARSLATCPVLGIGHSAYTM
                     ASLQGGGFCVVTSVENAVPVIKGNIETSGFGENCTLVKASGLSVLTIEQGGEEMLDQL
                     SQAILEAKDQYICQTVILGCAGMAMHHGVLARRTGTKLIDGVVASTHLAVAAALTLPE
                     KTP"
     gene            complement(427455..427928)
                     /locus_tag="MED193_01980"
     CDS             complement(427455..427928)
                     /locus_tag="MED193_01980"
                     /note="COG4337 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13584"
                     /translation="MQITHDEIETALETWGDGKISISKAFEEGGIEAARVVPSANIDS
                     YYGYDLGPVLFKPTMASGAQTFRPTKVGALAYFCGHSAEYPLDNGFAIMGWRAMESIP
                     SASFLQGDVAMWMGWVKLTNKDGSVTTVDKSFGYKKDQSGTLRIVLHHSSLPYQP"
     gene            complement(428124..428399)
                     /locus_tag="MED193_01985"
     CDS             complement(428124..428399)
                     /locus_tag="MED193_01985"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKQIKLRVVSDDGVEATISTDGSQGGVEDYYAVVSVDGFIKEKK
                     VYGIDPVQSFVLGLKLIEELTTDKRIGDDDDVAITPGASWRIEVVED"
     gene            complement(428368..429717)
                     /locus_tag="MED193_01990"
     CDS             complement(428368..429717)
                     /locus_tag="MED193_01990"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="probable transposase protein, Y4bF"
                     /db_xref="CDD:25582"
                     /translation="MGWLMMSERELNRVEVLAQVDDGQLSVDNAANMLDLTRRQIFRL
                     LKRYRQDGAAAIRHKSRGRTPNNQIHLAKRDYALTVIKEQYPDFGPTLAAEMLAENHG
                     FKVSRETLRKWMAEDGIWLSRKQRRQFHQPRLRRECIGELIQIDGSDHRWFEDRGPPC
                     TLLVFIDDATSTLMELRFVKSESTFSYFEALESYLRQHGRPVAFYSDKHTVFRVAKED
                     AKGGARMTQFGRALNQLNVEILCANSSQAKGRVERANRTLQDRLVKELRLADICDMDA
                     GNAYLQGFKERHNAKFAKAPAKPDNLHRALNVEPDRLDDVLCWRENRYVGKQLTFSYD
                     RKRIMLEESDVTRGLVGKYVDTYAFVDGRFEVRSKGRSLPYKIFDMDQRVTHAAITDN
                     KRLGAVLEHIKEIQDAAPPKYPVRTNSEKMGYKPQGRPSGSKAKRQRDETNQATRSI"
     gene            complement(<430008..430636)
                     /locus_tag="MED193_01995"
     CDS             complement(<430008..430636)
                     /locus_tag="MED193_01995"
                     /note="COG2207 AraC-type DNA-binding domain-containing
                     proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLEHALVLDSLGAPIRHRQKTHSADWDEVEDFCRSVYMRYRVRP
                     LDRLSLPDATMISAKAGCVTMTRFAYGTGIHLDRFDPDAGNILVLNTLRGALDHQTDG
                     GSIATAAGESFVVDCSRAEYWLEGDPDHMQLNLTIPHQAMVDTAERWFGFVPDDRLWT
                     SRVKIGGPNSAWPALLDYATRALTRAGEVSSDAVLVRHIEEMLCVELLR"
     gene            complement(430883..432883)
                     /locus_tag="MED193_02000"
     CDS             complement(430883..432883)
                     /locus_tag="MED193_02000"
                     /note="COG3505 Type IV secretory pathway, VirD4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system coupling protein"
                     /db_xref="CDD:12833"
                     /translation="MGKARIATGVLLVTLVTAAMGYTIASAVLTYQDLGFGAEIDFAY
                     IAQNYMAILDRRPEDAQLIHLIIGSFAAAGLMLSLALSGSALTRFGQTHWQTAREMKA
                     NGFFGAPGTGFILGKLGPPGSRANYICSKVFPHALIVAPTGRGKTTGFVIPNLLTWQG
                     SAVTLDVKGECFEATARHRAAQGDKVYRFAPTDWEGKRTHRYNPLLRIFELKDPARQQ
                     MELQLLATLFLQSDNDRVQGLLKGGIDLFVAAGLLAFQRKRPTLGEIYRIAASGGNKQ
                     KEYFARGHEVDNRAAKLIFTRLASTNNDTLTSYVSLLMTSGLDQWQNPAIDEATAVSD
                     FDFRTIRKKPFSVYLVVQPLMVKPLAPLIRLFFSDLLSAMQEKDPGPDEPWPVMIMLD
                     EFNRLGKMPIVVESIETLRTYRGHLAVVTQTIPALDEIYGENTRRALQGNAGVKLYLT
                     PSDEKTVEELSKAVGKTTKTVITRSQSIGKNPFEGRSQSTRTEESSLLPEDEARRLPL
                     DEIVMVIDAQMPVRAKRIQYFDDRLFKAIHATQTGELPFPKPGGGGLQGTLPLSVRAM
                     PMAPPPDGPSGPEADVDVAGQPTDAEHSGQSDVVPKKTAPVVQAVIAKEQRQMEMDFG
                     SQVVDAEAARVVDEAQMRSAVDGLDEMEAMLRENGGQKLVAR"
     gene            complement(432892..435225)
                     /locus_tag="MED193_02005"
     CDS             complement(432892..435225)
                     /locus_tag="MED193_02005"
                     /note="COG3843 Type IV secretory pathway, VirD2 components
                     (relaxase)"
                     /codon_start=1
                     /transl_table=11
                     /product="T-DNA border endonuclease"
                     /db_xref="CDD:26076"
                     /translation="MRLNDAVHAVTGEVFRDGWSRVRGSMQGLHVAKQTQLVRAAAGH
                     RPAVFKAIRGGGTHTKSQLANQLDYLTTKSTHIVDSSGFLDGKTKLEAGDIKDLTERF
                     AKRWDAGFKPKLGQTTHMLMSFPIGTRGEDVRDIATDVAERFFQTDKGHFDYIIAVHE
                     DRDHPHAHLVLNRRSQEGEFFFLGRNHRFNYDDFRLAMVEEAEKYGVRLEATRRVDRG
                     VVHYPARTSEVYAAKDEGRAPRERERVGQDLTRTLAEIANTRTVYHSLAAEASREARE
                     DIAAALFRAGEVLAHGGQMDRTGDVYMAEDQSFEDLRSLYAEKLARVQGMIAEKSDAE
                     RPVLEKRLIEIQTQVQHMQPLGLRSGSLSEAPSEGGIYSEANIDANQRERLAEPDLRS
                     RIDAALHGTGISTSEVVARIETAASSAALEHQWIADDLAKVAEARDLNLERRADLEQA
                     RDILNDVHVELGTLLERENVLRRDGVMEAEPVSERFHYHEGAVREMEGTIRQEMRAEG
                     LTAQQVEDRDWEVVSRAERRIETEQRAYLEAHPDLLARPGDVIDRSEPYRETITDAAR
                     ASAITREVDRIMEGRDVRTPVAGAVTDEFRERYPDMPSHLARGLGATYAAVVEIRDTE
                     AINQVRRETEMRDGLGVGTRDDILATRDGTPMRSDRADRLADEIARVLDHERAGELSA
                     PFESEAERDAFRGEIARVMDDRQLERLTSGDADALEKVLEDRLDRLYVAKVYLQSDAA
                     TANTEALRQVVDDLADTEYEKHRTGDVDGETERGQVH"
     gene            complement(435212..435793)
                     /locus_tag="MED193_02010"
     CDS             complement(435212..435793)
                     /locus_tag="MED193_02010"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSRSKRLTDADRMEIVREAAEGVSTSVLAERFGVSVRAIQYTLK
                     ADAERQTDAAIPVSAVSVKVTAAELAALDAVLATAGIESRAEGLRRLIQAAGGVFVPD
                     AQMAAEMARYRASLHEVGNGVAQIAKQMAQANRQGQGAGSEFTELRLAQMRGLARFIL
                     DSADEIDLLLRRRRDAMQLQATAALREFAHAAE"
     gene            complement(436315..436521)
                     /locus_tag="MED193_02015"
     CDS             complement(436315..436521)
                     /locus_tag="MED193_02015"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTNHYVATVPVKFTDTDGQERTRFQRVGAMFRNTRNGDGSEFFS
                     LKLDFPVAVSELVMFPPSAKDPQD"
     gene            complement(437060..437989)
                     /locus_tag="MED193_02020"
     CDS             complement(437060..437989)
                     /locus_tag="MED193_02020"
                     /note="COG2875 Precorrin-4 methylase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAYDTANTYETIELFGLTEKDAQLPIPEDHVLTDRIIRESFEAL
                     LGQLRNTGLEAEIEPLAHGLATILQRRKLALGKEVDRTADKIGALAKSHDGSEIAETA
                     IEEAQARFVQLREIVGAIEVMSEAAAECYEIETGHAFIPAAGSRASVRAQETGAVFEA
                     RQLLEQHDRETAEKSKVEGVPLIVSGATDWTDVDVIFNTLDKVRERIKQNRNQEIFLC
                     HKGGKHGAEMIAARWARARGVAQARFDPRWSAHGRAAPFKCNDEMLDDKFAATGVVLF
                     GGNGVALNLGQKAEAKGLTVMRVADPAKKASQD"
     gene            438620..438895
                     /locus_tag="MED193_02025"
     CDS             438620..438895
                     /locus_tag="MED193_02025"
                     /note="COG3609 Predicted transcriptional regulators
                     containing the CopG/Arc/MetJ DNA-binding domain"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSVQKQSVSFTDTAYTFAKELVEAGEYPNMSAAVSGELAKAKAE
                     RDRERSLFEAELERRLSLPLDQWEPVGEASDVTASARAHLAAMAKKT"
     gene            438895..439227
                     /locus_tag="MED193_02030"
     CDS             438895..439227
                     /locus_tag="MED193_02030"
                     /note="COG0031 Cysteine synthase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRFIRHPFFERDLIGIVDHIVDVTDGDLAAASRRLDEIDALIQN
                     IAANPKSGARLSGKLDGWLVRHGGTGQRLTIVFKPHVDAAQIYLALVAFGGRDWMRLA
                     SARQVFTD"
     gene            complement(439421..440134)
                     /locus_tag="MED193_02035"
     CDS             complement(439421..440134)
                     /locus_tag="MED193_02035"
                     /note="COG0666 FOG: Ankyrin repeat"
                     /codon_start=1
                     /transl_table=11
                     /product="Ankyrin"
                     /db_xref="CDD:14848"
                     /translation="MARPSGGGPLFLKGNIMFRFLLLALVIGSFGSAHAQTAPSASDI
                     ASYTGLHLAAHEGDVDVINRLIGAGADVDIRDRSQRTPAHVAAFASHDDALTALANGG
                     ADMNALENRVYDVLTIAAVANDPEMVSLAMELGNAPDLITSVYDGTALIAAAHLGHHD
                     VVARLVDGGAPLDHINNLAWTALIEAVVLGDGGPDHIKALQILVDAGADKSIGDRDGV
                     TPLQHATSRGYAEMVEILQ"
     gene            complement(440140..440622)
                     /locus_tag="MED193_02040"
     CDS             complement(440140..440622)
                     /locus_tag="MED193_02040"
                     /note="COG3193 Uncharacterized protein, possibly involved
                     in utilization of glycolate and propanediol"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12531"
                     /translation="MIRSIALATALLTPAAAFAQDLPTAPYLPLDMATTATQAAVAAC
                     SAEGHNVSVAIVARSGETKVLLRADNAGPHTVGSSTGKAFTSASMGRDTAGLAGFIGG
                     NPENGGLRDMDSRLVIQAGGLPIRIGGALVGGIGVGGAPSGAIDETCARAGLDAIGAE
                     "
     gene            complement(440729..441334)
                     /locus_tag="MED193_02045"
     CDS             complement(440729..441334)
                     /locus_tag="MED193_02045"
                     /note="COG4566 Response regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13729"
                     /translation="MTNHVYLVDDDEAVRNALSLLLETVGLNVCSFASPEKFLSQVAD
                     LTPGCLILDIRMPAISGLKLQEKLTEKGVSWPTVIISGHGDIEACRRAFRNGAIDFLS
                     KPVDEQNLIDAIQKGHAELEANQQALEERAEAVALVRNLSTREQQVLEMIAKGLTTKQ
                     IADALTLSPRTVESHRAAIAAKAGTSSAAELTRYWLDAQAD"
     gene            complement(441331..442785)
                     /locus_tag="MED193_02050"
     CDS             complement(441331..442785)
                     /locus_tag="MED193_02050"
                     /note="COG0642 Signal transduction histidine kinase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13451"
                     /translation="MLALGGVAFFERQNLVRELTIKSETLHRLASQRADQHDAHLTSL
                     SAIFVAGGMERQDLLLDVAATIRRFYPRITSVNVVPYVPSQTAIETQPGLSLQARERV
                     IELARRSTGALQIGPMPDLPDHYLLVKRTPNSDAARHGLALVIDARALIATDDPFWDT
                     PSASLRLSTPDGQTALVGEVSSGETGFSKPLGSASQPLVFETSLTIGLSDLLPVETVV
                     FVIALVTALFLLSAFGLKQRARTKDAEDRAKLSAQETRLAHASRVNAMGEMASGMAHE
                     LAQPLTAILSQAQAGRHLARRGEVARLGTVLDDTVSQAQRAANLLDRLRRWSKPNRAP
                     SEACSVHEAAQSVKNLLALEAKTKGAGITLSLYDHPLFIDADPVELEQVVFNLMRNAL
                     DASDEAQVTIRTYVDGPSVILDVSDTGPGVSDDLRPRVFEPFVTGKPDGTGLGLALCQ
                     RLIEEMGGDIKLLDDTDQTTFRLSLPRSIKTVRP"
     gene            complement(443152..443931)
                     /locus_tag="MED193_02055"
     CDS             complement(443152..443931)
                     /locus_tag="MED193_02055"
                     /note="COG5489 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:17661"
                     /translation="MRWQERQAPNNLKRNHPMFAGTLTRNVETAAAQYTGMIHSTRFD
                     IAIQLEARAKMSERSPDFDVTAVNKSGRKVRIGTAWNETGNTSGNPYVSMQIDVGLGP
                     FRVNAVQTKEARATQSGDFEIIPLVSNGLMKSGSISGELTAMDADNAFTGYIANMMFD
                     LEFMLIENSYKSEETHPDYRVEVSSPRGTPIRVGSAWMAKSSRTGNDYLSLLINTPDG
                     DLRVNAVQNEKQRGGQTFSIIPFIDSGEQPQDAGAGLSLVA"
     gene            complement(444006..444311)
                     /locus_tag="MED193_02060"
     CDS             complement(444006..444311)
                     /locus_tag="MED193_02060"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTLGEIKAAIDAGQTVHWANTGYRVHKDSLGQYLITFEPNGSTI
                     GLTDRSGQRLNGEEAEFFIAGSEEGDENTQDSHPRPDGQGRGVVPGGKVAQSFRRQR"
     gene            complement(444326..447766)
                     /locus_tag="MED193_02065"
     CDS             complement(444326..447766)
                     /locus_tag="MED193_02065"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MVFDKVQEDGEMIRAAVQDLEEVLPFVDAVAATRTEMRPVQRAA
                     AIPHTRSSVPSSAPRKAAAAPVAPSKPRAKAVVPLSFTSLQTPRDNTPISDIYARYRP
                     QRIEIASAQEHPTPLVESIAMASVAPPMPSNTGSDDLRLPAKLIEEGHLSEAQLETII
                     MAHDAHGRDLPGRFTIDYDQTKLTRADDDQDARAYRLGYFLGDGTGCGKGRECAGLIL
                     VNWLAGRRKAIWVSKSATLIEDAIRDWTDLGGSPADIQPLSKWKSDQPVPMGDGILFV
                     TYATLRSAGKCGTTRLSQILEWMGAEFEGVLAFDEAHAMQNAAGSEQGRGVKPSQQGL
                     AGLRLQLAAPRARVFYISATGATSVHNLAYAARLGLWGQGPEYPFPSRESFVSAMEAG
                     GVAAMEVVARDLKTLGLYTARALSFDGVEYDVLEHALTPAQIEIYDAYAGAFRTIHHN
                     LEAALTATGVNDASGETNASAARASAKSRFESTKQRFFNHLLMGMKAPSIIHAIKDDL
                     ATGKACVIQVVSTGESLLKRRLETMDPEDELVEGALTPRDYVLGYLEQAFPIHAQKLV
                     EIDGNMVAEPLRDETGALVVSREALALRDAAMMELMTLAPIPSALDQILWAFGDEAVA
                     EVTGRSIRPLKSEDGHLFIEKRAASSNSSETQAFMDGEKDILIFSDAGGTGRSYHAAQ
                     TAKNQKRRRHYLLEPGWRADAAIQGLGRTHRSAQVSAPFFRVCTSDVHGEKRFTSTIA
                     KRLDQLGALTKGQRETGSQGMFREEDNLESPIARAALRGYFADLAAGRAEAMSYESFT
                     DWTALRLIDKDGVLLEELPPIQRFLNRVLALPIHMQNALFAEFMRRIADQTERARAAG
                     TLDLGVETLRGEKIEQVSTEDLWTCPKSGAVTRIIGLEVTDPVHVLSADDALSRNPDK
                     LPMVNRASGRAALISARPMQMYDEDIVTLMRKAVRPNGSSYLEETRFESSAWEDIGRP
                     EFARLWDAEAASLPKTTTIKLYLLTGLLLPIWKDIPTTNERIYRVTPDGATAMIGRTL
                     SEEGAAALRARFLVSNPQTPQEMLTAALGTTAPVDLGRGLTLTRRRVAGEMRLELGGA
                     DRGMIDGLKALGCFTEIIAFQLRVFLPHGDGIDTAGILSRIVGTGPDATWDVTSVAAE
                     "
     gene            complement(447766..448662)
                     /locus_tag="MED193_02070"
     CDS             complement(447766..448662)
                     /locus_tag="MED193_02070"
                     /note="COG2813 16S RNA G1207 methylase RsmC"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12167"
                     /translation="MKSESGLFVLWNSDPDPKENPMSKPNPASPALSTSDADFTSALA
                     QIGAEIDHQPLRSSALARIMRETFHGSDAGGAWDWRIAYDLMQAAAIQVVLRGDGAAG
                     DFAAAKLLASRLLTETRRSEQQIRLQQFSTPLPFAALVLRAAAIRKGETVLEPSAGTG
                     ALAAFAARAGATLLLNDIDPFRQCLLRALFGGDVTGHDGEHIDDLLQTPVLPDVVVMN
                     PPFASSVDRSRDKHIAAKHLIGAAKRLAPGGRLVAIMPPGFTPERDAAHWSRACGLLT
                     PRLALTMPGQSTASSAPLSKPS"
     gene            complement(448702..448854)
                     /locus_tag="MED193_02075"
     CDS             complement(448702..448854)
                     /locus_tag="MED193_02075"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAAEANSYDAWFCAQVQAALEDARSGTSQVQVMQAAQALIDAKR
                     EVEAKS"
     gene            448853..449038
                     /locus_tag="MED193_02080"
     CDS             448853..449038
                     /locus_tag="MED193_02080"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MEMLLESFIQKLAKAMGHVCNVHRDWQTAPLHLGRALLIETKKW
                     PFLSRFVHCVFSNRVKA"
     gene            complement(449109..449627)
                     /locus_tag="MED193_02085"
     CDS             complement(449109..449627)
                     /locus_tag="MED193_02085"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSGDSVPAQAPLVVNGWSIYAHPLFLDQLEGLTLEVEARKARDP
                     KTWRKKNSTKRLAAIFKLVTEAIPADPGAAAFRQGGTLGDHRKHWFRAKFFQQYRLFY
                     RFNSDAKVIVVAWVNDDKTLRAYGSKTDTYATFKGMLEDGNPPDNFDALLKEAAAADK
                     RFETSLEAAPDR"
     gene            complement(449624..449950)
                     /locus_tag="MED193_02090"
     CDS             complement(449624..449950)
                     /locus_tag="MED193_02090"
                     /note="COG2002 Regulators of stationary/sporulation gene
                     expression"
                     /codon_start=1
                     /transl_table=11
                     /product="htrA suppressor protein sohA, putative"
                     /db_xref="CDD:11710"
                     /translation="MTALAQDVSKLTDRYQTTVPAGVRKQLKLGKGDQIRYCTEPSGR
                     VYIEPVRSDEEDPVLGAFLDFVEADIKAHPDRIRAFDGALHDRLAALVGDVDVDLDAP
                     LSLEDE"
     gene            complement(450077..450730)
                     /locus_tag="MED193_02095"
     CDS             complement(450077..450730)
                     /locus_tag="MED193_02095"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGWLFYTDRRVKTYADEKAEIARLCTSHGDTRKTELVKACKVGS
                     TWYAAARVTNLDGTAVEDATYVTDVDGSITFGAVFLTRYDDGCWGYKDMEESAGPNES
                     RAPLALIGLLSNLKDPDSYAQDWRQRCRDWAAIPDYEEGDKIRLATPVTLTDGSTCQI
                     VTATHYRRGRQKRRCYRIEETGGLVRLSKASLAGSELLSFAKGAASPVLAEYLAGRD"
     gene            complement(450833..451426)
                     /locus_tag="MED193_02100"
     CDS             complement(450833..451426)
                     /locus_tag="MED193_02100"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAILKFSASAVAAQIAHARACKTFLPNWNGPVDRPALILIVGNG
                     VHLRSNGIDGTTTRIVTTEQADPSFAFADGMNPFRDTDWMAQRRMAFRDLTGQFYTDT
                     LDDVQVLIDRGRGAIRLATDGHSIRVFVRRASDYLIGGTYEVPSGLGGTFRVILEDAC
                     DTFAIVQNCGNCEDFDAMQPYRVPLDALMEIDDRRAA"
     gene            complement(451503..453485)
                     /locus_tag="MED193_02105"
     CDS             complement(451503..453485)
                     /locus_tag="MED193_02105"
                     /note="COG1475 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="ParB-like nuclease"
                     /db_xref="CDD:2710"
                     /translation="MTTNFAPLTVAIGDLVPHPANVRSNSPETYDPENIAHLKASIAV
                     LGLLQPILVQKFDGKYAVLAGGRRHAALKELVADKAIKGFTAKTKVDCRLVPEDCDVT
                     TALSLAENVTQAPMNAIDEFEAFARMMEVDGQTPETIAKTFGTTVAAVKGRLRYGLIH
                     PDIRAAARGKVITLDTMKAFAEHPSQEAQREVFEALTKDGGYLQAYTVRQALKSRGVQ
                     VSDDIGAFVRVDYEARGGAVAADLLDEHSVLEDAALVETILLEKLGAAAEDARMRLGF
                     AWADAMVRYDYATMADYGRVYPGPIEPDEAAQKRVDEITAELEKLQLEMEDEGLEDGA
                     YNALYERVDALEEEARDLQEAYSAEDLARAGVIASWQGGQITLHIGLVRPEDTVKEEG
                     ARGSSANPTGEEAPDAGEITYPASLAEDLKTERAMALGAAMALHPEATLDLTLFKLVS
                     DVLASGMSVTQAIKIDARKEYRSHAKMDEIDETSLEQVAAAHDALDLSWLDDTRPPAD
                     QFAAFRALKTGEKAKLVAYATASTTQSCFARDRQRDSLMHAFEIEIMPDIRAHWTPNA
                     ALFNRFKKAWLLKILGEDLGLAQEAVTLASSSKKEIVAFCDKLFAEPFATLTDAQRAA
                     VAAWCPPMMQTAGVACDEAEPTAETPEPDSEVAQAA"
     gene            complement(453641..454030)
                     /locus_tag="MED193_02110"
     CDS             complement(453641..454030)
                     /locus_tag="MED193_02110"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSMTVQPLPDRPDPTVIAAQNDAFRKLACLGVPPARPIQGRMHV
                     TRALMEAGDGFMAEAVKATGEFATFEPENDPEGWHDFGAVEIRGETVFWKIDLYEADS
                     DFRYGAETPDNPATTMRVLTIMLARDW"
     gene            complement(454619..455590)
                     /locus_tag="MED193_02115"
     CDS             complement(454619..455590)
                     /locus_tag="MED193_02115"
                     /note="COG0491 Zn-dependent hydrolases, including
                     glyoxylases"
                     /codon_start=1
                     /transl_table=11
                     /product="metallo-beta-lactamase family protein"
                     /db_xref="CDD:10362"
                     /translation="MTSFDLSRRGLILGAAGGAALLAAGRPHPLQAAGHATAPLPTFY
                     DRMVGNLRVTTLLDGYFKLDQNLVTNLGDEQIAEGMKAAYLDPANPIPLAISTHVIRQ
                     GDQVSLVDAGAGSAFGPTAGRLRTSLELLGVAPEDVTRIVLTHMHPDHIGGLIADNGP
                     VFPNASLHVSETDHAFWTDEMIASGAPESSQGFFALARAVSEAYTQRTEMFGDNTDLG
                     GGLTTLAMPGHTPGHSGVRVSDGSDQLIIWGDSTAVASLQFSHPDAGIAFDADGVQAA
                     ETRRRVLDMVVADKIAVAGTHLPFPGIGHVEEKDGAYAWVPEEWQHI"
     gene            complement(455795..456736)
                     /locus_tag="MED193_02120"
     CDS             complement(455795..456736)
                     /locus_tag="MED193_02120"
                     /note="COG4227 Antirestriction protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13477"
                     /translation="MARSRTPKFDASEVITNEIIRIIERGVLPWRKPWTAGGSSRPLR
                     VGGEPYQGVNNFLLTMRTVMAGHSSPFWMTLPQANALDAKVRKGEKSSVVVYYGQSRK
                     DAGGDEHDRSDGDDHSEEARIFRFQKSYRVFNACQIDGLPDSFFPDPEPAPEHPPSEP
                     IPHMQAFFDALDITTVFTGTEAYYLPPVDKVFMPSIARFENPRNFYGVWAHELAHATK
                     APHRLKRDFGLSKFGNTSYAREEIVAELTSVFLGQTLGFTAHTLEMNAAYLYNWLRVL
                     RSDKNAIFKHAADAQRACNYLIARSEAGRAERSAKAA"
     gene            complement(456777..457247)
                     /locus_tag="MED193_02125"
     CDS             complement(456777..457247)
                     /locus_tag="MED193_02125"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MQTGVLRVLRATAASWWRHRELRRTGQTALAQRLERQTVLRDLG
                     YLKQAASLPNAHVICGDGGTFLHLGWTTVSTLAPIERFPLAALAVARGTPFIDIRSVT
                     DVTAFANLPCVARDGSVDPDPCGPGRSVSLTTYIDMVEGLGARIINDPRPRQSI"
     gene            complement(457325..457459)
                     /locus_tag="MED193_02130"
     CDS             complement(457325..457459)
                     /locus_tag="MED193_02130"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MPILPADLELLHEINGFGRRAGLFGFVVCPKGPEKEKVFFGFCD
                     "
     gene            457541..458743
                     /locus_tag="MED193_02135"
     CDS             457541..458743
                     /locus_tag="MED193_02135"
                     /note="COG3177 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12515"
                     /translation="MLETPARIEPCFFEEHIPTELADLSVDIQREATGLGQGLHPDSA
                     AELADLVRVMNCYYSNLIEGHNTRPRDIERALAGAELEEETRPLALEARAHVIVQRAI
                     DEMHRKGTLPRPTSVEFLTWVHKSFYDEMPDEFRVIEHPDGTQEPIVPGRMRQDDDRE
                     VAVGRHLPPSSSRVAAFMDHFDKRFQIAARSSSGRIIAIASAHHRLNYIHPFPDGNGR
                     VSRLMSHAMGLTAGIGGQGLWSVSRGLARGLTDRGEYKRMMDLADSPRRGDRDGRGNL
                     SEAALKTFSEWFLKVTLDQISFSARLFDLGGLDQRYRRLVADTIDDKRAPELISAVLR
                     HGALERGDAQIVLKTSERTARNTLSKLTAAGYMTSASPKTPVRLAFPLDYRERLFPNL
                     FGDGDLPQ"
     gene            complement(458956..460011)
                     /locus_tag="MED193_02140"
     CDS             complement(458956..460011)
                     /locus_tag="MED193_02140"
                     /codon_start=1
                     /transl_table=11
                     /product="Replication protein C"
                     /translation="MAFTKLSIEAAGADATRGSFPPSETDVWTIFRALRDARSVFGLR
                     PGHIQTLQAMLSFLKPGHGETVFASNNSLCQRVGGIDERTLRRHINRFVELGFIKRND
                     SSNRKRYRVRSSGGECISYGLSLTPLLQRASELIAIAQEMENNRRDRIFVRKQILTKL
                     AHLEEHDPSNAFINHARKALRRKLSLPEYHALLANTDAECQSLSTPDDPPETMELPAN
                     DGQTVRHQSKSEEEKKDLDSNIGLEALKPDLLTSVCDQATSFSTERLRNWLDIENHAR
                     TLAPMMGIHPETFEKAKNAVGAQKASCAIFIMLQLGKRIRDFGAYFHSITLGQRQNQF
                     DPLALIKRLSENNERTV"
     gene            complement(460250..461233)
                     /locus_tag="MED193_02145"
     CDS             complement(460250..461233)
                     /locus_tag="MED193_02145"
                     /note="COG1475 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="ParB-like partition protein"
                     /db_xref="CDD:11189"
                     /translation="MGASLMARNIFNQPPRNETESGAPSPTPPKAAKLPGSVGGLRDS
                     LREITANSIRDIEPDQIDMDGLRDRLVLEDSSIDELAESIRKHGQQVPIMVRPSAQPD
                     RYRIIYGRRRLAAIRKVGGTVKAIVRTLDDDASLIAQGQENNLRLDPSFIEKSLFIKE
                     MQESGYKPGVIQDALGLTRQGVSNHRVVIEQLPDGLVQLIGPAHGIGRRQWGDLAALS
                     VKVDLVDIAKEALAALPDDTPSSEKFQAVYSACSSKARSDKKPPNRGLTSVINDENGS
                     SLGTLTIDEKAIALKVTKKDNPEFGQWLEEHAEATLLQLFVQWRNERGSGS"
     gene            complement(461218..462417)
                     /locus_tag="MED193_02150"
     CDS             complement(461218..462417)
                     /locus_tag="MED193_02150"
                     /note="COG1192 ATPases involved in chromosome
                     partitioning"
                     /codon_start=1
                     /transl_table=11
                     /product="RepA partitioning protein/ATPase, ParA type"
                     /db_xref="CDD:10910"
                     /translation="MDDRNIGYTQGIGSSDIGAFADNLAESLDRQMKIAFEPEERKSL
                     RRFSSTEVAGLLRVSTSNLRNRHKDGSFPEVHTDNRGHRFYTAQEIDELRDVLGRTGK
                     NAESYRPGRRDGDRLQVISVVNFKGGSSKTTATIHLAQRYALRGYRVLVLDLDPQASL
                     TTFFGFRPELEFADGGTIYDALRYEDQVPLSNVIQKTYFHKLDMVPAGLMLSEYETET
                     ANALARRVQPIFAERLALALEEVEANYDIVLIDCPPQLGFLTLTALAASTGLLVTVVP
                     GMLDIASMSQFLKLASETVKAVEEAIGRRVTWDFVKFLITRYEPSDGPQTQMAGYLRS
                     ILAGQVMTEPMLKSTAISDAGMTQQTVYEVDPSQFIRKTIDRALTSVNGVGDELEQTI
                     QMAWGRR"
     gene            complement(462759..463667)
                     /locus_tag="MED193_02155"
     CDS             complement(462759..463667)
                     /locus_tag="MED193_02155"
                     /note="COG1961 Site-specific recombinases, DNA invertase
                     Pin homologs"
                     /codon_start=1
                     /transl_table=11
                     /product="TonB-dependent receptor protein"
                     /db_xref="CDD:15150"
                     /translation="MPLIGYARVSTEDQTPLPQSEALQTAGCVEIFEEHASGGNRARP
                     VLARLLERISKGDTLVVVRIDRLARSLSHLLEVIERLEARGAFFRSIQDPIDTGSPQG
                     KFTLQVLGAAAEFERALIRERTKAGLASARTKGRVGGNPGLRAKDPAALRKVRLARQD
                     GYMERLNETAQDWVPHVRRLRPDLAWEDVVRIINGPLPEARRWTQSRLLRAVKAYVGD
                     GFLPAEVLARAGRRETDDRLPAIVAGIKGADPDITLQAICTRLEAMRERTPRGRTRWQ
                     PSSVKMLLERAERLGLMPYESSQNQM"
     gene            463894..464973
                     /locus_tag="MED193_02160"
     CDS             463894..464973
                     /locus_tag="MED193_02160"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKPQVSTHYDSFDDPLVDSEGLEETSEDDLWSLPGPMEVEPDYL
                     PPGPRAELGETAVLDDWRKAEAVNAARLARVAGRIGALDDRLRRGPKGWRHRLALMEA
                     ADLSWFVGDRIGPDRLALWISMRLSGVQDNTAALARVGWAVRRLTGGPGPEVDLSAFL
                     DRRDPENIAGEAEPFADRAGGWLDLMAQAVDLHPITRACMGFHLWSLAGLGQQGDRME
                     AAVTAARIAASEGPNSNGGAIFAPLAMRGAGGLRASGPPAERLERWLEGMETACLTAM
                     RHLDDIQAWSARAETMMAPLSGKTPPALRAVLAEWPLVSAPMAETLTGASRAAVQRNL
                     VWMEARGLICEVTGQGRFRMWRTTT"
     gene            complement(465145..465348)
                     /locus_tag="MED193_02165"
     CDS             complement(465145..465348)
                     /locus_tag="MED193_02165"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLQSQILSKLAMEEGHIARFARAANGSMVNFDLHGDGGRQSSND
                     KQGRAVSKIPGVLLAAFTSNHRW"
     gene            465552..466214
                     /locus_tag="MED193_02170"
     CDS             465552..466214
                     /locus_tag="MED193_02170"
                     /note="COG1376 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11091"
                     /translation="MLTRRHFIQTTTALFSASVSSPLLADTWPTEAQKAEWDAQVTPP
                     GFDPAASNPWGLHPRFLPQRVVAKPGLVPGDIHVDAVARYLYHIEESGTAMRYGVAIA
                     RGNLYEPGVYTIKRKVRWPHWTPTQNMIERDPENARWADGMEPGPENALGSRAIYLYV
                     GDRDTYLRIHGTPYPRSIGGRASSGCVRMVMAHINELYPNVEIESTAHLYSAEDSVTA
                     RS"
     gene            complement(466263..466547)
                     /locus_tag="MED193_02175"
     CDS             complement(466263..466547)
                     /locus_tag="MED193_02175"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MQVLMLKQKMMVAVALFLTTGCAIQPTGPNDTADQTGNVPEAVV
                     AMAGPDQDVATARLVPEDGCYWYEHSGPVETTLLPLRTANGNPICVAREA"
     gene            466730..469084
                     /locus_tag="MED193_02180"
     CDS             466730..469084
                     /locus_tag="MED193_02180"
                     /note="COG2217 Cation transport ATPase"
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium-translocating P-type ATPase"
                     /db_xref="CDD:11924"
                     /translation="MPSDTHPHDHDHAEDAQASGGSCCGSAATCGDIAPTTPAPTGGR
                     SFQVSGLDCAEEVAILNKVIGPQIGGAEHLAFDVINGRMTILDSAKNVSDDEVAELVA
                     STGMTAKPWNSENASVDQAAHLARQRLFTALSGGFWAAGFLWHIVETGMGGALGLFAG
                     HGEAPMPLAEAGLFAVAILFGVWLVAPKAWSSARRLSPDMNLLMVVAVAGAIGLGEFF
                     EAATVAFFFSLSLFLESWSVGRARNAVSALLDLAPPTARVIRDDGSETDMPAAQVAVG
                     SSFIVRGGDRIPLDGEVTGGTGAVDQAPITGESALIPKEAGDEVYAGTINGEGTLTVR
                     ATKAASDTVLAKIIRMVGDAHARRAPVEQWVAKFARIYTPIVMVLAIAIALLPPLIFG
                     GAWDYWFYNALVLLVIACPCALVISTPVSIVAALTASARAGVLIKGGAYVEAPGRTTA
                     LAMDKTGTITMGEPEVAAVHPLGGASAQDLMTLAAGLEARSSHPLARAILARAEADGI
                     KVSAAEDTRTIPGRGLEGRIDGRSIWLGSDRFAEEKGFGGAIPKDLRERIEGAGSTLV
                     AVGDETGVTGILELRDRIRPDAKGIVAQLHAQGVKTIVMLTGDNERTARAVAAEVGID
                     EVRAELLPEDKVTAIEELVETHDMVAMIGDGVNDAPAMARAHYAIAMGAVGSDAAIET
                     ADIALMTDDLGKVPWLIGHSRRTMSIIHQNIGISLATKGVFVVATAFGMASMWGAIAA
                     DVGVSLLVVANALRLLNSQEAKAPPSGGEQVGPQMAKAALAHGH"
     gene            469148..469660
                     /locus_tag="MED193_02185"
     CDS             469148..469660
                     /locus_tag="MED193_02185"
                     /note="COG3034 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12374"
                     /translation="MKTIRFPRRAVLLGGLAAFLSGCAGKFRSYDGPEVTRLRLYKGQ
                     RLLVLDGSDRVLQTYPIGLGFAPQGHKQFEGDGRTPEGTYIVDKRNPESTYHLSVGIS
                     YPNEADIAFAAAQGLSPGGDIFIHGGPRPGIDPTDIRDWTAGCIAVTDRQIEDIYAMV
                     KDGTPIHIFA"
     gene            complement(469641..470633)
                     /locus_tag="MED193_02190"
     CDS             complement(469641..470633)
                     /locus_tag="MED193_02190"
                     /EC_number="2.3.1.-"
                     /note="COG0815 Apolipoprotein N-acyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="apolipoprotein N-acyltransferase"
                     /db_xref="CDD:10682"
                     /translation="MAVGRQRLIISLMPLAGIVTMWAVGTLRLQSDAPQPPDVDLRIV
                     QGNVPQEEKWAPENREATFARYIKLSTQPGDFDVLLWPETAFPGFLDEDAQARARIAA
                     ALPDGSVLLTGVPDRVLSEDGTRYFNTVQAFDDTNEILTGYAKHHLVPFGEYVPFRGW
                     LPIERLTAGLGDFTPGPGPRTLALPGMPLVAVAICYEIIFPGHVVDDMFRPDWIFNAT
                     NDSWFGTSIGPEQHLASARMRAVEEGLPVIRAANTGISAVIDANGEIIARLDTGERGI
                     IDADLPSAQPPTPYALFGDWMLLALILASWSWALAANATANHRRMRKTVMQRCG"
     gene            complement(471216..471719)
                     /locus_tag="MED193_02195"
     CDS             complement(471216..471719)
                     /locus_tag="MED193_02195"
                     /note="COG0597 Lipoprotein signal peptidase"
                     /codon_start=1
                     /transl_table=11
                     /product="lipoprotein signal peptidase"
                     /db_xref="CDD:10467"
                     /translation="MFGWGDAMPVHKLSPVIGIFAALTAFVIDQITKAIVVANAASLS
                     TGIAVFPGFNLVFYRNDGVTFGLLGGAPWWGLIALALAICGWLGVMLFRAENAVETLA
                     YGAIIGGALGNVIDRVRYRSVTDFLDFYINSTHWPAFNMADVFVVSGVGLLLAAPWIS
                     ARRPIKS"
     gene            complement(471703..472464)
                     /locus_tag="MED193_02200"
     CDS             complement(471703..472464)
                     /locus_tag="MED193_02200"
                     /note="COG0428 Predicted divalent heavy-metal cations
                     transporter"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10302"
                     /translation="MLGFLGSLAAGSLTAVGAIPVLFGRIPSRATRDLSLGFAAGVML
                     SASFFSLIIPALDAAEPMFENGAMPAAIVCVSILLGMGAVALMNERLPHEHFRTGREG
                     PEAASLRRVWLFIIAITIHNFPEGLAVGVGFGSGGMEGGLPLAIGIGLQNAPEGLAVA
                     VSLLGEGYPKLRAWGIAALTGMVEPIGGLLGAGIITLSEPLLPWGLAFAAGAMLYVIS
                     HEIIPETHRSGHQNKATLGLAIGLVLMLFLDVWLG"
     gene            complement(472498..472953)
                     /locus_tag="MED193_02205"
     CDS             complement(472498..472953)
                     /locus_tag="MED193_02205"
                     /note="COG3019 Predicted metal-binding protein"
                     /codon_start=1
                     /transl_table=11
                     /product="putative exported protein"
                     /db_xref="CDD:12361"
                     /translation="MKRMTQALTIALALFPAAQALAEATAIDVRKTNGCGCCLSWMNH
                     LEENGFAPTGENMFGGSLVRFKLDNGVPQRMVSCHTALIEGYVIEGHVPAADIRRLLE
                     ERPDAVGLAVPGMPYGSPGMGPEENREAYDVFLIREDGSTEVFSSYAEG"
     gene            complement(472957..474330)
                     /locus_tag="MED193_02210"
     CDS             complement(472957..474330)
                     /locus_tag="MED193_02210"
                     /note="COG0739 Membrane proteins related to
                     metalloendopeptidases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10607"
                     /translation="MRLRTFAAGVALAGTVSGAAIAFFDVLSKEPVPPELAQAGSWMP
                     QRPEAPRSLDIPLSLPATAWVEDTPGFGPLPLLQAAVVDRPMQAIEPPLLTWSRDISS
                     GETLDSLLSEAGLAGADRAEVALALGAEYDLRRLRPGNSVTVVSTMDGSPRTVSLAVE
                     DGVRIEVLFGEQVSTQVVAPDPEIVTLAGEAVIDTSIFAALDNAGIPARFAVDLAQML
                     GGTVDFRREMAGGETLRLLWRETRVGDDKIGQPDLAFAALEIGDSLYEIVWPDDGSGQ
                     ATIYVDGEVLRVFAQPVEGARLSSVFGRRTHPVYGNVRMHTGVDFAAASGTPVRTTAP
                     GRVSFIGWRGGYGRVVEISHGSETMTRYAHLSAVSEGLTQGQRVAAGDVIGRVGATGT
                     ATGPNLHYEVLVDGRPTDPLSDDRLAEAAENEVDDTAALLRLTEARALLTENLDSEIA
                     QTTTERL"
     gene            complement(474327..474953)
                     /locus_tag="MED193_02215"
     CDS             complement(474327..474953)
                     /locus_tag="MED193_02215"
                     /note="COG1999 Uncharacterized protein SCO1/SenC/PrrC,
                     involved in biogenesis of respiratory and photosynthetic
                     systems"
                     /codon_start=1
                     /transl_table=11
                     /product="SCO1/2 family protein"
                     /db_xref="CDD:11707"
                     /translation="MRRRTIAGYGAAGAGAIALTLFVGWWRVDGPGAPEPIEQRPMAL
                     TEMDFRLTDHEGNEVGPETLIGRPTMAFFGFTYCPDVCPTTLSDISGWLDDLGDEAKQ
                     LNVVFITVDPERDTVEAMAEYVSYFHPAIRGWTGPEGQIARIADGFRAAYERVPTEGG
                     DYTMNHTASVFLFGAAGRFVTMIDYHEPREFAVPKIRRALEEETEGAT"
     gene            complement(474953..475420)
                     /locus_tag="MED193_02220"
     CDS             complement(474953..475420)
                     /locus_tag="MED193_02220"
                     /note="COG2847 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12200"
                     /translation="MKKIIMTGTLAALLTFGGLSVPALAGPVDVVVESAWSRASIGMN
                     RPGAAYMTIRNTGDEPVTLIGLSTPLAMMPEIHETKTNAEGVSSMSAAGEIAIAPGES
                     VALEPGGLHAMLMRLQQPMTEGETFPLTLLFVDGGEVTVEVPILGIAARGPED"
     gene            complement(475444..476103)
                     /locus_tag="MED193_02225"
     CDS             complement(475444..476103)
                     /locus_tag="MED193_02225"
                     /note="COG1651 Protein-disulfide isomerase"
                     /codon_start=1
                     /transl_table=11
                     /product="dsbA-like thioredoxin domain protein"
                     /db_xref="CDD:11362"
                     /translation="MNRRGLILSVLALGVAGFGGATWYATRPGPAAEAKTVAPELADA
                     MIRSYSPILGPADAPVTIVEFFDPACEACRAFHPIVKDIMAQHGDAVRVVIRYTAFHG
                     EASEEAIRVLEAARMQGVYEPVLEAVLRDQPRWASHGAPEPGLILQIAATAGLDAEAA
                     RTQMLAPDVVAILNQDRADVETVGVRQTPTFFVNGKSLDPFGEAELRRLVAAEVAAVQ
                     S"
     gene            complement(476100..476522)
                     /locus_tag="MED193_02230"
     CDS             complement(476100..476522)
                     /locus_tag="MED193_02230"
                     /note="COG1495 Disulfide bond formation protein DsbB"
                     /codon_start=1
                     /transl_table=11
                     /product="disulfide bond formation protein, DsbB family"
                     /db_xref="CDD:3107"
                     /translation="MNRVPAETALGLAWIVALVASLAVLFIGEVMGQTPCVLCWFQRA
                     FMFPLAIILGLGLWWRDGSVGRYGIALALGGGVVALWHMGLYAGLIPERIQPCTATGP
                     SCTDDNQLVFGIPIPLMALVAFALIGFLSALSLKETQT"
     gene            complement(476528..477130)
                     /locus_tag="MED193_02235"
     CDS             complement(476528..477130)
                     /locus_tag="MED193_02235"
                     /note="COG1999 Uncharacterized protein SCO1/SenC/PrrC,
                     involved in biogenesis of respiratory and photosynthetic
                     systems"
                     /codon_start=1
                     /transl_table=11
                     /product="probable lipoprotein"
                     /db_xref="CDD:11707"
                     /translation="MSLTSAQKFLWVLAGAAALAFVWLLLWSDYRADRARTDTDPAFL
                     AAFELTDHQGMVRTEEDFSGRWMLVFFGFSNCPDVCPSTLSEVAAVMDGLGDNAARVQ
                     PIFITIDPERDTPMALAEFVPLFDANIIGLTGTPEQIAATSETFPIFFERIEEATAPD
                     GYTIGHTSHLFLFDPEAGFADSWPYGTSAEEILADLEERI"
     gene            477291..477731
                     /locus_tag="MED193_02240"
     CDS             477291..477731
                     /locus_tag="MED193_02240"
                     /note="COG0789 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, MerR family"
                     /db_xref="CDD:27755"
                     /translation="MEAKMLTIGTLSKKTGTKVQTIRYYEQIGLMPEPGRTEGGQRRY
                     DNAQLDRLSFIRHSRQLGFSLDAIRELLDLSDQPNRPCEEADAIARRQLKQVEQRMAR
                     LKALRTELKRMVHECSGGRTADCKVLEVLRDHSECLTEHDEIGA"
     gene            477733..478059
                     /locus_tag="MED193_02245"
     CDS             477733..478059
                     /locus_tag="MED193_02245"
                     /note="COG1742 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:3201"
                     /translation="MPAALAYPLAALAEIAGCFAIWSWWRLGASAAWLVPGIVALVVF
                     GWLLAQVETVAAGRAFAAYGGVYIAASVLWMWLAEGHRPDRWDALGTAVCLLGAAIIL
                     AAPRTN"
     gene            478258..478854
                     /locus_tag="MED193_02250"
     CDS             478258..478854
                     /locus_tag="MED193_02250"
                     /note="COG1230 Co/Zn/Cd efflux system component"
                     /codon_start=1
                     /transl_table=11
                     /product="Co/Zn/Cd efflux system component"
                     /db_xref="CDD:10948"
                     /translation="MAAEKRAERRTLWIVLGLNISLAAAFFATGTFGDSSALIANGLD
                     NLSDSLVYAISLFALSRSAKWKRGAANVSGGLLIVFAIGILYDAWRRYVGGSDPLGTV
                     MIVMALIAAAINSVCVWLLARLKDPDVNIRAANTFSWNDFAANLGIVVAGGLVAWLGT
                     NWPDLVVGVIIAGIAAWGGVNILRDAHGEHHKAVHTDK"
     gene            478944..479705
                     /locus_tag="MED193_02255"
     CDS             478944..479705
                     /locus_tag="MED193_02255"
                     /note="COG1305 Transglutaminase-like enzymes, putative
                     cysteine proteases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11021"
                     /translation="MQITNPLLAPTKLLDFDAAPLAHLIESRSWRDLSEYDRIGAAYD
                     FVRNEIAFGYNRADDIPASEVLSDGYGQCNTKGTLLMALLRGVGVRCRLHGFTIHKGL
                     QRGVVPELVYPLAPEEILHSWVEIEFQGAWINLEGFILDDAFLEVLQRSFSDTDSVCG
                     YGAGTDCLGAPPVAWNGEDTYIQKTGIVQDFGVYDTPDAFYLSHEQSFGRLRGALYRH
                     IIRHWMNARVRGFRSGRLKTDRRATHAHEEPANAA"
     gene            479695..480612
                     /locus_tag="MED193_02260"
     CDS             479695..480612
                     /locus_tag="MED193_02260"
                     /note="COG1230 Co/Zn/Cd efflux system component"
                     /codon_start=1
                     /transl_table=11
                     /product="cation efflux system protein"
                     /db_xref="CDD:10948"
                     /translation="MPHDHGHANIDPNSGDRRVAIAIWANGLLTVAQIVGGILSGSLA
                     LIADALHNFSDMASLVIAFAARKIARRPADERMTFGYGRVEIVAALINYTTLIVIGFY
                     LIYEGGMRMIDPPEVMGWTVVILGGIALVVDTLTAMLTYSMQKGSVNIRALFLHNLSD
                     ALASVAVIVGGTLIILYDMRWVDPAITIGIALYILYLSFTEIGAPIRTLMLGSPPDID
                     GNDVVRAIQIVDGVVDVHHVHLWQMQENAAALDCHIVVERDRMGEADKIKENVKSVLH
                     ERFSIEHSTLEFEATDNAHQEAQVFGHRS"
     gene            480609..481166
                     /locus_tag="MED193_02265"
     CDS             480609..481166
                     /locus_tag="MED193_02265"
                     /note="COG2020 Putative protein-S-isoprenylcysteine
                     methyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11728"
                     /translation="MTIAQGILVVVGLLSGLVLIGALLWSIVRPSKRIWPPNREHSVI
                     PIIAWGLTLAVFGAVIGLGIVDWKSASMPNALRWAVGPFLIAIGNLIAWWGAFIIGLK
                     ATSGVRDELITSGLYRFSRNPQYLADMAILIGLGLLFASPWVWPVVIVGVAALALAPL
                     AEEPWLCEQYGTKYRNYCAETRRYL"
     gene            complement(481786..482238)
                     /locus_tag="MED193_02270"
     CDS             complement(481786..482238)
                     /locus_tag="MED193_02270"
                     /note="COG3464 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:12792"
                     /translation="MEHQILEPVRGPETGHAISPVIAAALCIKPSGKLTSDQARKVDT
                     LKAGSPAFTTMRSLAMRFNGIMRGRQAGPLPAWIDDAIETGLTPIVRFARTLNRDFNV
                     VKKAIEMPCNNGQAEGQINRLKTLKRAMYGRAGPELLRARMLPFRHTD"
     gene            complement(482293..482703)
                     /locus_tag="MED193_02275"
     CDS             complement(482293..482703)
                     /locus_tag="MED193_02275"
                     /note="COG3464 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:12792"
                     /translation="MQNLRQAIEEQMNLHGPETGRALLADADNITAAGSLLKSRLAHR
                     TSREEIFTTIHALRNQGLNCSEIGRRTGFPRRSIAKWLQFETPPDRKQAALKPTSPWY
                     FEEFLSQSWKDGIRTGSALYRMIQERGYEGSQSH"
     gene            complement(482758..483171)
                     /locus_tag="MED193_02280"
     CDS             complement(482758..483171)
                     /locus_tag="MED193_02280"
                     /note="COG3464 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:4580"
                     /translation="MAPACPRRTFADQLTSIAHPFARSTSRVGEIVSHLGHATGGRPA
                     ERLLHRLGLGVSDYTVLRQLKKRAQGTAKPPTVIGIDDWSWRKSQTYGTIIVDLERRV
                     VIDILEDRDVVTCTNWLKRHPEVKVISRDRCGLYA"
     gene            complement(483468..483803)
                     /locus_tag="MED193_02285"
     CDS             complement(483468..483803)
                     /locus_tag="MED193_02285"
                     /note="COG0723 Rieske Fe-S protein"
                     /codon_start=1
                     /transl_table=11
                     /product="ubiquinol-cytochrome c reductase, iron-sulfur
                     subunit"
                     /db_xref="CDD:10592"
                     /translation="MEASEDTARRDFLYYATAGAGVVAAGAALWPLVNQMNPSADVRA
                     LAQITVDISDLAPGTQLTVNWRGKPVFIRHRTEAEMAQARAEAVSDQPDGKARNPNLP
                     ADALASRSP"
     gene            complement(483910..484434)
                     /locus_tag="MED193_02290"
     CDS             complement(483910..484434)
                     /locus_tag="MED193_02290"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRLIPFVLAIVMAAPVAAQHAHSATGHDMGGPQETGQSAFAALA
                     EIVAILQADPETDWERVDIDGLRRHLVDMDLLTQEAVVTRTLRPEGARFEIRGTPRVL
                     EAIRAMVPAHAPFLAAETGWDVVTEELEDGVALSVDGDAAQIQGLGFFGLMTIGAHHQ
                     EHHLMMAKGAAPHH"
     gene            484462..485076
                     /locus_tag="MED193_02295"
     CDS             484462..485076
                     /locus_tag="MED193_02295"
                     /note="COG0664 cAMP-binding proteins - catabolite gene
                     activator and regulatory subunit of cAMP-dependent protein
                     kinases"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:14778"
                     /translation="MFTLAGADASQYDFNHMLPGPYDLIPSSALRPLSGAVGDVVFHQ
                     GGSTHGLYVVQTGRVHLERVGPDGERFIIHRAQAGTSFAEASVFSEVYHCDAVCVEAG
                     ALIRIDKAAVLAAFADPAFARAYGRQAAQQIQAQRQMLEIVGIRLAEDRVMAGLVAGL
                     LEGSVVEFAARLQLSHEATYRALRKLVQDGRVKNPARGIYHLRP"
     gene            complement(485082..485534)
                     /locus_tag="MED193_02300"
     CDS             complement(485082..485534)
                     /locus_tag="MED193_02300"
                     /note="COG3019 Predicted metal-binding protein"
                     /codon_start=1
                     /transl_table=11
                     /product="putative exported protein"
                     /db_xref="CDD:12361"
                     /translation="MMKRRTFLLAGAAATLPLRALANTEPVIKVLKTPTCGCCTAWVD
                     HVRQAGFTVEAQDVDQDALYAFKDRLQIAPELAGCHTAIISDYFIEGHVPAADITRLL
                     AEQPVARGLTVPGMPMSSPGMGGPGAGDTFDTLLVGSDGVTSVFASHS"
     gene            complement(485531..486442)
                     /locus_tag="MED193_02305"
     CDS             complement(485531..486442)
                     /locus_tag="MED193_02305"
                     /note="COG3000 Sterol desaturase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12343"
                     /translation="MDTILAAEPEIRLTAFLSVLAAMALWELAAPRRRRDIPRVIRWS
                     NNLALVVIDTAILRLSFPILAVGLAVMGEERGWGLFNTIGAPYWLAVVLSMLLLDLAI
                     YLQHVMFHAVPTLWRLHRMHHADLEFDATTGLRFHPIEILISMAIKLSLVAALGPPAV
                     AVLLFEIILNATALFNHANINLPRPVDRWLRWIVVTPDMHRVHHSVDPRETNSNYGFN
                     LPWWDRLMGTYVAQPAKGHEGMTIGIEQFRTTRDLWVDKMLIQPLRGPASGHALDAPA
                     LSPTEQEQPLDSQTHSSTVSDTSKRNT"
     gene            complement(486449..487435)
                     /locus_tag="MED193_02310"
     CDS             complement(486449..487435)
                     /locus_tag="MED193_02310"
                     /note="COG1230 Co/Zn/Cd efflux system component"
                     /codon_start=1
                     /transl_table=11
                     /product="cobalt/cadmium/zinc transporter, CDF family"
                     /db_xref="CDD:10948"
                     /translation="MANHSHAGHMPTSGKALVISAWLTGVYFVIELAVGLWTGSIAVL
                     SDAFHTLSAVGGVLVAITAQRIARRPADSARSFGWYRAEIIGALVNGGFLLGMAILVI
                     WMGAMRLGNPIHLATGPMLWVAFGGLVTEVVSLALMWQSSKDDLNARGALWHIIQTFV
                     GSLLIIVTALVIEFTGFLAIDPILGMAFGVVLLWASVGVIKEAVYILMEGTPEGTDLD
                     AVTADLNGQDGVLDVHHVHAWTLTSGKHAFSAHIRHQSPAEAADLLNRAYRRLTEQYG
                     FHMVTLQLETACLDERHALDVDIVQIAAAKAAQEKTDVRDAHPHPSPNTEGP"
     gene            complement(487443..488099)
                     /locus_tag="MED193_02315"
     CDS             complement(487443..488099)
                     /locus_tag="MED193_02315"
                     /note="COG0398 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein, putative"
                     /db_xref="CDD:10272"
                     /translation="MMMRILLLAVILMGVVALAFPDVLGVDIRLPDRAEIDRWIEAAG
                     LAGPIVIVALMTIAIVASPLPSAPIALAAGAAYGHTFGTLFVVLGAELGALAAFGLAR
                     GLGRPFVERHLGQKINAGLFGSQNTLTFLVFGSRLLPFLSFDMISYAAGLSKLHLWRF
                     ALATLAGIIPASFLLAHMGSQAMNGDARTATWTALALGGFTGLSVLFAATRKTGAQRE
                     "
     gene            complement(488103..488552)
                     /locus_tag="MED193_02320"
     CDS             complement(488103..488552)
                     /locus_tag="MED193_02320"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAQIFKKTGDHLSHHRHGDILKFPVWVGVLIVLLSMPAHLFLDE
                     KSSIALASITLALIGGAYIGFGAADGRARVFWAELAVALLFGSAAFLGLIWHWAFLPL
                     GLALHALWDMSHHNSYRLARIPNWYIPFCVAFDLLAAAFFVLLYAVF"
     gene            complement(488714..489151)
                     /locus_tag="MED193_02325"
     CDS             complement(488714..489151)
                     /locus_tag="MED193_02325"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTELMAMFVGICAAILMGIVHHYALSGILKFSPQRSDGSGFRII
                     LTFSALLLLHVLELVTLAVFNTMVVASVLPQSFSNNPPMFQDVLYVTGISFSTLGYSS
                     IEVVGPFRLLLMLQSLLGFMLLTWSATFLYSACQQVWQKAKDD"
     gene            complement(489241..489714)
                     /locus_tag="MED193_02330"
     CDS             complement(489241..489714)
                     /locus_tag="MED193_02330"
                     /note="COG0607 Rhodanese-related sulfurtransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:27921"
                     /translation="MALDLNRRRFVMGAHMTVLTVTASPLLAQSRSVWSAENAFDALL
                     SDTARIIDVRTREEWQETGVGAGVWPISMHASGFPDRLFRAKELSGDRTVGLICATGG
                     RSASLLRALRQAGYSGYADISEGMLGSGEGPGWIASNLPTVPVDVALNGLPPALA"
     gene            489903..490625
                     /locus_tag="MED193_02335"
     CDS             489903..490625
                     /locus_tag="MED193_02335"
                     /note="COG0745 Response regulators consisting of a
                     CheY-like receiver domain and a winged-helix DNA-binding
                     domain"
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding response regulator"
                     /db_xref="CDD:10613"
                     /translation="MGPPPHILIVDDHAQIRESVARFLEKNGMRTTVARDAVEMDAKL
                     ATGHFDLLVLDVMMPGEDGLSVCRRLAPEGDLPIIMLTALGEETDRIVGLEIGADDYL
                     AKPFNPRELLARIKSVLRRSNRDEPVAGTLAGRKVCFAHWVLDTDRQVLIDEAATETP
                     LTTSEFKLLAVLLERARMVLSRDQLLDLTAGRTAGPMDRTIDNQISRLRRKIEPDVLR
                     PSVIKTVRNGGYCLAADVEDAT"
     gene            490625..492091
                     /locus_tag="MED193_02340"
     CDS             490625..492091
                     /locus_tag="MED193_02340"
                     /note="COG0642 Signal transduction histidine kinase"
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /db_xref="CDD:10512"
                     /translation="MWRAMSSLSGQLILLVVAALVVAQAISLFLFADERSLAIRAALG
                     FEAAGRAANVARLIEEAPLDLQDSILRAANSPLIRFDLSDAPSVEHTSHSHGDLVEGR
                     IRALMDDSYSRDIRVELHEIEGELRPLPNLSDEMTEMHLAMMRGELTAVEMNLSIAIK
                     GARWLNVGTRFERPPIQWPFYSMLTFGISAGLLLVAIFWFVMTRLTRPLRHLSKAADH
                     LGRGEDVPELTVAGPTEVRDLTVAFNRMQRRLTRFVSDRTRMLAALGHDLRSPLTAMR
                     VRAELVDEEETRDSLIASVEEMQSMVEATLTFARGLTGSEGAEVVDLRNFLDSLCSDM
                     AAHCTFAPSDDVAVRLRPNAFRRALRNLLENAVRYGGAAKVSWATHGSNLVLNIDDNG
                     PGIPVDQLEKVFDPFYRLEQSRSLETGGYGLGLSIARTIVQSHGGDIQLVNHNSAGLR
                     AIVTIPLDESELIEGETDETENAHSNVAGQLARQHGAS"
     gene            492078..492332
                     /locus_tag="MED193_02345"
     CDS             492078..492332
                     /locus_tag="MED193_02345"
                     /note="COG3462 Predicted membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12790"
                     /translation="MARADGPGSWTGHMWGGGYGFMGGFMMLAFWGAVIALIVFLVLR
                     LRDNGTRPPDSDAQEALRRRFANGEIDEEEFRRLKATLDE"
     gene            492397..494397
                     /locus_tag="MED193_02350"
     CDS             492397..494397
                     /locus_tag="MED193_02350"
                     /note="COG1138 Cytochrome c biogenesis factor"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10858"
                     /translation="MVPEIGHFALALALALALVQSVLPIAGASRGNTVWMKSAQATAL
                     GQVLFVSIAFAALMQAFIVSDFTVRNVVENSHSLKPMLYKVAGTWGSHEGSLLLWILI
                     LAVFGAGVAWFGSNIPAETKARTLSVQAWISVGFLTFLLLTSNPFDRVFPPPLDGNDL
                     NPLLQDMGLAMHPPLLYFGYVGFSIVFSFAVAALLEGRVDPAWARWVRPWTLAAWVSL
                     TAGIALGSWWAYYELGWGGWWFWDPVENVSFMPWLLGTALLHSAIVTEKRDAFKSWTI
                     LLAILTFSLSLLGTFIVRSGLLTSVHAFAVDPERGLYILGLLAVSIGGSLALYAWRAP
                     EMEPGGLFRPISREAGLLVNNLILAAATGTVLFGTLYPLILEAVTGDKISVGPPFFNA
                     AFIPMMLALVVFMGLGPFLSWKRADIAGLLDRIRFVAVLAVIAASAAWYLLNGGPIMA
                     YLAILGAAWLLFATLREWALRIRLFEVSLAESARRARNLPRASHGMTLAHAGVAVLMM
                     GMIGSTGWKSEEIVFAAPGTEVTIAGFDITFEGAAKVQGPNYIADRGTLVVRRDGELV
                     TTLFPERRYYPVAESQTTESAIRSTLAGDLYTSIATPASDQVNNAGAWTLRILYEPLV
                     NLIWIGSILLVIGGCLSLSDRRLRVGAPRRAKQPASDAVPAE"
     gene            494406..494972
                     /locus_tag="MED193_02355"
     CDS             494406..494972
                     /locus_tag="MED193_02355"
                     /note="COG0526 Thiol-disulfide isomerase and thioredoxins"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome c biogenesis protein CycX"
                     /db_xref="CDD:10397"
                     /translation="MKRLIAGLPFIAAVIFGGFFLWGLNPERDPNEIPSVLISQPAPA
                     FDLDPVPGLETPGLARSDLVGNERPVVVNVFASWCVPCRAEHAVLTRFVEREGMRLFG
                     INYKDKPEDAVKWLKDLGNPYERIGSDLSGRTGIEWGLSGVPETFIVDGDGTVLFRYV
                     GPVVGPDAVERFTQALKQAGALPNGAAS"
     gene            494969..495442
                     /locus_tag="MED193_02360"
     CDS             494969..495442
                     /locus_tag="MED193_02360"
                     /note="COG3088 Uncharacterized protein involved in
                     biosynthesis of c-type cytochromes"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12427"
                     /translation="MRQLIFAFCIGLFPFAANAVEPDEMLTDPVLEQRARGISKDLRC
                     VVCQNQDIDSSNAGVARDLRLLVRERLVAGDSDTEVIEYIRARYGDYVLLKPPLEPAT
                     YALWFAPIAFVLVGVFVGGGVLMSRRKQEPFEDLGSEDENTVSEILRQNEAGDAP"
     gene            495439..496590
                     /locus_tag="MED193_02365"
     CDS             495439..496590
                     /locus_tag="MED193_02365"
                     /note="COG4235 Cytochrome c biogenesis factor"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome c-type biogenesis protein cycH"
                     /db_xref="CDD:13484"
                     /translation="MIWGIFGFLTLLAIGIVLYPLLLSKSNTLTRGDAVPAILADQMQ
                     EIERDMDRGLISEQEAQAARLEIKKRILATTRNSEEKAGSSRSGGRVTLVVASVLAPV
                     IAAGYYLTMGSPEVPSMAFAARAEERAQTDEVTALAIQLRERLVSDPTGGPSEGWMLL
                     GQTYQRMGRAADAVAAFEVVAEREDATSATFSMLAEAVAVANDGVVIPRAKLAIDRAL
                     DLDPSNPAATYFESLYYLQKEETRRAYELLVSRLDQEEAYVPWMETYALQINRIAAAA
                     DLPIVDLPSAPTSPPGPSAADVAAASEMSGADRAEFIRSMVSRLAERLEDEPVDLDGW
                     MRLANAYAVLQEEDRAIEAYRKVEALLEQQPANDPRRAAVRDALERLGG"
     gene            complement(496619..498748)
                     /locus_tag="MED193_02370"
     CDS             complement(496619..498748)
                     /locus_tag="MED193_02370"
                     /note="COG4233 Uncharacterized protein predicted to be
                     involved in C-type cytochrome biogenesis"
                     /codon_start=1
                     /transl_table=11
                     /product="putative suppressor for copper-sensitivity B
                     precursor"
                     /db_xref="CDD:13482"
                     /translation="MIDCLLILRRVLLIPFVLLALVSGSVAAATSAEYQSAPLTAHLI
                     SAQEGVPENTLTLSAGLHLQLNENWKTYWRSPGEVGIPPSVEWTGSENVADVEFMWPF
                     PTRFTAFGIENFGYAGEVVFPLRITLKDPGAPVTLSAQVKLLVCSNVCVPEEFDLSLR
                     LGRGNGIDSTAAGLIGTFSERVPEGAEAGGVSEANAFIDEDLTELIVSLRVDEPLQSP
                     DVFPELGMGVALGKPDIRLGEEDRLLWARLPILSSNTDVTVVPSITVTDGENRAFTII
                     ADRVAQGIAPPFELAATTPDMLELIWIAAIALLGGLILNVMPCVLPVLSIKVSSVLKH
                     TDHDTTRVRFGFVAAAAGIMMFMWGLALVLWALQTAGLSVGWGLQFQSPLFLAVMIAV
                     LLVFSANLFGAFEFALPHGMQTRLAGAGGRNGYSADFFTGMFGAVMATPCSAPFLGTA
                     VAFALAGRGLDILIVFTSLGLGLALPYLVIAAFPRLVAFMPKPGRWMLIIKSVMGVLL
                     LATAVWLFWALDGVAGLASVIAVAALSGLAVLILSLPNVQSQFRWSIATASLVLALAA
                     GPLLQQSAPARSESQSALAWIAFDRSDIAKRVSEGEVVFVDVTADWCLTCKANKALVI
                     DPEPVRSALDTPGVTPMRADWTRPDARISRYLESFGRYGIPFNAVYGPSAPEGIVLSE
                     LLTTEDVMDALAQASGRDVSAKVAEQE"
     gene            complement(499034..499336)
                     /locus_tag="MED193_02375"
     CDS             complement(499034..499336)
                     /locus_tag="MED193_02375"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MDHQNHRKKPITDRLMHYGMMACCVVMLLPFAGFFLAGGTLAGV
                     WGNAAAFAPLLLCVGAHLAMHKFMGKSCHSDKANDSIEETPEPMTSAIPVVVRNRQ"
     gene            499492..500052
                     /locus_tag="MED193_02380"
     CDS             499492..500052
                     /locus_tag="MED193_02380"
                     /note="COG1376 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="ErfK/YbiS/YcfS/YnhG family protein"
                     /db_xref="CDD:26133"
                     /translation="MTTSRNNKINRRSLLGYAAVALVAPSVVRAETIRRNISSFRVHD
                     WQDHFDALGKGVIISDTVTMALQHWTSDGEMRIYPTSVPLTDELTKRGYTEVVEKRKK
                     PSWAPTPSMRERNPEWPARVEGGDPANPLGTRALYLSWQYYRIHGTQDTRKIGRRSSN
                     GCIGLFNEQVEELYERVPVGTQVKLI"
     gene            500081..500539
                     /locus_tag="MED193_02385"
     CDS             500081..500539
                     /locus_tag="MED193_02385"
                     /note="COG2010 Cytochrome c, mono- and diheme variants"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome c family protein"
                     /db_xref="CDD:12215"
                     /translation="MDKLTALIAAVVIAGGGVATWQFISAEDTAMGHSMTPPDTSRIE
                     AGDPIVQVQLPAEFSEQATIGKTIFEAKCSECHGANAAGQNGIAPPLVHKIYEPSHHS
                     DMAFVLAAQNGVRAHHWKFGNMPKIEGLTQGEVKMVAAYVRELQRANGID"
     gene            500912..501505
                     /locus_tag="MED193_02390"
     CDS             500912..501505
                     /locus_tag="MED193_02390"
                     /codon_start=1
                     /transl_table=11
                     /product="putative cytochrome C-like protein"
                     /db_xref="CDD:23181"
                     /translation="MKKTTIAAAVLIAGTAVTAFAHSGATGIVKERMDAMLAMGKAVK
                     TVAPMMRGETAYEAGAVGDAARLFQQHAGESMTKLFPEGTGGMPSEAKGEVWTDWDRF
                     AALANQLEEYSEGLERAADNGLGGMGGNTSMGGTSMMGGGSMMGSDTTMMGGSTMMGG
                     GGMMDAAAIAEMPADAAFTMTTQVCSACHERFRAEED"
     gene            501508..502425
                     /locus_tag="MED193_02395"
     CDS             501508..502425
                     /locus_tag="MED193_02395"
                     /note="COG2010 Cytochrome c, mono- and diheme variants"
                     /codon_start=1
                     /transl_table=11
                     /product="putative diheme cytochrome c-553"
                     /db_xref="CDD:11718"
                     /translation="MRRFLTLVSGVAVLGTAGLGAVIAWPVGSTVSPIATEGNVDRGA
                     YLARASGCIACHTNFEAGGAPLAGGAPLETPFGTFYPPNLTTDPEHGMGEWTAEQFAK
                     AVRQGIGPDGTPYYPSFPYTFYADFSDQDIADLWAAFQTVPPVDEPAPENDVSFPFDQ
                     RWGLKLWRAAFFYDPDTEPVERRSDAWNRGRELVRGAAHCGACHTPRNLAGGRDIGAS
                     FAGNAQLPGGSKAPAIRPKDLAKNDWTVSNLAYALQTGITPSGDAFGGSMAEVVREGT
                     RFLTPADREAIALFLLNKDTVEAENSASN"
     gene            502469..503863
                     /locus_tag="MED193_02400"
     CDS             502469..503863
                     /locus_tag="MED193_02400"
                     /note="COG2132 Putative multicopper oxidases"
                     /codon_start=1
                     /transl_table=11
                     /product="multicopper oxidase, putative"
                     /db_xref="CDD:11840"
                     /translation="MKQTRRDFLRNATLAACAAVIPRSAYAATPFEDVVAKVARRQLL
                     PDTYPETEIWGYDGLVPAPEIRVAQGDRVRRRFRNEVPDPSSVHWHGIRIDNAMDGVS
                     GLTQKAVAPGETFDYDFVVPDAGTYWYHAHNRSYEQVARGLRGALIVEEADRPDIDRE
                     EVIVLEDWLLDPESGQLFDNFEQPMMMSHGGRIGNFITTNGRYDLTLSAKRNERIRLR
                     IINAASARIFPLTLSGLSGWTVAVDGMPIGQPQQIDGELILGPAQRVDLIVDVTEDEG
                     GTAQLLRIGDDDQLTPLVSFLVNGTASSVPRGKPLPLPPNPAAHAPDLADARDLRLVM
                     SGGAMGRMQSALLGGERLGFRQLAQAGKFWALNDVAEMTDTPLADLSLNEPVRLKIEN
                     QTVFPHAMHLHGMHFRELRPDGAFGPMRDTILLAGNESREIAFTADNPGKWLFHCHML
                     SHAASGMTTWIRVT"
     gene            503911..504342
                     /locus_tag="MED193_02405"
     CDS             503911..504342
                     /locus_tag="MED193_02405"
                     /note="COG2010 Cytochrome c, mono- and diheme variants"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome c family protein"
                     /db_xref="CDD:25367"
                     /translation="MYWLSTSASSDVGSASKAESYDIEEGALLYAENCASCHGAGLEG
                     QPEWRTPGADGRLPAPPHDETGHTWHHPDSLLFDYTKLGGAALLARQGVEFDSGMPGF
                     ADVLTDQQIHNILAFIRSTWPDRIREVQAARTEADEQRGEN"
     gene            504344..505075
                     /locus_tag="MED193_02410"
     CDS             504344..505075
                     /locus_tag="MED193_02410"
                     /note="COG1651 Protein-disulfide isomerase"
                     /codon_start=1
                     /transl_table=11
                     /product="27kDa outer membrane protein"
                     /db_xref="CDD:11362"
                     /translation="MRFRQAFTTVAIAALLPIPALADELSESRVKELVLEAIREKPEI
                     VMEAVAILEQRQAQAQELSQAQVLNDQRDLIENDPNAPVLGNAEGDVTVVEFFDYNCP
                     YCRRVKPEVRALIEEDPNIRLVYREWPILGDGSVFAAKAALAARKQDKYEEFHWAMMG
                     LEGRAEEASVLRVAEEIGLDIAQLRKDMEAPEVEEHIATSMQLTQALGFNGTPSFVIG
                     DALVPGFVEKAQLADLVEEARKDED"
     gene            complement(505118..505318)
                     /locus_tag="MED193_02415"
     CDS             complement(505118..505318)
                     /locus_tag="MED193_02415"
                     /note="COG2608 Copper chaperone"
                     /codon_start=1
                     /transl_table=11
                     /product="YccA"
                     /db_xref="CDD:12125"
                     /translation="MKFSVPDMSCGHCTAAIESAVKTADPNAGVECDLSARQVRVDSV
                     LPADQVQAIIRDEGYDVEPAAA"
     gene            505446..507977
                     /locus_tag="MED193_02420"
     CDS             505446..507977
                     /locus_tag="MED193_02420"
                     /note="COG2217 Cation transport ATPase"
                     /codon_start=1
                     /transl_table=11
                     /product="copper-translocating P-type ATPase"
                     /db_xref="CDD:11924"
                     /translation="MEKQVTHMPEPKQISLPIEGMSCASCVGRVDRALNAIDGVEDVS
                     VNLASETARMSVDALKRIPDIIETLRELGYPARTAKAELTIAAMSCASCVGRVDKALS
                     AVPGVVEVNVNLASETATVVYVEGLVTTSDLENASGAAGYPATVATAQAGDDRVARKE
                     EEAQALAKRVTFAAILALPVFLIEMGGHVIPAVHMLIETTIGQQTSWLLQFVLTTIVL
                     FGPGRTFYTKGFPALFRGAPDMNSLVAVGTGAAYFYSVVATFVPSALPDTLRSVYFEA
                     AAVIVVLILLGRFLEARAKGRTGAAIQKLLGLQARTARVMRDGESIEIEIDALVQGDI
                     VIVRPGERIAVDGEVIEGTSRVDESMLTGEPIPAEKGAGDPVTGGTVNGAGSLQFRAT
                     RVGADTTLAQIIRMVEEAQGAKLPIQGLVNRITLWFVPAVMAIAAATVLVWLVFGPDP
                     ALTMALVAGVSVLIIACPCAMGLATPTSIMVGTGRAAEMGVLFRKGDALQQLDSVDVV
                     ALDKTGTVTEGRPALTDLVLAEGFDRPTTLSKIAAVESLSEHPVADAIVRAARAEGAP
                     LVGAEGFQSVTGYGVRALVEDVEVLVGADRYMARQGVDVSALAQEETNIASKGRTALY
                     AAIDGRVAAVIGVADPVKPASRAAIAALHEKGLAVAMITGDKRETAEAIARETGIDHV
                     VAGVLPDGKVAALDTLREGGKRIAFVGDGINDAPALAHADVGIAIGTGTDVAIESADV
                     VLMSGDLRGVVNAFEVSRRTMRNIRQNLFWAFAYNVALIPVAAGVLYPAFGLLLSPIL
                     AAGAMALSSVFVLTNALRLRGIAPAMDEQRAIPAEMAAATPAPAE"
     gene            507990..508388
                     /locus_tag="MED193_02425"
     CDS             507990..508388
                     /locus_tag="MED193_02425"
                     /note="COG0789 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="Cu(I)-responsive transcriptional regulator"
                     /db_xref="CDD:27755"
                     /translation="MNIGDVARQSGVPPKTIRYYEDIGLIRPNRSENGYRAFTENHVH
                     KLAFLGRARALGFTIEDCRTLLALYEDENRESVQVKAVAEEHLRQIEEKIEKLQSMRT
                     TLTELVEKCAGDHRPDCPILADLSPIRMSE"
     gene            complement(508410..509174)
                     /locus_tag="MED193_02430"
     CDS             complement(508410..509174)
                     /locus_tag="MED193_02430"
                     /note="COG0695 Glutaredoxin and related proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10564"
                     /translation="MPRDTDSKSAQLYRMVMPGHVCPYGLKSKDLLERQGFEVEDHPL
                     ETREDTDAFMEKHGVETTPQTFIGGERIGGYDDLRVFFDIDPPEEEQSDTTYQPVIAI
                     FSVAALLALGLSWHQYGSVLTLRGFEWFISLSMTILAIQKLQDVEGFSTMFLNYDLLA
                     RKWVRYGKVYPFGEALAGILMTAGALLWLSAPVALFIGTVGAVSVFKAVYIDKRELKC
                     ACVGGDSSVRLGFISLTENLMMIFMGIWMPVRAIWF"
     gene            complement(509187..510002)
                     /locus_tag="MED193_02435"
     CDS             complement(509187..510002)
                     /locus_tag="MED193_02435"
                     /note="COG3544 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12871"
                     /translation="MMIGTSTVVMFVLMYLNTYLWGHIFFSETRLYMAILMGATMAVI
                     MLACMLSMYQNTKVNIAIFVGAILVFAASLWPVRGQFTVQDRSYMRAMIPHHSIAIMT
                     STRAEITDPRVRGLADDIIYAQDKEIAEMRYLIADIEANGEASATPTEPPPQVVNAQQ
                     ALQTEVVSKVDPEFLTEDEIAAVFPNGGNCRFAYTSDSPAVLVTGETGEGFAAAMKIS
                     GDLVRLNAQGENAFSEGPLSARIAETDGDLTDLIVSAGTDYEAGFRGQFTCSG"
     gene            510038..510784
                     /locus_tag="MED193_02440"
     CDS             510038..510784
                     /locus_tag="MED193_02440"
                     /note="COG1376 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="ErfK/YbiS/YcfS/YnhG family protein/Tat domain
                     protein"
                     /db_xref="CDD:11091"
                     /translation="MQFFVKEEHSSAGEFQKREFSWFQGNKGASFAPVHGFFSLPLAR
                     TEFSWVRGDRAMQNFTRRELICAGALGCFLPTTAWAHKVKLPERFEPQLINTRRDDWM
                     NGDIHVVPDDFFLYFMLEDGMAIRYGVGVGRKGLYEPGEFTVDRKAKWPWWRPTNAMI
                     RREPHKYAKYKDGLKGGPNNPLGARALYLHDDDGRDTYLRIHGTNAPETIGSAVSNGC
                     ARLTNEHVKDLYDRVEIGARVFLYPKVTTA"
     gene            511224..512858
                     /locus_tag="MED193_02445"
     CDS             511224..512858
                     /locus_tag="MED193_02445"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:25582"
                     /translation="MENDDEESVALGAEEVRRAAVLRPLVQAYLKGTGSLESGINDAV
                     WELGVSRATVWRWIKRLAEEGGRTSALASRKRGRPTGTTLISGEVEAVIEEHLRRYFL
                     RRERPSLSRVVTEIRSACWQQGLQPPTRRTVQRRLDAMDAREIAKAREGAKAARQKFA
                     TVVGENKANQPLEVVQIDHTPADIILVDSFERQPIGRPWVTLAIDVATRMVTGYYTSL
                     EAPSRLSVALCLTQAVAPKAELLAALACNVPWPAQGKPHSIHVDNGRDFRSHAFRLAC
                     AEWGIDLVYRPPGSPHFGGHIERLIGTMMGAVHLLPGTTQSSVVAKGDYDAEGMATMT
                     LSDFDRWFALEICRYNNSIHSSLGCTPVAKWEALSAEMMGDIPFEMEAFRVSFLPSEL
                     RKVRRDGIHLFQIRYWSDALAGHIGRGDGKVVVRYDPRDISMIWVELDDGRYVEARYR
                     NLEIPPVPLWEYREAMRKARALGKSGSNELVLAELIRQQRQIEFESRGLTKAERRSRE
                     RKGTLEGTNSAVSKTERLRPIDTGDTSRPLFKVERW"
     gene            512860..513741
                     /locus_tag="MED193_02450"
     CDS             512860..513741
                     /locus_tag="MED193_02450"
                     /note="COG0599 Uncharacterized homolog of
                     gamma-carboxymuconolactone decarboxylase subunit"
                     /codon_start=1
                     /transl_table=11
                     /product="NTP-binding protein"
                     /db_xref="CDD:23845"
                     /translation="MRAGTTEEDGRIALIQSDIWIGFPRAEQVLDRLQGMIEAPRQTR
                     MPGLLVHGASGIGKTMIARNLSRRYAPEFDPTSGITRTPLLLLQAPPAPDERRFYLHI
                     LATVGAPATALSARAQNVASLEVRVVALLRDLGLRMIMIDEVHNLLAGTHREQRRFLN
                     VLRYLSNELEVSLVCLGVSEAVDAIRGDIQLARRLDEHHLPNWRDDAEFSDMIQTLIA
                     AMPLEKKSNLKVKSLKQILALTGGVTSRIFALIKDLSIDAIVTGDECITDDAIVKWTP
                     VWSRHANPHRRLEKSGV"
     gene            513738..514529
                     /locus_tag="MED193_02455"
     CDS             513738..514529
                     /locus_tag="MED193_02455"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKPHPLPKTVAPLPDELLSGWLSRLAAANYCDDAELLAHIEIDT
                     THGTSLDFNIDAAAAAKIANAARIDPDVVRSLTFPAMATREASLTAQIPFQHCLQCSR
                     EGLSLKHWRRAWAFDCQVCGTRLVPTLGKASGEQMPEKLINRARNGAARLEYAARLRS
                     SKQLRRAMRAVTFAISLKAFRGDPLHALQGHRLEVRLFCLAAIDAAQSRPLVKAAISS
                     SGIDDYARVALLRAFDKEPRLLAAVDYIARQRAKSIGAMAVESHN"
     gene            514588..515058
                     /locus_tag="MED193_02460"
     CDS             514588..515058
                     /locus_tag="MED193_02460"
                     /note="COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid
                     ligases II"
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding enzyme"
                     /db_xref="CDD:10192"
                     /translation="MIVSGDVVMAGYWGNETATASALRDGWLHTGDIGSVDAHGFLTL
                     KDRSKDVIISGGSNIYPREVEEVLLRHSGVVETNVVGREEAEWGEEVIAFVVAEPGVT
                     AQALDRFCLDNIARFKRPKAYCFVLELPKSSYGKILKTELRQMLTDPDTQFEKP"
     gene            515074..516258
                     /locus_tag="MED193_02465"
     CDS             515074..516258
                     /locus_tag="MED193_02465"
                     /note="COG0183 Acetyl-CoA acetyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="lipid-transfer protein"
                     /db_xref="CDD:27984"
                     /translation="MTAIIAGVGMIPFAKPGASAPYDEMGEVAIRLALDDAGIAFEDV
                     QQAYASYVYGDSTSGQRVIYRVGMTGIPIINVNNNCSSGSTALFLARQAVESGVAECV
                     LAVGFEQMAPGALGVVFPDRPSPLAEFDAATDRLIGDVDLPMTLRYFGGAGKAHMERF
                     GTKMETFAKIRAKASRHAANNPLSVFRKEMTTQDVMGAQVIWPGVMTRPMACPPTCGA
                     AAALVVSKGFAEKMGLDTTVQIRAQAMTTDKLLDPETGDMIEVVGARLSRDAARMVYE
                     KAGVGPDDIDVIELHDCFAQNELISYEALGLCAEGDGEKLVDDGDNTFGGKYVTNPSG
                     GLLSKGHPLGATGLAQCFELTNQLRGKAENRQVDNARLALQHNVGLGGAAVVTLYERI
                     TA"
     gene            516270..517070
                     /locus_tag="MED193_02470"
     CDS             516270..517070
                     /locus_tag="MED193_02470"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="3-oxoacyl-[acyl-carrier protein] reductase"
                     /db_xref="CDD:25396"
                     /translation="MRDRDDFGVALVTGAGSGIGQGIALRLAELGARVVVTDIAETGI
                     ADTVKQIEAAGGTALGQKLDVSDPASVNAAFDETERWDKCVDVLVNNAGIVGINPFLD
                     FPLEDWNRVMAINLTGSMLCAQLAAREMVRQRYGRIINITSVSGIRAGVGRTAYGTSK
                     AALVGLTRQIALEVAAHGVTANAIAPGAITTPLTESTYTEETVARLLPMIPAGYMADP
                     ADIAAAVAYLGSPDARYVNGETLVVDGGYVCGGMMQTGSLDLGTKSSS"
     gene            517282..518070
                     /locus_tag="MED193_02475"
     CDS             517282..518070
                     /locus_tag="MED193_02475"
                     /note="COG1024 Enoyl-CoA hydratase/carnithine racemase"
                     /codon_start=1
                     /transl_table=11
                     /product="Enoyl-CoA hydratase/isomerase"
                     /db_xref="CDD:10752"
                     /translation="MTQANVLVEYRGPVAWLTLNRANSLNALSVDLIGELRAAIREIA
                     VAKQVRAIVLTAAGRAFCAGANLKEVLAGLDDADTQKGDFLDAIGATFQALRDLPKPV
                     IGGLNGITVAGGLELAMCCDVLIAGESARIGDAHSNFGVFPGAGGAAVLPCRIGLANA
                     KYLLFSGQSLPARELMRMGLVQEVVGDDALEARLHEFSQLLATKSPLVLSQMKRVANA
                     SIEMTQVEALKQELAVLREHLKSNDAAEGLAAFGEKRKPVFTGT"
     gene            518083..519321
                     /locus_tag="MED193_02480"
     CDS             518083..519321
                     /locus_tag="MED193_02480"
                     /note="COG0183 Acetyl-CoA acetyltransferase"
                     /codon_start=1
                     /transl_table=11
                     /product="Thiolase"
                     /db_xref="CDD:27984"
                     /translation="MTKIYIAGVAMTKMGRLDGATVKSLTCEAVDGAMADAGIGKDDI
                     QAAYYANTTQRHLEAQLMIPGQITLREMGFEGIPMVNVENACASGSTALNLAAQFLKA
                     GEGDVALAVGAEKMWTGDKAKMFSFFDGAWDVSTVEENTEKLMALGKGIDVPNDTTSD
                     KPFSVFMAIYGAFGLAHMRTFGTTQKQIAAIAAKNHMHSVENEKAQFRAPYTVDEILS
                     APPITYPLTLPMCAPMSDGGAAAVLMTEAGLKKFGISRDRAIEVRASVIQTGSNRAPE
                     DYENHLTAIAARRAYEIAGIGPQDVSVAEVHDATAVGELIQIENLGLFPFGEGGAASE
                     RGDTSIGGRVPVNPSGGLECKGHPIGATGLGQVYELVSQLRGECGPRQVEGARIAIAE
                     NGGGLIGIEEAVASILILGR"
     gene            519331..520467
                     /locus_tag="MED193_02485"
     CDS             519331..520467
                     /locus_tag="MED193_02485"
                     /note="COG1960 Acyl-CoA dehydrogenases"
                     /codon_start=1
                     /transl_table=11
                     /product="acyl-CoA dehydrogenase"
                     /db_xref="CDD:27633"
                     /translation="MFKTEEQIMACDSLRRFLDDQIEPEYLKVKDAPFEKEVIQGFMT
                     RLAEFGLTSAPHPEEAGGMGLDWTTHLMLFEEVGVTAIDIALPILINVVAGEILLKLG
                     SDEIRKKYIGPLLAGEITASMGISEPNVGSDVAAVKTRARRDGDDWVINGEKTWITNG
                     RFSDFLICTCATDEGLTHILVDRKEHGYETRDIKKMGLNAQSTAQIFLDDVRVPIANT
                     IGEVGRGLQQTLVVFERARVHMAMWGISLARRALEESIRYAQERNQHGKQIAGHQLIA
                     DKIAVMATEIDAARLLTLRAAGMIDRGERCDKECAMAKWYGTEIAVNATRQAVQIHGG
                     NGVTTDFIVERLAREAIIGPIPDGTTEIQKLLIARTLTGVQAFK"
     gene            520476..521249
                     /locus_tag="MED193_02490"
     CDS             520476..521249
                     /locus_tag="MED193_02490"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="probable short-chain dehydrogenase"
                     /db_xref="CDD:10756"
                     /translation="MEIEGKTIIVTGGASGLGAATAKYLRARGAKIGIFDMSQGAGDA
                     LVKELGASNAMFCNVDVTDDEGVDAAVDAVVSKFGALHGCINCAGVVSPMKVIDRDGK
                     AASLDTFRRTVDINLVGTFNVMSKAVQRMLLNEPENGEERGVVVNVSSGAAMEGQIGQ
                     PAYSSSKAGVMGLNLPAARELGAKGIRVNAIAPGLFGTPMVMSLPDNVIANLEASVEA
                     PKRVGRMEEFAHCCAFLIENSYMNGETVRLDAATRLQAR"
     gene            521254..522369
                     /locus_tag="MED193_02495"
     CDS             521254..522369
                     /locus_tag="MED193_02495"
                     /note="COG1804 Predicted acyl-CoA transferases/carnitine
                     dehydratase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11514"
                     /translation="MLQRSGPLKGVRIVEMAGLGPAPFAAMHLADLGAEVVRIARPGQ
                     KFPLPIDAKYNLFNRSRRSLTLDLTKARDVDRLWQLIERAEVLIEGFRPGKMEKLGFG
                     PEQVQARNPALVYGRLTGWGQEGPLAHAAGHDMNYAAITGAVWGLGDADRPPPAPMNL
                     IADQGGGAMMLNVGILAALTHARATGQGQVVDTAMTDGVNLLMTMQHGLVACGAWSDK
                     RSGDFINGGVAWYRCYETGDGKYVSVGCLEPQFFAELLALLGLTDDPRFADQYAPTAQ
                     ASMMDALTEIFLTATQQEWCDILEGSDACFAPVVSLADASDHAHNRARGSFVTVGGIE
                     MPTPAPRFSRTQPDTPTTGDAGEISLDEILEHWGNNA"
     gene            522366..523247
                     /locus_tag="MED193_02500"
     CDS             522366..523247
                     /locus_tag="MED193_02500"
                     /note="COG0559 Branched-chain amino acid ABC-type
                     transport system, permease components"
                     /codon_start=1
                     /transl_table=11
                     /product="putative ABC transporter, permease protein"
                     /db_xref="CDD:10430"
                     /translation="MTALSFADAMQLFVVGLSQGCLYSLIAIGLVLVYKATEQVNFAQ
                     GEFMMLGAFVGYQFIVLMGMPYWLGAMLTLVFMGAFGYGVEALVVRRLTGQPVFTVFI
                     LTLALGIALRAVAGIIWGFGNYSLPAPVDGNLTLGPVIISWASVLSIVVTAVVASALY
                     LFFRYARQGVAMQALSLNQLAAFYMGIPVKRLTSSIWAMSAIFGGIAGLLLGPMTLVS
                     TQMGFIGFKAFAGAIVGGFGSIPGAVIGCLLIGVTEPFFDIMFPTLKGIGAYLIMFLV
                     LLIRPQGLLAQIYAKKV"
     gene            523251..524330
                     /locus_tag="MED193_02505"
     CDS             523251..524330
                     /locus_tag="MED193_02505"
                     /note="COG4177 ABC-type branched-chain amino acid
                     transport system, permease component"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter,
                     permease protein"
                     /db_xref="CDD:13442"
                     /translation="MRVIFRKSYVQDIQLFRDRGQAFWYLLFAAIALAAPLFLDGYFL
                     DELSFVFIYAIAGLGLMVLTGFSGQVSFGQAAFVAIGAYTHTILLTRYSVPWLLSLPI
                     AALVAGLVGLAVGRICGKMHGLYLAIATLSIAIVTERLIGGAGDFTGGHRGLSVPEIN
                     ILGLAIDESWKVYLLNFVIFVGCILIVRNLTRTRSGRAMIAIRDSEVSARALGTNVAF
                     FKAYAFFISAVFAGLAGGLLAHAFFYITPETFGMGESIRLLLMIVVGGIGTIHGAVFG
                     AFFIVLLPTVLSWVKIVLPSAVATSGGFDSLAFGLILLGFILFEPDGLYGRWTKIHHY
                     FNVFPMYKKRSFQRQKTFLKTERLR"
     gene            524327..525094
                     /locus_tag="MED193_02510"
     CDS             524327..525094
                     /locus_tag="MED193_02510"
                     /note="COG0411 ABC-type branched-chain amino acid
                     transport systems, ATPase component"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter,
                     ATP-binding protein"
                     /db_xref="CDD:10285"
                     /translation="MNGLEIDNVSLSFGGLKAVDGLSFSVEPGSVFTIIGPNGAGKST
                     VFNLICRIYDPSQGDIRFNGKSLRKAKSHEVINHGIARTFQNIELFEHASLLDNLLIG
                     RIRHGKFGPLSELFFTRSQMRQELAHRRKAEEIIEFLDLEGYRHARVADLPYGVRKKT
                     EMARALVSEPKILLLDEPSSGLTSEETDDTAFVIEDIREVLGVTVVMIEHDMKLVNKV
                     SDMVLAINEGRFLASGSASEVQSDPDVQAAYLGGQAA"
     gene            525091..525861
                     /locus_tag="MED193_02515"
     CDS             525091..525861
                     /locus_tag="MED193_02515"
                     /note="COG0410 ABC-type branched-chain amino acid
                     transport systems, ATPase component"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /db_xref="CDD:10284"
                     /translation="MTEVLRASNVETMYGRVMAIRGISLTVKEGSVVTVMGSNGAGKT
                     TILKTISGALDPFKGQVEFEGRDITALDPDVIARVGIAHSPEGREVFSLLSVKDNLMM
                     GAYCRKDRDEVARDLEKVLGWFPVLRTFLEKQAIYLSGGQQQMLALGRAFMQRPRVML
                     LDEPSLGLSPLLISEIFQIIKRINVEEGVTMLLVEQNASVALPAADFGYVLETGRIVM
                     EGERDVLMKSADIREFYLGIKAESARGDRRWKARKTWR"
     gene            525858..527705
                     /locus_tag="MED193_02520"
     CDS             525858..527705
                     /locus_tag="MED193_02520"
                     /note="COG1022 Long-chain acyl-CoA synthetases
                     (AMP-forming)"
                     /codon_start=1
                     /transl_table=11
                     /product="AMP-binding enzyme"
                     /db_xref="CDD:10750"
                     /translation="MNTMQDQSTAGWTPPPVQIDGCDTFSKLFRQNCKKFGNKIAIRE
                     KDFGIWKEFSWLDYYASARRVGCSLMALGYREGDVAAIISEDNKEWVFADLGIQCIGA
                     TTHGLYPTLQEKQVAYQLNDSGAKVLFVEDEEQLDKYLGVEDQLDHLEKVIVFDMEGL
                     RSFQHDKVIGWEEFLALSDAKIEELSVEFERRVDAGDPEDIATLIYTSGTTGAPKGAA
                     MSHRFFLAQSDNYPELPLGPGDEVLTFLPLCHAAERILSVCVPIRHGITINIAESGDT
                     FAADIQEVAPTFIFAVPRVWEKFYSRINFVMNDATAFGRFAYDQALKTAGRREALIAA
                     GKSVPTMLRLRHKVLDFLVLRNIRVELGLARAHTIVSGAAPISARLLSWFNALGVTVQ
                     EAYGQTETGIVTATIPGRSPIGSIGRAMRNVEAKLADDGEILIRSSSNFSGYLNQPEK
                     TAETVVDGWVYTGDVGTMDANGDLTILDRKKDIIITAGGKNITPSQLENELKFSPYIS
                     DAVIIGDKRKYLSVLIMIDHENVEKYAQEKRIPFSNYKSLCANTQIQDLIEGEVEQAN
                     SGFAPVEQVKKFRLIDVLLTAEDDELTPTMKLKRNEIERKYKDLIETMY"
     gene            527762..528889
                     /locus_tag="MED193_02525"
     CDS             527762..528889
                     /locus_tag="MED193_02525"
                     /note="COG0683 ABC-type branched-chain amino acid
                     transport systems, periplasmic component"
                     /codon_start=1
                     /transl_table=11
                     /product="branched-chain amino acid ABC transporter,
                     periplasmicsubstrate-binding protein"
                     /db_xref="CDD:10552"
                     /translation="MTATGAMAEGLQGVTDDMITLGTYTDLSGPLAVWGVPEANGLRM
                     RVDEINAAGGIHGRQLEIIIEDTQYQVPRAIQVANKLMRRDQIFAMVGALGTPMNLAI
                     MPQQIEAGIPNMFPMSAEVEMYEPLDPMKYAFFRSYTDQFRAGVAYFKENGDFSTPCI
                     AQLANEAGESMALGVTQQLAEYDMKVAAKTEHSATESDMLSSVTTLKNAGCDIVFLAG
                     GVRDTILVVATSKKLGFEPTFVTGMVSYMDAVATAADGAMDGLYLVSPFVFANAGDSE
                     GEAKRILESYSEIYGEKMAPQAQLGYVFIDLIAVALEAAGRDLTTEGFLAATEAITSY
                     VDPIGGQSVSFGPEDHQGIESLIMAKVEDGKWTIAARGLDY"
     gene            complement(528894..529040)
                     /locus_tag="MED193_02530"
     CDS             complement(528894..529040)
                     /locus_tag="MED193_02530"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRGQIEHGPPFQLLLAFGIFGFFVPMDSSQSYSFKTNGRNRSTA
                     RIYH"
     gene            529074..529571
                     /locus_tag="MED193_02535"
     CDS             529074..529571
                     /locus_tag="MED193_02535"
                     /note="COG1309 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="possible transcriptional regulator, TetR family"
                     /db_xref="CDD:11025"
                     /translation="MDDIAAALAVTKPALYYYAKNKEDILMQCARISLERVELCFTSA
                     KEVQGNGLDRIRVFFRVYANMVVSEFGSALMREARRNLTGENQKNLRQTMIDGQNFLE
                     SIIAEGIKDGSIRDCDSKRLAHVLFSAFNQMPIWYNPKGPLNPESIADEMLELIIHGV
                     GAKNT"
     gene            529757..530452
                     /locus_tag="MED193_02540"
     CDS             529757..530452
                     /locus_tag="MED193_02540"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MHHLIKKLLPSVAVALTVTGFTLPAPARAQTYPIDCAILLCLSG
                     GWPASVPCARARAEFIRRITPWPVEPPLQIWRCPMGASYENDRPSNNAGRIFEALYQA
                     DNRRPLQSLPVDDLVPTDEALRRVQDRADIDISGPEFNFVRSIRVFDVRYARQHESGR
                     DGDCNRSATVVLGTYGTQGDFSWQRSSITALPEAHVGLERWGQNCPGIYHRSVFVDWR
                     DYEGNYGFEQVNY"
     gene            complement(530773..531990)
                     /locus_tag="MED193_02545"
     CDS             complement(530773..531990)
                     /locus_tag="MED193_02545"
                     /note="COG0477 Permeases of the major facilitator
                     superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="Major facilitator superfamily"
                     /translation="MKTDEEKTPGLRAAILAGCMVAFLGFGFAATFGVFLTPMSQDLG
                     WGREVFSLSVAVQLLTWGFAQPIAGAVADRFGTARVLAFGAICAGIGFALRGMTTDPT
                     AFVLTGIFVGAGTGAASFPIVIGALGKIVSAERRSFILGLGTAAASLGMFVAAPTATT
                     MIGTIGWQTALIVIGCSFALILPFLIFIARVAKPTASGSSASDFGHALSVAFTDRSYL
                     CLFFGFFVCGFHVAFIQTHLPAYVMDLGLAASIGAWSLALIGLFNIAGSFFAGWSGQH
                     LSKKAVLSGIYFARAVVISLFVLVPVTEVSVLVFSAVMGLLWLSTVPLTMGLVAQTQG
                     LKFFSTLAGLVFFSHQTGSFIGAWLGGRIYDVAQDYTLMWWAAVVLGLLAALIHLPIR
                     EEPGPLARAEARG"
     gene            complement(532048..532833)
                     /locus_tag="MED193_02550"
     CDS             complement(532048..532833)
                     /locus_tag="MED193_02550"
                     /note="COG1024 Enoyl-CoA hydratase/carnithine racemase"
                     /codon_start=1
                     /transl_table=11
                     /product="enoyl-CoA hydratase/isomerase-like protein"
                     /db_xref="CDD:10752"
                     /translation="MDYETLRLEITGGIATITLDREDSPANALNARMAEELFDIGVRC
                     GAPDVRAVIVTSNGKMFCGGGDLAEMDAAPDKHAHLTRMATVLHAGLIRLARIDAPVI
                     MAVNGTAGGGGFSLVLSGDYVIASERAKFVSAYTSSGLTPDGSSTYYLAKHVGLLRAK
                     ELMLTNRVLTADEAQAWGLVNKVVPTETVMDEARAMAQCIASGPTKAFGGVKRLLDTA
                     FSDGLETQLDRETRSIADMMRTADGPAGIAAFLAKETPRFEGK"
     gene            complement(532855..533334)
                     /locus_tag="MED193_02555"
     CDS             complement(532855..533334)
                     /locus_tag="MED193_02555"
                     /note="COG1733 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:11444"
                     /translation="MSRSDLPSHTCTIARAVAQVGDEWTLLIVREMFLGTRRFDDFLR
                     LTGMSSHLLAQRLKKLEAEGVIRRAPYSERPPRHDYRLTEKGRDLWAVIIALKQWGDR
                     WLGTDDTPVQITHKACGKVVRPHMTCPDCGERIEAHDAEAQLSHTFELERQAERRAP"
     gene            533427..534029
                     /locus_tag="MED193_02560"
     CDS             533427..534029
                     /locus_tag="MED193_02560"
                     /note="COG0625 Glutathione S-transferase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative glutathione S-transferase protein"
                     /db_xref="CDD:10495"
                     /translation="MKVYFAPQSRAVRTVWLLEEMGQPYELVKFTLGQKEMRGPDYTA
                     INPNGRVPTLVDGDITISESTAIAQYLAAKYAPNLAAAPDAQNFAEYLQWLHYAEGMI
                     MPPINNYVVETILLPPERRNDEIAARALKLLNRTLAAVEHHMEGRDFLAGDFTIADTI
                     TGHAVVMSRRLGAAFENLPNLLAYADRLEARSAFQTAEAA"
     gene            534039..534776
                     /locus_tag="MED193_02565"
     CDS             534039..534776
                     /locus_tag="MED193_02565"
                     /note="COG1028 Dehydrogenases with different specificities
                     (related to short-chain alcohol dehydrogenases)"
                     /codon_start=1
                     /transl_table=11
                     /product="putative short chain dehydrogenase"
                     /db_xref="CDD:25396"
                     /translation="MTAKPICLIIGAGDYIGAAIARRFAKGGFHVVMGRRRGEMFAPL
                     VAEIEAAGGSAQGFSWDARKEETTTEMFAHVEAEIGPIEICIFNVGGNVRFPILDTTE
                     RVFRKVWEMCAYAAFLSGREAAKYMVERQKGSIFFTGATASVRGSAGYAAFASGKFAL
                     RGLAQSMARELGPKNIHVAHLVIDAGVDTAFVRDRVRQSGKDPDTLPPDTLMNPDSIA
                     EAYWTLHHQTRDGWTHEMDIRPFAETW"
     gene            534841..535755
                     /locus_tag="MED193_02570"
     CDS             534841..535755
                     /locus_tag="MED193_02570"
                     /note="COG0679 Predicted permeases"
                     /codon_start=1
                     /transl_table=11
                     /product="Auxin Efflux Carrier"
                     /db_xref="CDD:10548"
                     /translation="MLDQLLNGVLPVFGIGALGYVFGLRGTFDFNMAMALNKFVMFVA
                     MPALGFQLLANAPLAEFDFAMLGGYFVTEMVMYAVGFLIARLVFKTDVMEAALLGLAI
                     ALTNHILFVLPIAVTLFGETAATPIVAIISMDGILIFSCSLILMDVLSTKGASLGHTL
                     GKIARNPPLVAMVLGLVIGLLGVSVPTGFDIFADFLGATASPVLLFALGVILSQKASG
                     ARAMLPVAIAGVKLVVHPLLAWAIFAGVLQLTPEVRNPAMMVAAAPCGAMCFMLALNY
                     GVRVDAIARAILYSSIGSLITITVAASL"
     gene            536005..536205
                     /locus_tag="MED193_02575"
     CDS             536005..536205
                     /locus_tag="MED193_02575"
                     /note="COG3791 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13111"
                     /translation="MRRGFCATCGSPLFLINGAGEGAIVIYAGSLDDPSWYTPSRDIF
                     VKSAQPWDVMDPTLPKSQAMPG"
     gene            536658..537575
                     /locus_tag="MED193_02580"
     CDS             536658..537575
                     /locus_tag="MED193_02580"
                     /note="COG0697 Permeases of the drug/metabolite
                     transporter (DMT) superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein, putative"
                     /db_xref="CDD:12307"
                     /translation="MTVMSQPSNSTDGHRFGVLFVFAAGVLWSTVGLGIRLIEDAVVW
                     QILLYRSASLSVLLYVFIRMRSGESPFAQIRRTGFPAAIAGLSLVAAYSGGIYAIQAT
                     SVANAMLLFATAPFMAAVLGWIVLRERVRPATWVAIAVAIAGIAIMVADKSGGVALKG
                     SLAALGSAFGFAVFTVSLRWGKSGEMLPSVFLSGLFGIIVTSGICLFLDLSLVLSVRD
                     GGIAMGMGVFQVGAGLILYTLGSRSLPAAELALLSLAEVLLGPLWVWLFIGETATLNT
                     LTGGAVLLAAIAGNALSGKRRRPPPITLP"
     gene            complement(537724..537924)
                     /locus_tag="MED193_02585"
     CDS             complement(537724..537924)
                     /locus_tag="MED193_02585"
                     /note="COG0828 Ribosomal protein S21"
                     /codon_start=1
                     /transl_table=11
                     /product="30S ribosomal protein S21"
                     /translation="MQVSVRDNNIDQALRVLKKKLQREGVFREMKLKEHFEKPSEKRL
                     REKGEAIRRARKLARKKLEREG"
     gene            complement(538115..539176)
                     /locus_tag="MED193_02590"
     CDS             complement(538115..539176)
                     /locus_tag="MED193_02590"
                     /note="COG0697 Permeases of the drug/metabolite
                     transporter (DMT) superfamily"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein, putative"
                     /translation="MTASTYTDAPSLSRTLQGITCVLAGMVLFVGQDVLMKGMLTHYP
                     VWMLIFSRSIVALMTLLPLVLWLGAPHRILTPLWPWYLARAMLFASGFAMFYTAFPFM
                     GLAEVTTLFFAAPLMTATLAALFLQEKVGAHRIAALLVGFAGVVIAMNPTGGNFGWIS
                     VLPLFCALTYAISQIIVRKIGEQDTSLVIGLYTISFSGFVIVPMGFVVTQMIVVSPEL
                     NHLRMSWPVPNVKGIAMLALLGAIGTVAYTLVSRAYQIASASVIAPFDYSYLPLAAIL
                     AYLLWGEIPPHTTFIGMVLIIVSGMYTAYRELRVNRSADDNPPTAQTVFTPGAPSVVL
                     ADALDAEAMELDEFDKKLP"
     gene            complement(539899..540156)
                     /locus_tag="MED193_02595"
     CDS             complement(539899..540156)
                     /locus_tag="MED193_02595"
                     /note="COG1396 Predicted transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:16530"
                     /translation="MAKTIRSKGQVALCQALVDARIKAGLGQKDLADRLKCHQSLVAR
                     IESGERRIDVVELVVLARAIGFDPFEVLAIVEAATEPDHRI"
     gene            complement(540281..540532)
                     /locus_tag="MED193_02600"
     CDS             complement(540281..540532)
                     /locus_tag="MED193_02600"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MALLICVPGPVLAESCFAPSRPFLPSDSQAARDYADIIRGDFED
                     YIQDIQSYFRCLDSERARAFEEAREVSEEYGRFLQSVGD"
     gene            540743..541111
                     /locus_tag="MED193_02605"
     CDS             540743..541111
                     /locus_tag="MED193_02605"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MNWDIEAPNVVTEARFRELVESGYSAEILCQESAHKKGPSYYGV
                     WIMRVVTNEGVEKLLVTARTRTTYNDIKIREFKTISGVVSFFIGLGFAHVDLPLEAGT
                     SRTHKLAPSEKAPSDKGADT"
     gene            541155..541769
                     /locus_tag="MED193_02610"
     CDS             541155..541769
                     /locus_tag="MED193_02610"
                     /note="COG0741 Soluble lytic murein transglycosylase and
                     related regulatory proteins (some contain LysM/invasin
                     domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="transglycosylase SLT domain protein"
                     /db_xref="CDD:27995"
                     /translation="MVLVMESDGSLTPSRSQSGFARNYNDGIGQGSAYDGIAIFGELE
                     AEQEGVQVAALARPTPLPHADVLSGIQTTALRYAGHPGLRRAGLSVTDWLALYRANIE
                     VESAYRQDAISSAGAIGLGQLMPATARDLGVDPRDPLQNLDGSARYLAMMLETFGDPH
                     LALAAYNAGPDAVRQHGGIPPYRETQNHVARVMAVVARLEGSNS"
     gene            541766..542059
                     /locus_tag="MED193_02615"
     CDS             541766..542059
                     /locus_tag="MED193_02615"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:27028"
                     /translation="MKQISHLFVASLALFLLIAEPALAQSIDLSPIQSLLQGIVDALT
                     GPLGVVIATLAVLGVFLSWFFNIIDLRQALWVLVGIAGVAAAPTIVAAVFAGG"
     gene            542052..542330
                     /locus_tag="MED193_02620"
     CDS             542052..542330
                     /locus_tag="MED193_02620"
                     /note="COG3702 Type IV secretory pathway, VirB3
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13022"
                     /translation="MAERSPLFLGLVRPPKLLGLPIMYAMVWLFGSVLLFVWVQHIAV
                     LAVAALLYPVLWKAADWDPRFIDVMMTALQETPPTRNRSIHGGDSYAP"
     gene            542320..544695
                     /locus_tag="MED193_02625"
     CDS             542320..544695
                     /locus_tag="MED193_02625"
                     /note="COG3451 Type IV secretory pathway, VirB4
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein B4, putative"
                     /db_xref="CDD:12779"
                     /translation="MPRDDARDAALDPRTMTPEWYARETRLAHMLPYVSLVDDQTVRT
                     RVNELFRCIRLEGINSYTTDDAYLDKVTALFARIVAQLGPEFSYYVHKVSKAIKPDLD
                     PIREDSFAGEVDRRWRAKLETSGLRDKTLTLTVIHRPPPKSLLPFLSRSAPDRLREET
                     RKRQQRLGEAVNVFLSGLTELKPRLLSAGSGELVGFLGALNTGTELPLYPANTYGFLS
                     FNVANTRVTFHGDHFELSEGVVGHRYGKSFTIGEYSEGTSCTMFDMLNLPVDMIVTHS
                     FTPINSNLMAGRIKRQKRQMQASQDAALSLLEALDIAADDLEAKRQSFGEHHMVVTLF
                     CDTLDELQTLSAEIVNAAATEGVKMIGDRVAAKAHYLSQHPGNQPKRVRASAVTNRNF
                     ADFAAFHRTQLGKPAALTPWGRVVTYLPTPEQSAYRFSYHEQGSPDKEPTSGHTLIMG
                     RPGSGKSVLSAFLMTQARRAGARIFVFDYRLGMEMAVRANGGRYASLNAGQPTGLNPL
                     WTETDARGTAWLSDWLATLLYRADKPLTPAQTNRIQEVVRQNAQASNPALRNWRDFAS
                     LFVSTDDGGDLHQRLLEWTEDGRYGWIFGQSLEDTFSLKGDVVGFDLTGILDSEADKE
                     RMAVLSYLFRRVEREIEDRRPTIIVIDEAWKALDNAYFAERLSNWLVTARKQNTVAVM
                     MTQYASQLERTRTGKTIVEAVPTQILLPNIRAQPADYAMLNLTEKELDVLLNTGSNSR
                     LALIRDDQGSIVVDADLSALGPNLTILGGMDKGEALVGADYRDRTDFWRLS"
     gene            544692..544961
                     /locus_tag="MED193_02630"
     CDS             544692..544961
                     /locus_tag="MED193_02630"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIRIWRFEISPKNPASFFAFERSERQRTNDSRQSRNAKLLALAA
                     LGALASCAQYQEPQANCFTFLASTTAISPDCTFTPLGALEGDIEV"
     gene            544951..546105
                     /locus_tag="MED193_02635"
     CDS             544951..546105
                     /locus_tag="MED193_02635"
                     /note="COG0741 Soluble lytic murein transglycosylase and
                     related regulatory proteins (some contain LysM/invasin
                     domains)"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:27995"
                     /translation="MKSSLPHILALCLLPGLALSQGVPTNDSGLIARDIVETGDREAD
                     LAVQADKLAVRELIAEIEREQLETLQRILDAQTSFGGQGLPAMVSGLESGSGDPARSV
                     EAVYGNADIDPNPGGAQMFGDASETIEQLIIRVAQETSGFAGVGRAGLSPVQWRALLQ
                     ALIWQESRFTTGARSPVGAYGLTQIMPGTASDLGINPEYYDSPYLQVHGGARYLATQL
                     NTFDGNIINALAAYNAGPGRVFEYGGVPPFAETQHYVQVIPERYNLYLSRIGGIEALG
                     TIDPALLANANLSITGHGAAFYGNNSPAAIRQAAFRIADIVERISETEDVQESIALNT
                     YARAELVRLVAARIRLQAARTRVLSAEELAQASARMAEGAFMDFTIREIE"
     gene            546105..546914
                     /locus_tag="MED193_02640"
     CDS             546105..546914
                     /locus_tag="MED193_02640"
                     /note="COG0840 Methyl-accepting chemotaxis protein"
                     /codon_start=1
                     /transl_table=11
                     /product="TraF protein"
                     /db_xref="CDD:27519"
                     /translation="MGPLLVRTALATTLGIGLHLGALSPALAQGVPVVDTQNIAQNIQ
                     QLRQMIEDEILQNEQLTQLREQLATLTDQLAELQRTYEALTRLAELPEIIRTEMEDEL
                     NGLLDQEFGDILATIEAIKTGDFSGLSGSGAGEIETQMDRVLADLGFDEDTLSEMATS
                     GNPGANRVATQATTGALVSAAAQNSYEDAGQSLERVDRLVGLIDDMEELKQSVDLNTR
                     VTAELAIALVAMWQLEAIQTVGDGTGGVIDAATIAEEQRFMDFTLPNLRAD"
     gene            547026..547682
                     /locus_tag="MED193_02645"
     CDS             547026..547682
                     /locus_tag="MED193_02645"
                     /note="COG3736 Type IV secretory pathway, component VirB8"
                     /codon_start=1
                     /transl_table=11
                     /product="VirB8 type IV secretion protein"
                     /db_xref="CDD:13056"
                     /translation="MVASEQEIIEEELVYGALRRERLSQRLGLIGLVFGIIGCLSAAA
                     VSILDVDPPPVVVPYDPATGFALPEASVGASSVTANQAIIQAEVFRYVTDREVYNQLD
                     NDLRIRSVLRRSDGAAESGLRQIWNSANENYPPTVYGPNARLDVEILSINRIGTNRAT
                     VRLRKRLTSINGTQTGLFTATLLFEFRPETRRSIDEVWTNPFGFTVLEYSIRSDRLEN
                     "
     gene            547685..548380
                     /locus_tag="MED193_02650"
     CDS             547685..548380
                     /locus_tag="MED193_02650"
                     /note="COG3504 Type IV secretory pathway, VirB9
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein, trbG"
                     /db_xref="CDD:15554"
                     /translation="MLFIRSLIFVIALLPGLASAEAIPRGGPNDSRVRLATYQEGQVY
                     RLSVSLTHVTTIEFGEGESIRSIIAGDTEGFEIDGVPGGQAFAIKPVARGVHTNVTVY
                     TNRRSYYFNVEEVRSPTFYVVQFRYPDDDARPTRAIAAQAPNYNYGASARTEFTPTRI
                     WDDGTFTYFAFPRNAPVPAIFRYAGGRERTVNTQTPEDGVIRVSGVNRQWVLRLGEEV
                     VCIEVIPPAEATS"
     gene            548377..549756
                     /locus_tag="MED193_02655"
     CDS             548377..549756
                     /locus_tag="MED193_02655"
                     /note="COG2948 Type IV secretory pathway, VirB10
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /db_xref="CDD:8701"
                     /translation="MSDTGNTELEKRLAALEKGSARAPTAAQRRSPLLALIVVLVIGA
                     GGALLYLLSQPEEEEALPTATPDVFQNEGDGFGAIETLPPPEPEVVFVGPDPVEPNAE
                     LLAQITALQAQIEELRNAPEPVVEEDTAAAEAIDALTAQIAALQAASEAAQQRFQDEL
                     TARDRSLEQLRMDLELAQLEASRPQPAPAGPTEDELRAREQERLRREEEARRMAELER
                     RAAEERAFQERRIASPTVAFGGTSGANETALTERTFGEVTDFVLNGALPSTVTQAEVI
                     ANPSNTIIQGTMIQAIMETALDSSLPGQTRAVVSEDVYSVDGTRLLIPRGSRLIGRYR
                     AGVDIAQRRVTIAWDRIILPAGQTVQISSFGGDELGRSGVTGLIDTRFAARFGSAALI
                     SLISAAPSAAASEVQDETAADVLEDVGDDLADATDSVIGDYLSIGPVIYVDQGARVTV
                     MVDRDLEIF"
     gene            549761..550747
                     /locus_tag="MED193_02660"
     CDS             549761..550747
                     /locus_tag="MED193_02660"
                     /note="COG0630 Type IV secretory pathway, VirB11
                     components, and related ATPases involved in archaeal
                     flagella biosynthesis"
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein B11, putative"
                     /db_xref="CDD:27822"
                     /translation="MSLSYLETSLDRIDAAARDDVIEICINPDGTCWGEFQGDHFMRA
                     LDQRLTSVQVRDLGNQIASSANTTMSKDRPIVSVSITYKGRPIRAQVITPPAVLSAMS
                     ISLRFFSSLPLEGIALDFLYGKERKLEDLRVEKKRALRAVVAAGLIDDALAFCVENKL
                     NMIVSGGTSTGKTVAARKILSHVPAEERIVTIEEAAELLPTQPNAVTLIANRDAEFQT
                     ADVLLTATLRMRPDRIILGEVRGKEAMTFLEAINTGHGGSMTTLHAETPQLAVQRLAI
                     AALKTEIPMTYADMIQYIENSIDVIIQAGRHDGKRGITEFYLPGATEIGTSP"
     gene            550744..550938
                     /locus_tag="MED193_02665"
     CDS             550744..550938
                     /locus_tag="MED193_02665"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MKTFEYDILSFPMTRKTGLSDMQASLNAKGAEGWEVVSISSSEF
                     ANVGHTVFLKRETTTVGTAA"
     gene            550935..551354
                     /locus_tag="MED193_02670"
     CDS             550935..551354
                     /locus_tag="MED193_02670"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRVTRFRLALAALALGLSLTFTPAFAERDLVPTLERRFDVCPDR
                     PAELSWMQEIPLRQAYQRVLVQDIYRAQNLERVVEIGNCDCATRFPSWDAAEAMFRES
                     YASDERWEMLEASEGYNRRANAARTAAKAICDAAGNW"
     gene            551367..552443
                     /locus_tag="MED193_02675"
     CDS             551367..552443
                     /locus_tag="MED193_02675"
                     /note="COG3704 Type IV secretory pathway, VirB6
                     components"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13024"
                     /translation="MSVVTYFVETSQAYLDTAAETQFGAVAATVGTLLVLGTTLVVIL
                     VGINMIYQYRAMDGHTAFWLAVKIGLIGIFATNWMQFNAFSSAILYGIDSIAGALVAS
                     VGGGSPGPSGTFAEEFDRLIAELGDYLNAAGSELNWMAGAMLDIVGVLLLSILGGLAA
                     FILVASRLMIALLIGIAPVMIFLTLFEVTKDYFARWLSALISFALYPIVVAGVFATIT
                     GVSSALIGELGDPEGASNIGALIPFFMMVLMAKGFIIATPFIVRAISGNIMMPALSGG
                     LSGGYSFARAAMGSQQAYNRYLIGGASGAEYAALRARQFFGVQQMPVRQGMGQTGSGG
                     GTGSADSGSKMLAQLARLGRLGRR"
     gene            552589..552936
                     /locus_tag="MED193_02680"
     CDS             552589..552936
                     /locus_tag="MED193_02680"
                     /note="COG0582 Integrase"
                     /codon_start=1
                     /transl_table=11
                     /product="integrase/recombinase"
                     /db_xref="CDD:27734"
                     /translation="MTEERVTPLRQRMIDDMRIRGMGEKAQKSHIRAIKDFAAFLGRP
                     PDTATPEDLRAYQLHMTDSGVTPSTFNVRIVALRFFFSMTCGREEMKRYMQFRTEPRK
                     LPVVFSVEECPTS"
     gene            complement(<553188..553741)
                     /locus_tag="MED193_02685"
     CDS             complement(<553188..553741)
                     /locus_tag="MED193_02685"
                     /note="COG0646 Methionine synthase I
                     (cobalamin-dependent), methyltransferase domain"
                     /codon_start=1
                     /transl_table=11
                     /product="methionine synthase I"
                     /db_xref="CDD:10516"
                     /translation="MTTFFADFLAEKDVLLADGATGTNLFNMGLQSGDAPELWNTDEP
                     KKIMALYQGSVDAGSDLFLTNSFGGTAARLKLHDAQGRVRELNRAAAELGREVADKMD
                     RKIAVAGSVGPTGEIMLPVGELSHELAVEMFHEQAEALKEGGVDVLWVETISAPEEFR
                     AAAEAFALADMPWCGTMSFDTAGRT"
     gene            553768..553899
                     /locus_tag="MED193_02690"
     CDS             553768..553899
                     /locus_tag="MED193_02690"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGAQGQGGPVPLGWSCCVMGAVKAQLHNPQLDYEAHIEAPLLF"
     gene            complement(553906..555873)
                     /locus_tag="MED193_02695"
     CDS             complement(553906..555873)
                     /locus_tag="MED193_02695"
                     /note="COG0392 Predicted integral membrane protein"
                     /codon_start=1
                     /transl_table=11
                     /product="membrane protein, putative"
                     /db_xref="CDD:12248"
                     /translation="MQSLKLLSAAPPLQILRLTAPFAMAALCLWALSTRIELPSLAAL
                     GSLLGQLQLWQWLAAFGATGLSFWALGRYDSVAHRHLQTGLDGPQARRAGMAAIAFSQ
                     LVGFGLFTGAYARWRLVPGLTALQAAQLTGLVGLTFMAALALLCGLAMIMVPVFAWFR
                     PLGALLVTLTLAGGLMSFAAPRLRLGAFSLRWPSLPAMAALTVWAFMDVVAAGSALWI
                     LLPETLAISWATLLVVYAIALGAAILSSAPGGTGPLELMIFTLLPAHDSTGLLAALLA
                     FRLVYYALPATIACILMVLPDRLKSMRAPVTDSDLLGAQSLPVEHLPYDRLRAETGVI
                     RQNGGHIQAFGFNQLALLDSPQISVALFDPVTGNLDETLAPLRRYARQRNATPCIYKC
                     SARNALAARKAGWVVLRIAAEAVVSPTSFSEAGSSHRQLRRKLRHAEKAGISVRPAPP
                     NLPLEQMQALDQVWQQRHGGARGTTMGRFEANYLAGQRVFLAWQNEHIIGFITLHTAS
                     GEWCLDLIRICPDAPDGTGHILLRAAIAAAKVEEIPRLSLAAVPDHRFAARMDPGLRR
                     FKACFAPQWQPRYMTCPSWYDMTIAGFELYRLIHHPDPVLQAAPAATPSESPQTKENA
                     SEEGRADAAWDKQQPKDQSQQYDMPNSAQAS"
     gene            complement(556098..556424)
                     /locus_tag="MED193_02700"
     CDS             complement(556098..556424)
                     /locus_tag="MED193_02700"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTTFDDRAQAFEAKFAHDLDLRFQARARCNKLLGQWAADILGLD
                     AAQTEEYAAEVVSADLQHPGHDDVLNKITSDIAAHKHSQFTAEDVKRQMAEFLSQASE
                     EVLEAT"
     gene            556732..557493
                     /locus_tag="MED193_02705"
     CDS             556732..557493
                     /locus_tag="MED193_02705"
                     /EC_number="6.3.2.6"
                     /note="COG0152
                     Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR)
                     synthase"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylaminoimidazole-succinocarboxamide
                     synthase"
                     /db_xref="CDD:27785"
                     /translation="MARRKKIYEGKAKTLYEGPEPGTIVQYFKDDATAFNAEKKDVIE
                     GKGVLNNLLSEYFMVGLGQIGVPTHFLKRLNMREQLVRSCEIIPLEVIVRNYAAGSMS
                     KRLGIDEGTQLPRPIVEYCYKDDSLGDPLVSEEHIAAFGWASQQDMDDILSLALRVND
                     FMSGVMFGVGIRLVDFKIEIGRVYDGDFQRLVVADEISPDSCRLWDIESGQKLDKDVF
                     RRDLGSLTDAYSEVARRLGVMPNNPPAPSKPTLVN"
     gene            557604..557834
                     /locus_tag="MED193_02710"
     CDS             557604..557834
                     /locus_tag="MED193_02710"
                     /note="COG1828 Phosphoribosylformylglycinamidine (FGAM)
                     synthase, PurS component"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase, PurS
                     protein"
                     /db_xref="CDD:11538"
                     /translation="MKARVHVMLKNGVLDPQGEAVRHALGALGFDKVEGVRQGKVIDL
                     DLAADATEADVTEMCEKLLANTVIESYSIEMK"
     gene            557834..558502
                     /locus_tag="MED193_02715"
     CDS             557834..558502
                     /locus_tag="MED193_02715"
                     /note="COG0047 Phosphoribosylformylglycinamidine (FGAM)
                     synthase, glutamine amidotransferase domain"
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylformylglycinamidine synthase I"
                     /db_xref="CDD:9922"
                     /translation="MKAAVVVFPGSNCDRDLAVAFEQAGFDVSMVWHKDSVLPEGVDI
                     VGVPGGFSYGDYLRCGAIAAQSPICQAVVEHANRGGYAMGVCNGFQILTETGVLPGAL
                     LRNAGLKYICRTVDLQVATEDSVFTQGYAKGDVIGIPIAHHDGNYFADADTIAALKDQ
                     DRIAFTYADNPNGSVDDIAGILSENRRVLGMMPHPERAADEGHGGTDGTAVFRALAGI
                     LATA"
     gene            558539..560311
                     /locus_tag="MED193_02720"
     CDS             558539..560311
                     /locus_tag="MED193_02720"
                     /note="COG4191 Signal transduction histidine kinase
                     regulating C4-dicarboxylate transport system"
                     /codon_start=1
                     /transl_table=11
                     /product="C4-dicarboxylate transport sensor protein DctB,
                     putative"
                     /db_xref="CDD:13451"
                     /translation="MNAPQTSKPPPANETGSRTIPWGARLALLLFMAVAAVTVWVTNQ
                     QLTHRFTDSTRNRGELRLALYSGNLVSELRRHAIVPQLLARDQTLIAALQSQDFSLST
                     QRLLSFIDEIGANSIMLMASDGRTVAATNRNRLGENHRNEAYFVDAARAKSTVFSVIK
                     REVGGYRFTYSRRMVDSSGLLGVIVIEVDLRKFERAWAGVSDAVMVTDSKGNIVLATE
                     ARWRGLQEEEALLLQTPESAIQRAIRATADWSTLPPDAYLQGEAVMRLDNRVPFQGWR
                     MTSFTPFASIREKVNAVLALEIMGFAILLALAFYALSRKTALRMALFQRESAELRVLN
                     ARLQREIAERERMQKTLAVAEQSLAQSSKLAALGEMSAAVSHELNQPLAAMKTYLAGA
                     RLLLNRNRPDEALASFGRIDDLIERMGAITRQLKSYARKGGDAFSPVNLGDALASSLS
                     MMEPQLRQRHVKITRLLPEDPVFVMADRMRLEQVMVNLLRNALDATKSVEEPEVEILL
                     AAGETATLTVRDNGVGIEDFGSLFDPFYTTKQAGDGVGLGLAISSGIVNDLGGRLAAR
                     NGQKSGAVFEMQLPILADGIEAAE"
     gene            560346..561683
                     /locus_tag="MED193_02725"
     CDS             560346..561683
                     /locus_tag="MED193_02725"
                     /note="COG2204 Response regulator containing CheY-like
                     receiver, AAA-type ATPase, and DNA-binding domains"
                     /codon_start=1
                     /transl_table=11
                     /product="C4-dicarboxylate transport transcriptional
                     regulatory protein DctD"
                     /db_xref="CDD:11911"
                     /translation="MAQAMKIAIVDDEQDMRQSISQWLALSGYDTETFASAEEALKEL
                     GADYPGIVISDIKMPGMDGMQFLKKLMGSDSGLPVIMITGHGDVPMAVEAMRVGAFDF
                     LEKPFNPDRMSELAKRATGARRLTLDNRALRRELSDGSQIMKKLIGMSPVMERLREDI
                     LDLGQADGHVLIDGETGTGKTLVAHALHAVGSRAGKKFVLISCSALEEEALSKRLFGP
                     MQPEDSLLPALEEARGGTLVLEGVEALSEALQAKLLSAINEQGMPGETRIIAISNLQE
                     AGKTCEDALRPDLFYRLAALRIMVPPLRQRGEDILTLFTRLCEQFAEEYGCDAPQVSA
                     QEAAQLLQAPWPGNVRQLINVAERAVLQARRGSGTIASLLMSDHEEMQPVMTTEGKPL
                     KEYVEAFERMLIDNTMRRHKGSIASVMEELCLPRRTLNEKMAKYALQRSDYLG"
     gene            562312..565452
                     /locus_tag="MED193_02730"
     CDS             562312..565452
                     /locus_tag="MED193_02730"
                     /note="COG1530 Ribonucleases G and E"
                     /codon_start=1
                     /transl_table=11
                     /product="ribonuclease, Rne/Rng family"
                     /db_xref="CDD:11244"
                     /translation="MAKKMLIDATHAEETRVVVVDGNKVEEFDFESENKRQLAGNIYL
                     AKVTRVEPSLQAAFVEYGGNRHGFLAFSEIHPDYYQIPVADREALMEEERAYAEAQRA
                     RDDEEESKPSRSRSRGRKGSRSKAAKVNSGDAVETKEVAPAKAEPAATPDVTENETPV
                     VSEIAGMETIDLVDEVESDEAKLAEVPEGSSPMERVADTPVEEPDGAEGIAAEQVSPE
                     PAVSVETGSQTDEPDAVETPAQEASEDTAAEPVAEEASVSEAPVAAEASSGDAVIQSA
                     GSDDANADTDTAAGDDSGESEEEAKAPSDASAKDESIESVADEDDSEDIRPARKPRPR
                     RYKIQEVIKVRQVLLVQVVKEERGNKGAALTTYLSLAGRYCVLMPNTARGGGISRKIT
                     NAVDRKKLKDIATEIDVPSGAGLIVRTAGAKRTKAEIKRDYEYLQRLWEQIRELTLKS
                     VAPAKIYEEGDLIKRSIRDLYNREIDEVLVEGERGYRIAKDFMKMIMPSHAKNVKNYQ
                     ETLPLFARFQVESYLGGMFNPTVQLKSGGYIVIDTTEALVAVDVNSGRATKQSSIEET
                     ALNTNLEAAEEVARQLRLRDLAGLIVIDFIDMDERKNNAAVENRMKDKLKTDRARIQV
                     GRISGFGLMEMSRQRLRPGMIEATTQPCPHCHGTGLIRSDDSMALSILRQIEEEGTRR
                     RSREVLVRCPIDIANYLMNQKREHIAQIEARYGLSVRIEGDAHLVSPDFTLEKFKTAT
                     RVVAVSAAPVVSADTSLMAQVDADEAEADEDELPQDENSDAVADSGSNGEDKPKRKRR
                     RRRRRKSGNGGENSESDRNGSEAGGGSEASETAAENAAEGEENPASETGEEAGSEEKK
                     TSRKRTRTRGGRSRSKKTEASDAPSVDTAEGAETPAEQGGESAPSEGEAKPALEAEPV
                     PEAAADTVTAAPAEAVAQADPSVVEDVAVAEPAESAEAAASEAPAQDVVAEPAVEPAD
                     PEAETVAVEEATAAAEVVDAPSAEQDVIAAEAAEPVAEAAEKPAENAEPEVAPAVEPE
                     PAAPPKPKRRGWWSIG"
     gene            565547..565939
                     /locus_tag="MED193_02735"
     CDS             565547..565939
                     /locus_tag="MED193_02735"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTSNGDPNLLSEILEHETRVWQALVTGDIAADKAALDADFLGVY
                     PSGFATRSEHCDQLSEGATVVSFELNEARLLSLGGNHVCLSYLARYLRPNAEAQEEMY
                     VSSIWQRQNEGWINIFSQDTPVAGAIPV"
     gene            complement(566003..566248)
                     /locus_tag="MED193_02740"
     CDS             complement(566003..566248)
                     /locus_tag="MED193_02740"
                     /note="COG0425 Predicted redox protein, regulator of
                     disulfide bond formation"
                     /codon_start=1
                     /transl_table=11
                     /product="SirA family protein"
                     /db_xref="CDD:10299"
                     /translation="MTTPAPQNDATLDAIGLLCPLPVLKARKRLKSMAEGEVLQVLAD
                     DPAAIIDIPHFCTESGHALLGQSAVESHQIYHIRKGG"
     gene            566298..567116
                     /locus_tag="MED193_02745"
     CDS             566298..567116
                     /locus_tag="MED193_02745"
                     /note="COG0785 Cytochrome c biogenesis protein"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome c-type biogenesis protein CcdA"
                     /db_xref="CDD:3190"
                     /translation="MPPVTFATGWSMGHESLVLGNEMFGIEIIDAGLLPAMFVALLGG
                     LVSFLSPCVLPIVPPYLAYMSGVSIGEMQGTEAARRKVILSALFFVLGLSTVFLLLGF
                     TASFFGAFVLQNQEWFARASGVVVIIFGLHFLSVFRIPILDREARVDAGQAGGSVVGA
                     YVLGLAFAFGWTPCIGPQLGAILALAASEASVSRGTLLLGIYALGLGVPFLLAAIFLN
                     RSMVVMNKMKRHMGLIEKLMGGLLLLVGLMLVTGLFSTFSWWLLEAFPFLATLG"
     gene            567254..568564
                     /locus_tag="MED193_02750"
     CDS             567254..568564
                     /locus_tag="MED193_02750"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MDSTTAGATGQGLRTSETIEAAPVRARRVFYIPGYDPIHPRRYR
                     ELYRKEGAAQAEISNYDLSLTPQPPAPGGTGQRPYGWQVSAEIDGQEVRTEFSVLVWS
                     DIVRDSMDASILGTYLQLIRTAWIYISSGTLGRLMRLRKGPVIAALYPVAMLLIQALL
                     ALVLLWACVAGWSAAMALVVERGQGLALLPGWGIGAVAALALLRWFKKQDGKFFAYYL
                     MHDYAYSAASRGENPKDLEARIAGFKREISAALQAGDIDELLVVGHSSGAHVGVSVLA
                     DLIREGLPDPCPEIGFLTLGQVVPMVSFLPHASRLRGDLRYLSQREEIAWIDVSAPGD
                     GCAFALCDPVAVSGVAPADKRWPLVFSAAFTQTLSPARWAELRWRFFRLHFQYLCAFD
                     RPGDYDYFRITAGAQTLRQRYKSRKASASRIDVPVSKYTSVKPQ"
     gene            568561..569949
                     /locus_tag="MED193_02755"
     CDS             568561..569949
                     /locus_tag="MED193_02755"
                     /note="COG2124 Cytochrome P450"
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome P450 family protein"
                     /db_xref="CDD:25378"
                     /translation="MNGPKRQPPKPAARPSRVSLWRYVKLFREDILSAQPGKLYRAWM
                     AEFRAPSFRSYLINQPDLIKRVLKEQPDDFPKSDRIAEGLKPLLGSSVFLTNGKTWKR
                     QRRIIDPAFEGGRLKVTYPAMRAAADSAILRLQTRVGQGRNIEVEEVTSHVAADVIFR
                     TLFSIPIENEVASEVFTRFRDYQRSQPLLNLAAFVPLPKWMPRFFRRGTRPNANVIRA
                     LITDLTESRMAEIKAGKAPEDLATKIMTTTDPETGERFDAQEMVDQVAIFFLAGHETS
                     ASALAWSLYLLALYPDWQEQLAQEAEALADESFAAISKLRLSRDVFREALRLYPPVPM
                     MVREATCPVQFRNRAVPKGAQIVLSPWHLHRHERLWDNPDGFDPSRWQTENGKQCQRE
                     AYIPFSAGPRVCPGAGFAMVEGALILSMILRHFKITCVEGAEPVPVAHLTVRSKSGIW
                     LQFTPRTAADHS"
     gene            complement(569940..570173)
                     /locus_tag="MED193_02760"
     CDS             complement(569940..570173)
                     /locus_tag="MED193_02760"
                     /note="COG4321 Uncharacterized protein related to
                     arylsulfate sulfotransferase involved in siderophore
                     biosynthesis"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:13568"
                     /translation="MNSRPRKHSLTLRGHRTSVSLEDPFWLAFRQIATRTSRPINELA
                     AEIDEARGADCGLASAIRLFVLHDLQSRLPTQE"
     gene            complement(570170..570358)
                     /locus_tag="MED193_02765"
     CDS             complement(570170..570358)
                     /locus_tag="MED193_02765"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGKPVNLNRYRKTQARAKDRARADENAVKFGRNKLDKELEKARA
                     AKAKRDLDGHLNGDKSDP"
     gene            complement(570358..571836)
                     /locus_tag="MED193_02770"
     CDS             complement(570358..571836)
                     /locus_tag="MED193_02770"
                     /note="COG0114 Fumarase"
                     /codon_start=1
                     /transl_table=11
                     /product="fumarate hydratase, class II"
                     /db_xref="CDD:9989"
                     /translation="MLRANGQLRRVDAAYKRHATAYQTEIDKMSDTRTETDSFGPLEV
                     PTDKYWGAQTQRSIMNFPIGWEKQPVAIVRALGVIKKACAMANKASGKMEDRIADAVI
                     AAAGEVIEGKFDDNFPLVVWQTGSGTQSNMNSNEVIANRAIEMLGGVIGSKDPVHPND
                     HCNMGQSSNDTFPTAMHIATAMSVRDVLLPGLEKLAKGLENKSEEFKDIIKIGRTHTQ
                     DATPLTLGQEFGGYAHQIRQGIARVELAMPGIYELAQGGTAVGTGLNTQKGWSEEVAA
                     NMAEITDLPFVTAPNKFEALAAHDAMVFLSGALATIAGSCYKIASDIRFLGSGPRSGL
                     GELILPENEPGSSIMPGKVNPTQAEALTQVAAHVMGNDAAIKFAGSQGHFELNVYNPM
                     MSYNLLQSIQLLGDATDSFTERMLNGIQANEPRIDKLMKESLMLVTALAPTIGYDNAT
                     KVAKTAHKNGTTLKEEAIALGFVDEATFDAVVRPEQMIGPKD"
     gene            complement(571950..572015)
                     /locus_tag="MED193_02775"
     CDS             complement(571950..572015)
                     /locus_tag="MED193_02775"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MAFSAGFACLVATVWITVISY"
     gene            572065..572583
                     /locus_tag="MED193_02780"
     CDS             572065..572583
                     /locus_tag="MED193_02780"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MFLTLALLWGTAVRASAHDISDFWGSYAGSVEVVNSDGEKDLRD
                     LSVVLTRTAKGFVVQWSTVTEKGDGRRKEKAYTVEFIPSEREGIYSAAMQRNVFGHEV
                     QQDPMKGQPYVWARLSHDTLTVFSMFIHENGDYEMQQYDRRVTPEGLSLVFTARVNGL
                     PVRQIEADLLRR"
     gene            complement(572802..573278)
                     /locus_tag="MED193_02785"
     CDS             complement(572802..573278)
                     /locus_tag="MED193_02785"
                     /note="COG3814 Uncharacterized protein conserved in
                     bacteria"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MSREIDYGNLMHSAMRGLIRTVLQDVADKGLPGNHHFFITFDTN
                     HPDAQLADWLRDRYPGAMTVVMQHWYDNLEVGEDGFGITLNFGDAPEPLYIPYDAIET
                     FVDPSVEFGLRFEAAEESDDEGDDTVDHLDDEDEAADVAKRPSEGDVVSLDSFRKP"
     gene            complement(573414..574676)
                     /locus_tag="MED193_02790"
     CDS             complement(573414..574676)
                     /locus_tag="MED193_02790"
                     /note="COG2059 Chromate transport protein ChrA"
                     /codon_start=1
                     /transl_table=11
                     /product="chromate transporter"
                     /db_xref="CDD:11767"
                     /translation="MWRTFGKIGLMSFGGPAAQIAVMHRELVEKRPWLDEESFLRGLS
                     FCMLLPGPEAMQLCTYTGWRLRGVLGGVLAGLLFVLPGALVIAALVWLYAVFGALPPV
                     QAAFLGIKAAVVVIVLQALWKLSHKALKHRRDWGLAGFGFIALFAFGLPFPLVILAAG
                     LFGLMTMAGSRQSHTPPPFTKAAPTIGVQHTLNTVLIWGGLWLLPLICLSLFGGSFLA
                     SIGWFFAKLAVVTFGGAYAVLAYMSQAVVQQHQWINAGEMIDALGLAETTPGPLILVT
                     QFVAMLAGLKQGGLALFLAAGATALWATFMPCFLWIFAAAPYVERLAALPRLASALKA
                     ITATVTGVILNLMVWFTLHVLFEEVTQLQSGPLTMPWPDLTSLNIAALGLTLAAALAA
                     CVLRGRLLGQLAVMALAGLGTQSIPSIL"
     gene            complement(575450..576181)
                     /locus_tag="MED193_02795"
     CDS             complement(575450..576181)
                     /locus_tag="MED193_02795"
                     /note="COG2186 Transcriptional regulators"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, GntR family"
                     /db_xref="CDD:11894"
                     /translation="MKIDPTSSADLSVQIAQSIKAAIINGDLIVDQRLPSESELADQF
                     QVSRPTVREALKRLAAQSLIRTQRGATGGAFVNRLSFEDAYAQQVTTSTLLLSMNEVS
                     FQTACEARYALERACAPLSVLRRNADQLATMRSEIFRQGQPDLSDEAFCASDVTFHRA
                     LVDAAANPVLSYQLAGAVEAMQPLMNMITFSARDRARIVALHSQIVEAIDQRDGTAAT
                     DGLQALETETLNLAQKVFETRSAKT"
     gene            576462..577565
                     /locus_tag="MED193_02800"
     CDS             576462..577565
                     /locus_tag="MED193_02800"
                     /note="COG0404 Glycine cleavage system T protein
                     (aminomethyltransferase)"
                     /codon_start=1
                     /transl_table=11
                     /product="aminomethyl transferase family protein"
                     /db_xref="CDD:10278"
                     /translation="MAFISPSRRLRRTPFSEGVEAAQVKAYTVYNHMLLPTVFESPEA
                     DYHHLKKHVQIWDVSCERQVELRGPDAGRLMQMLTPRDLRGMLPGQCYYVPIVDETGG
                     MLNDPVAVKLAEDRWWISIADSDLLYWVKGIANGWRLDVLVDEPDVSPLAIQGPKSEE
                     LLVRVFGESIRSIRFFRFGTFQFQGRDLVIARSGYSKQGGFEIYVEDSEIGMPLWNKL
                     FEAGQDLEVRAGCPNLIERIEGGLLSYGNDMTDDNTPHECGLGRFCDTHTAIGCIGRD
                     ALLRVAKEGPVQQIRAISIAGEPVPACTEFWPLYAGGKRVGRVSSAAWSPDFRTNVAI
                     GMVRMTHWDAGAKLEVETPDGMRQATVREKFWI"
     gene            577596..578591
                     /locus_tag="MED193_02805"
     CDS             577596..578591
                     /locus_tag="MED193_02805"
                     /note="COG0604 NADPH:quinone reductase and related
                     Zn-dependent oxidoreductases"
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase, zinc-binding dehydrogenase
                     family"
                     /db_xref="CDD:10474"
                     /translation="MFNAVVMNKDEDSGLATASVEQIGLDQLPEGNVTVAVEYSTVNY
                     KDGLCLSPKGGGLVRKYPHVPGIDFAGTVEDSADDRYQPGDKVVLTGWRVGEAHWGGY
                     TQKARVNADWLVPLPSGLDSRQAMAVGTAGLTAMLSVMALEDHGLKPGQGPVLVTGAA
                     GGVGSVATAILANLGYEVAGVTGRPETEAYLRELGATQIVAREDLNETVKRPLESETW
                     AGCVDAVGGEMLARVLGQMKYGASVAAVGLAGGAGLPATVIPFLLRGVNLLGIDSVMQ
                     PYDNRLRAWQRLAADLPMEKLEAMVTPAVLSDLPQLGADILKGQVKGRVVVDVNA"
     gene            578864..580093
                     /locus_tag="MED193_02810"
     CDS             578864..580093
                     /locus_tag="MED193_02810"
                     /note="COG0520 Selenocysteine lyase"
                     /codon_start=1
                     /transl_table=11
                     /product="aminotransferase, class V"
                     /db_xref="CDD:10391"
                     /translation="MGMALDIDFVRRQFPAFQEPSLQGQAFFENAGGSYTCGQVIDRL
                     TRYYTQRKVQPYAPYEASRLAGAEMDEARQRIAALMGVESDELSFGPSTTQNTYVLAQ
                     AFRQFLQPGEAIIVTNQDHEANTGPWRRLADEGIEVREWEIDPQTGHLDPIRLEALLD
                     DKVRLVCFPHCSNVVGEINPVTEITALSHAAGAFVCVDGVSYAPHGLPNVGDLGPDIY
                     LFSAYKTFGPHQGVMVMRRELGALLPNQGHFFNADCLYKRFTPAGPDHAQVAASAGMA
                     DYFDALCDHHSGPSEGATARGAFVHDLMRAHEVELLQPLLDAVKERNDLRLLGPSEAA
                     RRAPTVALALNRPALEVAAELANFGIMAGGGDFYAGRALKAMGVDPDQGVLRVSFTHY
                     TCKGEVDKLINALDQVL"
     gene            580171..580611
                     /locus_tag="MED193_02815"
     CDS             580171..580611
                     /locus_tag="MED193_02815"
                     /note="COG0004 Ammonia permease"
                     /codon_start=1
                     /transl_table=11
                     /product="tellurite resistance protein"
                     /translation="MPTAARLIAAIALGLLAIVISVQVVPLMPEGTDFGYFFHINVAL
                     GLLTGWIFMGRRVGYGVVPAINNGLTGAAVMVLWALFIQGAWEMFDRAMRNRYGGPFE
                     ALLAIFTLSLEYFFVIAVPSVLLPLVIGGCLAGLLAENVHRRWP"
     gene            580639..581763
                     /locus_tag="MED193_02820"
     CDS             580639..581763
                     /locus_tag="MED193_02820"
                     /note="COG0494 NTP pyrophosphohydrolases including
                     oxidative damage repair enzymes"
                     /codon_start=1
                     /transl_table=11
                     /product="tellurite resistance protein"
                     /db_xref="CDD:25476"
                     /translation="MIDLFFYGTLRYVPLLERVLGRGGAGLDTTVASLPDHAVYAVKD
                     QIFPMIVEAEGETAIGLLVRGLSAQDLAALDFYEGGFDYVLKPITVSLAEGATAAAQV
                     YFPTPGQWQASAPWDLEAWIAESGALTLRAAEEVMAYQGRVTPEQMRQSFPSIRRRAS
                     AWLMAQSRPEDPAHDLSRDVEVETHKRAYVNFFAMEEMDLKFRRYDGSMSPVINRGVA
                     LVGRASVVLPYDPLRDQVLLVEQFRAATYIAGETRPWMWEPVAGLIDPGETPQQAACR
                     EAMEEAGVTVSQLEEVTQAYPSSGSSGEFIYIYVGLTDLSDIRGGGGVAGENEDLRSE
                     IISFDALMAGVDSHRYQDIPLITAALWLARHRDRLRAQAG"
     gene            581834..582868
                     /locus_tag="MED193_02825"
     CDS             581834..582868
                     /locus_tag="MED193_02825"
                     /note="COG0031 Cysteine synthase"
                     /codon_start=1
                     /transl_table=11
                     /product="pyridoxal-phosphate dependent enzyme"
                     /db_xref="CDD:9907"
                     /translation="MRIARDLADAIGHTPLIRLNRVSDETGCEILGKAEFMNPGQSVK
                     DRAALYIIKDAIARGDLKPGGTIVEGTAGNTGIGLALVGASMGFKTVIVIPETQSEEK
                     KDMLRLAGAQLVQVPAAPYRNPNNFVRYSERLANELAKTEPNGAIWANQFDNVANRQA
                     HVETTGPEIWEQTDGKVDGFTCAVGSGGTLAGVAEVLQPKGVKVALADPMGAGLYSYY
                     TTGEIAMEGGSIAEGIGQVRITKNLEGLKPDFNYQITDTEALPYVFDLLHEEGLVLGG
                     SSAINIAGAVRLAKEMGPGKTIVTILCDYGTRYQSKLFNPDFLREKDLPVPDWMTHAP
                     ASIPGVFEDV"
     gene            582865..585396
                     /locus_tag="MED193_02830"
     CDS             582865..585396
                     /locus_tag="MED193_02830"
                     /note="COG3264 Small-conductance mechanosensitive channel"
                     /codon_start=1
                     /transl_table=11
                     /product="mechanosensitive ion channel family protein"
                     /db_xref="CDD:12600"
                     /translation="MSRVLGQNAQANKGATDLWPHALSWRLICALALWLCLAVLGSVA
                     LSGSAWAQERTQQQIYLEDWQNTALRAERAIDSSRASTAAFEQLRKELAEFRQQFQAE
                     RSKNTQRIQTLNKQIEALGAAPADGESEPEDIAILRSQLTLQLNQLNVPRIVAEQAFS
                     RADGLVSEVDTIIRERRTRYLLERGPSPLNPELWPAAFETLFRAGRTLWLETRTKIGS
                     DTTIEKIWGGMPDLLALVLLGSFLLFWGRSWARRLGEHLRGLGARGTGLWTFVVSLLQ
                     VALPFLGIMLLATALELAGVLGVRATLMLEHLPAWAFILLSFHWLGDQLFKTSREVNL
                     LPLAVVRRGEARLMIDLLAVTLVLQDLLIQLYLLENTGQDTQAVLSFPLILVAALVLY
                     RLHKIGGARSRAPQEERDPEQETRISAGASRVFEVVRRGAFFLGVVAPVLAAIGYINA
                     AEALIYPAIQTLLLLAALFVLQRFAGDLYGFASRQGEAARDSLVLVAIGFTLSLLSLP
                     VLALIWGARVADLTEIWSRFLLGFQIGDTQISPVAFLSFVVVFAIGYGVTRVVQSSLR
                     TSLLPKTNIDPGGQNAIVSGLGYVGVFLAALVAISMAGLDLSSLAIVAGALSVGIGFG
                     LQTIVSNFVSGIILLVERPISKGDWIEVGGLMGYVRDISVRSTRIETFDRSDVIVPNS
                     DLITGTVTNYTRGNTVGRVIVPVGVAYGTDPRRVEAILKEIAQSHPMVLLNPAPSVIF
                     QGFGADSLDFEIRAILRDVNWVLAVKSDLNFEIAKRFAAEDIEIPFAQRDLWIRNPEA
                     LVAGRAQEPEPGQDREARGSEGGAAGPDLDDLQASEADGEPDIDR"
     gene            585511..585678
                     /locus_tag="MED193_02835"
     CDS             585511..585678
                     /locus_tag="MED193_02835"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MGKGPRWSCICLIEKGFEKGVIFVRTGLAIPFLIGQKSAQRRGG
                     RVVEGARLESV"
     gene            585632..585718
                     /locus_tag="MED193_t03122"
     tRNA            585632..585718
                     /locus_tag="MED193_t03122"
                     /product="tRNA-Ser"
     gene            complement(586452..587054)
                     /locus_tag="MED193_02840"
     CDS             complement(586452..587054)
                     /locus_tag="MED193_02840"
                     /note="COG3665 Uncharacterized conserved protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:12988"
                     /translation="MNHTYTIDARCGVAVRVRAGQQLAVINPSGHQVCDFWVFAADDV
                     GEYSSMEHLHTALGSIFPKVGDGVTSNLRRPLMTIMEDTSVGVHDTIIACCDHARYQQ
                     LGCTVYHDNCADNLRQALMAIGLKAPAIPAPFNLWMNVPVKADGSTSFAPPVSKPGDQ
                     MAFRADMDVIAVMSACPQDVTPVNGVGVAPDILEFYVTGT"
     gene            587442..588179
                     /locus_tag="MED193_02845"
     CDS             587442..588179
                     /locus_tag="MED193_02845"
                     /note="COG0434 Predicted TIM-barrel enzyme"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10308"
                     /translation="MDRNDFKQNFGATGPVILPVIHVLDSEQAEQNIKTAVAGGCSGV
                     FLINHDFEKEKLVPIIKEMRQAFPDIWLGVNFLAVTGKYAFPILGELQKNGCKVDGYW
                     ADDARMDERRAEHDQPEADEIDAIRDSSGWTGLYIGGTAFKKQRDVDPAQYGKSARIA
                     TNYMDVVVTSGVATGHAADVSKIDTFREHCGDTALGLASGITPENAAQYADAVDLFMV
                     ATGINHDGDFYNIDPERLKRLMDLTQT"
     gene            588192..588812
                     /locus_tag="MED193_02850"
     CDS             588192..588812
                     /locus_tag="MED193_02850"
                     /EC_number="2.4.2.7"
                     /note="COG0503 Adenine/guanine phosphoribosyltransferases
                     and related PRPP-binding proteins"
                     /codon_start=1
                     /transl_table=11
                     /product="adenine phosphoribosyltransferase"
                     /db_xref="CDD:10374"
                     /translation="MAQDKGPRYDRWYFSLMAPNTKGDKFAWLDPTSIYINGKAYHDL
                     LDDLVADLDADEIDVIAGLDAMGFVLAAGIAARIGKGFLPIRKPGKLCVDTDSASMTN
                     YSGQTQSMEMRLPAFAPGTRVLLVDQWVETGGTMHGAVQLVEQQKGTVAGMVAIVMEE
                     NDNTKSYREKYKVVTAIQPGTEWQRQANAQYLESFKTYKPEMAFPI"
     gene            588865..589797
                     /locus_tag="MED193_02855"
     CDS             588865..589797
                     /locus_tag="MED193_02855"
                     /EC_number="2.7.6.1"
                     /note="COG0462 Phosphoribosylpyrophosphate synthetase"
                     /codon_start=1
                     /transl_table=11
                     /product="ribose-phosphate pyrophosphokinase"
                     /db_xref="CDD:10335"
                     /translation="MKLICGNSNRPLAEAIAAHMRVPLAECNVRRFADEEVFVEIQEN
                     VRGDDVYVIQSTSYPANDNLMELLVLIDALRRSSAGRITAVIPYFGYARQDRKSAPRT
                     PITAKLVANMITQAGAHRVLTMDLHAGQIQGFFDIPTDNLYAVPEIVRDIEKQKDRDN
                     VMVVSPDVGGVVRARALAKRLSTGLAIVDKRRDKPGSSEVMNIIGDVSGKSCMLVDDI
                     IDSGGTLCSAATALLESGAAEVSAYITHGVLSGKAVDRINASDLSSLVITDTIGATDA
                     VTASSKIREISISPMFAKAITRIANGESVSVLFE"
     gene            589871..590755
                     /locus_tag="MED193_02860"
     CDS             589871..590755
                     /locus_tag="MED193_02860"
                     /note="COG0583 Transcriptional regulator"
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator, LysR family"
                     /db_xref="CDD:10453"
                     /translation="MGAVNLSTELLRAFITVIEVASFTRAAEILGRTQPAISLQVKRL
                     EEAVGYPLIARKGKEISLTERGEALAIHARQILRLNDLAMAEFEQRDPAARLRVGLPV
                     DYAVNTLQACLTDVVRQFPDTQIEIRCDLSKHLLMAMRSNEIDIAVALFDGDDQQFLF
                     RNWKEQPTWVGANAFEIPENTDIPLVAHPYGCVYRDRMATALKLAGKSWRIAYSSPGI
                     GGVQRAVQDGLGLSCLTAPTVQSGMRTFSEQDGLPVLAPLHIGLFARQAQLGAGGYAA
                     MDAMINTLEQRSSSAVDA"
     gene            590940..592043
                     /locus_tag="MED193_02865"
     CDS             590940..592043
                     /locus_tag="MED193_02865"
                     /note="COG0687 Spermidine/putrescine-binding periplasmic
                     protein"
                     /codon_start=1
                     /transl_table=11
                     /product="probable binding protein component of ABC
                     transporter"
                     /db_xref="CDD:10556"
                     /translation="MNRRQLLKAGGAAVLTTPFVSRAWAATTEINMLAWYGHGEPDVV
                     AEYEEANNVKFVPKYYAGGDNMLALIAQSPPGTYDLILSDAEFVQQLNAAGYIEEMNA
                     ADYPLDDMLHEDFSQFPGHWADGKMYSMILRGGHLGVSYNKNSVTEEEAQSYACFWKP
                     ELEGKVGHFDWHLPTLGMMSLYDGNGAGLWDLNDDQWAKVQETTMSLRKQVGGFFDYG
                     GTFNGLKNGEMQAMCGIGDWITGVLEKDGAPVASVIPKEGGIQFTESYSIGKGSEKAD
                     EAKKFIQYMMSPAGQVKSAQMAAYPGFCVTKAGRAALVEADMAEAKRSHQIDGDSQDP
                     ITLIKEGRIHYRDIPQQQTLEDWNDFWSEYKSA"
     gene            592115..592978
                     /locus_tag="MED193_02870"
     CDS             592115..592978
                     /locus_tag="MED193_02870"
                     /note="COG1176 ABC-type spermidine/putrescine transport
                     system, permease component I"
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease protein"
                     /db_xref="CDD:10894"
                     /translation="MSSNPEQRPNLYALTWRLPIIFWQLIFFVGPVLFMVAMSFFLVK
                     NYRMTEAFEFVNWSRMLTRGFFWDSYWYTIGIATLSTVCAMCIAFPAAFALAFRASES
                     TRRWAIFLLIIPFFTSYLVRTFSWFVILSESGVVNAMLGYVGLGPYTMLNTNFGTLVG
                     YMTLTLPLVVILQTVTMANIDKNLIEAARNLGCSPLRTIWQVIIPLSKTGLIIAAIFC
                     FILSFGDFVAPFYLGGSQEPTLPILILDTTKSGQQWPRAAVVAIMMMVTLFAIAFTGI
                     ALAYRKGKGAK"
     gene            592975..593775
                     /locus_tag="MED193_02875"
     CDS             592975..593775
                     /locus_tag="MED193_02875"
                     /note="COG1177 ABC-type spermidine/putrescine transport
                     system, permease component II"
                     /codon_start=1
                     /transl_table=11
                     /product="permease protein of polyamine ABC transporter"
                     /db_xref="CDD:10895"
                     /translation="MKQSRSLNFILGIYVVLIFAFVFAPIIFSMIFSFNSQRFPTIPL
                     GEFSTEWYAKVLADPDIWKAARNSLIVSCSTAVIATFLGFCTAYSDFRYNFRFKGPYL
                     ALILLPPTIPLIIMALAMLAWLSKIGMSGQLYSIIIAHSVLTAPFAMAVIRLRLNQMD
                     PDLESAAWNLGGSEWQTMRHVIIPFCKPAIFSSLFLTAAVSFDEFAVSWFVSGLNSTL
                     PVVVLEIVQGNIDPQVNAIGTFVFLTSMTLVVLAQLFFASRQIKGIQS"
     gene            593772..594857
                     /locus_tag="MED193_02880"
     CDS             593772..594857
                     /locus_tag="MED193_02880"
                     /note="COG3842 ABC-type spermidine/putrescine transport
                     systems, ATPase components"
                     /codon_start=1
                     /transl_table=11
                     /product="Spermidine/putrescine transport ATP-binding
                     protein potA"
                     /db_xref="CDD:13158"
                     /translation="MTKPLVVFDKVQKHFGNFVAVKELDFEIREGEFLAIMGPSGCGK
                     TTTLRMLAGLEAPSIGEIRLNGQVMNDVAPHERDTPLVWQSLALFPFLTARENVEFGL
                     KMRGVDKAERKERAFKWLDKMGILEFENRHISTLSGGQKQRVALARSLVMEPQILLLD
                     EPLSALDAHLVIRMQAVLTDLQRELGITFVYVTHSQSEAFAMADRVIIMGKGEIGQIG
                     TPKEIYRAPANQFVAEFVGRNNILAGKVKSVDGGTARITTPSGEFTVPTNEVNLVEDH
                     NASFVISADLVHIATEEPDGGNKAYCKLISEEFVGSMVTLFLEDAQGHEFKVQMQERE
                     LSKFDLHSGDEIWLSWDTQSAHVLNES"
     gene            594908..595756
                     /locus_tag="MED193_02885"
     CDS             594908..595756
                     /locus_tag="MED193_02885"
                     /note="COG0726 Predicted xylanase/chitin deacetylase"
                     /codon_start=1
                     /transl_table=11
                     /product="putative saccharide deacetylase, slightly
                     similar to NodB protein"
                     /db_xref="CDD:25772"
                     /translation="MAITFDMDADSLIHIAKPEDSHDRLYPISMGRYGPLVALPRILD
                     TYRRLGLKQSFFIPGWCLETYPDVAEAILKDGHEIGHHGYLHEDPIKTRGEQREWFER
                     TLDAHLRICGQKPRGYRAPVYNITHEVVDLMIEHGIRYDSSMMADDIPYRLDTEGGSL
                     YEMPVHWGTDDWPPFAHYDEIGYMMPVRGPSQGLAGFWEEFEAQYDAGGFFMLIIHPF
                     LTGRLARWKQVEAWIAKTQETKDVWFATLDEIADHMDHLQKDGIWTPSVERLPYYDGP
                     ILGDTT"
     gene            595753..596196
                     /locus_tag="MED193_02890"
     CDS             595753..596196
                     /locus_tag="MED193_02890"
                     /note="COG0590 Cytosine/adenosine deaminases"
                     /codon_start=1
                     /transl_table=11
                     /product="cytosine deaminase"
                     /db_xref="CDD:28033"
                     /translation="MNADDTRLLRIAYEEAKAGFDEGGCPIGSVLARGGEVVAQGRNQ
                     RVQKGDPIAHGEMDALRKAGRQKTYRDTTLYTSLSPCMMCTGTIIQFGIPRVVIGENK
                     NFGGNEEFLRSKGVEVIVADDPDCIALMRRFIDEEPELWAEDIAE"
     gene            complement(596326..596985)
                     /locus_tag="MED193_02895"
     CDS             complement(596326..596985)
                     /locus_tag="MED193_02895"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family element, transposase orfB"
                     /db_xref="CDD:25582"
                     /translation="MTEELKEIGLNVGHRRVGRLMRQNGISVVRTRKHKVTTDSDHKF
                     NIAPNLLDRNFSADLPNQKWAGDISYVWTREGWLYLAVILDLHSRRVIGWAVSNRMKR
                     DLAIRALNMAIAFRQPPKGCIHHTDRGSQYCSHDYQKILRQNGFKVSMSGKGNCYDNA
                     AVETFFKTIKAELIWRHPWETRRKAEMAIFEYINGFYNPRRRHSALGWKSPVAFERKV
                     A"
     gene            complement(597180..597455)
                     /locus_tag="MED193_02900"
     CDS             complement(597180..597455)
                     /locus_tag="MED193_02900"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:23225"
                     /translation="MGLKRTDEFRQDAVRIALTSGLTRKQVADDLGVGMSTLNKWITA
                     HRDTDVVSKEDLSLAQENDRLRRENRLLKEEREILKKATQFFAGLKQ"
     gene            complement(597732..597983)
                     /locus_tag="MED193_02905"
     CDS             complement(597732..597983)
                     /locus_tag="MED193_02905"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="ISxac3 transposase"
                     /db_xref="CDD:23225"
                     /translation="MSGQIRYSDEFKIDAVAQVTERGYSVKDVANRLGISTKSLYTWM
                     AQFSKPQRQTDQEAEVRRLKKELARVGTTADRTVCNYRA"
     gene            complement(598072..599697)
                     /locus_tag="MED193_02910"
     CDS             complement(598072..599697)
                     /locus_tag="MED193_02910"
                     /note="COG3409 Putative peptidoglycan-binding
                     domain-containing protein"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MRWGDYLTKTVLFVYIRGRVNLRENYMKKSLIAAWVALTLLATP
                     AQAQQEKYLIRELQKMLNYLGYEAGEADGISGSQTRSALDRAATSTGTNFSGKTLKKI
                     NAELRKLVSTARMTSGRPKVTDEFALSQSKQHWFNRYLYPIDLDGDNLDELIIAGFES
                     QGQKHSDISASRIAIFAWRGFQLVEVTSDWLNEVENVFFGVGDIATGDFNGDGTVDIF
                     LSAYTDSDKKVDAYVLYNVGGRFERQRIDRAGWQHGAAVGDLNADGISDVFAAGYHGS
                     YALYLGTLDGLQKYKFSSQRYFGGSGAAFGKFLGTSEVLLLLTDNAGRNRSPRLDSNL
                     YRVILDKKRKTAKLELIAHLPHPEFEGREWDHFFSASSRRSHEIRARAIDLNGDRFED
                     LMIVSTGVYSKTRTGLHLSAIQLIESTSSGFENVTHKRVIGHNYIAGPPYSPVLRDLD
                     GDGDMDIFISEQDSHGFADSTDVFLQDENGMFVSIGSDALLSVMPASAHADIATAMRG
                     PNGKMYFVRTQTKRKLGLPTHSLVYAVMAFDKG"
     gene            complement(599783..600772)
                     /locus_tag="MED193_02915"
     CDS             complement(599783..600772)
                     /locus_tag="MED193_02915"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="Integrase core domain containing protein"
                     /db_xref="CDD:25582"
                     /translation="MKAQVAILRARIPTQRIILSPAEKAELLRIGAEIGHDVDGLMEV
                     AKPATYKRWLAQMRAGRPFKAVGRPRLTQELRDVVTRIGSENLLWGYKRIVGELKKLG
                     LYAGANSVKRILNEAGIHPSPERRNKKPALPWSTFISAHMESMVACDFFTKTVFTLRG
                     PRTAYVLMFIHLGSRRVYCSAPSYSPDSAWVTQQARNTLMWCAEQGISPSFLIRDADT
                     KFSASYDAVWTSEGARIIQTPHRAPDANAFAESFIGTIKRECLDFFVCLSRSQLDYIL
                     RTWVRHYNVDRPHRGRDIGNNVLQVDFQPIRDGPIRRNRQLGGIVTSYTRDAA"
     gene            complement(600912..601040)
                     /locus_tag="MED193_02920"
     CDS             complement(600912..601040)
                     /locus_tag="MED193_02920"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLSIATTHISGPKNPDMPPALAKFRPFTDTDVFDIYERGAKM"
     gene            complement(601219..602073)
                     /locus_tag="MED193_02925"
     CDS             complement(601219..602073)
                     /locus_tag="MED193_02925"
                     /note="COG2801 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /db_xref="CDD:25582"
                     /translation="MSLSERREMIRKDNTDLSLTRQCKLLKISRSSIYYTPVGFDQAT
                     IDLMHEIDRIFTKYPFFGSRQIAAYLPQSGFSAGRHRVRRLMGIMGLQAIYKGPNTSK
                     KHPQHKIWPYLLRKLSITRPNHVWCSDITYIPVKNGFLYLVAIMDWATRKVLSWRLSN
                     TLDASFCVEALDEAIAKYGKPEIMNTDQGSQYTGADWIKTLTKADIKISMDGRGRYLD
                     NIFIERLWRSLKQEAVYLHEITNGFQAKRIIDDWIGFYNAERPHTALDKRTPDAAYFE
                     QSETRKAA"
     gene            complement(602070..602348)
                     /locus_tag="MED193_02930"
     CDS             complement(602070..602348)
                     /locus_tag="MED193_02930"
                     /note="COG2963 Transposase and inactivated derivatives"
                     /codon_start=1
                     /transl_table=11
                     /product="transposase (class V)"
                     /db_xref="CDD:23225"
                     /translation="MTKRRNFSDKFKATVALEALRGDKTVQEIASKRQLHPTQVSTWK
                     RQAIDGMVNVFSDKVKKAENKDGEIKELHAKIGQLAVENDFLSQGLKR"
     gene            complement(602737..603369)
                     /locus_tag="MED193_02935"
     CDS             complement(602737..603369)
                     /locus_tag="MED193_02935"
                     /note="COG2197 Response regulator containing a CheY-like
                     receiver domain and an HTH DNA-binding domain"
                     /codon_start=1
                     /transl_table=11
                     /product="Two Component Transcriptional Regulator, LuxR
                     family"
                     /db_xref="CDD:11904"
                     /translation="MYKTMVICDHVFTRAGFQHLIEPCAGFDLQAAAAYSPEIVETCS
                     RDGYEVVIVDLGSLDQPMKVLRAFRKSCDMVRILAFCSQKGIDMAVDALDAGASGILT
                     YNSEMSDLRAAARRVMNGDNYVQPDMAMDIFAKLRQAEAKRKEAERLRLTARESQVVR
                     HLMQGMTNRQISAELNISEKTVKHYVGSLKDKFGAANRLEVVLEAQRLGV"
     gene            604045..604968
                     /locus_tag="MED193_02940"
     CDS             604045..604968
                     /locus_tag="MED193_02940"
                     /note="COG0642 Signal transduction histidine kinase"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /db_xref="CDD:10512"
                     /translation="MLTMSRDTSLSKVLVVLITLVGAELCIMLALAEVEKQLTWLTEH
                     VWGEAALDALLLFCIMAPVFYWLLIRPLQRSNTIKLRFIDMVSDDLRNTLNALQGIAM
                     ASREDPSLAAGLETARQEALQWMQLRVERVVAFSALDAEASLPTGRPTDLQGLAAELH
                     KRFEFMFQANGNSLNIRCEGPHLSIGPTQSEILMQLMFSMLEIARMSSGDAATHVSIQ
                     TSHEGADRILIRTTHVGKTAPCNTANGAVTGPFERIKLAGDILEYMATRAGCDYISES
                     ACSQSLIIPIKRPTSLDEAGIRPLSRPLFRR"
     gene            complement(604958..607087)
                     /locus_tag="MED193_02945"
     CDS             complement(604958..607087)
                     /locus_tag="MED193_02945"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MTLAMDCKKRNRDIEEDSMSEESFQISFTRDGETRVITLEGSRK
                     DYEFEYEDLELEIEAREGDFEWEFEDVESFEFLSFGSEDDLVDSGVSSPEPDRVVTLS
                     GPLHDFDFLLQDGALAVRNRFDGEIESLSEFDSFVAGVETFRTADILAQLEQPGPDLL
                     AEGGPRLMMVNTPEATPSVIWDQILQSIIVESGGGPTNASQSFSIMHTAIYDAQASYD
                     PVAQRVSIDIEGDNLELSALSDASDTEIETAMHVAAHRVLSELYPQYQEKFDQVLSQR
                     LELDVSDDSQAYEVGIDAAQDGLTPRQAEAARLAAQSEGFYTPVNSDPAPETRKDIAR
                     WTPEKQGILSPTPDALQTFLTPELSLAEGFALPETLNGETDTVLTRPDGPEPFFTLEH
                     VDTLLDFQTRTMTLAAPAEINGVAVAAGTTIPVDKFLIGPVINPAFIAQAEAIVQTSA
                     TLTEDQKMVAEFWEDGPGTSFPPGAWMTLGQYVSQRDGHDAATDALLFMTMGNAMFDA
                     AIATWDAKAFFDYARPVTVIRDLGHLGLIGEQGVDELTGETGFVIQALGGIDPDTGTS
                     FGTRTILAENFITYQLPGGEQSPPFAEYTSGHSTFSAAGAAVLKAFTGSDHLDAHITV
                     PPGTSAFDAALPGDVYQFQWDTFSEAAIDAGASRIYGGIHFSDGNLDGLSAGADIGAD
                     AYALAVDFASGTAQPEQQPFFDEFFIA"
     gene            complement(607176..607589)
                     /locus_tag="MED193_02950"
     CDS             complement(607176..607589)
                     /locus_tag="MED193_02950"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MLRNILPTLALLVASSATAQEKNMTWKALEGDRLNLNGMIINVH
                     GISCPPPILASGMSAKRLANTFLRGGVVVCATSLTEDGSEFVDCAKQGNNGLTLSQML
                     VFSDLCIPLRDQECLPLFIDALPTYALPPPRPRDG"
     gene            complement(607594..608922)
                     /locus_tag="MED193_02955"
     CDS             complement(607594..608922)
                     /locus_tag="MED193_02955"
                     /note="COG0845 Membrane-fusion protein"
                     /codon_start=1
                     /transl_table=11
                     /product="putative toxin secretion transmembrane protein"
                     /db_xref="CDD:25537"
                     /translation="MSRKTTDPNAAKNAIYSFRGHVITGIFMAGLLVAAVFGWAANSN
                     LVSAVVVSGEVSVDRDLRVVQHRDGGIVKDIPVSAGDHVRKGDILLRLDDTSASTERA
                     ILHGKIAELAIRKSRLEAQRDLHEEFSTPSGLDEFIVSPAALQAIYVGEHRIFEGNLS
                     SFIRRKEQIDLGIEQVRTEIDGLEARLDAKQDEILLVQAESARVEDLSERQLTVRNVA
                     FSIERENVRLRGEHGEILSALGRARSRVSELELEILSMQETLRTDAQRELREIETQLS
                     ELTEKRFVIEDTLSRTAIRAPISGLINDMNVNSVGGVISPAEILATIVPEEAELVFTA
                     RVPAASIEQVDTGHAARMRFVAFDQNETPEIEGTVSYVAAAATSDPQMPGDFYSIKVD
                     VTPDQLARLGGKELRPGMPVEVYVTTAERTALSYLVKPFSDQFARAFKER"
     gene            complement(608937..610610)
                     /locus_tag="MED193_02960"
     CDS             complement(608937..610610)
                     /locus_tag="MED193_02960"
                     /note="COG1530 Ribonucleases G and E"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /translation="MIEVKSSKKAKTPGTARLEDMVSLRETVSAIPKRKIGMGVTVMF
                     ALIAYIKTLFGGSEVAA